SG11201807077RA - Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof - Google Patents
Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereofInfo
- Publication number
- SG11201807077RA SG11201807077RA SG11201807077RA SG11201807077RA SG11201807077RA SG 11201807077R A SG11201807077R A SG 11201807077RA SG 11201807077R A SG11201807077R A SG 11201807077RA SG 11201807077R A SG11201807077R A SG 11201807077RA SG 11201807077R A SG11201807077R A SG 11201807077RA
- Authority
- SG
- Singapore
- Prior art keywords
- california
- gilead
- apollo
- llc
- foster city
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000007787 solid Substances 0.000 title abstract 3
- QAFVXBQPQCSSLI-UHFFFAOYSA-N 1h-thieno[3,2-d]pyrimidine-2,4-dione Chemical compound O=C1NC(=O)NC2=C1SC=C2 QAFVXBQPQCSSLI-UHFFFAOYSA-N 0.000 title abstract 2
- 229940121373 acetyl-coa carboxylase inhibitor Drugs 0.000 title abstract 2
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 abstract 3
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 abstract 3
- 108010018763 Biotin carboxylase Proteins 0.000 abstract 3
- 102220240796 rs553605556 Human genes 0.000 abstract 2
- 229940126656 GS-4224 Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662302755P | 2016-03-02 | 2016-03-02 | |
| US201662303237P | 2016-03-03 | 2016-03-03 | |
| PCT/US2017/020271 WO2017151816A1 (en) | 2016-03-02 | 2017-03-01 | Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201807077RA true SG11201807077RA (en) | 2018-09-27 |
Family
ID=58347936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201807077RA SG11201807077RA (en) | 2016-03-02 | 2017-03-01 | Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10183951B2 (zh) |
| EP (2) | EP3423456B1 (zh) |
| JP (3) | JP6944462B2 (zh) |
| KR (3) | KR102744343B1 (zh) |
| CN (3) | CN119977993A (zh) |
| AU (3) | AU2017226267B2 (zh) |
| BR (1) | BR112018067408A2 (zh) |
| CA (4) | CA3172549A1 (zh) |
| ES (1) | ES2972487T3 (zh) |
| IL (1) | IL261255A (zh) |
| MX (1) | MX2018010427A (zh) |
| PL (1) | PL3423456T3 (zh) |
| SG (1) | SG11201807077RA (zh) |
| TW (3) | TWI844474B (zh) |
| WO (1) | WO2017151816A1 (zh) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI598347B (zh) | 2009-07-13 | 2017-09-11 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| KR102060290B1 (ko) | 2011-11-11 | 2019-12-27 | 길리어드 아폴로, 엘엘씨 | Ａｃｃ 억제제 및 이의 용도 |
| HRP20190853T1 (hr) | 2015-07-06 | 2019-06-28 | Gilead Sciences, Inc. | Cot modulatori i postupci za njihovu upotrebu |
| AR106472A1 (es) | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
| US20170166585A1 (en) | 2015-11-25 | 2017-06-15 | Gilead Apollo, Llc | Pesticidal compositions and uses thereof |
| KR20180082558A (ko) | 2015-11-25 | 2018-07-18 | 길리어드 아폴로, 엘엘씨 | 에스테르 acc 억제제 및 그의 용도 |
| CN108349995B (zh) | 2015-11-25 | 2021-08-03 | 吉利德阿波罗公司 | 吡唑acc抑制剂及其用途 |
| MX2018010427A (es) | 2016-03-02 | 2019-03-06 | Gilead Apollo Llc | Formas solidas de un inhibidor de tienopirimidindiona acetil coa carboxilasa y metodos para su produccion. |
