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SG11201408186TA - Pyridinone and pyridazinone derivatives - Google Patents

Pyridinone and pyridazinone derivatives

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Publication number
SG11201408186TA
SG11201408186TA SG11201408186TA SG11201408186TA SG11201408186TA SG 11201408186T A SG11201408186T A SG 11201408186TA SG 11201408186T A SG11201408186T A SG 11201408186TA SG 11201408186T A SG11201408186T A SG 11201408186TA SG 11201408186T A SG11201408186T A SG 11201408186TA
Authority
SG
Singapore
Prior art keywords
lllll
international
road
north
llll
Prior art date
Application number
SG11201408186TA
Inventor
Robert D Hubbard
Le Wang
Chang H Park
Chaohong Sun
Keith F Mcdaniel
John K Pratt
Todd N Soltwedel
Michael D Wendt
John H Holms
Dachun Liu
George S Sheppard
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of SG11201408186TA publication Critical patent/SG11201408186TA/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 December 2013 (19.12.2013) WIPOIPCT (10) International Publication Number WO 2013/188381 A1 (51) International Patent Classification: C07D 403/12 C07D 401/14 C07D 213/74 C07D 213/81 C07D 401/02 C07D 401/04 C07D 401/10 C07D 401/12 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) C07D 403/04 C07D 237/14 C07D 403/10 C07D 407/04 C07D 407/12 C07D 409/04 C07D 413/10 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (21) International Application Number: PCT/US2013/045151 11 June 2013 (11.06.2013) (22) International Filing Date: (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/CN2012/076748 12 June 2012 (12.06.2012) CN 13/796,437 12 March 2013 (12.03.2013) US (71) Applicant: ABBVIE INC. [US/US]; 1 North Waukegan Road, North Chicago, IL 60064 (US). (72) Inventors: HUBBARD, Robert, D.; 7684 Marker Road, San Diego, CA 92130 (US). WANG, Le; 338 East Coloni­ al Drive, Vernon Hills, IL 60061 (US). PARK, Chang, H.; 2871 N. Southern Hills Drive, Wadsworth, IL 60083 (US). SUN, Chaohong; 390 Churchill Lane, Gurnee, IL 60031 (US). MCDANIEL, Keith, F.; 26029 W. Laurel Court, Wauconda, IL 60084 (US). PRATT, John, K.; 8210 61st. Avenue, Kenosha, WI 53142 (US). SOLTWEDEL, Todd, N.; 4808 W. Strong Street, Chicago, IL 60646 (US). WENDT, Michael, D.; 1445 Maidstone Drive, Vernon Hills, IL 60061 (US). HOLMS, John, H.; 1239 Pine Grove Avenue, Gurnee, IL 60031 (US). LIU, Dachun; 1276 Georgetown Way, Vernon Hills, IL 60061 (US). SHEPPARD, George, S.; 807 Locust Road, Wilmette, IL 60091 (US). (74) Agents: BAUDE, Eric, J. et al.; AbbVie Inc., 1 North Waukegan Road, AP34-2/V377, North Chicago, IL 60064 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, [Continued on next page] (54) Title: PYRIDINONE AND PYRIDAZINONE DERIVATIVES 00 m oo oo X 2a (Ha) (Kb) T-H o CJ (57) Abstract: The present invention provides for compounds of formula (I) Wherein J is a group of formula 11a or lib: A', A , 2 A3, A4, J, and X 3 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are use - fill as agents in the treatment of diseases and conditions, including inflammatory diseases, diabetes, obesity, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula 1. WO 2013/188381 Al I lllll llllllll II llllll III lllll lllll III III III lllll lllll lllll lllll lllll llll llll lllllll llll llll TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Published: KM, ML, MR, NE, SN, TD, TG). — internationa i searc h report (Art. 21(3))
SG11201408186TA 2012-06-12 2013-06-11 Pyridinone and pyridazinone derivatives SG11201408186TA (en)

Applications Claiming Priority (3)

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PCT/CN2012/076748 WO2013185284A1 (en) 2012-06-12 2012-06-12 Pyridinone and pyridazinone derivatives
US13/796,437 US9561231B2 (en) 2012-06-12 2013-03-12 Pyridinone and pyridazinone derivatives
PCT/US2013/045151 WO2013188381A1 (en) 2012-06-12 2013-06-11 Pyridinone and pyridazinone derivatives

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