SG11201610093QA - Histone deacetylase inhibitors and compositions and methods of use thereof - Google Patents
Histone deacetylase inhibitors and compositions and methods of use thereofInfo
- Publication number
- SG11201610093QA SG11201610093QA SG11201610093QA SG11201610093QA SG11201610093QA SG 11201610093Q A SG11201610093Q A SG 11201610093QA SG 11201610093Q A SG11201610093Q A SG 11201610093QA SG 11201610093Q A SG11201610093Q A SG 11201610093QA SG 11201610093Q A SG11201610093Q A SG 11201610093QA
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- methods
- histone deacetylase
- deacetylase inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462006534P | 2014-06-02 | 2014-06-02 | |
PCT/US2015/033511 WO2015187542A1 (en) | 2014-06-02 | 2015-06-01 | Histone deacetylase inhibitors and compositions and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201610093QA true SG11201610093QA (en) | 2016-12-29 |
Family
ID=54767239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201610093QA SG11201610093QA (en) | 2014-06-02 | 2015-06-01 | Histone deacetylase inhibitors and compositions and methods of use thereof |
Country Status (10)
Country | Link |
---|---|
US (2) | US10065948B2 (en) |
EP (1) | EP3148539B1 (en) |
JP (1) | JP6600319B2 (en) |
KR (1) | KR20170012404A (en) |
CN (1) | CN106535891A (en) |
AU (1) | AU2015270926A1 (en) |
CA (1) | CA2951026A1 (en) |
IL (1) | IL249339A0 (en) |
SG (1) | SG11201610093QA (en) |
WO (1) | WO2015187542A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2968233A4 (en) | 2013-03-14 | 2016-08-03 | Chdi Foundation Inc | Histone deacetylase inhibitors and compositions and methods of use thereof |
US9562021B2 (en) | 2013-03-14 | 2017-02-07 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
US9617259B2 (en) | 2013-03-14 | 2017-04-11 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
US10065948B2 (en) | 2014-06-02 | 2018-09-04 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
US10357493B2 (en) | 2017-03-10 | 2019-07-23 | Selenity Therapeutics (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
HRP20220648T1 (en) * | 2017-08-07 | 2022-09-02 | Alkermes, Inc. | Bicyclic inhibitors of histone deacetylase |
CN108379585B (en) * | 2018-04-16 | 2020-10-16 | 复旦大学附属中山医院 | Use of HDAC4 inhibitors for the preparation of a medicament for the treatment of heart failure |
KR102118689B1 (en) * | 2018-10-17 | 2020-06-09 | 최돈수 | Compound for organic light emitting diode, organic light emitting diode having the same, and display apparatus having organic light emitting diode |
WO2023177249A1 (en) * | 2022-03-17 | 2023-09-21 | 숙명여자대학교산학협력단 | Novel binary histone deacetylase inhibitor and pharmaceutical composition containing same |
WO2023177250A1 (en) * | 2022-03-17 | 2023-09-21 | 숙명여자대학교산학협력단 | Novel heterocyclic inhibitor for histone deacetylase, and pharmaceutical composition comprising same |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4003859A (en) | 1974-01-30 | 1977-01-18 | The Upjohn Company | Novel process for trimerizing polyisocyanates |
DE3434942A1 (en) | 1984-09-22 | 1986-04-03 | Basf Ag, 6700 Ludwigshafen | TETRALINE DERIVATIVES, THEIR PRODUCTION AND USE |
US5250732A (en) | 1991-07-18 | 1993-10-05 | Genentech, Inc. | Ketamine analogues for treatment of thrombocytopenia |
AUPP029197A0 (en) | 1997-11-10 | 1997-12-04 | Fujisawa Pharmaceutical Co., Ltd. | Benzocycloheptene derivatives |
EP1446155A1 (en) | 2001-11-09 | 2004-08-18 | Novo Nordisk A/S | Pharmaceutical composition comprising factor vii polypeptides and aprotinin polypeptides |
DK1648906T3 (en) | 2003-07-09 | 2008-02-04 | Takeda Cambridge Ltd | Organo-silicon compounds and their use |
WO2005034880A2 (en) * | 2003-10-09 | 2005-04-21 | Aton Pharma, Inc. | Thiophene and benzothiophene hydroxamic acid derivatives |
