Nothing Special   »   [go: up one dir, main page]

SG11201610093QA - Histone deacetylase inhibitors and compositions and methods of use thereof - Google Patents

Histone deacetylase inhibitors and compositions and methods of use thereof

Info

Publication number
SG11201610093QA
SG11201610093QA SG11201610093QA SG11201610093QA SG11201610093QA SG 11201610093Q A SG11201610093Q A SG 11201610093QA SG 11201610093Q A SG11201610093Q A SG 11201610093QA SG 11201610093Q A SG11201610093Q A SG 11201610093QA SG 11201610093Q A SG11201610093Q A SG 11201610093QA
Authority
SG
Singapore
Prior art keywords
compositions
methods
histone deacetylase
deacetylase inhibitors
inhibitors
Prior art date
Application number
SG11201610093QA
Inventor
Celia Dominguez
Ignacio MuñOz-Sanjuan
Christopher A Luckhurst
Daniel R Allen
Gilles Raphy
Roland W Bûrli
Perla Breccia
Alan F Haughan
Grant Wishart
Samantah J Hughes
Rebecca E Jarvis
Huw D Vater
Stephen D Penrose
Michael Wall
Andrew J Stott
Elizabeth Saville-Stones
Original Assignee
Chdi Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chdi Foundation Inc filed Critical Chdi Foundation Inc
Publication of SG11201610093QA publication Critical patent/SG11201610093QA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/4161,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/423Oxazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/428Thiazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/08Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/74Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D275/00Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
SG11201610093QA 2014-06-02 2015-06-01 Histone deacetylase inhibitors and compositions and methods of use thereof SG11201610093QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462006534P 2014-06-02 2014-06-02
PCT/US2015/033511 WO2015187542A1 (en) 2014-06-02 2015-06-01 Histone deacetylase inhibitors and compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
SG11201610093QA true SG11201610093QA (en) 2016-12-29

Family

ID=54767239

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201610093QA SG11201610093QA (en) 2014-06-02 2015-06-01 Histone deacetylase inhibitors and compositions and methods of use thereof

Country Status (10)

Country Link
US (2) US10065948B2 (en)
EP (1) EP3148539B1 (en)
JP (1) JP6600319B2 (en)
KR (1) KR20170012404A (en)
CN (1) CN106535891A (en)
AU (1) AU2015270926A1 (en)
CA (1) CA2951026A1 (en)
IL (1) IL249339A0 (en)
SG (1) SG11201610093QA (en)
WO (1) WO2015187542A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2968233A4 (en) 2013-03-14 2016-08-03 Chdi Foundation Inc Histone deacetylase inhibitors and compositions and methods of use thereof
US9562021B2 (en) 2013-03-14 2017-02-07 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
US9617259B2 (en) 2013-03-14 2017-04-11 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
US10065948B2 (en) 2014-06-02 2018-09-04 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
US10357493B2 (en) 2017-03-10 2019-07-23 Selenity Therapeutics (Bermuda), Ltd. Metalloenzyme inhibitor compounds
HRP20220648T1 (en) * 2017-08-07 2022-09-02 Alkermes, Inc. Bicyclic inhibitors of histone deacetylase
CN108379585B (en) * 2018-04-16 2020-10-16 复旦大学附属中山医院 Use of HDAC4 inhibitors for the preparation of a medicament for the treatment of heart failure
KR102118689B1 (en) * 2018-10-17 2020-06-09 최돈수 Compound for organic light emitting diode, organic light emitting diode having the same, and display apparatus having organic light emitting diode
WO2023177249A1 (en) * 2022-03-17 2023-09-21 숙명여자대학교산학협력단 Novel binary histone deacetylase inhibitor and pharmaceutical composition containing same
WO2023177250A1 (en) * 2022-03-17 2023-09-21 숙명여자대학교산학협력단 Novel heterocyclic inhibitor for histone deacetylase, and pharmaceutical composition comprising same

