SG11201601612UA - Polymer-flavonoid conjugates and hydrogels for biomedical applications - Google Patents
Polymer-flavonoid conjugates and hydrogels for biomedical applicationsInfo
- Publication number
- SG11201601612UA SG11201601612UA SG11201601612UA SG11201601612UA SG11201601612UA SG 11201601612U A SG11201601612U A SG 11201601612UA SG 11201601612U A SG11201601612U A SG 11201601612UA SG 11201601612U A SG11201601612U A SG 11201601612UA SG 11201601612U A SG11201601612U A SG 11201601612UA
- Authority
- SG
- Singapore
- Prior art keywords
- hydrogels
- polymer
- biomedical applications
- flavonoid conjugates
- flavonoid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Surgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SG11201601612UA SG11201601612UA (en) | 2013-09-03 | 2014-09-01 | Polymer-flavonoid conjugates and hydrogels for biomedical applications |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SG2013066444 | 2013-09-03 | ||
PCT/SG2014/000412 WO2015034436A1 (en) | 2013-09-03 | 2014-09-01 | Polymer-flavonoid conjugates and hydrogels for biomedical applications |
SG11201601612UA SG11201601612UA (en) | 2013-09-03 | 2014-09-01 | Polymer-flavonoid conjugates and hydrogels for biomedical applications |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201601612UA true SG11201601612UA (en) | 2016-04-28 |
Family
ID=52628759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201601612UA SG11201601612UA (en) | 2013-09-03 | 2014-09-01 | Polymer-flavonoid conjugates and hydrogels for biomedical applications |
Country Status (6)
Country | Link |
---|---|
US (1) | US10716959B2 (en) |
EP (1) | EP3041830B1 (en) |
JP (1) | JP6484633B2 (en) |
CN (1) | CN105658633A (en) |
SG (1) | SG11201601612UA (en) |
WO (1) | WO2015034436A1 (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102102093B1 (en) | 2014-05-09 | 2020-04-17 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | A micellar nanocomplex |
JP6661546B2 (en) * | 2014-05-15 | 2020-03-11 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | Polymer-flavonoid conjugates and uses thereof |
KR20180120142A (en) | 2015-12-29 | 2018-11-05 | 갈데르마 소시에떼아노님 | Carbohydrate cross-linking agent |
CN106432420B (en) * | 2016-09-18 | 2019-08-20 | 四川大学 | Peptide modified tannic acid and the preparation method and application thereof |
AU2018216540B2 (en) * | 2017-02-02 | 2021-02-18 | Amtixbio Co., Ltd. | Hydrogel using, as substrate, hyaluronic acid derivative modified with gallol group and use thereof |
US10500138B2 (en) * | 2017-03-29 | 2019-12-10 | Dentsply Sirona Inc. | Polyphenols/PEG based hydrogel system for a dental varnish |
KR20190050416A (en) | 2017-11-03 | 2019-05-13 | 전북대학교산학협력단 | Composition for Gellan-gum Hydrogels Containing miRNA-140-5p and Composition for treatment of Cartilage Regeneration using it |
KR102158730B1 (en) * | 2018-04-02 | 2020-09-22 | 주식회사 옵티팜 | Alginate microcapsules for cell membrane formation and a method for producing the same |
CN108888610B (en) * | 2018-07-18 | 2021-08-24 | 南京林业大学 | Preparation of responsive chitosan microsphere/cellulose hydrogel drug-loaded composite membrane and product |
CN108852856A (en) * | 2018-08-17 | 2018-11-23 | 柳州市人民医院 | Application of the Epigallo-catechin gallate (EGCG) in orthodontic art |
SG11202105128RA (en) * | 2018-12-12 | 2021-06-29 | Agency Science Tech & Res | Conjugates and nanoparticles of hyaluronic acid and epigallocatechin-3-o-gallate and uses thereof |
CN110124087B (en) * | 2019-06-10 | 2021-01-26 | 江苏农林职业技术学院 | Preparation method of band-aid based on flavonoid active ingredients in tassel leaves |
CN110302155B (en) * | 2019-07-31 | 2021-09-21 | 江南大学 | Preparation method and application of xanthan gum copolymer nano micelle |
KR102156602B1 (en) | 2019-10-17 | 2020-09-16 | 전북대학교산학협력단 | Composition for Gellan-gum Hydrogels Containing miRNA-140-5p and Composition for treatment of Cartilage Regeneration using it |
CN110755677B (en) * | 2019-11-11 | 2021-07-30 | 苏州大学 | Polyamino acid hydrogel dressing and preparation method and application thereof |
WO2021111303A1 (en) | 2019-12-02 | 2021-06-10 | Galderma Holding SA | High molecular weight esthetic compositions |
CN111234322B (en) * | 2020-02-17 | 2021-11-05 | 天津大学 | High-oxidation-resistance edible packaging film and preparation method thereof |