US20060069157A1 (en) | 2004-02-19 | 2006-03-30 | U.S. Department Of Veterans Affairs | Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as Huntington's disease, by sodium butyrate chemotherapy |
US7276631B2 (en) | 2004-07-20 | 2007-10-02 | Bristol-Myers Squibb Company | Cyclopentylamine and cyclohexylamine derivatives as NK-1/SSRI antagonists |
GB0510204D0 (en) * | 2005-05-19 | 2005-06-22 | Chroma Therapeutics Ltd | Enzyme inhibitors |
GB0521244D0 (en) | 2005-10-19 | 2005-11-30 | Astrazeneca Ab | Benzamide compounds |
ES2288803B1 (en) * | 2006-07-07 | 2008-12-16 | Universidad De Granada | DERIVATIVES OF BENZO (D) ISOTIAZOLES AS INHIBITORS OF SLOW HISTONES. |
EP2139850B1 (en) * | 2007-04-09 | 2018-09-12 | MethylGene Inc. | Inhibitors of histone deacetylase |
AU2008307575A1 (en) * | 2007-10-04 | 2009-04-09 | Merck Sharp & Dohme Corp. | N-hydroxy-naphthalene dicarboxamide and N-hydroxy-biphenyl-dicarboxamide compounds as histone deacetylase inhibitors |
AU2009242219B2 (en) | 2008-04-28 | 2013-03-21 | Janssen Pharmaceutica Nv | Benzocycloheptane and benzoxepine derivatives |
CN101759683B (en) | 2008-12-25 | 2011-12-28 | 哈尔滨誉衡药业股份有限公司 | Preparation method of hydrindene amide compound, medical composition comprising hydrindene amide compound and application thereof as protein kinase inhibitor |
WO2011106632A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
US20120015942A1 (en) * | 2010-07-19 | 2012-01-19 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
US8614223B2 (en) | 2010-11-16 | 2013-12-24 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof |
TW201245115A (en) | 2011-01-24 | 2012-11-16 | Chdi Foundation Inc | Histone deacetylase inhibitors and compositions and methods of use thereof |
CN102775368B (en) * | 2011-05-10 | 2016-08-17 | 上海驺虞医药科技有限公司 | One class thiazole compound and its production and use |
TW201408628A (en) | 2012-07-16 | 2014-03-01 | Chdi Foundation Inc | Histone deacetylase inhibitors and compositions and methods of use thereof |
US9562021B2 (en) | 2013-03-14 | 2017-02-07 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
US9617259B2 (en) | 2013-03-14 | 2017-04-11 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
US20160031863A1 (en) | 2013-03-14 | 2016-02-04 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
EP2968233A4 (en) | 2013-03-14 | 2016-08-03 | Chdi Foundation Inc | Histone deacetylase inhibitors and compositions and methods of use thereof |
US10065948B2 (en) | 2014-06-02 | 2018-09-04 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
-
2015
- 2015-06-01 US US15/315,713 patent/US10065948B2/en active Active
- 2015-06-01 EP EP15803976.8A patent/EP3148539B1/en active Active
- 2015-06-01 JP JP2016570849A patent/JP6600319B2/en active Active
- 2015-06-01 KR KR1020167036225A patent/KR20170012404A/en unknown
- 2015-06-01 CA CA2951026A patent/CA2951026A1/en not_active Abandoned
- 2015-06-01 SG SG11201610093QA patent/SG11201610093QA/en unknown
- 2015-06-01 CN CN201580039279.7A patent/CN106535891A/en active Pending
- 2015-06-01 AU AU2015270926A patent/AU2015270926A1/en not_active Abandoned
- 2015-06-01 WO PCT/US2015/033511 patent/WO2015187542A1/en active Application Filing
-
2016
- 2016-12-01 IL IL249339A patent/IL249339A0/en unknown
-
2018
- 2018-07-30 US US16/049,482 patent/US10457675B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2017518305A (en) | 2017-07-06 |
US10457675B2 (en) | 2019-10-29 |
CN106535891A (en) | 2017-03-22 |
EP3148539A4 (en) | 2018-01-03 |
US20190062321A1 (en) | 2019-02-28 |
KR20170012404A (en) | 2017-02-02 |
US10065948B2 (en) | 2018-09-04 |
WO2015187542A1 (en) | 2015-12-10 |
WO2015187542A8 (en) | 2016-12-29 |
US20170101402A1 (en) | 2017-04-13 |
IL249339A0 (en) | 2017-02-28 |
AU2015270926A1 (en) | 2017-01-05 |
EP3148539A1 (en) | 2017-04-05 |
EP3148539B1 (en) | 2021-02-17 |
CA2951026A1 (en) | 2015-12-10 |
JP6600319B2 (en) | 2019-10-30 |
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