SG11201805191SA - Yeast cell - Google Patents
Yeast cellInfo
- Publication number
- SG11201805191SA SG11201805191SA SG11201805191SA SG11201805191SA SG11201805191SA SG 11201805191S A SG11201805191S A SG 11201805191SA SG 11201805191S A SG11201805191S A SG 11201805191SA SG 11201805191S A SG11201805191S A SG 11201805191SA SG 11201805191S A SG11201805191S A SG 11201805191SA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- yeast cell
- pct
- graz
- promoter
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0093—Oxidoreductases (1.) acting on CH or CH2 groups (1.17)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 29 June 2017 (29.06.2017) WIPO I PCT (10) International Publication Number WO 2017/109082 Al 1111111111111101110101011111010111110 III 0101101111011111101011111111111110111111 (51) International Patent Classification: C42P 21/02 (2006.01) Cl 2N 1/19 (2006.01) C12N 15/63 (2006.01) CJ2R 1/84 (2006.01) (21) International Application Number: PCT/EP2016/082398 (22) International Filing Date: 22 December 2016 (22.12.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 15202233.1 22 December 2015 (22.12.2015) EP (71) Applicant: TECHNISCHE UNIVERSITAT GRAZ [AT/AT]; RechbauerstraBe 12, 8010 Graz (AT). (72) Inventors: VOGL, Thomas; ThalerseestraBe 7, 8052 Graz (AT). GLIEDER, Anton; Wetzawinkel 20, 8200 Hofstat- ten an der Raab (AT). (74) Agent: KLIMENT & HENHAPEL PATENTAN- WAELTE OG; Singerstrasse 8/3/9, 1010 Wien (AT). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) W O 20 17 / 10908 2 Al (54) Title: YEAST CELL (57) : The present invention relates to a yeast cell of the Komagataella genus comprising an orthologous promoter of a methylotrophic yeast cell or a variant thereof inducible by derepression, wherein the orthologous promoter is an orthologous formate dehydrogenase (FMD) promoter of a methylotrophic yeast cell.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15202233.1A EP3184642B1 (en) | 2015-12-22 | 2015-12-22 | Yeast cell |
| PCT/EP2016/082398 WO2017109082A1 (en) | 2015-12-22 | 2016-12-22 | Yeast cell |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201805191SA true SG11201805191SA (en) | 2018-07-30 |
Family
ID=55068836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201805191SA SG11201805191SA (en) | 2015-12-22 | 2016-12-22 | Yeast cell |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11891418B2 (en) |
| EP (2) | EP3184642B1 (en) |
| JP (1) | JP6910358B2 (en) |
| KR (1) | KR102730604B1 (en) |
| CN (1) | CN108603213B (en) |
| AU (1) | AU2016378641B2 (en) |
| CA (1) | CA3009272A1 (en) |
| DK (2) | DK3184642T3 (en) |
| ES (1) | ES2740449T3 (en) |
| MX (1) | MX2018007725A (en) |
| SG (1) | SG11201805191SA (en) |
| UA (1) | UA126112C2 (en) |
| WO (1) | WO2017109082A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3994252A1 (en) | 2019-07-05 | 2022-05-11 | bisy GmbH | Recombinant heme thiolate oxygenases |
| BR112022000545A2 (en) | 2019-07-11 | 2022-04-05 | Clara Foods Co | Protein compositions and consumer products of these |
| US12096784B2 (en) | 2019-07-11 | 2024-09-24 | Clara Foods Co. | Protein compositions and consumable products thereof |
| US10927360B1 (en) | 2019-08-07 | 2021-02-23 | Clara Foods Co. | Compositions comprising digestive enzymes |
| EP3922726A1 (en) | 2020-06-10 | 2021-12-15 | Erber Aktiengesellschaft | Truncated promoter for recombinant gene expression |
| CN117203323A (en) | 2020-12-29 | 2023-12-08 | 比西有限公司 | Novel yeast strain |
