SG11201803043VA - Derivation of human skin organoids from pluripotent stem cells - Google Patents
Derivation of human skin organoids from pluripotent stem cellsInfo
- Publication number
- SG11201803043VA SG11201803043VA SG11201803043VA SG11201803043VA SG11201803043VA SG 11201803043V A SG11201803043V A SG 11201803043VA SG 11201803043V A SG11201803043V A SG 11201803043VA SG 11201803043V A SG11201803043V A SG 11201803043VA SG 11201803043V A SG11201803043V A SG 11201803043VA
- Authority
- SG
- Singapore
- Prior art keywords
- derivation
- stem cells
- pluripotent stem
- human skin
- skin organoids
- Prior art date
Links
Classifications
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
- C12N5/0698—Skin equivalents
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- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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US201562244612P | 2015-10-21 | 2015-10-21 | |
PCT/US2016/058174 WO2017070506A1 (en) | 2015-10-21 | 2016-10-21 | Derivation of human skin organoids from pluripotent stem cells |
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WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
CN106661548B (en) | 2014-05-28 | 2020-12-11 | 儿童医院医疗中心 | Methods and systems for converting precursor cells to stomach tissue via directed differentiation |
EP3207123A1 (en) | 2014-10-17 | 2017-08-23 | Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
SG11201803061UA (en) | 2015-10-21 | 2018-05-30 | Univ Indiana Res & Tech Corp | Methods of generating human inner ear sensory epithelia and sensory neurons |
US11066650B2 (en) | 2016-05-05 | 2021-07-20 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
JP7044330B2 (en) * | 2016-06-17 | 2022-03-30 | 国立大学法人横浜国立大学 | Cell-embedded beads for hair regeneration and their manufacturing method, and hair regeneration kit |
KR20190020736A (en) * | 2016-06-21 | 2019-03-04 | 가부시키가이샤 오간 테크놀로지즈 | Method for manufacturing artificial skin having hair follicles, sebaceous glands and pores |
CA3045145A1 (en) | 2016-12-05 | 2018-06-14 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
KR102122039B1 (en) | 2017-07-19 | 2020-06-11 | 서울대학교산학협력단 | Method for differentiation of dermal papilla precursor cells from human pluripotent stem cells and uses thereof |
WO2019017691A2 (en) * | 2017-07-19 | 2019-01-24 | 서울대학교 산학협력단 | Method of differentiation of human induced pluripotent stem cell to dermal papilla precursor cell and use thereof |
WO2019148395A1 (en) * | 2018-01-31 | 2019-08-08 | 深圳市祥云生物科技有限公司 | Artificial hair follicle, preparation method therefor and use thereof |
CN110093306B (en) * | 2018-01-31 | 2022-12-02 | 中山大学 | Artificial hair follicle and preparation method and application thereof |
JP7078925B2 (en) * | 2018-02-07 | 2022-06-01 | 国立大学法人横浜国立大学 | Hair follicle epithelial stem cell culture method and culture kit |
CN112334771A (en) * | 2018-06-28 | 2021-02-05 | 欧莱雅 | Kit for in vitro screening of active compounds, method and use of the kit |
US20210340498A1 (en) * | 2018-09-07 | 2021-11-04 | Cha Biotech Co., Ltd. | Medium for direct differentiation of pluripotent stem cell-derived mesenchymal stem cell, method for preparing mesenchymal stem cell by using same, and mesenchymal stem cell prepared thereby |
CN111088213B (en) * | 2018-10-24 | 2022-04-08 | 澳门大学 | Method for inducing stem cells to gradually differentiate to form keratinocytes and keratinocytes |
WO2020095592A1 (en) | 2018-11-07 | 2020-05-14 | 剛士 田邊 | Pharmaceutical composition and cosmetic composition |
