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SG11201911572YA - Adenoviral vectors - Google Patents

Adenoviral vectors

Info

Publication number
SG11201911572YA
SG11201911572YA SG11201911572YA SG11201911572YA SG11201911572YA SG 11201911572Y A SG11201911572Y A SG 11201911572YA SG 11201911572Y A SG11201911572Y A SG 11201911572YA SG 11201911572Y A SG11201911572Y A SG 11201911572YA SG 11201911572Y A SG11201911572Y A SG 11201911572YA
Authority
SG
Singapore
Prior art keywords
oxford
international
medawar
avenue
floor
Prior art date
Application number
SG11201911572YA
Inventor
Ryan Cawood
Weiheng Su
Original Assignee
Oxford Genetics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1711971.0A external-priority patent/GB201711971D0/en
Priority claimed from GBGB1806375.0A external-priority patent/GB201806375D0/en
Application filed by Oxford Genetics Ltd filed Critical Oxford Genetics Ltd
Publication of SG11201911572YA publication Critical patent/SG11201911572YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
    • C12N2810/6018—Adenoviridae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

FigureW O 20 19/02099 2 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 31 January 2019 (31.01.2019) WIPO I PCT omit liononoi Imo lII ow (10) International Publication Number WO 2019/020992 Al (51) International Patent Classification: C12N 7/00 (2006.01) (21) International Application Number: PCT/GB2018/052083 (22) International Filing Date: 24 July 2018 (24.07.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1711971.0 25 July 2017 (25.07.2017) GB 1806375.0 19 April 2018 (19.04.2018) GB (71) Applicant: OXFORD GENETICS LIMITED [GB/GB]; First Floor, Medawar 1, Robert Robinson Avenue, The Ox- ford Science Park, Oxford Oxfordshire OX4 4GA (GB). (72) Inventors: CAWOOD, Ryan; c/o Oxford Genetics Ltd, First Floor, Medawar 1, Robert Robinson Avenue, The Ox- ford Science Park, Oxford Oxfordshire OX4 4GA (GB). SU, Weiheng; c/o Oxford Genetics Ltd, First Floor, Medawar 1, Robert Robinson Avenue, The Oxford Science Park, Oxford Oxfordshire OX4 4GA (GB). (74) Agent: DEHNS; St Bride's House, 10 Salisbury Square, London Greater London EC4Y 8JD (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). — (54) Title: ADENOVIRAL VECTORS (57) : The present invention relates to an adenoviral vector com- prising a regulatable Major Late Promoter and an exogenous transgene. The invention also provides cells comprising such adenoviral vectors, and processes using such vectors. [Continued on next page] WO 2019/020992 Al MIDEDIMOMOIDIONOICIEHM01010110111011101011MOVOIMIE Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
SG11201911572YA 2017-07-25 2018-07-24 Adenoviral vectors SG11201911572YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1711971.0A GB201711971D0 (en) 2017-07-25 2017-07-25 Vectors
GBGB1806375.0A GB201806375D0 (en) 2018-04-19 2018-04-19 Vectors
PCT/GB2018/052083 WO2019020992A1 (en) 2017-07-25 2018-07-24 Adenoviral vectors

Publications (1)

Publication Number Publication Date
SG11201911572YA true SG11201911572YA (en) 2020-02-27

Family

ID=63077905

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201911572YA SG11201911572YA (en) 2017-07-25 2018-07-24 Adenoviral vectors

Country Status (10)

