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SG11201601612UA - Polymer-flavonoid conjugates and hydrogels for biomedical applications - Google Patents

Polymer-flavonoid conjugates and hydrogels for biomedical applications

Info

Publication number
SG11201601612UA
SG11201601612UA SG11201601612UA SG11201601612UA SG11201601612UA SG 11201601612U A SG11201601612U A SG 11201601612UA SG 11201601612U A SG11201601612U A SG 11201601612UA SG 11201601612U A SG11201601612U A SG 11201601612UA SG 11201601612U A SG11201601612U A SG 11201601612UA
Authority
SG
Singapore
Prior art keywords
hydrogels
polymer
biomedical applications
flavonoid conjugates
flavonoid
Prior art date
Application number
SG11201601612UA
Inventor
Kurisawa Motoichi
Ki Hyun Bae
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Priority to SG11201601612UA priority Critical patent/SG11201601612UA/en
Publication of SG11201601612UA publication Critical patent/SG11201601612UA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/042Gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/322,3-Dihydro derivatives, e.g. flavanones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91Injection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
SG11201601612UA 2013-09-03 2014-09-01 Polymer-flavonoid conjugates and hydrogels for biomedical applications SG11201601612UA (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SG11201601612UA SG11201601612UA (en) 2013-09-03 2014-09-01 Polymer-flavonoid conjugates and hydrogels for biomedical applications

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SG2013066444 2013-09-03
PCT/SG2014/000412 WO2015034436A1 (en) 2013-09-03 2014-09-01 Polymer-flavonoid conjugates and hydrogels for biomedical applications
SG11201601612UA SG11201601612UA (en) 2013-09-03 2014-09-01 Polymer-flavonoid conjugates and hydrogels for biomedical applications

Publications (1)

Publication Number Publication Date
SG11201601612UA true SG11201601612UA (en) 2016-04-28

Family

ID=52628759

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201601612UA SG11201601612UA (en) 2013-09-03 2014-09-01 Polymer-flavonoid conjugates and hydrogels for biomedical applications

Country Status (6)

Country Link
US (1) US10716959B2 (en)
EP (1) EP3041830B1 (en)
JP (1) JP6484633B2 (en)
CN (1) CN105658633A (en)
SG (1) SG11201601612UA (en)
WO (1) WO2015034436A1 (en)

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KR102102093B1 (en) 2014-05-09 2020-04-17 에이전시 포 사이언스, 테크놀로지 앤드 리서치 A micellar nanocomplex
JP6661546B2 (en) * 2014-05-15 2020-03-11 エージェンシー フォー サイエンス,テクノロジー アンド リサーチ Polymer-flavonoid conjugates and uses thereof
KR20180120142A (en) 2015-12-29 2018-11-05 갈데르마 소시에떼아노님 Carbohydrate cross-linking agent
CN106432420B (en) * 2016-09-18 2019-08-20 四川大学 Peptide modified tannic acid and the preparation method and application thereof
AU2018216540B2 (en) * 2017-02-02 2021-02-18 Amtixbio Co., Ltd. Hydrogel using, as substrate, hyaluronic acid derivative modified with gallol group and use thereof
US10500138B2 (en) * 2017-03-29 2019-12-10 Dentsply Sirona Inc. Polyphenols/PEG based hydrogel system for a dental varnish
KR20190050416A (en) 2017-11-03 2019-05-13 전북대학교산학협력단 Composition for Gellan-gum Hydrogels Containing miRNA-140-5p and Composition for treatment of Cartilage Regeneration using it
KR102158730B1 (en) * 2018-04-02 2020-09-22 주식회사 옵티팜 Alginate microcapsules for cell membrane formation and a method for producing the same
CN108888610B (en) * 2018-07-18 2021-08-24 南京林业大学 Preparation of responsive chitosan microsphere/cellulose hydrogel drug-loaded composite membrane and product
CN108852856A (en) * 2018-08-17 2018-11-23 柳州市人民医院 Application of the Epigallo-catechin gallate (EGCG) in orthodontic art
SG11202105128RA (en) * 2018-12-12 2021-06-29 Agency Science Tech & Res Conjugates and nanoparticles of hyaluronic acid and epigallocatechin-3-o-gallate and uses thereof
CN110124087B (en) * 2019-06-10 2021-01-26 江苏农林职业技术学院 Preparation method of band-aid based on flavonoid active ingredients in tassel leaves
CN110302155B (en) * 2019-07-31 2021-09-21 江南大学 Preparation method and application of xanthan gum copolymer nano micelle
KR102156602B1 (en) 2019-10-17 2020-09-16 전북대학교산학협력단 Composition for Gellan-gum Hydrogels Containing miRNA-140-5p and Composition for treatment of Cartilage Regeneration using it
CN110755677B (en) * 2019-11-11 2021-07-30 苏州大学 Polyamino acid hydrogel dressing and preparation method and application thereof
WO2021111303A1 (en) 2019-12-02 2021-06-10 Galderma Holding SA High molecular weight esthetic compositions
CN111234322B (en) * 2020-02-17 2021-11-05 天津大学 High-oxidation-resistance edible packaging film and preparation method thereof
EP4139366A4 (en) * 2020-04-23 2024-05-22 Pleryon Therapeutics (Shenzhen) Limited Biocompatible material and methods for making and using the same
CN111607101A (en) * 2020-06-29 2020-09-01 南京大学 Dendritic macromolecule with active oxygen responsiveness and preparation method and application thereof
CN112111021B (en) * 2020-09-24 2021-10-29 江南大学 Carboxymethyl yeast beta-glucan-epigallocatechin gallate derivative
CN112915077A (en) * 2021-02-18 2021-06-08 南昌大学附属口腔医院(江西省口腔医院) Oral acid etching agent and preparation method and application thereof
WO2022211493A1 (en) * 2021-03-31 2022-10-06 연세대학교 산학협력단 Pectin modified with gallol derivative and use thereof
CN113341146B (en) * 2021-04-29 2023-06-13 重庆医科大学 Colorimetric sensor for detecting hepatitis B virus and preparation and application thereof
CN114015733B (en) * 2021-11-12 2023-08-08 中国农业科学院茶叶研究所 Enzyme-salt coupling catalytic synthesis method of polyester catechin
CN114515353A (en) * 2022-02-23 2022-05-20 浙江卫未生物医药科技有限公司 Composite hydrogel based on umbilical cord stem cells and umbilical cord stem cell exosomes, and preparation method and application thereof
CN116144012A (en) * 2022-12-31 2023-05-23 河北工业大学 Method for modifying flavonoid polyphenol compound by using polyethylene glycol

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JP6661546B2 (en) 2014-05-15 2020-03-11 エージェンシー フォー サイエンス,テクノロジー アンド リサーチ Polymer-flavonoid conjugates and uses thereof

Also Published As

Publication number Publication date
JP6484633B2 (en) 2019-03-13
EP3041830A4 (en) 2017-04-05
US20160213787A1 (en) 2016-07-28
CN105658633A (en) 2016-06-08
JP2016534136A (en) 2016-11-04
EP3041830A1 (en) 2016-07-13
EP3041830B1 (en) 2023-10-25
WO2015034436A1 (en) 2015-03-12
US10716959B2 (en) 2020-07-21

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