SG11201708030XA - Conjugate compounds of ursodeoxycholic, berberine or l-carnitine, and compositions and methods thereof - Google Patents
Conjugate compounds of ursodeoxycholic, berberine or l-carnitine, and compositions and methods thereofInfo
- Publication number
- SG11201708030XA SG11201708030XA SG11201708030XA SG11201708030XA SG11201708030XA SG 11201708030X A SG11201708030X A SG 11201708030XA SG 11201708030X A SG11201708030X A SG 11201708030XA SG 11201708030X A SG11201708030X A SG 11201708030XA SG 11201708030X A SG11201708030X A SG 11201708030XA
- Authority
- SG
- Singapore
- Prior art keywords
- ursodeoxycholic
- berberine
- carnitine
- compositions
- methods
- Prior art date
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 title 1
- 229940093265 berberine Drugs 0.000 title 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 229960001518 levocarnitine Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
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- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
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- Engineering & Computer Science (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Botany (AREA)
- Child & Adolescent Psychology (AREA)
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- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201562143734P | 2015-04-06 | 2015-04-06 | |
PCT/CN2016/078414 WO2016161921A1 (en) | 2015-04-06 | 2016-04-05 | Conjugate compounds of ursodeoxycholic, berberine or l-carnitine, and compositions and methods thereof |
Publications (1)
Publication Number | Publication Date |
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SG11201708030XA true SG11201708030XA (en) | 2017-10-30 |
Family
ID=57072197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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SG11201708030XA SG11201708030XA (en) | 2015-04-06 | 2016-04-05 | Conjugate compounds of ursodeoxycholic, berberine or l-carnitine, and compositions and methods thereof |
Country Status (9)
Country | Link |
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US (2) | US20180050048A1 (en) |
EP (1) | EP3280712A4 (en) |
JP (1) | JP2018517666A (en) |
CN (1) | CN108137575A (en) |
AU (1) | AU2016245590A1 (en) |
CA (1) | CA2981754A1 (en) |
IL (1) | IL254831A0 (en) |
SG (1) | SG11201708030XA (en) |
WO (1) | WO2016161921A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2019050850A1 (en) * | 2017-09-05 | 2019-03-14 | Primetime Life Sciences, Llc | Biguanidine derivatives of therapeutic agents and methods of preparation and use thereof |
CN108395429A (en) * | 2018-01-23 | 2018-08-14 | 北京宜生堂医药科技研究有限公司 | A kind of compound and its preparation method and application |
WO2020068705A1 (en) | 2018-09-25 | 2020-04-02 | Ponce De Leon Health Designated Activity Company | Process of making calcium alpha-ketoglutarate |
EP4129283A4 (en) * | 2020-03-31 | 2024-04-24 | Natural Medicine Institute of Zhejiang Yangshengtang Co., Ltd. | Pharmaceutical combination and use thereof |
US20230181547A1 (en) * | 2020-05-15 | 2023-06-15 | Nguyen Anh VAN | Solid lipid nano-composition containing berberine and cinnamonaldehyde effective in treating diabetes, dyslipidemia, and method of preparing the same |
CN114195850B (en) * | 2020-09-18 | 2024-08-16 | 成都贝诺科成生物科技有限公司 | Compound for preventing and treating liver diseases and pharmaceutical application thereof |
CN113045689B (en) * | 2021-03-24 | 2022-03-29 | 齐鲁工业大学 | Berberine-cyclodextrin conjugate |
US20230102471A1 (en) * | 2021-09-29 | 2023-03-30 | Cannogen Biosciences, Inc. | Composition And Method for Modulating Hydrogen Ion Physiology Related to Weight Loss and Metabolism |