Country Link
US (1) US12071631B2 (en)
EP (1) EP3658668A1 (en)
JP (1) JP7105866B2 (en)
KR (1) KR102609021B1 (en)
CN (1) CN110892064A (en)
AU (1) AU2018307569B2 (en)
BR (1) BR112019027765A2 (en)
CA (1) CA3070654C (en)
SG (1) SG11201911572YA (en)
WO (1) WO2019020992A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021055369A1 (en) * 2019-09-16 2021-03-25 Excepgen Inc. Systems and methods for protein expression
BR112022013581A2 (en) 2020-02-04 2022-09-13 Oxford Genetics Ltd PROCESS TO PREPARE ADENO-ASSOCIATED VIRAL VECTORS
GB202001484D0 (en) * 2020-02-04 2020-03-18 Oxford Genetics Ltd DNA amplification method
KR20230054840A (en) 2020-07-30 2023-04-25 셰이프 테라퓨틱스 인코포레이티드 Stabilized cell lines for directed production of rAAV virions
GB202013057D0 (en) 2020-08-21 2020-10-07 Oxford Genetics Ltd Method of making recombinant aavs
GB202013060D0 (en) 2020-08-21 2020-10-07 Oxford Genetics Ltd Cell line
GB202013058D0 (en) 2020-08-21 2020-10-07 Oxford Genetics Ltd Process for making a recombinant AAV library
EP4200316A1 (en) 2020-08-21 2023-06-28 Oxford Genetics Limited Process for making a recombinant aav library
CN112501209B (en) * 2020-12-07 2024-02-13 和元生物技术（上海）股份有限公司 Method for packaging adeno-associated virus with controllable expression of exogenous gene
CN112501207B (en) * 2020-12-07 2022-08-09 和元生物技术（上海）股份有限公司 Adenovirus packaging method capable of realizing controllable expression of exogenous gene
GB202105581D0 (en) 2021-04-19 2021-06-02 Oxford Genetics Ltd DNA amplification method
JP2024517104A (en) 2021-04-19 2024-04-19 オックスフォード ジェネティクス リミテッド DNA amplification method using CARE element
EP4112731A1 (en) * 2021-07-01 2023-01-04 Charité - Universitätsmedizin Berlin System for high-level raav production

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DK0728214T3 (en) 1993-11-09 2004-11-29 Targeted Genetics Corp Stable cell lines capable of expressing the adeno-associated virus replication gene
EP0733103B1 (en) 1993-11-09 2004-03-03 Targeted Genetics Corporation Generation of high titers of recombinant aav vectors
US5856152A (en) 1994-10-28 1999-01-05 The Trustees Of The University Of Pennsylvania Hybrid adenovirus-AAV vector and methods of use therefor
WO1999053085A2 (en) 1998-04-15 1999-10-21 The Research Foundation Of State University Of New York Selective regulation of adenovirus production
WO1999057296A1 (en) 1998-05-01 1999-11-11 Genzyme Corporation Partially deleted adenoviral vectors
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AU5689699A (en) * 1998-08-24 2000-03-14 Uab Research Foundation Methods of producing high titer recombinant adeno-associated virus
PL347898A1 (en) 1998-10-15 2002-04-22 Canji Selectively replicating viral vectors
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CN101035901A (en) 2004-07-22 2007-09-12 细胞基因系统有限公司 Addition of transgenes into adenoviral vectors
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CN102533657B (en) 2010-12-28 2015-04-22 中国疾病预防控制中心病毒病预防控制所 Human 41 type adenovirus (Ad41) packaging cell line and application thereof
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GB202013057D0 (en) 2020-08-21 2020-10-07 Oxford Genetics Ltd Method of making recombinant aavs
EP4200316A1 (en) 2020-08-21 2023-06-28 Oxford Genetics Limited Process for making a recombinant aav library

Also Published As

Publication number Publication date
CA3070654C (en) 2021-07-27
AU2018307569B2 (en) 2022-03-10
JP2020533956A (en) 2020-11-26
KR20200031141A (en) 2020-03-23
JP7105866B2 (en) 2022-07-25
AU2018307569A1 (en) 2020-02-20
CN110892064A (en) 2020-03-17
BR112019027765A2 (en) 2020-07-14
CA3070654A1 (en) 2019-01-31
US12071631B2 (en) 2024-08-27
US20200239909A1 (en) 2020-07-30
EP3658668A1 (en) 2020-06-03
KR102609021B1 (en) 2023-12-06
WO2019020992A1 (en) 2019-01-31

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