| KR102424042B1 (ko) * | 2017-03-03 | 2022-07-22 | 길리애드 사이언시즈, 인코포레이티드 | Acc 억제제 및 그의 고체 형태를 제조하는 방법 |
| KR102743630B1 (ko) | 2017-03-28 | 2024-12-18 | 길리애드 사이언시즈, 인코포레이티드 | 간 질환을 치료하기 위한 치료 조합물 |
| CN111201234A (zh) * | 2017-07-17 | 2020-05-26 | 南京瑞捷医药科技有限公司 | 新型化合物及其作为acc抑制剂的用途 |
| KR20190036705A (ko) * | 2017-09-28 | 2019-04-05 | 한미약품 주식회사 | (2r)-2-(2-메톡시페닐)-2-(옥산-4-일옥시)에탄-1-올 화합물의 신규 제조방법 및 이에 사용되는 중간체 |
| EP3691648A1 (en) | 2017-10-06 | 2020-08-12 | Gilead Sciences, Inc. | Combination therapy comprising an acc inhibitor |
| CN109810085B (zh) * | 2019-04-19 | 2019-07-19 | 上海皓元生物医药科技有限公司 | Acc抑制剂及其中间体的制备方法 |
| TW202235416A (zh) | 2019-06-14 | 2022-09-16 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
| AR119594A1 (es) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
| EP4031137A1 (en) | 2019-09-19 | 2022-07-27 | Novartis AG | Treatment comprising fxr agonists |
| CN112574253B (zh) * | 2019-09-29 | 2021-08-27 | 上海喀露蓝科技有限公司 | 磷酸或磷酸酯类衍生物、其制备方法及其在医药上的用途 |
| CN110746439B (zh) * | 2019-10-18 | 2020-10-30 | 南京瑞捷医药科技有限公司 | 一种噻吩并嘧啶二酮化合物的制备方法 |
| CN112778325A (zh) * | 2019-11-07 | 2021-05-11 | 南京瑞捷医药科技有限公司 | 一种acc抑制剂及其用途 |
| AU2020384883B2 (en) | 2019-11-15 | 2023-11-16 | Gilead Sciences, Inc. | Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof |
| CN114787166B (zh) * | 2019-12-05 | 2023-09-19 | 漳州片仔癀药业股份有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类化合物的晶型及其制备方法和应用 |
| ES2965380T3 (es) * | 2019-12-05 | 2024-04-15 | Zhangzhou Pien Tze Huang Pharm | Forma cristalina como inhibidor de ACC1 y ACC2, y método de preparación de la misma y uso de la misma |
| EP4126231A1 (en) | 2020-03-30 | 2023-02-08 | Gilead Sciences, Inc. | Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound |
| EP4126862B1 (en) | 2020-04-02 | 2025-05-21 | Gilead Sciences, Inc. | Process for preparing a cot inhibitor compound |
| US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| TWI843503B (zh) | 2020-06-03 | 2024-05-21 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| JP7591066B2 (ja) | 2020-06-03 | 2024-11-27 | ギリアード サイエンシーズ， インコーポレイテッド | Ｌｐａ受容体アンタゴニスト及びそれらの使用 |
| EP4304711A1 (en) | 2021-03-11 | 2024-01-17 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
| EP4313967A1 (en) | 2021-03-29 | 2024-02-07 | Gilead Sciences, Inc. | Khk inhibitors |
| CN117295717A (zh) | 2021-05-11 | 2023-12-26 | 吉利德科学公司 | Lpa受体拮抗剂及其用途 |
| AU2022273702B2 (en) | 2021-05-13 | 2025-05-15 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| TW202345826A (zh) | 2021-06-04 | 2023-12-01 | 美商基利科學股份有限公司 | 治療nash之方法 |
| TW202311256A (zh) | 2021-06-18 | 2023-03-16 | 美商基利科學股份有限公司 | 用於治療ｆｘｒ誘發之搔癢之ｉｌ－３１調節劑 |
| KR102309616B1 (ko) | 2021-07-27 | 2021-10-05 | 최금실 | 호호바오일을 포함하는 피부 재생 및 피부 보습용 화장료 조성물 및 이의 제조방법 |
| KR102337422B1 (ko) | 2021-07-27 | 2021-12-08 | (주)최금실 | 호호바오일을 포함하는 피부진정 및 트러블 개선용 화장료 조성물 및 이의 제조방법 |
