SK322192A3 - Substituted pyrimidines, process for their preparation, pharmaceutical composition containing the same and their use - Google Patents

Substituted pyrimidines, process for their preparation, pharmaceutical composition containing the same and their use Download PDF

Info

Publication number: SK322192A3
Authority: SK; Slovakia
Prior art keywords: methyl; formula; compound; pyrimidin; pharmaceutically acceptable
Prior art date: 1991-10-24

Application number

SK3221-92A

Other languages

English (en)

Slovak (sk)

Other versions

SK280292B6 (sk

Inventor

John W Ellingboe

Madelene Nikaido

Jehan F Bagli

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-24

Filing date

1992-10-26

Publication date

1999-11-08

1991-10-24 Priority claimed from US07/782,025 external-priority patent/US5149699A/en

1992-04-07 Priority claimed from GB9207560A external-priority patent/GB2265899A/en

1992-06-25 Priority claimed from US07/901,485 external-priority patent/US5256654A/en

1992-10-26 Application filed by American Home Prod filed Critical American Home Prod

1999-11-08 Publication of SK280292B6 publication Critical patent/SK280292B6/sk

1999-11-08 Publication of SK322192A3 publication Critical patent/SK322192A3/sk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SK3221-92A 1991-10-24 1992-10-26 Substituted pyrimidines, process for their preparation, pharmaceutical composition containing the same and their use SK322192A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/782,025 US5149699A (en)	1991-10-24	1991-10-24	Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560A GB2265899A (en)	1992-04-07	1992-04-07	Substituted pyrimidines
US07/901,485 US5256654A (en)	1991-10-24	1992-06-25	Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists

Publications (2)

Publication Number	Publication Date
SK280292B6 SK280292B6 (sk)	1999-11-08
SK322192A3 true SK322192A3 (en)	1999-11-08

Family

ID=27266132

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK3221-92A SK322192A3 (en)	1991-10-24	1992-10-26	Substituted pyrimidines, process for their preparation, pharmaceutical composition containing the same and their use

Country Status (21)

