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SG11202007494TA - Anti-folate receptor 1 antibodies and uses thereof - Google Patents

Anti-folate receptor 1 antibodies and uses thereof

Info

Publication number
SG11202007494TA
SG11202007494TA SG11202007494TA SG11202007494TA SG11202007494TA SG 11202007494T A SG11202007494T A SG 11202007494TA SG 11202007494T A SG11202007494T A SG 11202007494TA SG 11202007494T A SG11202007494T A SG 11202007494TA SG 11202007494T A SG11202007494T A SG 11202007494TA
Authority
SG
Singapore
Prior art keywords
antibodies
folate receptor
folate
receptor
Prior art date
Application number
SG11202007494TA
Inventor
Minghan Wang
Hui Zou
Haiqun Jia
Original Assignee
Phanes Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phanes Therapeutics Inc filed Critical Phanes Therapeutics Inc
Publication of SG11202007494TA publication Critical patent/SG11202007494TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11202007494TA 2018-03-13 2019-03-07 Anti-folate receptor 1 antibodies and uses thereof SG11202007494TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862642213P 2018-03-13 2018-03-13
PCT/US2019/021084 WO2019177854A1 (en) 2018-03-13 2019-03-07 Anti-folate receptor 1 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
SG11202007494TA true SG11202007494TA (en) 2020-09-29

Family

ID=67906883

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202007494TA SG11202007494TA (en) 2018-03-13 2019-03-07 Anti-folate receptor 1 antibodies and uses thereof

Country Status (13)

Country Link
US (1) US11873335B2 (en)
EP (1) EP3765521A4 (en)
JP (2) JP7433236B2 (en)
KR (1) KR20200132900A (en)
CN (2) CN111954681B (en)
AU (1) AU2019236091A1 (en)
BR (1) BR112020016469A2 (en)
CA (1) CA3091683A1 (en)
EA (1) EA202092125A1 (en)
IL (1) IL276949A (en)
MX (1) MX2020009522A (en)
SG (1) SG11202007494TA (en)
WO (1) WO2019177854A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102275930B1 (en) * 2018-03-14 2021-07-12 (주)알테오젠 Antibody specifically binding to FOLR1 and Use thereof
WO2021126538A1 (en) * 2019-12-17 2021-06-24 Phanes Therapeutics, Inc. Bispecific antibodies with alternatively matched interchain cycteines and uses thereof
TW202233684A (en) * 2020-11-18 2022-09-01 美商泰尼歐生物公司 Heavy chain antibodies binding to folate receptor alpha
CN115491358B (en) * 2021-06-17 2024-09-06 复星凯特生物科技有限公司 Preparation and application of targeting B7-H3 and FOLR1 double-targeting CAR T
CN116462768B (en) * 2023-06-13 2023-09-22 浙江时迈药业有限公司 Bispecific antibodies against FOLR1 and uses thereof
CN118344485B (en) * 2024-06-18 2024-10-15 南京欧凯生物科技有限公司 Anti-folic acid and monoclonal antibody of binding protein complex thereof or antigen binding fragment thereof, preparation method and application thereof

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WO2005080431A2 (en) * 2004-02-12 2005-09-01 Morphotek, Inc. Monoclonal antibodies that specifically bind to folate receptor alpha
US20060239910A1 (en) 2005-04-22 2006-10-26 Morphotek Inc. Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells
EP1900752A1 (en) 2006-09-15 2008-03-19 DOMPE' pha.r.ma s.p.a. Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma
WO2008145136A1 (en) 2007-05-30 2008-12-04 Aarhus Universitet Stat3 inactivation by inhibition of the folate receptor pathway
FR2929946B1 (en) 2008-04-11 2010-05-28 Pf Medicament NOVEL ANTI-CD151 ANTIBODIES AND THEIR USE FOR THE TREATMENT OF CANCER
US8900588B2 (en) 2010-01-08 2014-12-02 Les Laboratories Servier Methods for treating breast cancer
EP2538976B8 (en) * 2010-02-24 2017-05-24 ImmunoGen, Inc. Immunoconjugates against folate receptor 1 and uses thereof
KR20140032944A (en) 2010-10-20 2014-03-17 모르포테크, 인크. Anti-folate receptor alpha antibody glycoforms
ES2627061T3 (en) * 2010-11-05 2017-07-26 Morphotek, Inc. Folate alpha receptor as diagnosis and prognosis for marker folate receptor of alpha-expressing cancers
CN103442768A (en) 2011-01-18 2013-12-11 宾夕法尼亚大学董事会 Compositions and methods for treating cancer
ES2661466T3 (en) * 2011-04-01 2018-04-02 Immunogen, Inc. Methods to increase the effectiveness of cancer therapy with FOLR1
JP6220333B2 (en) 2011-07-15 2017-10-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 Antifolate receptor alpha antibodies and uses thereof
MX362497B (en) 2012-05-15 2019-01-21 Eisai Inc Methods for treatment of gastric cancer.
HUE049693T2 (en) 2012-08-31 2020-10-28 Immunogen Inc Diagnostic assays and kits for detection of folate receptor 1
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JP2016536330A (en) 2013-08-30 2016-11-24 イミュノジェン， インコーポレイテッド Antibodies and assays for detection of folate receptor 1
PT3653228T (en) 2013-10-08 2024-07-17 Immunogen Inc Anti-folr1 immunoconjugate dosing regimens
WO2015085003A1 (en) 2013-12-04 2015-06-11 Immunogen, Inc. Compositions and methods for antibody production
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Also Published As

Publication number Publication date
WO2019177854A1 (en) 2019-09-19
EP3765521A1 (en) 2021-01-20
CA3091683A1 (en) 2019-09-19
EP3765521A4 (en) 2022-03-23
JP2024056787A (en) 2024-04-23
CN115925952A (en) 2023-04-07
JP2021517459A (en) 2021-07-26
IL276949A (en) 2020-10-29
MX2020009522A (en) 2020-10-22
CN111954681A (en) 2020-11-17
US20210002363A1 (en) 2021-01-07
BR112020016469A2 (en) 2020-12-15
EA202092125A1 (en) 2020-12-15
JP7433236B2 (en) 2024-02-19
US11873335B2 (en) 2024-01-16
KR20200132900A (en) 2020-11-25
CN111954681B (en) 2022-12-06
AU2019236091A1 (en) 2020-09-03

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