| EP4444707A1 (en) | 2021-12-08 | 2024-10-16 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| CN115785066B (zh) | 2022-12-08 | 2024-05-31 | 广东工业大学 | 曲格列汀晶型f及其制备方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4670560A (en) | 1986-04-28 | 1987-06-02 | Ortho Pharmaceutical Corporation | Thienopyrimidine-2,4-dione derivatives and intermediates thereof |
| JPH02225485A (ja) | 1989-02-27 | 1990-09-07 | Taiho Yakuhin Kogyo Kk | チエノピリミジン―３―酢酸誘導体 |
| TW276256B (zh) | 1993-08-26 | 1996-05-21 | Takeda Pharm Industry Co Ltd | |
| JP3811196B2 (ja) | 1993-08-26 | 2006-08-16 | 武田薬品工業株式会社 | エンドセリン拮抗剤、チエノピリミジン誘導体およびその製造法 |
| US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
| ATE227726T1 (de) | 1995-08-17 | 2002-11-15 | Takeda Chemical Industries Ltd | Thienopyrimidinderivate als endothelin antagonisten |
| JPH09110873A (ja) | 1995-08-17 | 1997-04-28 | Takeda Chem Ind Ltd | チエノピリミジン誘導体、その製造法および用途 |
| JP2007302703A (ja) | 1996-04-30 | 2007-11-22 | Takeda Chem Ind Ltd | 医薬組成物 |
| AU2407997A (en) | 1996-04-30 | 1997-11-19 | Takeda Chemical Industries Ltd. | Combined use of gnrh agonist and antagonist |
| SE9702001D0 (sv) | 1997-05-28 | 1997-05-28 | Astra Pharma Prod | Novel compounds |
| US6984644B2 (en) | 1997-05-28 | 2006-01-10 | Astrazeneca Ab | Treatment of skin disorders using thieno[2,3-D]pyrimidinediones |
| DE19754082A1 (de) | 1997-12-05 | 1999-06-10 | Knoll Ag | Methode zur Bekämpfung der Fettleibigkeit |
| JP2002541258A (ja) | 1999-04-09 | 2002-12-03 | セル セラピューティクス インコーポレーテッド | インターリューキン−１２シグナルを阻害するための治療用化合物及びその使用方法 |
| MXPA03004926A (es) | 2001-02-14 | 2005-02-14 | Warner Lambert Co | Inhibidores de metaloproteinasas de matriz basados en pirimidinonas fusionadas. |
| US7655658B2 (en) | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| EA200400980A1 (ru) | 2002-02-27 | 2005-02-24 | Пфайзер Продактс Инк. | Ингибиторы асс |
| WO2004014916A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
| EP1585392B1 (en) | 2003-01-06 | 2009-03-18 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Herbicides inhibiting the action of plant acetyl-coa carboxylase for use as pesticides. |
| KR101074462B1 (ko) | 2003-01-29 | 2011-10-18 | 다케다 야쿠힌 고교 가부시키가이샤 | 티에노피리미딘 화합물 및 그 용도 |
| US7947691B2 (en) | 2004-07-21 | 2011-05-24 | Athersys, Inc. | Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof |
| CA2644996A1 (en) | 2006-03-02 | 2007-09-13 | Cv Therapeutics, Inc. | A2a adenosine receptor antagonists |
| US8501750B2 (en) | 2007-05-21 | 2013-08-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| AU2009259839A1 (en) | 2008-06-20 | 2009-12-23 | Kinemed, Inc. | Compositions for the treatment of fibrotic diseases or conditions |
| WO2010050445A1 (ja) | 2008-10-27 | 2010-05-06 | 武田薬品工業株式会社 | 二環性化合物 |
| US20100113473A1 (en) | 2008-10-30 | 2010-05-06 | Player Mark R | Aryl amide compound as an acetyl coenzyme a carboxylase inhibitor |
| PT2519527E (pt) | 2009-12-29 | 2014-02-17 | Poxel | Tieno[2,3-b]piridinodiona como activadores de ampk e suas utilizações terapêuticas |