Country	Link
EP (1)	EP0539086B1 (es)
JP (1)	JP3240192B2 (es)
KR (1)	KR100286624B1 (es)
CN (2)	CN1039324C (es)
AT (1)	ATE161537T1 (es)
AU (1)	AU653635B2 (es)
CA (1)	CA2080705C (es)
DE (1)	DE69223734T2 (es)
DK (1)	DK0539086T3 (es)
ES (1)	ES2111617T3 (es)
FI (1)	FI103971B1 (es)
GR (1)	GR3025926T3 (es)
HK (1)	HK1003031A1 (es)
HU (2)	HU218786B (es)
IL (1)	IL103436A (es)
LV (1)	LV12047B (es)
NO (1)	NO301275B1 (es)
SG (1)	SG47626A1 (es)
SK (1)	SK322192A3 (es)
TW (1)	TW226375B (es)
UA (1)	UA27748C2 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE395341T1 (de) *	1991-11-18	2008-05-15	Du Pont	2-(2'-triphenylmethyl-2'h-tetrazol-5'- yl)phenylborsäure als zwischenprodukt zur synthese von a ii receptorenantagonisten
DE69415706T2 (de) *	1993-03-24	1999-05-20	American Home Products Corp., Madison, N.J.	Substituierte Pyridopyrimidine als Antihypertensiva
ES2129850T3 (es) *	1994-09-20	1999-06-16	Wakunaga Seiyaku Kk	Procedimiento de produccion de un derivado de n-bifenilmetiltiadiazolina o una sal de este y su producto intermediario de produccion.
IT1292437B1 (it) *	1997-06-30	1999-02-08	Zambon Spa	Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US6638937B2 (en)	1998-07-06	2003-10-28	Bristol-Myers Squibb Co.	Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
PE20020617A1 (es)	2000-08-22	2002-08-05	Novartis Ag	Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina
US8168616B1 (en)	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0327839D0 (en)	2003-12-01	2003-12-31	Novartis Ag	Organic compounds
GB0402262D0 (en)	2004-02-02	2004-03-10	Novartis Ag	Process for the manufacture of organic compounds
NZ549535A (en)	2004-03-17	2010-11-26	Novartis Ag	Use of aliskiren for treating renal and other disorders
JP2008515903A (ja)	2004-10-08	2008-05-15	ノバルティスアクチエンゲゼルシャフト	拡張機能障害または拡張期心不全の予防または処置のためのレニン阻害剤の使用
EP1749828A1 (en)	2005-08-04	2007-02-07	Farmaprojects S.L.	Process for preparing an angiotensin II receptor antagonist
EP2117540A1 (en)	2007-03-01	2009-11-18	Probiodrug AG	New use of glutaminyl cyclase inhibitors
US9656991B2 (en)	2007-04-18	2017-05-23	Probiodrug Ag	Inhibitors of glutaminyl cyclase
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2559319T3 (es)	2007-06-04	2016-02-11	Synergy Pharmaceuticals Inc.	Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
EP2160190B1 (en) *	2007-06-07	2015-11-04	SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.	5beta, 14beta-androstane derivatives useful for the treatment of diseases due to organ fibrosis
JP2011522828A (ja)	2008-06-04	2011-08-04	シナジーファーマシューティカルズインコーポレイテッド	胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
WO2010009319A2 (en)	2008-07-16	2010-01-21	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
AU2010294214B2 (en)	2009-09-11	2015-05-07	Vivoryon Therapeutics N.V.	Heterocylcic derivatives as inhibitors of glutaminyl cyclase
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
KR101790806B1 (ko)	2010-03-10	2017-11-20	프로비오드룩 아게	글루타미닐 사이클라제(ｑｃ, ｅｃ 2.3.2.5)의 헤테로사이클릭 억제제
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
DK2686313T3 (en)	2011-03-16	2016-05-02	Probiodrug Ag	Benzimidazole derivatives as inhibitors of glutaminyl cyclase
US20130158080A1 (en)	2011-12-15	2013-06-20	Takeda Pharmaceuticals U.S.A., Inc.	Methods for treating hypertension in black patients
US9708367B2 (en)	2013-03-15	2017-07-18	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
EP2968439A2 (en)	2013-03-15	2016-01-20	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
PT3004138T (pt)	2013-06-05	2024-06-18	Bausch Health Ireland Ltd	Agonistas ultrapuros de guanilato ciclase c, método de produção e utilização dos mesmos
DK3461819T3 (da)	2017-09-29	2020-08-10	Probiodrug Ag	Inhibitorer af glutaminylcyklase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0407342A3 (en) *	1989-07-06	1991-07-10	Ciba-Geigy Ag	Pyrimidine derivatives
US5100897A (en) *	1989-08-28	1992-03-31	Merck & Co., Inc.	Substituted pyrimidinones as angiotensin ii antagonists
EP0415886A3 (en) *	1989-08-30	1991-10-23	Ciba-Geigy Ag	Aza compounds
CA2075637A1 (en) *	1990-02-13	1991-08-14	William J. Greenlee	Angiotensin ii antagonists incorporating a substituted benzyl element
US5149699A (en) *	1991-10-24	1992-09-22	American Home Products Corporation	Substituted pyridopyrimidines useful as antgiotensin II antagonists

