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SG11201600743WA - Oxoquinazolinyl-butanamide derivatives - Google Patents

Oxoquinazolinyl-butanamide derivatives

Info

Publication number
SG11201600743WA
SG11201600743WA SG11201600743WA SG11201600743WA SG11201600743WA SG 11201600743W A SG11201600743W A SG 11201600743WA SG 11201600743W A SG11201600743W A SG 11201600743WA SG 11201600743W A SG11201600743W A SG 11201600743WA SG 11201600743W A SG11201600743W A SG 11201600743WA
Authority
SG
Singapore
Prior art keywords
oxoquinazolinyl
butanamide derivatives
butanamide
derivatives
Prior art date
Application number
SG11201600743WA
Inventor
Dieter Dorsch
Hans-Peter Buchstaller
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SG11201600743WA publication Critical patent/SG11201600743WA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG11201600743WA 2013-07-31 2014-07-10 Oxoquinazolinyl-butanamide derivatives SG11201600743WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13003815 2013-07-31
PCT/EP2014/001895 WO2015014442A1 (en) 2013-07-31 2014-07-10 Oxoquinazolinyl-butanamide derivatives

Publications (1)

Publication Number Publication Date
SG11201600743WA true SG11201600743WA (en) 2016-02-26

Family

ID=48915813

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201600743WA SG11201600743WA (en) 2013-07-31 2014-07-10 Oxoquinazolinyl-butanamide derivatives

Country Status (26)

Country Link
US (1) US9901577B2 (en)
EP (1) EP3027598B1 (en)
JP (1) JP6423875B2 (en)
KR (1) KR102331389B1 (en)
CN (1) CN105392784B (en)
AR (1) AR097087A1 (en)
AU (1) AU2014298955B2 (en)
BR (1) BR112016001645B1 (en)
CA (1) CA2919905C (en)
DK (1) DK3027598T3 (en)
ES (1) ES2632988T3 (en)
HK (1) HK1222391A1 (en)
HR (1) HRP20171053T1 (en)
HU (1) HUE032846T2 (en)
IL (1) IL243734B (en)
LT (1) LT3027598T (en)
MX (1) MX359656B (en)
NZ (1) NZ716593A (en)
PL (1) PL3027598T3 (en)
PT (1) PT3027598T (en)
RS (1) RS56211B1 (en)
RU (1) RU2669393C2 (en)
SG (1) SG11201600743WA (en)
SI (1) SI3027598T1 (en)
WO (1) WO2015014442A1 (en)
ZA (1) ZA201601333B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6673853B2 (en) * 2014-05-07 2020-03-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung Heterocyclyl-butanamide derivative
KR20180073681A (en) 2015-11-02 2018-07-02 메르크 파텐트 게엠베하 1,4-Dicarbonyl-piperidyl derivatives
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
TWI794171B (en) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-l1 inhibitors
TWI808055B (en) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-1 inhibitors
GB201615282D0 (en) * 2016-09-08 2016-10-26 Univ Bath Tankyrase inhibitors
MX2019007870A (en) 2016-12-30 2019-08-16 Mitobridge Inc Poly-adp ribose polymerase (parp) inhibitors.
CN111699176A (en) 2017-12-21 2020-09-22 里邦医疗公司 Quinazolinones as PARP14 inhibitors
CN109180702B (en) * 2018-10-29 2021-11-30 四川大学 Thienopyrimidone compound and application thereof
US20220096454A1 (en) 2018-12-03 2022-03-31 Merck Patent Gmbh Carboxylic acid derivatives
WO2023161881A1 (en) * 2022-02-25 2023-08-31 Glaxosmithkline Intellectual Property Development Limited Cytotoxicity targeting chimeras for ccr2-expressing cells

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
MXPA02011641A (en) * 2000-05-26 2004-07-30 Idenix Cayman Ltd METHODS OF TREATING HEPATITIS DELTA VIRUS INFECTION WITH bgr;-L-2 - DEOXY-NUCLEOSIDES.
AUPR201600A0 (en) * 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
US20040176361A1 (en) * 2001-05-23 2004-09-09 Masakazu Fujio Fused heterocyclic compound and medicinal use thereof
BRPI0408284B8 (en) * 2003-03-12 2021-05-25 Kudos Pharm Ltd phthalazinone derivatives, their use and pharmaceutical composition comprising them
DE602005026391D1 (en) * 2004-06-30 2011-03-31 Janssen Pharmaceutica Nv CHINAZOLINONE DERIVATIVES AS PARP HEMMER
UY31603A1 (en) * 2008-01-23 2009-08-31 DERIVATIVES OF FTALAZINONA
CN101492425A (en) * 2009-02-27 2009-07-29 无锡市凯奥善生物医药科技有限公司 Compounds of PARP restrainer
JP2014520858A (en) 2011-07-13 2014-08-25 ノバルティス アーゲー Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
EP2890696A1 (en) * 2012-08-29 2015-07-08 Amgen, Inc. Quinazolinone compounds and derivatives thereof

Also Published As

Publication number Publication date
BR112016001645A2 (en) 2017-08-01
PT3027598T (en) 2017-07-17
AR097087A1 (en) 2016-02-17
CN105392784B (en) 2018-10-09
RU2016106952A (en) 2017-09-04
RS56211B1 (en) 2017-11-30
CA2919905C (en) 2021-08-10
NZ716593A (en) 2021-07-30
AU2014298955B2 (en) 2018-03-01
RU2669393C2 (en) 2018-10-11
ES2632988T3 (en) 2017-09-18
US9901577B2 (en) 2018-02-27
PL3027598T3 (en) 2017-09-29
EP3027598A1 (en) 2016-06-08
CN105392784A (en) 2016-03-09
BR112016001645B1 (en) 2023-04-11
JP2016525556A (en) 2016-08-25
LT3027598T (en) 2017-06-12
US20160184310A1 (en) 2016-06-30
IL243734B (en) 2019-09-26
SI3027598T1 (en) 2017-08-31
IL243734A0 (en) 2016-04-21
HRP20171053T1 (en) 2017-10-06
CA2919905A1 (en) 2015-02-05
BR112016001645A8 (en) 2020-01-21
AU2014298955A1 (en) 2016-03-10
KR20160037985A (en) 2016-04-06
MX2016001136A (en) 2016-04-29
MX359656B (en) 2018-10-05
EP3027598B1 (en) 2017-04-12
RU2016106952A3 (en) 2018-05-14
HK1222391A1 (en) 2017-06-30
ZA201601333B (en) 2019-12-18
JP6423875B2 (en) 2018-11-14
KR102331389B1 (en) 2021-11-26
DK3027598T3 (en) 2017-05-22
HUE032846T2 (en) 2017-11-28
WO2015014442A1 (en) 2015-02-05

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