SG10202102822RA - Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof - Google Patents
Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereofInfo
- Publication number
- SG10202102822RA SG10202102822RA SG10202102822RA SG10202102822RA SG10202102822RA SG 10202102822R A SG10202102822R A SG 10202102822RA SG 10202102822R A SG10202102822R A SG 10202102822RA SG 10202102822R A SG10202102822R A SG 10202102822RA SG 10202102822R A SG10202102822R A SG 10202102822RA
- Authority
- SG
- Singapore
- Prior art keywords
- alkynyl
- preparation
- heterocyclic compound
- substituted heterocyclic
- method therefor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610833890.3A CN107840842A (en) | 2016-09-19 | 2016-09-19 | Alkynes is for heterocyclic compound, its preparation method and its in application pharmaceutically |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10202102822RA true SG10202102822RA (en) | 2021-05-28 |
Family
ID=61618562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202102822RA SG10202102822RA (en) | 2016-09-19 | 2017-01-25 | Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10710981B2 (en) |
| EP (1) | EP3517535B1 (en) |
| JP (1) | JP6906811B2 (en) |
| KR (1) | KR20190052113A (en) |
| CN (2) | CN107840842A (en) |
| AU (1) | AU2017327954B2 (en) |
| CA (1) | CA3036594C (en) |
| ES (1) | ES2925212T3 (en) |
| MX (1) | MX2019003143A (en) |
| RU (1) | RU2729069C1 (en) |
| SG (1) | SG10202102822RA (en) |
| WO (1) | WO2018049781A1 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113227077B (en) * | 2018-12-13 | 2024-10-29 | 英特维特国际股份有限公司 | Method for preparing 1- [ (3R, 4S) -4-cyano tetrahydropyran-3-yl ] -3- [ (2-fluoro-6-methoxy-4-pyridyl) amino ] pyrazole-4-carboxamide |
| WO2020131674A1 (en) | 2018-12-19 | 2020-06-25 | Array Biopharma Inc. | 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| CN114787149A (en) * | 2019-12-26 | 2022-07-22 | 北京诺诚健华医药科技有限公司 | Crystalline forms of (S) -1- (1-acryloylpyrrolidin-3-yl) -3- ((3, 5-dimethoxyphenyl) ethynyl) -5- (methylamino) -1H-pyrazole-4-carboxamide |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| KR20230035031A (en) * | 2020-06-05 | 2023-03-10 | 킨네이트 바이오파마 인크. | Inhibitors of fibroblast growth factor receptor kinase |
| WO2021247971A1 (en) * | 2020-06-05 | 2021-12-09 | Kinnate Biopharma Inc. | Inhibitors of fibroblast growth factor receptor kinases |
| WO2022042613A1 (en) * | 2020-08-27 | 2022-03-03 | 上海和誉生物医药科技有限公司 | 1h-pyrazol-4-amide derivative, preparation method therefor, and use thereof |
| AU2022206989A1 (en) * | 2021-01-12 | 2023-08-24 | Beijing Innocare Pharma Tech Co., Ltd. | Process for preparing (s)-1-(1-acryloylpyrrolidin-3-yl)-3-((3,5-dimethoxyphenyl) ethynyl)-5-(methylamino)-1h-pyrazole-4-carboxamide |
| CN115433190B (en) * | 2021-06-02 | 2024-09-20 | 药雅科技(上海)有限公司 | Preparation method and application of irreversible heterocyclic compound FGFR inhibitor |
| CN114853739B (en) * | 2021-02-03 | 2023-09-22 | 药雅科技(上海)有限公司 | Acetylenic pyrazine FGFR inhibitor and preparation method and application thereof |
| CN115043832B (en) * | 2021-03-08 | 2023-08-22 | 药雅科技(上海)有限公司 | FGFR inhibitor acetylenic heterocyclic compound and preparation method and application thereof |
| CA3235435A1 (en) * | 2021-11-03 | 2023-05-11 | Xiangyang Chen | Amorphous solid dispersion comprising (s)-1-(1-acryloylpyrrolidin-3-yl)-3-((3,5-dimethoxyphenyl) ethynyl)-5-(methylamino)-1h-pyrazole-4-carboxamide |
| WO2023088105A1 (en) * | 2021-11-16 | 2023-05-25 | Beijing Innocare Pharma Tech Co., Ltd. | Method for treating head and neck cancer |
| TW202333686A (en) * | 2021-12-08 | 2023-09-01 | 美商奇奈特生物製藥公司 | Treatment of cancer with an fgfr kinase inhibitor |
| IL313359A (en) * | 2021-12-08 | 2024-08-01 | Kinnate Biopharma Inc | Solid state forms of an fgfr inhibitor |
| WO2023107870A1 (en) * | 2021-12-08 | 2023-06-15 | Kinnate Biopharma Inc. | Inhibitors of fibroblast growth factor receptor kinases |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2833948B1 (en) * | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | NOVEL BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MEDICAMENTS |
| RU2340605C2 (en) | 2002-06-27 | 2008-12-10 | Ново Нордиск А/С | Arylcarbonyl derivatives as therapeutic agents |