1992
- 1992-08-27 TW TW081106755A patent/TW226375B/zh active
- 1992-09-30 FI FI924397A patent/FI103971B1/fi not_active IP Right Cessation
- 1992-10-01 AU AU26079/92A patent/AU653635B2/en not_active Ceased
- 1992-10-06 HU HU9203161A patent/HU218786B/hu not_active IP Right Cessation
- 1992-10-14 EP EP92309333A patent/EP0539086B1/en not_active Expired - Lifetime
- 1992-10-14 DK DK92309333.0T patent/DK0539086T3/da active
- 1992-10-14 AT AT92309333T patent/ATE161537T1/de not_active IP Right Cessation
- 1992-10-14 SG SG1996003253A patent/SG47626A1/en unknown
- 1992-10-14 DE DE69223734T patent/DE69223734T2/de not_active Expired - Fee Related
- 1992-10-14 ES ES92309333T patent/ES2111617T3/es not_active Expired - Lifetime
- 1992-10-15 IL IL10343692A patent/IL103436A/en not_active IP Right Cessation
- 1992-10-16 CA CA002080705A patent/CA2080705C/en not_active Expired - Fee Related
- 1992-10-23 KR KR1019920019580A patent/KR100286624B1/ko not_active IP Right Cessation
- 1992-10-23 JP JP28588592A patent/JP3240192B2/ja not_active Expired - Fee Related
- 1992-10-23 NO NO924121A patent/NO301275B1/no not_active IP Right Cessation
- 1992-10-23 CN CN92113781A patent/CN1039324C/zh not_active Expired - Fee Related
- 1992-10-26 SK SK3221-92A patent/SK322192A3/sk unknown
1993
- 1993-06-18 UA UA93003129A patent/UA27748C2/uk unknown
1995
- 1995-06-29 HU HU95P/P00549P patent/HU211915A9/hu unknown
1997
- 1997-05-13 CN CN97111592A patent/CN1175414A/zh active Pending
1998
- 1998-01-15 GR GR980400096T patent/GR3025926T3/el unknown
- 1998-03-09 LV LVP-98-45A patent/LV12047B/en unknown
- 1998-03-12 HK HK98102075A patent/HK1003031A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO924121L (no)	1993-04-26
JP3240192B2 (ja)	2001-12-17
TW226375B (es)	1994-07-11
KR100286624B1 (ko)	2001-05-02
FI924397A0 (fi)	1992-09-30
SG47626A1 (en)	1998-04-17
CN1039324C (zh)	1998-07-29
ATE161537T1 (de)	1998-01-15
NO301275B1 (no)	1997-10-06
SK280292B6 (sk)	1999-11-08
LV12047B (en)	1998-08-20
HK1003031A1 (en)	1998-09-30
HUT62893A (en)	1993-06-28
AU2607992A (en)	1993-04-29
EP0539086A2 (en)	1993-04-28
DK0539086T3 (da)	1998-02-02
FI924397A (fi)	1993-04-25
FI103971B (fi)	1999-10-29
FI103971B1 (fi)	1999-10-29
CA2080705C (en)	2002-12-03
HU218786B (hu)	2000-12-28
EP0539086A3 (en)	1993-06-16
ES2111617T3 (es)	1998-03-16
EP0539086B1 (en)	1997-12-29
IL103436A (en)	1996-03-31
AU653635B2 (en)	1994-10-06
DE69223734T2 (de)	1998-04-16
HU9203161D0 (en)	1992-12-28
IL103436A0 (en)	1993-03-15
CN1072682A (zh)	1993-06-02
GR3025926T3 (en)	1998-04-30
KR930007949A (ko)	1993-05-20
HU211915A9 (en)	1996-01-29
DE69223734D1 (de)	1998-02-05
JPH05222039A (ja)	1993-08-31
CN1175414A (zh)	1998-03-11
NO924121D0 (no)	1992-10-23
LV12047A (lv)	1998-05-20
UA27748C2 (uk)	2000-10-16
CA2080705A1 (en)	1993-04-25

Publication	Publication Date	Title
SK322192A3 (en)	1999-11-08	Substituted pyrimidines, process for their preparation, pharmaceutical composition containing the same and their use
RU2113437C1 (ru)	1998-06-20	Замещенные пиримидины, или их фармацевтически приемлемые соли, или n-оксиды, способы их получения и фармацевтическая композиция на их основе
DE69233113T2 (de)	2004-06-03	Kondensierte heterocyclische Verbindungen, ihre Herstellung und Verwendung
IL94282A (en)	1995-12-31	Imadazopyridines and imidazodiazines are converted into their preparations and pharmaceutical preparations containing them
US5466692A (en)	1995-11-14	Substituted pyridopyrimidines and antihypertensives
SK73293A3 (en)	1994-04-06	Benzimidazoles, process for their preparation and medicaments contained this compounds
JPH05186462A (ja)	1993-07-27	複素環式化合物、その製造方法および該化合物を含有する高血圧症およびうつ血性心麻痺用の医薬調剤
US5283242A (en)	1994-02-01	Substituted benzimidazoles and quinazolines as antihypertensives
US5256654A (en)	1993-10-26	Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
EP0618207B1 (en)	1999-01-07	Substituted pyridopyrimidines as antihypertensives
JP2000063275A (ja)	2000-02-29	医薬組成物
JP3466694B2 (ja)	2003-11-17	ピラゾロ〔１，５−ａ〕ピリミジン−７（４Ｈ）−オン誘導体
WO1994000450A1 (en)	1994-01-06	Chromanderivatives as angiotensin ii antagonists
GB2265899A (en)	1993-10-13	Substituted pyrimidines