SG11201604921TA - Tetrahydropyridopyrazines modulators of gpr6 - Google Patents

Tetrahydropyridopyrazines modulators of gpr6

Info

Publication number: SG11201604921TA
Authority: SG; Singapore
Prior art keywords: tetrahydropyridopyrazines; gpr6; modulators; tetrahydropyridopyrazines modulators
Prior art date: 2013-12-20

Application number

SG11201604921TA

Other languages

English (en)

Inventor

Jason Brown

Stephen Hitchcock

Maria Hopkins

Shota Kikuchi

Holger Monenschein

Holly Reichard

Kristin Schleicher

Hukai Sun

Todd Macklin

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-12-20

Filing date

2014-12-19

Publication date

2016-07-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52440811&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201604921T(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-12-19 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2016-07-28 Publication of SG11201604921TA publication Critical patent/SG11201604921TA/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Addiction (AREA)
Psychology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Nutrition Science (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

SG11201604921TA 2013-12-20 2014-12-19 Tetrahydropyridopyrazines modulators of gpr6 SG11201604921TA (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201361919661P	2013-12-20	2013-12-20
PCT/US2014/071543 WO2015095728A1 (en)	2013-12-20	2014-12-19	Tetrahydropyridopyrazines modulators of gpr6

Publications (1)

Publication Number	Publication Date
SG11201604921TA true SG11201604921TA (en)	2016-07-28

Family

ID=52440811

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG11201604921TA SG11201604921TA (en)	2013-12-20	2014-12-19	Tetrahydropyridopyrazines modulators of gpr6

Country Status (42)

Country	Link
US (4)	US9181249B2 (el)
EP (2)	EP3453709A1 (el)
JP (1)	JP6538697B2 (el)
KR (1)	KR102441531B1 (el)
CN (2)	CN105829309B (el)
AR (2)	AR098872A1 (el)
AU (1)	AU2014368992C1 (el)
BR (1)	BR112016014020B1 (el)
CA (1)	CA2934247C (el)
CL (1)	CL2016001595A1 (el)
CR (1)	CR20160321A (el)
CY (1)	CY1121395T1 (el)
DK (1)	DK3083620T3 (el)
DO (1)	DOP2016000144A (el)
EA (1)	EA032443B1 (el)
EC (1)	ECSP16061758A (el)
ES (1)	ES2702187T3 (el)
GE (1)	GEP201706783B (el)
HR (1)	HRP20182004T1 (el)
HU (1)	HUE042443T2 (el)
IL (1)	IL246177B (el)
JO (1)	JO3466B1 (el)
LT (1)	LT3083620T (el)
MA (1)	MA39193B1 (el)
MX (1)	MX2016008188A (el)
MY (1)	MY177031A (el)
NZ (1)	NZ721723A (el)
PE (1)	PE20160751A1 (el)
PH (1)	PH12016501192A1 (el)
PL (1)	PL3083620T3 (el)
PT (1)	PT3083620T (el)
RS (1)	RS58092B1 (el)
SG (1)	SG11201604921TA (el)
SI (1)	SI3083620T1 (el)
SM (1)	SMT201800668T1 (el)
TN (1)	TN2016000244A1 (el)
TR (1)	TR201900038T4 (el)
TW (2)	TWI730937B (el)
UA (1)	UA120427C2 (el)
UY (1)	UY35908A (el)
WO (1)	WO2015095728A1 (el)
ZA (1)	ZA201604703B (el)