| CN1508130A (en) | 2002-12-18 | 2004-06-30 | 中国科学院大连化学物理研究所 | N-phenyl-N'-pyrimidinyl-substituted urea derivative synthesizing method |
| US7150894B2 (en) * | 2003-05-01 | 2006-12-19 | Kraft Foods Holdings, Inc. | Acid whey texture system |
| PT1761520E (en) | 2004-06-23 | 2008-09-15 | Lilly Co Eli | Kinase inhibitors |
| FR2889526B1 (en) | 2005-08-04 | 2012-02-17 | Aventis Pharma Sa | SUBSTITUTED 7-AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PROCESS FOR PRODUCTION AND USE |
| EP1966222A2 (en) | 2005-11-16 | 2008-09-10 | SGX Pharmaceuticals, Inc. | Pyrazolothiazole protein kinase modulators |
| FR2908409B1 (en) | 2006-11-10 | 2009-01-09 | Sanofi Aventis Sa | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SAME, PROCESS FOR PRODUCTION AND USE |
| US7737149B2 (en) * | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
| ES2364864T3 (en) * | 2006-12-21 | 2011-09-15 | Astrazeneca Ab | ACILAMINOPIRAZOLES AS FGFR INHIBITORS. |
| EP2303021B1 (en) | 2008-06-16 | 2018-12-19 | University of Tennessee Research Foundation | Compounds for the treatment of cancer |
| FR2947546B1 (en) | 2009-07-03 | 2011-07-01 | Sanofi Aventis | PYRAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| GB2474748B (en) * | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
| WO2011109059A1 (en) | 2010-03-01 | 2011-09-09 | Gtx, Inc. | Compounds for treatment of cancer |
| JP6016915B2 (en) * | 2011-07-28 | 2016-10-26 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | Alkynyl-substituted pyrimidinylpyrroles active as kinase inhibitors |
| WO2013024427A1 (en) | 2011-08-16 | 2013-02-21 | Glenmark Pharmaceuticals S.A. | Novel urea derivatives as tec kinase inhibitors and uses thereof |
| CN103848810A (en) * | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | Bruton's tyrosine kinases inhibitor |
| JP6084292B2 (en) * | 2013-07-18 | 2017-02-22 | 大鵬薬品工業株式会社 | FGFR inhibitor resistant cancer therapeutics |
| WO2015008839A1 (en) * | 2013-07-18 | 2015-01-22 | 大鵬薬品工業株式会社 | Antitumor drug for intermittent administration of fgfr inhibitor |
| CA2927252C (en) | 2013-10-25 | 2021-09-28 | Novartis Ag | Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
| BR112017016817A2 (en) | 2015-03-25 | 2018-04-03 | Novartis Ag | heterocyclic derivatives formulated as fgfr4 inhibitors |
-
2016
- 2016-09-19 CN CN201610833890.3A patent/CN107840842A/en not_active Withdrawn
-
2017
- 2017-01-25 CN CN201780057036.5A patent/CN109843873B/en active Active
- 2017-01-25 KR KR1020197011454A patent/KR20190052113A/en not_active Application Discontinuation
- 2017-01-25 MX MX2019003143A patent/MX2019003143A/en unknown
- 2017-01-25 CA CA3036594A patent/CA3036594C/en active Active
- 2017-01-25 JP JP2019515464A patent/JP6906811B2/en active Active
- 2017-01-25 AU AU2017327954A patent/AU2017327954B2/en active Active
- 2017-01-25 RU RU2019112046A patent/RU2729069C1/en active
- 2017-01-25 EP EP17849992.7A patent/EP3517535B1/en active Active
- 2017-01-25 SG SG10202102822RA patent/SG10202102822RA/en unknown
- 2017-01-25 ES ES17849992T patent/ES2925212T3/en active Active
- 2017-01-25 WO PCT/CN2017/072570 patent/WO2018049781A1/en unknown
-
2019
- 2019-03-14 US US16/353,806 patent/US10710981B2/en active Active
-
2020
- 2020-07-10 US US16/925,738 patent/US11059805B2/en active Active
-
2021
- 2021-07-07 US US17/369,850 patent/US11572353B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20190052113A (en) | 2019-05-15 |
| US20210332027A1 (en) | 2021-10-28 |
| US20190210997A1 (en) | 2019-07-11 |
| EP3517535B1 (en) | 2022-06-29 |
| US11059805B2 (en) | 2021-07-13 |
| US11572353B2 (en) | 2023-02-07 |
| EP3517535A4 (en) | 2020-02-26 |
| WO2018049781A1 (en) | 2018-03-22 |
| JP2019529444A (en) | 2019-10-17 |
| CN107840842A (en) | 2018-03-27 |
| CN109843873B (en) | 2022-06-17 |
| ES2925212T3 (en) | 2022-10-14 |
| RU2729069C1 (en) | 2020-08-04 |
| AU2017327954A1 (en) | 2019-05-02 |
| CA3036594C (en) | 2024-02-13 |
| EP3517535A1 (en) | 2019-07-31 |
| US10710981B2 (en) | 2020-07-14 |
| AU2017327954B2 (en) | 2022-02-03 |
| MX2019003143A (en) | 2019-06-17 |
| JP6906811B2 (en) | 2021-07-21 |
| CN109843873A (en) | 2019-06-04 |
| US20200339541A1 (en) | 2020-10-29 |
| CA3036594A1 (en) | 2018-03-22 |
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