JP7246066B2 (en) * | 2018-12-11 | 2023-03-27 | 日本メナード化粧品株式会社 | Three-dimensional cultured epidermis model and manufacturing method thereof |
EP4022037A1 (en) * | 2019-07-10 | 2022-07-06 | Helmuth Heinrich Kunz | Methods for deriving autologous and hypoimmunogenic hair follicle containing sheets in vitro |
KR20210092408A (en) | 2020-01-16 | 2021-07-26 | 삼성전자주식회사 | Bio-electroceutical device using cell cluster |
CN111471643B (en) * | 2020-04-09 | 2020-12-29 | 创芯国际生物科技(广州)有限公司 | Universal culture medium and culture method for upper respiratory mucosa organoid |
JP2023547088A (en) * | 2020-10-21 | 2023-11-09 | カンステム バイオテック カンパニー リミテッド | Method for creating an atopic dermatitis model using skin organoids derived from pluripotent stem cells |
CN112746074B (en) * | 2020-12-16 | 2022-12-02 | 南方医科大学皮肤病医院(广东省皮肤病医院、广东省皮肤性病防治中心、中国麻风防治研究中心) | Construction and induced differentiation method of hESCs cell line knocked in by Keratin 5-IRES-eGFP |
US20230101335A1 (en) | 2021-05-06 | 2023-03-30 | Massachusetts Institute Of Technology | Ex vivo tissue explant and graft platform and uses thereof |
GB202201229D0 (en) * | 2022-01-31 | 2022-03-16 | Alcyomics Ltd | An innervated cellular composite |
JP7315184B2 (en) * | 2022-02-16 | 2023-07-26 | 株式会社コーセー | Method for inducing differentiation from pluripotent stem cells to epidermal keratinocytes |
WO2024044229A2 (en) * | 2022-08-24 | 2024-02-29 | Vitrolabs Inc | Scaffold materials for artificial dermal layer |
KR20240043723A (en) * | 2022-09-27 | 2024-04-03 | 오알지 주식회사 | Skin organoids, method for preparing the same and method for evaluating drug using the same |
CN115418386B (en) * | 2022-11-03 | 2023-03-24 | 成都诺医德医学检验实验室有限公司 | Damage healing evaluation method based on skin organoid, model and application |
CN118086185B (en) * | 2024-04-29 | 2024-07-19 | 广州中医药大学(广州中医药研究院) | Application and method of tortoise plastron extract for inducing pluripotent stem cells to differentiate to form skin organoids |
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DE10162814B4 (en) * | 2001-12-19 | 2005-06-23 | Henkel Kgaa | Reconstructed hair follicle model |
JP4565112B2 (en) * | 2004-09-15 | 2010-10-20 | 独立行政法人産業技術総合研究所 | Hair growth promoter, hair growth promoter, and alopecia treatment |
CN101431962A (en) * | 2006-02-07 | 2009-05-13 | 器官发生有限公司 | Bioengineered tissue constructs and cardiac uses thereof |
CA2675445C (en) | 2007-01-17 | 2014-11-04 | Wisconsin Alumni Research Foundation | Improved culture of stem cells |
CN102186969A (en) * | 2008-06-25 | 2011-09-14 | 国家健康与医学研究院 | Methods for preparing human skin substitutes from human pluripotent stem cells |
US20110321180A1 (en) * | 2008-11-20 | 2011-12-29 | University Of Southern California | Compositions and methods to generate pilosebaceous units |
US20120148541A1 (en) * | 2010-10-28 | 2012-06-14 | University Of Southern California | Compositions and methods to generate pilosebaceous units |
WO2013166488A1 (en) * | 2012-05-04 | 2013-11-07 | Indiana University Research & Technology Corporation | Methods for generating the inner ear and other cranial placode-derived tissues using pluripotent stem cells |
CN103785064B (en) * | 2013-08-26 | 2015-02-25 | 济南磐升生物技术有限公司 | Human skin module and application thereof |
US10080771B2 (en) * | 2015-01-28 | 2018-09-25 | The Trustees Of The University Of Pennsylvania | Compositions and methods for generation of human epithelial stem cells |
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