EP4139366A4 (en) * | 2020-04-23 | 2024-05-22 | Pleryon Therapeutics (Shenzhen) Limited | Biocompatible material and methods for making and using the same |
CN111607101A (en) * | 2020-06-29 | 2020-09-01 | 南京大学 | Dendritic macromolecule with active oxygen responsiveness and preparation method and application thereof |
CN112111021B (en) * | 2020-09-24 | 2021-10-29 | 江南大学 | Carboxymethyl yeast beta-glucan-epigallocatechin gallate derivative |
CN112915077A (en) * | 2021-02-18 | 2021-06-08 | 南昌大学附属口腔医院(江西省口腔医院) | Oral acid etching agent and preparation method and application thereof |
WO2022211493A1 (en) * | 2021-03-31 | 2022-10-06 | 연세대학교 산학협력단 | Pectin modified with gallol derivative and use thereof |
CN113341146B (en) * | 2021-04-29 | 2023-06-13 | 重庆医科大学 | Colorimetric sensor for detecting hepatitis B virus and preparation and application thereof |
CN114015733B (en) * | 2021-11-12 | 2023-08-08 | 中国农业科学院茶叶研究所 | Enzyme-salt coupling catalytic synthesis method of polyester catechin |
CN114515353A (en) * | 2022-02-23 | 2022-05-20 | 浙江卫未生物医药科技有限公司 | Composite hydrogel based on umbilical cord stem cells and umbilical cord stem cell exosomes, and preparation method and application thereof |
CN116144012A (en) * | 2022-12-31 | 2023-05-23 | 河北工业大学 | Method for modifying flavonoid polyphenol compound by using polyethylene glycol |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003501381A (en) * | 1999-06-07 | 2003-01-14 | ユニバーシティ・オブ・シェフィールド | Arthritis treatment |
ES2171142B1 (en) * | 2000-12-22 | 2003-12-16 | Consejo Superior Investigacion | CONJUGATES OF FLAVANOLES AND CISTEAMINE. |
WO2003080593A1 (en) | 2002-03-22 | 2003-10-02 | Beijing Jiankai Technology Co., Ltd. | Hydrophilic polymers-flavonoids conjugates and pharmaceutical compositions comprising them |
KR100465484B1 (en) * | 2002-07-16 | 2005-01-13 | (주)리젠메드 | Collagen-catechin complexes, processes for the prepartion thereof, and compositions containing the same |
US7858080B2 (en) | 2005-05-20 | 2010-12-28 | Agency For Science, Technology And Research | Aldehyde conjugated flavonoid preparations |
EP1888651B1 (en) | 2005-05-20 | 2014-07-30 | Agency for Science, Technology and Research | Aldehyde conjugated flavonoid preparations |
JP2009528080A (en) | 2006-02-27 | 2009-08-06 | エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ | Hardenable bone cement |
CN101909655B (en) | 2007-10-23 | 2013-04-10 | 新加坡科技研究局 | Method of delivering an anti-cancer agent to a cell |
US8541016B2 (en) | 2009-05-29 | 2013-09-24 | Agency For Science, Technology And Research | Cell-adhesive, enzymatically crosslinked flavonoid hydrogels and methods for making same |
EP2464388B1 (en) | 2009-08-11 | 2017-05-10 | Agency for Science, Technology and Research | Particulate hyaluronic acid formulations for cellular delivery of bioactive agents |
JP5954877B2 (en) | 2010-03-11 | 2016-07-20 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | Anticancer drug delivery vehicle capable of improving loading rate |
EP2771030A4 (en) * | 2011-10-24 | 2015-07-22 | Intellect Neurosciences Inc | Compositions and methods for treatment of proteinopathies |
KR102102093B1 (en) | 2014-05-09 | 2020-04-17 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | A micellar nanocomplex |
JP6661546B2 (en) | 2014-05-15 | 2020-03-11 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | Polymer-flavonoid conjugates and uses thereof |
-
2014
- 2014-09-01 SG SG11201601612UA patent/SG11201601612UA/en unknown
- 2014-09-01 CN CN201480057766.1A patent/CN105658633A/en active Pending
- 2014-09-01 WO PCT/SG2014/000412 patent/WO2015034436A1/en active Application Filing
- 2014-09-01 EP EP14842488.0A patent/EP3041830B1/en active Active
- 2014-09-01 US US14/916,559 patent/US10716959B2/en active Active
- 2014-09-01 JP JP2016540854A patent/JP6484633B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP6484633B2 (en) | 2019-03-13 |
EP3041830A4 (en) | 2017-04-05 |
US20160213787A1 (en) | 2016-07-28 |
CN105658633A (en) | 2016-06-08 |
JP2016534136A (en) | 2016-11-04 |
EP3041830A1 (en) | 2016-07-13 |
EP3041830B1 (en) | 2023-10-25 |
WO2015034436A1 (en) | 2015-03-12 |
US10716959B2 (en) | 2020-07-21 |
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