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SG11202000979SA - Antibody-resin coupling apparatus and methods - Google Patents

Antibody-resin coupling apparatus and methods

Info

Publication number
SG11202000979SA
SG11202000979SA SG11202000979SA SG11202000979SA SG11202000979SA SG 11202000979S A SG11202000979S A SG 11202000979SA SG 11202000979S A SG11202000979S A SG 11202000979SA SG 11202000979S A SG11202000979S A SG 11202000979SA SG 11202000979S A SG11202000979S A SG 11202000979SA
Authority
SG
Singapore
Prior art keywords
antibody
methods
coupling apparatus
resin coupling
resin
Prior art date
Application number
SG11202000979SA
Inventor
Robert Toso
Richard Spanggord
Mei Tan
Van Tairiol
Yekaterina Lin
Original Assignee
Shire Human Genetic Therapies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Human Genetic Therapies filed Critical Shire Human Genetic Therapies
Publication of SG11202000979SA publication Critical patent/SG11202000979SA/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00Feed or outlet devices; Feed or outlet control devices
    • B01J4/001Feed or outlet devices as such, e.g. feeding tubes
    • B01J4/004Sparger-type elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05Stirrers
    • B01F27/11Stirrers characterised by the configuration of the stirrers
    • B01F27/112Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
    • B01F27/1125Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/45Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18Stationary reactors having moving elements inside
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D29/00Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/01Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05Stirrers
    • B01F27/11Stirrers characterised by the configuration of the stirrers
    • B01F27/111Centrifugal stirrers, i.e. stirrers with radial outlets; Stirrers of the turbine type, e.g. with means to guide the flow
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05Stirrers
    • B01F27/11Stirrers characterised by the configuration of the stirrers
    • B01F27/13Openwork frame or cage stirrers not provided for in other groups of this subclass
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/181Preventing generation of dust or dirt; Sieves; Filters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/45Closures or doors specially adapted for mixing receptacles; Operating mechanisms therefor
    • B01F35/451Closures or doors specially adapted for mixing receptacles; Operating mechanisms therefor by rotating them about an axis parallel to the plane of the opening
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50Mixing receptacles
    • B01F35/52Receptacles with two or more compartments
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71Feed mechanisms
    • B01F35/712Feed mechanisms for feeding fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71Feed mechanisms
    • B01F35/717Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75Discharge mechanisms
    • B01F35/754Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/7547Discharge mechanisms characterised by the means for discharging the components from the mixer using valves, gates, orifices or openings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053Details of the reactor
    • B01J19/0066Stirrers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/26Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30Processes for preparing, regenerating, or reactivating
    • B01J20/32Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/005Separating solid material from the gas/liquid stream
    • B01J8/006Separating solid material from the gas/liquid stream by filtration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00Auxiliary or complementary information in relation with mixing
    • B01F2215/04Technical information in relation with mixing
    • B01F2215/0413Numerical information
    • B01F2215/0418Geometrical information
    • B01F2215/0431Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00Auxiliary or complementary information in relation with mixing
    • B01F2215/04Technical information in relation with mixing
    • B01F2215/0413Numerical information
    • B01F2215/0436Operational information
    • B01F2215/0477Numerical time values
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00Auxiliary or complementary information in relation with mixing
    • B01F2215/04Technical information in relation with mixing
    • B01F2215/0413Numerical information
    • B01F2215/0436Operational information
    • B01F2215/0481Numerical speed values
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2208/00Processes carried out in the presence of solid particles; Reactors therefor
    • B01J2208/00796Details of the reactor or of the particulate material
    • B01J2208/00805Details of the particulate material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2208/00Processes carried out in the presence of solid particles; Reactors therefor
    • B01J2208/00796Details of the reactor or of the particulate material
    • B01J2208/00823Mixing elements
    • B01J2208/00858Moving elements

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Accessories For Mixers (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Glanulating (AREA)
  • Cleaning By Liquid Or Steam (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
SG11202000979SA 2017-08-04 2018-07-30 Antibody-resin coupling apparatus and methods SG11202000979SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762541601P 2017-08-04 2017-08-04
PCT/US2018/044324 WO2019027876A1 (en) 2017-08-04 2018-07-30 Antibody-resin coupling apparatus and methods

Publications (1)

Publication Number Publication Date
SG11202000979SA true SG11202000979SA (en) 2020-02-27

Family

ID=65231972

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202000979SA SG11202000979SA (en) 2017-08-04 2018-07-30 Antibody-resin coupling apparatus and methods

