Nothing Special   »   [go: up one dir, main page]

SG11201913556SA - Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same - Google Patents

Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same

Info

Publication number
SG11201913556SA
SG11201913556SA SG11201913556SA SG11201913556SA SG11201913556SA SG 11201913556S A SG11201913556S A SG 11201913556SA SG 11201913556S A SG11201913556S A SG 11201913556SA SG 11201913556S A SG11201913556S A SG 11201913556SA SG 11201913556S A SG11201913556S A SG 11201913556SA
Authority
SG
Singapore
Prior art keywords
synthesis
preparing
processes
same
protein kinase
Prior art date
Application number
SG11201913556SA
Inventor
Sang-Ho Oh
Ja-Heouk Khoo
Jong-Chul Lim
Doo-Byung Lee
Jung-Ae Lee
Jun-Sup Lee
Hyun Ju
Woo-Seob Shin
Sang-Seol Jeon
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=65040643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201913556S(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of SG11201913556SA publication Critical patent/SG11201913556SA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
SG11201913556SA 2017-07-28 2018-07-25 Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same SG11201913556SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20170096226 2017-07-28
PCT/KR2018/008383 WO2019022487A1 (en) 2017-07-28 2018-07-25 Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same

Publications (1)

Publication Number Publication Date
SG11201913556SA true SG11201913556SA (en) 2020-02-27

Family

ID=65040643

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201913556SA SG11201913556SA (en) 2017-07-28 2018-07-25 Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same

Country Status (28)

Country Link
US (1) US11198684B2 (en)
EP (1) EP3658547B1 (en)
JP (1) JP7189932B2 (en)
KR (2) KR102671396B1 (en)
CN (1) CN111295381A (en)
AU (1) AU2018308164B2 (en)
BR (1) BR112020001457A2 (en)
CA (1) CA3070070A1 (en)
CO (1) CO2020000371A2 (en)
DK (1) DK3658547T3 (en)
EA (1) EA038078B1 (en)
ES (1) ES2959967T3 (en)
FI (1) FI3658547T3 (en)
HR (1) HRP20231020T1 (en)
HU (1) HUE063043T2 (en)
IL (1) IL271975B (en)
LT (1) LT3658547T (en)
MA (1) MA49705A (en)
NZ (1) NZ761158A (en)
PH (1) PH12020500093A1 (en)
PL (1) PL3658547T3 (en)
PT (1) PT3658547T (en)
RS (1) RS64545B1 (en)
SA (1) SA520411115B1 (en)
SG (1) SG11201913556SA (en)
SI (1) SI3658547T1 (en)
UA (1) UA125595C2 (en)
WO (1) WO2019022487A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019022485A1 (en) * 2017-07-28 2019-01-31 Yuhan Corporation Improved process for preparing aminopyrimidine derivatives
CN111032650A (en) * 2017-07-28 2020-04-17 株式会社柳韩洋行 Novel intermediate useful for synthesis of aminopyrimidine derivative, method for preparing same, and method for preparing aminopyrimidine derivative using same
US11879013B2 (en) 2019-05-14 2024-01-23 Janssen Biotech, Inc. Combination therapies with bispecific anti-EGFR/c-Met antibodies and third generation EGFR tyrosine kinase inhibitors
US11850248B2 (en) 2019-05-14 2023-12-26 Yuhan Corporation Therapies with 3rd generation EGFR tyrosine kinase inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009262068C1 (en) * 2008-06-27 2015-07-02 Celgene Car Llc Heteroaryl compounds and uses thereof
JP5740409B2 (en) 2009-11-13 2015-06-24 ジェノスコ Kinase inhibitor
ME02382B (en) * 2011-07-27 2016-06-20 Astrazeneca Ab 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer
JP2015503504A (en) 2011-12-23 2015-02-02 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. Heteroaryl and uses thereof
PL2804861T3 (en) * 2012-01-20 2018-08-31 Genosco Substituted pyrimidine compounds and their use as syk inhibitors
JP6321821B2 (en) * 2014-04-14 2018-05-09 シャンハイ ハイヤン ファーマシューティカル テクノロジー カンパニー リミテッドShanghai Haiyan Pharmaceutical Technology Co., Ltd. 2,3,4,6-4-substituted benzene-1,5-diamine derivatives, their production and use in pharmaceuticals
CN105461695B (en) * 2014-09-29 2018-03-27 齐鲁制药有限公司 Pyrimidine or pyrrolotriazine derivatives and its production and use
CN105524068B (en) 2014-09-30 2017-11-24 上海海雁医药科技有限公司 Azabicyclic derivatives, its preparation method and purposes pharmaceutically
DK3207035T3 (en) 2014-10-13 2020-01-27 Yuhan Corp COMPOUNDS AND COMPOSITIONS FOR MODULATING EGFR MUTANT KINASE ACTIVITIES
CN105859721B (en) * 2015-01-22 2018-04-17 浙江京新药业股份有限公司 A kind of Yi Bulu replaces the preparation method of Buddhist nun
CN104788427B (en) * 2015-02-05 2017-05-31 上海泓博智源医药股份有限公司 3 (2 pyrimdinyl-amino) phenylacryloyl amine compounds and its application
JP2019501222A (en) 2016-01-07 2019-01-17 シーエス ファーマテック リミテッド Selective inhibitors of clinically important variants of EGFR tyrosine kinase
CN106083736A (en) 2016-06-21 2016-11-09 郑州泰基鸿诺医药股份有限公司 A kind of pyrimidines, EGFR inhibitor and application thereof

