SG11201803095UA - 6-[5-amino-6-(2-ethoxyethoxy)-imidazo[4,5-b]pyridin-3-yl]-nicotinonitrile derivatives and their use as irak inhibitors - Google Patents

6-[5-amino-6-(2-ethoxyethoxy)-imidazo[4,5-b]pyridin-3-yl]-nicotinonitrile derivatives and their use as irak inhibitors

Info

Publication number: SG11201803095UA
Authority: SG; Singapore
Prior art keywords: ethoxyethoxy; imidazo; pyridin; amino; irak inhibitors
Prior art date: 2015-10-19

Application number

SG11201803095UA

Inventor

Reginald Brys

Raphaël Geney

Agnès Joncour

Julien Doyon

Frédéric Labéguère

Jean-Michel Lefrancois

Oscar Mammoliti

Benoît Schmitt

Der Plas Steven Van

Christel Menet

Original Assignee

Galapagos Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-10-19

Filing date

2016-10-14

Publication date

2018-05-30

2016-10-14 Application filed by Galapagos Nv filed Critical Galapagos Nv

2018-05-30 Publication of SG11201803095UA publication Critical patent/SG11201803095UA/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SG11201803095UA 2015-10-19 2016-10-14 6-[5-amino-6-(2-ethoxyethoxy)-imidazo[4,5-b]pyridin-3-yl]-nicotinonitrile derivatives and their use as irak inhibitors SG11201803095UA (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB1518456.7A GB201518456D0 (en)	2015-10-19	2015-10-19	Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory, autoimmune and/or proliferative diseases
PCT/EP2016/074662 WO2017067848A1 (en)	2015-10-19	2016-10-14	6-[5-amino-6-(2-ethoxyethoxy)-imidazo[4,5-b]pyridin-3-yl]-nicotinonitrile derivatives and their use as irak inhibitors

Publications (1)

Publication Number	Publication Date
SG11201803095UA true SG11201803095UA (en)	2018-05-30

Family

ID=55131239

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG11201803095UA SG11201803095UA (en)	2015-10-19	2016-10-14	6-[5-amino-6-(2-ethoxyethoxy)-imidazo[4,5-b]pyridin-3-yl]-nicotinonitrile derivatives and their use as irak inhibitors

Country Status (18)

Country	Link
US (1)	US10508111B2 (en)
EP (1)	EP3365341B1 (en)
JP (1)	JP2018530617A (en)
KR (1)	KR20180064528A (en)
CN (1)	CN108137584A (en)
AR (1)	AR106384A1 (en)
AU (1)	AU2016343225A1 (en)
BR (1)	BR112018007392A2 (en)
CA (1)	CA3002255A1 (en)
CO (1)	CO2018004765A2 (en)
GB (1)	GB201518456D0 (en)
IL (1)	IL258707A (en)
MX (1)	MX2018004517A (en)
PH (1)	PH12018500827A1 (en)
RU (1)	RU2018117499A (en)
SG (1)	SG11201803095UA (en)
TW (1)	TW201718582A (en)
WO (1)	WO2017067848A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JOP20180011A1 (en)	2017-02-16	2019-01-30	Gilead Sciences Inc	PYRROLO[1,2-b] PYRIDAZINE DERIVATIVES
GB201702603D0 (en) *	2017-02-17	2017-04-05	Galápagos Nv	Novel compositions and pharmaceutical compositions thereof for the treatment of inflammatory disorders
WO2019111218A1 (en)	2017-12-08	2019-06-13	Cadila Healthcare Limited	Novel heterocyclic compounds as irak4 inhibitors
TWI842978B (en)	2018-07-13	2024-05-21	美商基利科學股份有限公司	Pyrrolo[1,2-b]pyridazine derivatives
GB201904373D0 (en) *	2019-03-29	2019-05-15	Galapagos Nv	Novel compounds and pharamaceutical compositions thereof for the treatment of inflammatory disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UY28506A1 (en) *	2003-09-12	2005-04-29	Basf Ag	6-HALOGEN- (1,2,4) TRIAZOL (1,5-A) PYRIMIDINS TO COMBAT ANIMAL PESTS.
MXPA06007640A (en) *	2004-01-12	2007-04-17	Cytopia Res Pty Ltd	Selective kinase inhibitors.
EP2673269A1 (en) *	2011-02-09	2013-12-18	F.Hoffmann-La Roche Ag	Heterocyclic compounds as pi3 kinase inhibitors
WO2015048281A1 (en) *	2013-09-27	2015-04-02	Nimbus Iris, Inc.	Irak inhibitors and uses thereof
AR098991A1 (en) *	2014-01-03	2016-06-22	Bristol Myers Squibb Co	NICOTINAMIDE COMPOUNDS REPLACED WITH HETEROARILE