Country Status (13)

Country Link
US (3) US11123704B2 (en)
EP (2) EP3661636B1 (en)
JP (3) JP7054412B2 (en)
KR (2) KR102584321B1 (en)
CN (2) CN111871246B (en)
AU (2) AU2018309662B2 (en)
BR (1) BR112020001998B1 (en)
CA (1) CA3070724A1 (en)
ES (1) ES2968828T3 (en)
PL (1) PL3661636T3 (en)
RU (2) RU2021134375A (en)
SG (1) SG11202000979SA (en)
WO (1) WO2019027876A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115041083B (en) * 2022-04-28 2024-04-09 天津益创能源科技有限公司 Production equipment and preparation method of self-generated fiber sand control water plugging agent

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4153403A (en) * 1977-11-18 1979-05-08 Schneider Howard S Machine for automatically making plaster slurry and dispensing it to dental molds
JPS54123118A (en) * 1978-03-16 1979-09-25 Nippon Sheet Glass Co Ltd Granulation of glass raw material
US4869595A (en) * 1983-08-01 1989-09-26 James M. Montgomery, Consulting Engineers, Inc. Hydraulic diffusion flash mixing
US5200270A (en) 1986-02-25 1993-04-06 Toyo Soda Manufacturing Co., Ltd. Carrier for a biologically active component for immunoassay or enzymatic reaction
US5358690A (en) 1989-01-10 1994-10-25 Lamina, Ltd. Environmental sample collection and membrane testing device
US4961432A (en) 1989-01-10 1990-10-09 Cancer Diagnostics, Inc. Modular fluid sample preparation assembly
US5133363A (en) 1989-06-21 1992-07-28 La Mina Ltd. Modular multiple fluid sample preparation assembly
FR2665088B1 (en) * 1990-07-27 1992-10-16 Air Liquide METHOD AND DEVICE FOR MIXING TWO GASES.
US5686315A (en) 1991-06-14 1997-11-11 Quidel Corporation Assay device for one step detection of analyte
US5388906A (en) 1991-12-18 1995-02-14 E. I. Du Pont De Nemours And Company Static mixer for two or more fluids
US6197526B1 (en) 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
TR200101887T2 (en) * 1998-12-29 2001-12-21 Pirelli Cavi E Sistemi S.P.A. A method and tool for continuously injecting a substance in the liquid phase into plastic grains.
JP2002018260A (en) 2000-07-07 2002-01-22 Sumitomo Heavy Ind Ltd Stirring device for liquid storage tank
US7905653B2 (en) * 2001-07-31 2011-03-15 Mega Fluid Systems, Inc. Method and apparatus for blending process materials
JP2002058975A (en) * 2000-08-15 2002-02-26 Fuji Photo Film Co Ltd Apparatus and method for dissolving gel
FR2816621A1 (en) 2000-11-13 2002-05-17 Bioracs - Crosslinked polystyrene resins functionalized by L-tyrosine methyl ester sulfamide groups useful for purification of antifactor VIII antibodies
CN1257772C (en) * 2004-04-20 2006-05-31 苏州天马医药集团精细化学品有限公司 Dynamic ion exchange unit
US8247072B2 (en) * 2006-02-14 2012-08-21 Eastman Chemical Company Resol beads, methods of making them and methods of using them
CN100595232C (en) * 2006-05-17 2010-03-24 张发饶 Production of high-specific weight resin
RU2357790C1 (en) * 2008-03-17 2009-06-10 Государственное образовательное учреждение высшего профессионального образования Балтийский государственный технический университет "ВОЕНМЕХ" им. Д.Ф. Устинова (БГТУ "ВОЕНМЕХ") Mixer for fluids
BR112012015200B1 (en) * 2009-12-22 2021-07-20 Evonik Corporation PROCESS TO PREPARE MICROPARTICLES, AND, WORK HEAD ASSEMBLY FOR A MIXER THROUGH NON-STATIC FLOW
CN201735210U (en) * 2010-06-28 2011-02-09 濮阳泓天威药业有限公司 Extraction multi-chamber mixer used in antibiotic production
KR101731668B1 (en) 2010-07-01 2017-04-28 어드밴스드 퓨젼 시스템스 엘엘씨 Method and system for inducing chemical reactions by x-ray irradiation
US8506797B2 (en) 2011-04-10 2013-08-13 Therapeutic Proteins International, LLC Downstream bioprocessing device
CN202778300U (en) * 2012-07-03 2013-03-13 南京金水环境技术有限公司 Dosing flow-uniformizing mixer
US9051183B2 (en) 2012-08-24 2015-06-09 Intelligent Energy Inc. Hydrogen generator having reactant pellet with concentration gradient
JP2014205094A (en) 2013-04-11 2014-10-30 アシストV株式会社 Beater and mixer using the same
US9643146B2 (en) 2013-11-29 2017-05-09 Uop Llc Unit for processing a liquid/gas phase mixture, mercaptan oxidation system including the same, and method of processing a liquid/gas phase mixture
CN103831075B (en) * 2013-12-24 2016-08-17 北京化工大学 A kind of electric motor built-in hypergravity swinging bed device and application thereof
DK3097118T3 (en) 2014-01-20 2018-11-05 Octapharma Ag PROCEDURE FOR MANUFACTURING FACTOR VIII WITH AN IMPROVED FVIII: C / FVIII: AG RELATIONSHIP
PL3107651T3 (en) * 2014-02-20 2020-02-28 Spinchem Ab Reactor arrangement and method of using such reactor arrangement
RU2553861C1 (en) * 2014-03-12 2015-06-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Тамбовский государственный технический университет" ФГБОУ ВПО ТГТУ Hydrodynamic mixer
CN104941521A (en) * 2014-03-31 2015-09-30 英尼奥斯欧洲股份公司 Feeding distributor designed for ammonia oxidation reactor
US9340627B1 (en) * 2014-05-21 2016-05-17 Chevron Phillips Chemical Company, Lp Elbow and horizontal configurations in a loop reactor
CN104998855A (en) * 2015-07-27 2015-10-28 江苏建亚树脂科技有限公司 Ion exchange resin cleaning tower
CN105032225B (en) * 2015-09-02 2017-10-03 中冶华天工程技术有限公司 Rotational flow mixing device
RU2618078C1 (en) * 2016-04-25 2017-05-02 Федеральное государственное бюджетное образовательное учреждение высшего образования "Тамбовский государственный технический университет" ФГБОУ ВО "ТГТУ" Hydrodynamic mixer
CN106040196B (en) * 2016-06-27 2018-11-20 新乡医学院 A kind of preparation method of platelet cofactor Ⅰ affinity chromatography resin
CN206168387U (en) * 2016-10-24 2017-05-17 张家口原轼新型材料有限公司 Integrated form solid catalyst activating treatment reactor
CN106914170A (en) * 2017-04-06 2017-07-04 中国矿业大学 A kind of biomass type coal adhesive preparation facilities and preparation method