CN114716498B (en) * | 2022-01-20 | 2024-01-23 | 成都贝诺科成生物科技有限公司 | High-stability carbon-loss ursodeoxycholic acid berberine salt crystal form and preparation method thereof |
CN114747570B (en) * | 2022-03-15 | 2023-03-28 | 浙江蓝德能源科技发展有限公司 | Supramolecular salt antibacterial liquid and preparation method thereof |
TW202432104A (en) * | 2022-12-30 | 2024-08-16 | 大陸商深圳君聖泰生物技術有限公司 | Pharmaceutical combination, pharmaceutical composition and use thereof |
WO2024179570A1 (en) * | 2023-03-01 | 2024-09-06 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions and methods for treating severe hypertriglyceridemia |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2553884C (en) * | 2004-01-28 | 2013-06-25 | Nestec S.A. | Nutritional composition for improving skin condition and preventing skin diseases |
WO2007095760A1 (en) * | 2006-02-23 | 2007-08-30 | Nou Life Sciences, Inc. | Cleavable carnitine compound |
CN101113149B (en) * | 2006-07-25 | 2011-04-27 | 复旦大学 | Aliphatic organic acid salt of berberine type alkaloid and preparation method and usage thereof |
CN102060809B (en) * | 2009-05-01 | 2015-05-20 | 常州高新技术产业开发区三维工业技术研究所有限公司 | Rhein derivatives and preparation and application thereof |
CN101935319A (en) * | 2010-09-09 | 2011-01-05 | 陕西科技大学 | Berberine organic acid salt, berberine organic acid salt inclusion compound and preparation methods thereof |
CN102225913B (en) * | 2011-04-07 | 2013-09-04 | 栗进才 | Rheinic acid derivatives and treatment application thereof |
CN102229636A (en) * | 2011-04-21 | 2011-11-02 | 东北林业大学 | New derivatives of berberine coupled with cholic acid at ninth position through ester bond and preparation methods thereof |
CN102225962A (en) * | 2011-04-21 | 2011-10-26 | 东北林业大学 | New derivative bonded by berberine and cholic acid at 9th position of berberine and preparation method thereof |
CN102225961A (en) * | 2011-04-21 | 2011-10-26 | 东北林业大学 | Novel berberine 9-position coupled cholic acid derivative and preparation method thereof |
EP3498271A1 (en) * | 2011-05-02 | 2019-06-19 | Biokier, Inc. | Composition and method for treatment of diabetes |
CN103319479B (en) * | 2012-03-20 | 2015-08-26 | 王从品 | Rhubarb yellow berberine ion-pair compound, preparation method and application |
CN103989677A (en) * | 2013-12-20 | 2014-08-20 | 中国药科大学 | Use of demethyleneberberine in preparation of blood sugar-reduction drug |
BR112017001623B1 (en) * | 2014-07-29 | 2022-11-29 | Shenzhen Hightide Biopharmaceutical, Ltd | ACID-BASE ADDITION SALT IN SUBSTANTIALLY PURE FORM, PHARMACEUTICAL COMPOSITION COMPRISING AN AMOUNT OF SAID SALT AND ITS USES |
-
2016
- 2016-04-05 SG SG11201708030XA patent/SG11201708030XA/en unknown
- 2016-04-05 AU AU2016245590A patent/AU2016245590A1/en not_active Abandoned
- 2016-04-05 JP JP2017552432A patent/JP2018517666A/en active Pending
- 2016-04-05 CA CA2981754A patent/CA2981754A1/en not_active Abandoned
- 2016-04-05 EP EP16776096.6A patent/EP3280712A4/en not_active Withdrawn
- 2016-04-05 US US15/557,199 patent/US20180050048A1/en not_active Abandoned
- 2016-04-05 CN CN201680032575.9A patent/CN108137575A/en active Pending
- 2016-04-05 WO PCT/CN2016/078414 patent/WO2016161921A1/en active Application Filing
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2017
- 2017-10-02 IL IL254831A patent/IL254831A0/en unknown
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2019
- 2019-04-23 US US16/392,385 patent/US20200022992A1/en not_active Abandoned
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AU2016245590A1 (en) | 2017-10-19 |
WO2016161921A1 (en) | 2016-10-13 |
US20200022992A1 (en) | 2020-01-23 |
EP3280712A4 (en) | 2019-01-09 |
CN108137575A (en) | 2018-06-08 |
US20180050048A1 (en) | 2018-02-22 |
IL254831A0 (en) | 2017-12-31 |
EP3280712A1 (en) | 2018-02-14 |
CA2981754A1 (en) | 2016-10-13 |
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