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SG11201401608PA - Method for inhibition of deubiquitinating activity - Google Patents

Method for inhibition of deubiquitinating activity

Info

Publication number
SG11201401608PA
SG11201401608PA SG11201401608PA SG11201401608PA SG11201401608PA SG 11201401608P A SG11201401608P A SG 11201401608PA SG 11201401608P A SG11201401608P A SG 11201401608PA SG 11201401608P A SG11201401608P A SG 11201401608PA SG 11201401608P A SG11201401608P A SG 11201401608PA
Authority
SG
Singapore
Prior art keywords
inhibition
deubiquitinating activity
deubiquitinating
activity
Prior art date
Application number
SG11201401608PA
Inventor
Stig Linder
Rolf Larsson
Original Assignee
Vivolux Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vivolux Ab filed Critical Vivolux Ab
Publication of SG11201401608PA publication Critical patent/SG11201401608PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
SG11201401608PA 2011-10-19 2012-10-15 Method for inhibition of deubiquitinating activity SG11201401608PA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1100776 2011-10-19
SE1200303 2012-05-16
PCT/SE2012/000158 WO2013058691A1 (en) 2011-10-19 2012-10-15 Method for inhibition of deubiquitinating activity

Publications (1)

Publication Number Publication Date
SG11201401608PA true SG11201401608PA (en) 2014-07-30

Family

ID=48141165

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201401608PA SG11201401608PA (en) 2011-10-19 2012-10-15 Method for inhibition of deubiquitinating activity

Country Status (22)

Country Link
US (1) US9221761B2 (en)
EP (1) EP2780326B1 (en)
JP (1) JP6165748B2 (en)
KR (1) KR102022575B1 (en)
CN (1) CN104271557B (en)
AU (1) AU2012326682B2 (en)
BR (1) BR112014009365B1 (en)
CA (1) CA2852518C (en)
CL (1) CL2014000998A1 (en)
DK (1) DK2780326T3 (en)
EA (1) EA026409B1 (en)
ES (1) ES2713484T3 (en)
HK (1) HK1203194A1 (en)
HU (1) HUE041816T2 (en)
IL (1) IL232118A (en)
MX (1) MX345467B (en)
MY (1) MY169330A (en)
PL (1) PL2780326T3 (en)
PT (1) PT2780326T (en)
SG (1) SG11201401608PA (en)
WO (1) WO2013058691A1 (en)
ZA (1) ZA201403302B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2780326T (en) * 2011-10-19 2019-03-04 Vivolux Ab Method for inhibition of deubiquitinating activity
WO2014105952A2 (en) 2012-12-28 2014-07-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibitors of the usp1/uaf1 deubiquitinase complex and uses thereof
EP3164506A4 (en) * 2014-07-01 2018-02-28 Mayo Foundation for Medical Education and Research Methods and materials for identifying and treating mammals resistant to proteasome inhibitor treatments
GB201416754D0 (en) * 2014-09-23 2014-11-05 Mission Therapeutics Ltd Novel compounds
SG11201706542TA (en) * 2015-03-30 2017-10-30 Mission Therapeutics Ltd 1-cyano-pyrrolidine compounds as usp30 inhibitors
CN106146542A (en) * 2015-04-23 2016-11-23 北京大学 Curcumin boronic acid derivatives, its preparation method and application
GB201522768D0 (en) * 2015-12-23 2016-02-03 Mission Therapeutics Ltd Novel compounds
US10416163B2 (en) * 2016-02-26 2019-09-17 Regents Of The University Of Minnesota Method and treatment of recurring endometrial cancer with an inhibitor of USP14
WO2018140907A1 (en) * 2017-01-30 2018-08-02 Up Therapeutics Inc. Novel spiro and cyclic bis-benzylidine proteasome inhibitor for the treatment of cancer, diabetes and neurological disorders
CN111956804B (en) * 2020-07-21 2022-01-07 广州医科大学 Novel use of inhibitors of OTUB1
CN114959036A (en) * 2022-06-07 2022-08-30 北京大学 Application of RPN11 marker in detection of myeloma and its disease risk, prognosis analysis and treatment medicine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1242379A1 (en) * 1999-12-03 2002-09-25 Emory University Curcumin analogues for treating cancer
US20060229239A9 (en) * 2002-03-08 2006-10-12 Mamoru Shoji Novel curcuminoid-factor VIIa constructs as suppressors of tumor growth and angiogenesis
US20070010488A1 (en) * 2005-04-13 2007-01-11 Khairia Youssef Compounds for modulating cell proliferation
ATE411300T1 (en) * 2005-08-05 2008-10-15 Hybrigenics Sa NEW CYSTEINE PROTEASE HEMMERS AND THEIR THERAPEUTIC APPLICATIONS
WO2007059613A1 (en) * 2005-11-22 2007-05-31 University Of Saskatchewan Antineoplastic compounds
US20120316203A1 (en) * 2009-07-06 2012-12-13 The Ohio State University Research Foundation Compositions and Methods for Inhibition of Cancers
PT2780326T (en) * 2011-10-19 2019-03-04 Vivolux Ab Method for inhibition of deubiquitinating activity

Also Published As

Publication number Publication date
HK1203194A1 (en) 2015-10-23
PL2780326T3 (en) 2019-06-28
EA201490800A1 (en) 2014-09-30
MX2014004646A (en) 2014-08-01
EA026409B1 (en) 2017-04-28
ES2713484T3 (en) 2019-05-22
BR112014009365B1 (en) 2021-08-03
CN104271557A (en) 2015-01-07
CL2014000998A1 (en) 2014-10-10
BR112014009365A2 (en) 2017-04-18
JP6165748B2 (en) 2017-07-19
JP2014530852A (en) 2014-11-20
CN104271557B (en) 2017-12-05
KR20140078742A (en) 2014-06-25
MX345467B (en) 2017-02-01
EP2780326A4 (en) 2015-04-22
KR102022575B1 (en) 2019-09-18
US9221761B2 (en) 2015-12-29
CA2852518A1 (en) 2013-04-25
PT2780326T (en) 2019-03-04
NZ624019A (en) 2016-07-29
IL232118A0 (en) 2014-05-28
EP2780326A1 (en) 2014-09-24
EP2780326B1 (en) 2018-12-26
CA2852518C (en) 2019-09-24
AU2012326682B2 (en) 2016-02-18
US20140228354A1 (en) 2014-08-14
WO2013058691A1 (en) 2013-04-25
ZA201403302B (en) 2015-05-27
AU2012326682A1 (en) 2014-05-01
HUE041816T2 (en) 2019-05-28
MY169330A (en) 2019-03-21
DK2780326T3 (en) 2019-03-04
IL232118A (en) 2016-06-30

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