Also Published As

Publication number Publication date
EP3661636B1 (en) 2023-11-15
BR122021014832A2 (en) 2020-08-18
RU2021134375A (en) 2021-12-29
RU2020109344A3 (en) 2021-09-28
WO2019027876A1 (en) 2019-02-07
US20240342680A1 (en) 2024-10-17
ES2968828T3 (en) 2024-05-14
RU2761024C2 (en) 2021-12-02
US20190039042A1 (en) 2019-02-07
US11123704B2 (en) 2021-09-21
CN110997123A (en) 2020-04-10
KR20200035294A (en) 2020-04-02
AU2023285783A1 (en) 2024-01-18
US11969703B2 (en) 2024-04-30
EP4338830A3 (en) 2024-06-12
KR102584321B1 (en) 2023-10-05
BR122021014832A8 (en) 2023-03-21
JP2022100329A (en) 2022-07-05
AU2018309662B2 (en) 2023-10-19
EP3661636A1 (en) 2020-06-10
BR112020001998A2 (en) 2020-08-18
CN111871246B (en) 2022-05-27
AU2018309662A1 (en) 2020-02-13
KR20230143193A (en) 2023-10-11
CN111871246A (en) 2020-11-03
JP2020531247A (en) 2020-11-05
JP2024022632A (en) 2024-02-16
JP7054412B2 (en) 2022-04-13
EP3661636A4 (en) 2021-04-14
BR112020001998B1 (en) 2024-03-05
US20220105490A1 (en) 2022-04-07
PL3661636T3 (en) 2024-03-18
EP3661636C0 (en) 2023-11-15
EP4338830A2 (en) 2024-03-20
JP7455153B2 (en) 2024-03-25
CA3070724A1 (en) 2019-02-07
RU2020109344A (en) 2021-09-06

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