Also Published As

Publication number Publication date
JP7189932B2 (en) 2022-12-14
PH12020500093A1 (en) 2020-09-14
FI3658547T3 (en) 2023-10-26
WO2019022487A1 (en) 2019-01-31
US20210155607A1 (en) 2021-05-27
SI3658547T1 (en) 2023-10-30
LT3658547T (en) 2023-10-10
EP3658547A1 (en) 2020-06-03
EP3658547B1 (en) 2023-08-16
MA49705A (en) 2021-03-31
PL3658547T3 (en) 2024-01-03
CN111295381A (en) 2020-06-16
UA125595C2 (en) 2022-04-27
AU2018308164A1 (en) 2020-01-30
NZ761158A (en) 2022-08-26
KR20230137282A (en) 2023-10-04
ES2959967T3 (en) 2024-02-29
PT3658547T (en) 2023-10-20
DK3658547T3 (en) 2023-10-16
IL271975B (en) 2022-08-01
KR102671396B1 (en) 2024-05-31
EA202090384A1 (en) 2020-05-20
KR20190013555A (en) 2019-02-11
EP3658547A4 (en) 2021-03-31
EA038078B1 (en) 2021-07-02
CA3070070A1 (en) 2019-01-31
US11198684B2 (en) 2021-12-14
CO2020000371A2 (en) 2020-05-05
HUE063043T2 (en) 2023-12-28
RS64545B1 (en) 2023-09-29
HRP20231020T1 (en) 2023-12-08
IL271975A (en) 2020-02-27
SA520411115B1 (en) 2023-01-18
BR112020001457A2 (en) 2020-07-28
AU2018308164B2 (en) 2021-12-09
JP2020528916A (en) 2020-10-01

Similar Documents

Publication Publication Date Title
IL287136A (en) Inhibitors of receptor-interacting protein kinase 1
IL270872A (en) Crystalline forms of a fgfr inhibitor and processes for preparing the same
IL271940A (en) Method for the preparation of ammonia synthesis gas
IL271939A (en) Method for the preparation of synthesis gas
IL271938A (en) Method for the preparation of synthesis gas
IL271942A (en) Process for the co-production of methanol and ammonia
IL271937B1 (en) Method for the preparation of ammonia synthesis gas
IL271941A (en) Method for the preparation of synthesis gas
IL271975A (en) Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same
EP3712130A4 (en) Method for synthesis of roxadustat and intermediate compounds thereof
GB201801768D0 (en) Synthesis method
PT3611171T (en) Method for synthesis of eliglustat and intermediate compounds thereof
EP3376870A4 (en) Process for the preparation of kinase inhibitors and intermediates thereof
ZA202101837B (en) Method for the preparation of synthesis gas
ZA202003590B (en) Process for the preparation of opicapone and intermediates thereof
HUE062956T2 (en) Processes for the preparation of niraparib and intermediates thereof
ZA202004466B (en) Processes for the synthesis of sulfentrazone
IL291221A (en) Processes for the synthesis of valbenazine
PL3498665T3 (en) Method for the production of synthesis gas
PT3759082T (en) Process for the synthesis of 6-chloromethyluracil
PT3713952T (en) Method for the synthesis of glutathione derivatives
EP3452447A4 (en) Inhibitors of ires-mediated protein synthesis
KR102198102B9 (en) - fischer-tropsch synthesis catalyst and manufacturing method of the same
PL3609877T3 (en) Process for the synthesis of firocoxib
GB201809404D0 (en) Method of synthesis