| WO2012090219A2 (en) | 2010-12-31 | 2012-07-05 | Jubilant Biosys Ltd. | Thiazole compounds useful as acetyl-coa carboxylase (acc) inhibitors |
| KR102060290B1 (ko) * | 2011-11-11 | 2019-12-27 | 길리어드 아폴로, 엘엘씨 | Ａｃｃ 억제제 및 이의 용도 |
| KR20170010342A (ko) | 2012-02-15 | 2017-01-31 | 로베르트 보쉬 게엠베하 | 도핑된 전극을 갖는 압력 센서 |
| JP5842804B2 (ja) * | 2012-12-28 | 2016-01-13 | カシオ計算機株式会社 | 表示端末装置及びプログラム |
| JP6417401B2 (ja) | 2013-05-10 | 2018-11-07 | ギリアド アポロ， エルエルシー | Ａｃｃ阻害剤及びその使用 |
| MX2015015421A (es) | 2013-05-10 | 2016-06-21 | Nimbus Apollo Inc | Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos. |
| WO2015007451A1 (en) * | 2013-07-15 | 2015-01-22 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
| CN107106873A (zh) | 2015-01-09 | 2017-08-29 | 吉利德阿波罗公司 | 用于治疗非酒精性脂肪肝病的acc抑制剂组合治疗 |
| AR106472A1 (es) * | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
| KR20180082558A (ko) | 2015-11-25 | 2018-07-18 | 길리어드 아폴로, 엘엘씨 | 에스테르 acc 억제제 및 그의 용도 |
| US20170166584A1 (en) * | 2015-11-25 | 2017-06-15 | Gilead Apollo, Llc | Triazole acc inhibitors and uses thereof |
| US20170166585A1 (en) | 2015-11-25 | 2017-06-15 | Gilead Apollo, Llc | Pesticidal compositions and uses thereof |
| CN108349995B (zh) * | 2015-11-25 | 2021-08-03 | 吉利德阿波罗公司 | 吡唑acc抑制剂及其用途 |
| MX2018010427A (es) | 2016-03-02 | 2019-03-06 | Gilead Apollo Llc | Formas solidas de un inhibidor de tienopirimidindiona acetil coa carboxilasa y metodos para su produccion. |
| KR102577824B1 (ko) | 2017-01-22 | 2023-09-13 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 티에노피리미딘 유도체 및 의약에서 이의 용도 |
| KR20190036705A (ko) | 2017-09-28 | 2019-04-05 | 한미약품 주식회사 | (2r)-2-(2-메톡시페닐)-2-(옥산-4-일옥시)에탄-1-올 화합물의 신규 제조방법 및 이에 사용되는 중간체 |
| US12323113B2 (en) | 2021-11-29 | 2025-06-03 | Macom Technology Solutions Holdings, Inc. | Circuit and method of shutdown for bias network in high voltage amplifier |
-
2017
- 2017-03-01 MX MX2018010427A patent/MX2018010427A/es unknown
- 2017-03-01 TW TW112134636A patent/TWI844474B/zh active
- 2017-03-01 BR BR112018067408A patent/BR112018067408A2/pt not_active Application Discontinuation
- 2017-03-01 SG SG11201807077RA patent/SG11201807077RA/en unknown
- 2017-03-01 JP JP2018545600A patent/JP6944462B2/ja active Active
- 2017-03-01 US US15/446,873 patent/US10183951B2/en active Active
- 2017-03-01 CN CN202411834934.5A patent/CN119977993A/zh active Pending
- 2017-03-01 TW TW106106735A patent/TWI788281B/zh active
- 2017-03-01 CN CN202110182955.3A patent/CN112920200A/zh active Pending
- 2017-03-01 ES ES17711446T patent/ES2972487T3/es active Active
- 2017-03-01 KR KR1020247028256A patent/KR102744343B1/ko active Active
- 2017-03-01 PL PL17711446.9T patent/PL3423456T3/pl unknown
- 2017-03-01 TW TW111147581A patent/TWI818828B/zh active
- 2017-03-01 CA CA3172549A patent/CA3172549A1/en active Pending
- 2017-03-01 CA CA3220447A patent/CA3220447A1/en active Pending
- 2017-03-01 WO PCT/US2017/020271 patent/WO2017151816A1/en active Application Filing
- 2017-03-01 KR KR1020187027295A patent/KR102622161B1/ko active Active