| US11993792B2 (en) | 2021-05-27 | 2024-05-28 | New England Biolabs, Inc. | DNase I variants, compositions, methods, and kits |
| EP4116408B8 (en) * | 2021-06-24 | 2024-11-27 | BioBoost Synbio Consulting Inc. | Method for methanol free culturing of methylotrophic yeast for the biosynthesis of added value products |
| WO2024253122A1 (en) * | 2023-06-06 | 2024-12-12 | 富士フイルム株式会社 | Recombinant yeast, method for producing target protein, and kit and method for producing recombinant yeast |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3765978D1 (en) * | 1986-11-24 | 1990-12-13 | Unilever Nv | METHOD FOR PRODUCING A CATALASE-FREE, OXIDASE-CONTAINING YEAR AND THE USE THEREOF. |
| JP3794748B2 (en) * | 1996-03-04 | 2006-07-12 | 第一アスビオファーマ株式会社 | Method for culturing microorganisms with methanol metabolism |
| WO2000056903A2 (en) * | 1999-03-22 | 2000-09-28 | Zymogenetics, Inc. | IMPROVED METHODS FOR PRODUCING PROTEINS IN TRANSFORMED $i(PICHIA) |
| CA2444006A1 (en) * | 2001-04-24 | 2002-10-31 | Innogenetics N.V. | Expression of core-glycosylated hcv envelope proteins in yeast |
| DE10220894A1 (en) * | 2002-05-10 | 2003-11-27 | Rhein Biotech Proz & Prod Gmbh | Promoters with changed transcription efficiency |
| DK2106447T3 (en) * | 2007-01-26 | 2013-06-24 | Novozymes As | Method for methanol-independent induction from methanol-inducible promoters in Pichia |
| WO2010004042A2 (en) * | 2008-07-11 | 2010-01-14 | Novozymes A/S | Pichia pastoris das promoter variants |
| EP2862933B8 (en) | 2013-07-05 | 2019-12-11 | bisy e.U. | Bidirectional promoter |
-
2015
- 2015-12-22 ES ES15202233T patent/ES2740449T3/en active Active
- 2015-12-22 EP EP15202233.1A patent/EP3184642B1/en active Active
- 2015-12-22 DK DK15202233.1T patent/DK3184642T3/en active
-
2016
- 2016-12-22 JP JP2018533214A patent/JP6910358B2/en active Active
- 2016-12-22 SG SG11201805191SA patent/SG11201805191SA/en unknown
- 2016-12-22 CA CA3009272A patent/CA3009272A1/en active Pending
- 2016-12-22 DK DK16825759.0T patent/DK3394281T3/en active
- 2016-12-22 UA UAA201807012A patent/UA126112C2/en unknown
- 2016-12-22 KR KR1020187020509A patent/KR102730604B1/en active IP Right Grant
- 2016-12-22 WO PCT/EP2016/082398 patent/WO2017109082A1/en active Application Filing
- 2016-12-22 US US16/065,377 patent/US11891418B2/en active Active
- 2016-12-22 EP EP16825759.0A patent/EP3394281B1/en active Active
- 2016-12-22 AU AU2016378641A patent/AU2016378641B2/en active Active
- 2016-12-22 MX MX2018007725A patent/MX2018007725A/en unknown
- 2016-12-22 CN CN201680081026.0A patent/CN108603213B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2740449T3 (en) | 2020-02-05 |
| MX2018007725A (en) | 2018-11-09 |
| WO2017109082A1 (en) | 2017-06-29 |
| KR20180088733A (en) | 2018-08-06 |
| US20210355173A1 (en) | 2021-11-18 |
| EP3394281B1 (en) | 2020-08-19 |
| AU2016378641B2 (en) | 2021-04-08 |
| EP3394281A1 (en) | 2018-10-31 |
| EP3184642A1 (en) | 2017-06-28 |
| JP6910358B2 (en) | 2021-07-28 |
| AU2016378641A1 (en) | 2018-07-05 |
| EP3184642B1 (en) | 2019-05-08 |
| KR102730604B1 (en) | 2024-11-14 |
| US11891418B2 (en) | 2024-02-06 |
| CN108603213A (en) | 2018-09-28 |
| CA3009272A1 (en) | 2017-06-29 |
| DK3394281T3 (en) | 2020-11-09 |
| DK3184642T3 (en) | 2019-08-12 |
| UA126112C2 (en) | 2022-08-17 |
| CN108603213B (en) | 2022-05-03 |
| JP2019505194A (en) | 2019-02-28 |
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