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MX359634B (es)	2011-12-21	2018-10-03	Novira Therapeutics Inc	Agentes antivirales contra la hepatitis b.
US9487526B2 (en)	2012-08-13	2016-11-08	Takeda Pharmaceutical Company Limited	Quinoxaline derivatives as GPR6 modulators
MX373711B (es)	2012-08-28	2020-05-08	Janssen Sciences Ireland Uc	Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b.
CA2899706C (en)	2013-02-28	2021-10-19	Janssen Sciences Ireland Uc	Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
EP2981536B1 (en)	2013-04-03	2017-06-14	Janssen Sciences Ireland UC	N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
HUE040446T2 (hu)	2013-05-17	2019-03-28	Janssen Sciences Ireland Uc	Szulfamoiltiofenamid-származékok és gyógyszerként történõ alkalmazásuk hepatitis B kezelésére
JO3603B1 (ar)	2013-05-17	2020-07-05	Janssen Sciences Ireland Uc	مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
PT3024819T (pt)	2013-07-25	2018-05-25	Janssen Sciences Ireland Uc	Derivados da pirrolamida substituída com glioxamida e sua utilização como medicamentos para o tratamento da hepatite b
NZ717629A (en)	2013-10-23	2021-12-24	Janssen Sciences Ireland Uc	Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
JO3466B1 (ar) *	2013-12-20	2020-07-05	Takeda Pharmaceuticals Co	مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6
US9169212B2 (en)	2014-01-16	2015-10-27	Novira Therapeutics, Inc.	Azepane derivatives and methods of treating hepatitis B infections
US10392349B2 (en)	2014-01-16	2019-08-27	Novira Therapeutics, Inc.	Azepane derivatives and methods of treating hepatitis B infections
JP6553059B2 (ja)	2014-02-05	2019-07-31	ノヴィラ・セラピューティクス・インコーポレイテッド	Ｈｂｖ感染の治療のための併用療法
DK3102572T3 (en)	2014-02-06	2019-02-04	Janssen Sciences Ireland Uc	SULFAMOYLPYRROLAMIDE DERIVATIVES AND THEIR USE AS MEDICINES TO TREAT HEPATITIS B
US10179783B2 (en) *	2014-02-14	2019-01-15	Taketa Pharmaceutical Company Limited	Tetrahydropyridopyrazines as modulators of GPR6
US9884831B2 (en)	2015-03-19	2018-02-06	Novira Therapeutics, Inc.	Azocane and azonane derivatives and methods of treating hepatitis B infections
US10875876B2 (en)	2015-07-02	2020-12-29	Janssen Sciences Ireland Uc	Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
TW201718496A (zh)	2015-09-29	2017-06-01	諾維拉治療公司	B型肝炎抗病毒劑之晶型
MX2018012557A (es)	2016-04-15	2019-07-04	Janssen Sciences Ireland Uc	Combinaciones y métodos que comprenden un inhibidor del ensamblaje de la cápside.
JOP20180057A1 (ar) *	2017-06-15	2019-01-30	Takeda Pharmaceuticals Co	مركبات رابع هيدروبيريدو بيرازين والتي تعمل كمعدلات gpr6
MX2020009531A (es)	2018-03-14	2020-10-05	Janssen Sciences Ireland Unlimited Co	Regimen posologico del modulador del ensamblaje de la capside.
EP3927698A1 (en)	2019-02-22	2021-12-29	Janssen Sciences Ireland Unlimited Company	Amide derivatives useful in the treatment of hbv infection or hbv-induced diseases
CA3132554A1 (en)	2019-05-06	2020-11-12	Bart Rudolf Romanie Kesteleyn	Amide derivatives useful in the treatment of hbv infection or hbv-induced diseases