- 2017-03-01 CN CN201780014543.0A patent/CN108699078A/zh active Pending
- 2017-03-01 AU AU2017226267A patent/AU2017226267B2/en active Active
- 2017-03-01 EP EP17711446.9A patent/EP3423456B1/en active Active
- 2017-03-01 KR KR1020237007117A patent/KR102700008B1/ko active Active
- 2017-03-01 EP EP23219327.6A patent/EP4364795A3/en active Pending
- 2017-03-01 CA CA3155220A patent/CA3155220C/en active Active
- 2017-03-01 CA CA3015526A patent/CA3015526C/en active Active
-
2018
- 2018-08-20 IL IL261255A patent/IL261255A/en unknown
- 2018-12-12 US US16/217,935 patent/US10487090B2/en active Active
-
2019
- 2019-10-10 US US16/598,411 patent/US11104687B2/en active Active
-
2021
- 2021-07-26 AU AU2021209149A patent/AU2021209149B2/en active Active
- 2021-08-03 US US17/393,030 patent/US11912718B2/en active Active
- 2021-09-10 JP JP2021147802A patent/JP7184988B2/ja active Active
-
2022
- 2022-11-24 JP JP2022187472A patent/JP7356564B2/ja active Active
-
2023
- 2023-07-18 AU AU2023206094A patent/AU2023206094A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201807077RA (en) | Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof | |
| SG11201908532UA (en) | Macrocyclic compounds as ros1 kinase inhibitors | |
| SG11201804373VA (en) | Compositions and methods for immunooncology | |
| SG11201811491YA (en) | Quinazoline and indole compounds to treat medical disorders | |
| SG11201807269PA (en) | Filamentous fungal biomats, methods of their production and methods of their use | |
| SG11201806302RA (en) | Inhibitors of receptor-interacting protein kinase 1 | |
| SG11201907056XA (en) | Compositions and methods for the treatment of hemoglobinopathies | |
| SG11201901131VA (en) | Substituted pyrrolizine compounds and uses thereof | |
| SG11201809344QA (en) | Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde | |
| SG11201809714TA (en) | Piperidines as menin inhibitors | |
| SG11201804294WA (en) | Tank-binding kinase inhibitor compounds | |
| SG11201408739VA (en) | Inhibitors of hepatitis c virus | |
| SG11201407115XA (en) | Carboxylic acid compounds | |
| SG11201809922YA (en) | Pyrazole derivatives as plasma kallikrein inhibitors | |
| SG11201805300QA (en) | Heterocyclic compounds as immunomodulators | |
| SG11201807809XA (en) | A transient commensal microorganism for improving gut health | |
| SG11201907356SA (en) | Piperidine-substituted mnk inhibitors and methods related thereto | |
| SG11201408013WA (en) | Solid forms of an antiviral compound | |
| SG11201804890TA (en) | Bipyrazolyl derivatives useful for the treatment of autoimmune diseases | |
| SG11201407533SA (en) | Antiviral compounds | |
| SG11201909155VA (en) | Ask1 inhibitor compounds and uses thereof | |
| SG11201900464TA (en) | HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-ß) | |
| SG11201901063SA (en) | Therapeutic agents for neurodegenerative diseases | |
| SG11201909376TA (en) | Crystalline forms of a jak inhibitor compound | |
| SG11201805001UA (en) | Method of treating influenza a |