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003859A (en) 1974-01-30 1977-01-18 The Upjohn Company Novel process for trimerizing polyisocyanates
DE3434942A1 (en) 1984-09-22 1986-04-03 Basf Ag, 6700 Ludwigshafen TETRALINE DERIVATIVES, THEIR PRODUCTION AND USE
US5250732A (en) 1991-07-18 1993-10-05 Genentech, Inc. Ketamine analogues for treatment of thrombocytopenia
AUPP029197A0 (en) 1997-11-10 1997-12-04 Fujisawa Pharmaceutical Co., Ltd. Benzocycloheptene derivatives
EP1446155A1 (en) 2001-11-09 2004-08-18 Novo Nordisk A/S Pharmaceutical composition comprising factor vii polypeptides and aprotinin polypeptides
DK1648906T3 (en) 2003-07-09 2008-02-04 Takeda Cambridge Ltd Organo-silicon compounds and their use
WO2005034880A2 (en) * 2003-10-09 2005-04-21 Aton Pharma, Inc. Thiophene and benzothiophene hydroxamic acid derivatives
US20060069157A1 (en) 2004-02-19 2006-03-30 U.S. Department Of Veterans Affairs Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as Huntington's disease, by sodium butyrate chemotherapy
US7276631B2 (en) 2004-07-20 2007-10-02 Bristol-Myers Squibb Company Cyclopentylamine and cyclohexylamine derivatives as NK-1/SSRI antagonists
GB0510204D0 (en) * 2005-05-19 2005-06-22 Chroma Therapeutics Ltd Enzyme inhibitors
GB0521244D0 (en) 2005-10-19 2005-11-30 Astrazeneca Ab Benzamide compounds
ES2288803B1 (en) * 2006-07-07 2008-12-16 Universidad De Granada DERIVATIVES OF BENZO (D) ISOTIAZOLES AS INHIBITORS OF SLOW HISTONES.
EP2139850B1 (en) * 2007-04-09 2018-09-12 MethylGene Inc. Inhibitors of histone deacetylase
AU2008307575A1 (en) * 2007-10-04 2009-04-09 Merck Sharp & Dohme Corp. N-hydroxy-naphthalene dicarboxamide and N-hydroxy-biphenyl-dicarboxamide compounds as histone deacetylase inhibitors
AU2009242219B2 (en) 2008-04-28 2013-03-21 Janssen Pharmaceutica Nv Benzocycloheptane and benzoxepine derivatives
CN101759683B (en) 2008-12-25 2011-12-28 哈尔滨誉衡药业股份有限公司 Preparation method of hydrindene amide compound, medical composition comprising hydrindene amide compound and application thereof as protein kinase inhibitor
WO2011106632A1 (en) * 2010-02-26 2011-09-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US20120015942A1 (en) * 2010-07-19 2012-01-19 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US8614223B2 (en) 2010-11-16 2013-12-24 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
TW201245115A (en) 2011-01-24 2012-11-16 Chdi Foundation Inc Histone deacetylase inhibitors and compositions and methods of use thereof
CN102775368B (en) * 2011-05-10 2016-08-17 上海驺虞医药科技有限公司 One class thiazole compound and its production and use
TW201408628A (en) 2012-07-16 2014-03-01 Chdi Foundation Inc Histone deacetylase inhibitors and compositions and methods of use thereof
US9562021B2 (en) 2013-03-14 2017-02-07 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
US9617259B2 (en) 2013-03-14 2017-04-11 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
US20160031863A1 (en) 2013-03-14 2016-02-04 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
EP2968233A4 (en) 2013-03-14 2016-08-03 Chdi Foundation Inc Histone deacetylase inhibitors and compositions and methods of use thereof
US10065948B2 (en) 2014-06-02 2018-09-04 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof

Also Published As

Publication number Publication date
JP2017518305A (en) 2017-07-06
US10457675B2 (en) 2019-10-29
CN106535891A (en) 2017-03-22
EP3148539A4 (en) 2018-01-03
US20190062321A1 (en) 2019-02-28
KR20170012404A (en) 2017-02-02
US10065948B2 (en) 2018-09-04
WO2015187542A1 (en) 2015-12-10
WO2015187542A8 (en) 2016-12-29
US20170101402A1 (en) 2017-04-13
IL249339A0 (en) 2017-02-28
AU2015270926A1 (en) 2017-01-05
EP3148539A1 (en) 2017-04-05
EP3148539B1 (en) 2021-02-17
CA2951026A1 (en) 2015-12-10
JP6600319B2 (en) 2019-10-30

Similar Documents

Publication Publication Date Title
HK1252489A1 (en) Histone deacetylase inhibitors and compositions and methods of use thereof
HK1259232A1 (en) Substituted inhibitors of menin-mll and methods of use
PT3319959T (en) Hetero-halo inhibitors of histone deacetylase
IL249935A0 (en) Treatment of leukemia with histone deacetylase inhibitors
IL249339A0 (en) Histone deacetylase inhibitors and compositions and methods of use thereof
IL267291A (en) Ectonucleotidase inhibitors and methods of use thereof
ZA201805066B (en) Use of histone deacetylase inhibitors for enhancing immunotherapies
HK1220407A1 (en) Histone deacetylase inhibitors and compositions and methods of use thereof
GB201901338D0 (en) Histone deacetylase inhibitors for use in immunotherapy
IL259801A (en) Inhibitors of ezh2 and methods of use thereof
IL263360A (en) Combinations comprising histone deacetylase inhibitors
HK1252487A1 (en) Histone deacetylase inhibitors and compositions and methods of use thereof
IL267465A (en) Histone deacetylase inhibitors
EP3129373A4 (en) Histone deacetylase inhibitors
HK1257171A1 (en) Inhibitors of alk and srpk and methods of use
EP3177327A4 (en) Inhibitors of myh7b and uses thereof
IL251860A0 (en) Diheteroaryl histone deacetylase inhibitors and their use in therapy
HK1220461A1 (en) Histone deacetylase inhibitors and compositions and methods of use thereof
IL236686A0 (en) Histone deacetylase inhibitors and compositions and methods of use thereof
HK1220406A1 (en) Histone deacetylase inhibitors and compositions
IL256438B (en) Histone deacetylase inhibitors
HK1243404A1 (en) Tryptamide compositions and methods of use
IL266344A (en) Inhibitors of mtor-deptor interactions and methods of use thereof
HK1245144A1 (en) Composition and method for inhibiting histone deacetylase