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SI2651965T1 - Analogne molekule ciklosporina, modificirane pri aminokislini 1 v 3 - Google Patents

Analogne molekule ciklosporina, modificirane pri aminokislini 1 v 3

Info

Publication number
SI2651965T1
SI2651965T1 SI201131640T SI201131640T SI2651965T1 SI 2651965 T1 SI2651965 T1 SI 2651965T1 SI 201131640 T SI201131640 T SI 201131640T SI 201131640 T SI201131640 T SI 201131640T SI 2651965 T1 SI2651965 T1 SI 2651965T1
Authority
SI
Slovenia
Prior art keywords
amino acid
molecules modified
analogue molecules
cyclosporine analogue
cyclosporine
Prior art date
Application number
SI201131640T
Other languages
English (en)
Inventor
Alexander Hegmans
Bruce W. Fenske
Dan J. Trepanier
Mark D. Abel
Shin Sugiyama
Daren R. Ure
Original Assignee
Contravir Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Contravir Pharmaceuticals, Inc. filed Critical Contravir Pharmaceuticals, Inc.
Publication of SI2651965T1 publication Critical patent/SI2651965T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
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  • Biochemistry (AREA)
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  • Obesity (AREA)
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  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
SI201131640T 2010-12-15 2011-12-14 Analogne molekule ciklosporina, modificirane pri aminokislini 1 v 3 SI2651965T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42357610P 2010-12-15 2010-12-15
EP11848865.9A EP2651965B1 (en) 2010-12-15 2011-12-14 Cyclosporine analogue molecules modified at amino acid 1 and 3
PCT/CA2011/050773 WO2012079172A1 (en) 2010-12-15 2011-12-14 Cyclosporine analogue molecules modified at amino acid 1 and 3

Publications (1)

Publication Number Publication Date
SI2651965T1 true SI2651965T1 (sl) 2019-03-29

Family

ID=46243924

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201131640T SI2651965T1 (sl) 2010-12-15 2011-12-14 Analogne molekule ciklosporina, modificirane pri aminokislini 1 v 3

Country Status (25)

Country Link
US (2) US9200038B2 (sl)
EP (2) EP2651965B1 (sl)
JP (3) JP6144627B2 (sl)
KR (3) KR102011339B1 (sl)
CN (2) CN103443119B (sl)
AU (1) AU2011342284C1 (sl)
BR (1) BR112013014890B1 (sl)
CA (1) CA2821009C (sl)
DK (1) DK2651965T3 (sl)
ES (1) ES2705750T3 (sl)
HK (1) HK1243633A1 (sl)
HR (1) HRP20190096T1 (sl)
HU (1) HUE042490T2 (sl)
IL (1) IL226792A (sl)
LT (1) LT2651965T (sl)
MX (1) MX353720B (sl)
MY (2) MY192981A (sl)
NZ (1) NZ611620A (sl)
PL (1) PL2651965T3 (sl)
PT (1) PT2651965T (sl)
RU (1) RU2630690C9 (sl)
SG (2) SG191069A1 (sl)
SI (1) SI2651965T1 (sl)
TR (1) TR201900128T4 (sl)
WO (1) WO2012079172A1 (sl)

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TW201639873A (zh) 2015-01-08 2016-11-16 歐樂根公司 Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物
CN118324867A (zh) * 2016-05-17 2024-07-12 美国科技环球有限公司 新型环孢菌素衍生物及其用途
CA3044526A1 (en) 2016-12-07 2018-06-14 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
WO2018106928A1 (en) 2016-12-08 2018-06-14 Contravir Pharmaceuticals, Inc. Treatment and prevention of hbv diseases by cyclosporine analogue molecules modified at amino acides 1 and 3
EP3554346B1 (en) 2016-12-14 2024-01-31 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with an immunosuppressant
TW201902507A (zh) 2017-04-14 2019-01-16 美商康特維爾製藥公司 治療病毒感染之組合療法
WO2018193114A1 (en) 2017-04-20 2018-10-25 Novintum Biotechnology Gmbh Triphenylphosphonium-tethered tetracycyclines for use in treating cancer
US20230041197A1 (en) 2018-06-20 2023-02-09 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
CA3110250A1 (en) * 2018-08-22 2020-02-27 Bacainn Therapeutics, Ltd. Cyclosporine compositions and methods of use
AR121404A1 (es) * 2020-02-25 2022-06-01 Hepion Pharmaceuticals Inc Uso de análogos de ciclosporina para tratar cáncer
EP4126905A4 (en) 2020-03-26 2024-05-29 Farsight Medical Technology (Shanghai) Co., Ltd. CYCLOPHILIN INHIBITORS AND THEIR USES
CN115315432A (zh) * 2020-03-26 2022-11-08 睿诺医疗科技（上海）有限公司 亲环蛋白抑制剂及其用途
KR20230116002A (ko) * 2020-11-29 2023-08-03 헤피온 파마슈티컬스, 인크. 항혈전제로서 시클로스포린 유사체의 용도
CN113173974B (zh) * 2021-03-18 2024-09-06 北京大学深圳研究生院 环孢素衍生物的合成方法
CN115677533B (zh) * 2021-07-30 2023-12-05 沈阳化工研究院有限公司 一种4-庚基苯甲腈的制备方法
WO2024157132A1 (en) * 2023-01-25 2024-08-02 Indena S.P.A. Process for the preparation of an intermediate useful for the synthesis of voclosporin

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