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SG11201810076WA - Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety - Google Patents

Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety

Info

Publication number
SG11201810076WA
SG11201810076WA SG11201810076WA SG11201810076WA SG11201810076WA SG 11201810076W A SG11201810076W A SG 11201810076WA SG 11201810076W A SG11201810076W A SG 11201810076WA SG 11201810076W A SG11201810076W A SG 11201810076WA SG 11201810076W A SG11201810076W A SG 11201810076WA
Authority
SG
Singapore
Prior art keywords
roche
schlieren
wagistrasse
glycart
international
Prior art date
Application number
SG11201810076WA
Inventor
Koller Claudia Ferrara
Christina Claus
Christian Klein
Stefan Seeber
Maria Amann
Sandra Grau-Richards
Peter Bruenker
Pablo Umana
Viktor Levitski
Ekkehard Moessner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11201810076WA publication Critical patent/SG11201810076WA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111101011111111111011101 IIIIIIIIIIII100111111111111110111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2017/194641 Al 16 November 2017 (16.11.2017) WIPO I PCT (51) International Patent Classification: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, C07K 14/705 (2006.01) C07K 16/28 (2006.01) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, A61K 39/395 (2006.01) Cl 2N 15/62 (2006.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (21) International Application Number: (84) Designated States (unless otherwise indicated, for every PCT/EP2017/061241 kind of regional protection available): ARIPO (BW, GH, (22) International Filing Date: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 11 May 2017 (11.05.2017) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (25) Filing Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (26) Publication Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (30) Priority Data: KM, ML, MR, NE, SN, TD, TG). 16169487.2 13 May 2016 (13.05.2016) EP Declarations under Rule 4.17: (71) Applicant (for all designated States except US): F. HOFF- — of inventorship (Rule 4.17(iv)) MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). Published: — with international search report (Art. 21(3)) (71) Applicant (for US only): HOFFMANN-LA ROCHE — with sequence listing part of description (Rule 5.2(a)) INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jer- sey 07424 (US). — = Inventors: FERRARA KOLLER, Claudia; c/o Roche (72) Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). = CLAUS, Christina; c/o Roche Glycart AG, Wagistrasse _ — 18, 8952 Schlieren (CH). KLEIN, Christian; c/o Roche = Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). SEE- BER, Stefan; c/o Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg (DE). AMANN, Maria; c/o Roche Gly- cart AG, Wagistrasse 18, 8952 Schlieren (CH). GRAU- = = RICHARDS, Sandra; c/o Roche Glycart AG, Wagis- trasse 18, 8952 Schlieren (CH). BRUENKER, Peter; c/o - = Roche Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). _ UMANA, Pablo; c/o Roche Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). LEVITSKI, Viktor; c/o Roche Gly- cart AG, Wagistrasse 18, 8952 Schlieren (CH). MOESSN- = _ = ER, Ekkehard; c/o Roche Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). = Agent: KLOSTERMEYER, Doerte; F. HOFFMANN-LA (74) = ROCHE AG, Grenzacherstrasse 124, 4070 Basel (CH). = Designated States (unless otherwise indicated, for every (81) = — kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, — 1-1 1-1 71' HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 71' (54) Title: ANTIGEN BINDING MOLECULES COMPRISING A TNF FAMILY LIGAND TRIMER AND PD1 BINDING MOIETY 1-1 ---- (57) : The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least IN , 1 one moiety capable of specific binding to PD1 and (b) a first and a second polypeptide that are linked to each other by a disulfide C::::) bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that N are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand 0 family member or a fragment thereof.
SG11201810076WA 2016-05-13 2017-05-11 Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety SG11201810076WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16169487.2A EP3243832A1 (en) 2016-05-13 2016-05-13 Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety
PCT/EP2017/061241 WO2017194641A1 (en) 2016-05-13 2017-05-11 Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety

Publications (1)

Publication Number Publication Date
SG11201810076WA true SG11201810076WA (en) 2018-12-28

Family

ID=56014831

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201810076WA SG11201810076WA (en) 2016-05-13 2017-05-11 Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety

Country Status (22)

Country Link
US (2) US20190185566A1 (en)
EP (2) EP3243832A1 (en)
JP (1) JP6801006B2 (en)
KR (1) KR20190004802A (en)
CN (1) CN109563146B (en)
AR (1) AR108453A1 (en)
AU (1) AU2017264548A1 (en)
BR (1) BR112018073289A2 (en)
CA (1) CA3023393A1 (en)
CL (1) CL2018003205A1 (en)
CO (1) CO2018012083A2 (en)
CR (1) CR20180538A (en)
IL (1) IL262843A (en)
MA (1) MA44973A (en)
MX (1) MX2018013675A (en)
PE (1) PE20190436A1 (en)
PH (1) PH12018502367A1 (en)
RU (1) RU2018143439A (en)
SG (1) SG11201810076WA (en)
TW (1) TW201805306A (en)
WO (1) WO2017194641A1 (en)
ZA (1) ZA201807581B (en)

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CN114751989A (en) 2015-03-31 2022-07-15 豪夫迈·罗氏有限公司 Antigen binding molecules comprising trimeric TNF family ligands
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