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SG11202101400UA - Microsatellite instability detection in cell-free dna - Google Patents

Microsatellite instability detection in cell-free dna

Info

Publication number
SG11202101400UA
SG11202101400UA SG11202101400UA SG11202101400UA SG11202101400UA SG 11202101400U A SG11202101400U A SG 11202101400UA SG 11202101400U A SG11202101400U A SG 11202101400UA SG 11202101400U A SG11202101400U A SG 11202101400UA SG 11202101400U A SG11202101400U A SG 11202101400UA
Authority
SG
Singapore
Prior art keywords
cell
free dna
microsatellite instability
instability detection
detection
Prior art date
Application number
SG11202101400UA
Inventor
Aliaksandr Artsiomenka
Marcin Sikora
Catalin Barbacioru
Darya Chudova
Martina I Lefterova
Original Assignee
Guardant Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guardant Health Inc filed Critical Guardant Health Inc
Publication of SG11202101400UA publication Critical patent/SG11202101400UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Data Mining & Analysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Artificial Intelligence (AREA)
  • Public Health (AREA)
  • Evolutionary Computation (AREA)
  • Databases & Information Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioethics (AREA)
  • Software Systems (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11202101400UA 2018-08-31 2019-08-30 Microsatellite instability detection in cell-free dna SG11202101400UA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862726182P 2018-08-31 2018-08-31
US201962823578P 2019-03-25 2019-03-25
US201962857048P 2019-06-04 2019-06-04
PCT/US2019/048999 WO2020047378A1 (en) 2018-08-31 2019-08-30 Microsatellite instability detection in cell-free dna

Publications (1)

Publication Number Publication Date
SG11202101400UA true SG11202101400UA (en) 2021-03-30

Family

ID=67982149

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202101400UA SG11202101400UA (en) 2018-08-31 2019-08-30 Microsatellite instability detection in cell-free dna

Country Status (9)

Country Link
US (3) US11773451B2 (en)
EP (1) EP3844761A1 (en)
JP (2) JP7539367B2 (en)
KR (1) KR20210052511A (en)
CN (1) CN112930569A (en)
AU (1) AU2019328344A1 (en)
CA (1) CA3109539A1 (en)
SG (1) SG11202101400UA (en)
WO (1) WO2020047378A1 (en)

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WO2023287410A1 (en) * 2021-07-14 2023-01-19 Foundation Medicine, Inc. Methods and systems for determining microsatellite instability
WO2023017402A1 (en) * 2021-08-09 2023-02-16 Canexia Health Inc. Methods for identifying microsatellite instability high (msi-h) in dna samples
KR20230023278A (en) * 2021-08-10 2023-02-17 (주)디엑솜 Method of diagnosing microsatellite instability using difference between maximum and minimum value of sequence length at microsatellite locus
KR102688594B1 (en) * 2021-08-10 2024-07-24 (주)디엑솜 Method of diagnosing microsatellite instability using rate of change in sequence length at microsatellite locus
CN113744251B (en) * 2021-09-07 2023-08-29 上海桐树生物科技有限公司 Method for predicting microsatellite instability from pathological pictures based on self-attention mechanism
WO2023225560A1 (en) 2022-05-17 2023-11-23 Guardant Health, Inc. Methods for identifying druggable targets and treating cancer
WO2024103018A2 (en) * 2022-11-11 2024-05-16 Memorial Sloan-Kettering Cancer Center Methods for predicting cancer-associated venous thromboembolism using circulating tumor dna
CN116543835B (en) * 2023-04-21 2024-02-06 苏州吉因加生物医学工程有限公司 Method and device for detecting microsatellite state of plasma sample
CN116312781B (en) * 2023-05-17 2023-08-18 普瑞基准科技（北京）有限公司 Genome instability assessment method and system based on machine learning

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Also Published As

Publication number Publication date
JP2024084802A (en) 2024-06-25
US20240247319A1 (en) 2024-07-25
WO2020047378A1 (en) 2020-03-05
JP7539367B2 (en) 2024-08-23
JP2021535489A (en) 2021-12-16
EP3844761A1 (en) 2021-07-07
CA3109539A1 (en) 2020-03-05
US20230416843A1 (en) 2023-12-28
CN112930569A (en) 2021-06-08
US20210363586A1 (en) 2021-11-25
US11773451B2 (en) 2023-10-03
AU2019328344A1 (en) 2021-04-08
KR20210052511A (en) 2021-05-10

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