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2014
- 2014-12-18 JO JOP/2014/0369A patent/JO3466B1/ar active
- 2014-12-19 UA UAA201606659A patent/UA120427C2/uk unknown
- 2014-12-19 TR TR2019/00038T patent/TR201900038T4/tr unknown
- 2014-12-19 SG SG11201604921TA patent/SG11201604921TA/en unknown
- 2014-12-19 GE GEAP201414210A patent/GEP201706783B/en unknown
- 2014-12-19 PT PT14833425T patent/PT3083620T/pt unknown
- 2014-12-19 SI SI201430995T patent/SI3083620T1/sl unknown
- 2014-12-19 KR KR1020167019644A patent/KR102441531B1/ko active Active
- 2014-12-19 PL PL14833425T patent/PL3083620T3/pl unknown
- 2014-12-19 CR CR20160321A patent/CR20160321A/es unknown
- 2014-12-19 TW TW103144660A patent/TWI730937B/zh active
- 2014-12-19 TW TW110118089A patent/TWI809395B/zh active
- 2014-12-19 SM SM20180668T patent/SMT201800668T1/it unknown
- 2014-12-19 HU HUE14833425A patent/HUE042443T2/hu unknown
- 2014-12-19 RS RS20181548A patent/RS58092B1/sr unknown
- 2014-12-19 LT LTEP14833425.3T patent/LT3083620T/lt unknown
- 2014-12-19 TN TN2016000244A patent/TN2016000244A1/en unknown
- 2014-12-19 ES ES14833425T patent/ES2702187T3/es active Active
- 2014-12-19 NZ NZ721723A patent/NZ721723A/en unknown
- 2014-12-19 MX MX2016008188A patent/MX2016008188A/es active IP Right Grant
- 2014-12-19 MY MYPI2016001142A patent/MY177031A/en unknown
- 2014-12-19 PE PE2016000838A patent/PE20160751A1/es unknown
- 2014-12-19 CN CN201480069550.7A patent/CN105829309B/zh active Active
- 2014-12-19 EP EP18187138.5A patent/EP3453709A1/en not_active Withdrawn
- 2014-12-19 UY UY0001035908A patent/UY35908A/es not_active Application Discontinuation
- 2014-12-19 EP EP14833425.3A patent/EP3083620B1/en active Active
- 2014-12-19 MA MA39193A patent/MA39193B1/fr unknown
- 2014-12-19 DK DK14833425.3T patent/DK3083620T3/en active
- 2014-12-19 HR HRP20182004TT patent/HRP20182004T1/hr unknown
- 2014-12-19 JP JP2016541330A patent/JP6538697B2/ja active Active
- 2014-12-19 AU AU2014368992A patent/AU2014368992C1/en active Active
- 2014-12-19 CA CA2934247A patent/CA2934247C/en active Active
- 2014-12-19 WO PCT/US2014/071543 patent/WO2015095728A1/en active Application Filing
- 2014-12-19 CN CN201810356710.6A patent/CN108658978A/zh active Pending
- 2014-12-19 AR ARP140104807A patent/AR098872A1/es active IP Right Grant
- 2014-12-19 EA EA201691272A patent/EA032443B1/ru unknown
- 2014-12-19 US US14/577,480 patent/US9181249B2/en active Active
- 2014-12-19 BR BR112016014020-6A patent/BR112016014020B1/pt active IP Right Grant
2015
- 2015-10-14 US US14/883,174 patent/US9708313B2/en active Active
2016
- 2016-06-13 IL IL24617716A patent/IL246177B/en active IP Right Grant
- 2016-06-17 DO DO2016000144A patent/DOP2016000144A/es unknown
- 2016-06-17 PH PH12016501192A patent/PH12016501192A1/en unknown
- 2016-06-20 CL CL2016001595A patent/CL2016001595A1/es unknown
- 2016-07-08 ZA ZA2016/04703A patent/ZA201604703B/en unknown
- 2016-07-20 EC ECIEPI201661758A patent/ECSP16061758A/es unknown
2017
- 2017-06-13 US US15/621,761 patent/US10077266B2/en active Active
2018
- 2018-08-07 US US16/057,350 patent/US10738046B2/en active Active
2019
- 2019-01-03 CY CY20191100008T patent/CY1121395T1/el unknown
2023
- 2023-06-15 AR ARP230101544A patent/AR129635A2/es unknown