2015
- 2015-10-19 GB GBGB1518456.7A patent/GB201518456D0/en not_active Ceased
2016
- 2016-10-14 EP EP16794525.2A patent/EP3365341B1/en active Active
- 2016-10-14 KR KR1020187013738A patent/KR20180064528A/en unknown
- 2016-10-14 JP JP2018538935A patent/JP2018530617A/en not_active Ceased
- 2016-10-14 CA CA3002255A patent/CA3002255A1/en not_active Abandoned
- 2016-10-14 AU AU2016343225A patent/AU2016343225A1/en not_active Abandoned
- 2016-10-14 RU RU2018117499A patent/RU2018117499A/en not_active Application Discontinuation
- 2016-10-14 MX MX2018004517A patent/MX2018004517A/en unknown
- 2016-10-14 SG SG11201803095UA patent/SG11201803095UA/en unknown
- 2016-10-14 WO PCT/EP2016/074662 patent/WO2017067848A1/en active Application Filing
- 2016-10-14 US US15/769,260 patent/US10508111B2/en not_active Expired - Fee Related
- 2016-10-14 BR BR112018007392A patent/BR112018007392A2/en not_active Application Discontinuation
- 2016-10-14 CN CN201680060910.6A patent/CN108137584A/en active Pending
- 2016-10-17 AR ARP160103166A patent/AR106384A1/en unknown
- 2016-10-18 TW TW105133608A patent/TW201718582A/en unknown
2018
- 2018-04-15 IL IL258707A patent/IL258707A/en unknown
- 2018-04-17 PH PH12018500827A patent/PH12018500827A1/en unknown
- 2018-05-03 CO CONC2018/0004765A patent/CO2018004765A2/en unknown

Also Published As

Publication number	Publication date
IL258707A (en)	2018-06-28
RU2018117499A3 (en)	2020-01-24
RU2018117499A (en)	2019-11-21
CA3002255A1 (en)	2017-04-27
KR20180064528A (en)	2018-06-14
CN108137584A (en)	2018-06-08
WO2017067848A1 (en)	2017-04-27
US10508111B2 (en)	2019-12-17
BR112018007392A2 (en)	2018-10-16
PH12018500827A1 (en)	2018-10-29
EP3365341B1 (en)	2020-05-13
EP3365341A1 (en)	2018-08-29
US20180305351A1 (en)	2018-10-25
GB201518456D0 (en)	2015-12-02
AU2016343225A1 (en)	2018-05-10
MX2018004517A (en)	2018-06-27
AR106384A1 (en)	2018-01-10
CO2018004765A2 (en)	2018-07-19
JP2018530617A (en)	2018-10-18
TW201718582A (en)	2017-06-01

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HK1244787A1 (en)	2018-08-17	Novel 5 or 8-substituted imidazo [1, 5-a] pyridines as indoleamine and/or tryptophane 2, 3-dioxygenases
HK1248240A1 (en)	2018-10-12	Nicotinic acid riboside or nicotinamide riboside compositions, reduced derivatives thereof, and the use thereof
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IL258978B (en)	2021-04-29	Use of pyrimidine and pyridine derivatives in the treatment of multiple sclerosis
HK1225723A1 (en)	2017-09-15	Substituted imidazo[1,2-a]pyridinecarboxamides and their use
PT3487851T (en)	2022-01-07	Aminopyridine derivatives and their use as selective alk-2 inhibitors
IL266986B (en)	2022-03-01	Imidazo [1,5-a] pyrazine derivatives as pi3kdelta inhibitors
GB201802644D0 (en)	2018-04-04	Monocyclic,thieno, pyrido and pyrrolo pyrimidine compounds and methods of use and manufacture of the same
IL263652A (en)	2019-01-31	Bicyclic pyridine, pyrazine, and pyrimidine derivatives as pi3k beta inhibitors
IL258690A (en)	2018-06-28	Pyridone derivatives and their use as kinase inhibitors
HK1245274A1 (en)	2018-08-24	1 -amino-triazolo(1,5-a)pyridine-substituted urea derivative and uses thereof
TH1601003263A (en)	2017-09-21	pyrrolo[2,3-D]pyrimidinyl, pyrrolo[2,3-B]pyrazinil and pyrrolo[2,3-D]pyridinyl ac Rylamide