Also Published As

Publication number	Publication date
CN105829309B (zh)	2018-05-15
BR112016014020A2 (pt)	2017-08-08
EA201691272A1 (ru)	2017-05-31
US10738046B2 (en)	2020-08-11
GEP201706783B (en)	2017-11-27
PH12016501192B1 (en)	2016-08-15
JP6538697B2 (ja)	2019-07-03
AR129635A2 (es)	2024-09-11
NZ721723A (en)	2021-07-30
PL3083620T4 (pl)	2019-09-30
WO2015095728A1 (en)	2015-06-25
MA39193A1 (fr)	2017-06-30
EP3453709A1 (en)	2019-03-13
PE20160751A1 (es)	2016-08-01
TWI730937B (zh)	2021-06-21
MY177031A (en)	2020-09-02
MX2016008188A (es)	2016-09-29
PH12016501192A1 (en)	2016-08-15
CN108658978A (zh)	2018-10-16
DK3083620T3 (en)	2019-01-14
PT3083620T (pt)	2019-01-17
ZA201604703B (en)	2018-11-28
US10077266B2 (en)	2018-09-18
CR20160321A (es)	2016-09-28
IL246177A0 (en)	2016-08-02
PL3083620T3 (pl)	2019-09-30
JO3466B1 (ar)	2020-07-05
US9181249B2 (en)	2015-11-10
KR102441531B1 (ko)	2022-09-07
IL246177B (en)	2019-11-28
US20170283414A1 (en)	2017-10-05
CL2016001595A1 (es)	2017-01-13
JP2017502027A (ja)	2017-01-19
DOP2016000144A (es)	2016-08-15
BR112016014020A8 (pt)	2018-01-30
LT3083620T (lt)	2019-02-11
US20150175602A1 (en)	2015-06-25
AR098872A1 (es)	2016-06-22
UY35908A (es)	2015-07-31
CA2934247C (en)	2023-01-17
TWI809395B (zh)	2023-07-21
RS58092B1 (sr)	2019-02-28
US20160031881A1 (en)	2016-02-04
SMT201800668T1 (it)	2019-01-11
BR112016014020B1 (pt)	2023-02-28
ES2702187T3 (es)	2019-02-27
TR201900038T4 (tr)	2019-01-21
TN2016000244A1 (en)	2017-10-06
US9708313B2 (en)	2017-07-18
KR20160099705A (ko)	2016-08-22
AU2014368992A1 (en)	2016-07-07
CN105829309A (zh)	2016-08-03
CA2934247A1 (en)	2015-06-25
SI3083620T1 (sl)	2019-02-28
MA39193B1 (fr)	2018-04-30
AU2014368992B2 (en)	2018-09-13
EP3083620A1 (en)	2016-10-26
EA032443B1 (ru)	2019-05-31
HUE042443T2 (hu)	2019-06-28
TW201605854A (zh)	2016-02-16
EP3083620B1 (en)	2018-10-03
TW202202497A (zh)	2022-01-16
US20180346464A1 (en)	2018-12-06
HRP20182004T1 (hr)	2019-02-08
ECSP16061758A (es)	2018-02-28
UA120427C2 (uk)	2019-12-10
AU2014368992C1 (en)	2019-02-21
CY1121395T1 (el)	2020-05-29

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ZA201507110B (en)	2017-09-27	Crystal modifications of elobixibat
SG11201506876XA (en)	2015-09-29	Modification of polypeptides
AU353440S (en)	2014-01-23	Watch
GB201312059D0 (en)	2013-08-21	Novel GAK modulators
AU351857S (en)	2013-11-04	Watch
IL245020A0 (en)	2016-05-31	Methylene-linked quinolinyls are ror–gamma–t modulators
TWI560487B (en)	2016-12-01	Electro-optical modulator
GB201312800D0 (en)	2013-08-28	mGlu5 modulators
GB201321601D0 (en)	2014-01-22	Modulator
GB201312727D0 (en)	2013-08-28	Modulators
TWM475821U (en)	2014-04-11	Structure of mosquito-catch
GB201318298D0 (en)	2013-11-27	Modulators
GB201317988D0 (en)	2013-11-27	Modulators
GB201304473D0 (en)	2013-04-24	Modulators
GB201314051D0 (en)	2013-09-18	Novel DRAK modulators
TWM475524U (en)	2014-04-01	Structure of rivet-pulling
GB201304608D0 (en)	2013-05-01	BenTime of Yisrael operable arrangement
GB201318284D0 (en)	2013-11-27	Construction of surfaces
GB201306008D0 (en)	2013-05-15	Modulators of miRNA-184 mediated pathways
GB201313171D0 (en)	2013-09-04	Novel use of aggregates
GB201322342D0 (en)	2014-01-29	Procedure
GB201301990D0 (en)	2013-03-20	Novel Timepiece