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SG10201901559SA - Retinal ganglion cells and progenitors thereof - Google Patents

Retinal ganglion cells and progenitors thereof

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Publication number
SG10201901559SA
SG10201901559SA SG10201901559SA SG10201901559SA SG10201901559SA SG 10201901559S A SG10201901559S A SG 10201901559SA SG 10201901559S A SG10201901559S A SG 10201901559SA SG 10201901559S A SG10201901559S A SG 10201901559SA SG 10201901559S A SG10201901559S A SG 10201901559SA
Authority
SG
Singapore
Prior art keywords
cells
retinal ganglion
progenitors
mature
methods
Prior art date
Application number
SG10201901559SA
Inventor
Wei Wang
Shi-Jiang Lu
Robert Lanza
Original Assignee
Astellas Inst For Regenerative Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Inst For Regenerative Medicine filed Critical Astellas Inst For Regenerative Medicine
Publication of SG10201901559SA publication Critical patent/SG10201901559SA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/42—Notch; Delta; Jagged; Serrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

RETINAL GANGLION CELLS AND PROGENITORS THEREOF Methods are provided for the production of retinal ganglion (RG) progenitor cells and mature RG cells from pluripotent stem cells optionally under feeder- free conditions, and further optionally under xeno-free conditions. Additionally provided are compositions ofRG progenitor cells and mature RG cells, as well as methods of use thereof including therapeutic use thereof. Exemplary methods may produce substantially pure populations and cultures of RG progenitor cells and mature RG cells. FIG.14D
SG10201901559SA 2014-09-05 2015-09-05 Retinal ganglion cells and progenitors thereof SG10201901559SA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462046165P 2014-09-05 2014-09-05

Publications (1)

Publication Number Publication Date
SG10201901559SA true SG10201901559SA (en) 2019-03-28

Family

ID=55440432

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201901559SA SG10201901559SA (en) 2014-09-05 2015-09-05 Retinal ganglion cells and progenitors thereof
SG10201912296RA SG10201912296RA (en) 2014-09-05 2015-09-05 Retinal ganglion cells and progenitors thereof
SG11201701709YA SG11201701709YA (en) 2014-09-05 2015-09-05 Retinal ganglion cells and progenitors thereof

Family Applications After (2)

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SG10201912296RA SG10201912296RA (en) 2014-09-05 2015-09-05 Retinal ganglion cells and progenitors thereof
SG11201701709YA SG11201701709YA (en) 2014-09-05 2015-09-05 Retinal ganglion cells and progenitors thereof

Country Status (13)

Country Link
US (1) US20170274019A1 (en)
EP (2) EP3189135B1 (en)
JP (2) JP6778181B2 (en)
KR (1) KR20170077117A (en)
CN (1) CN107148276A (en)
AU (2) AU2015311702A1 (en)
CA (1) CA2960211A1 (en)
ES (1) ES2883600T3 (en)
IL (3) IL250924B (en)
PL (1) PL3189135T3 (en)
PT (1) PT3189135T (en)
SG (3) SG10201901559SA (en)
WO (1) WO2016037159A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102054904B1 (en) * 2011-11-14 2019-12-11 아스텔라스 인스티튜트 포 리제너러티브 메디슨 Pharmaceutical preparations of human RPE cells and uses thereof
JP6902474B2 (en) 2015-03-23 2021-07-14 アステラス インスティテュート フォー リジェネレイティブ メディシン Improved assay for the ability of human retinal pigment epithelial (RPE) cells and photoreceptor progenitor cells
CA2995977A1 (en) 2015-08-18 2017-02-23 Astellas Institute For Regenerative Medicine Clinical formulations
WO2019078781A1 (en) * 2017-10-17 2019-04-25 National University Of Singapore Systems and methods for producing photoreceptor progenitors
US20220175844A1 (en) * 2018-02-02 2022-06-09 University Of Maryland, Baltimore Methods of treating optic nerve diseases using neural progenitor cell growth factors
US11621058B2 (en) * 2018-02-08 2023-04-04 Ohio State Innovation Foundation Synthetic IHC-stained digital sides generated using artificial neural networks
PT3810758T (en) * 2018-06-20 2023-10-13 Biolamina Ab Methods and compositions for producing retinal pigment epithelium cells
KR102196069B1 (en) 2019-04-17 2020-12-29 경북대학교 산학협력단 Method for Isolating of Retinal Ganglion Cell and Uses of the Cells Thereby Isolated
CN112251408B (en) * 2020-09-14 2022-04-12 郑州大学 Preparation method of retinal ganglion cells
CN114917367A (en) * 2021-06-02 2022-08-19 中国科学院动物研究所 Application of LHX2 in promoting injury repair and regeneration of central system neurons
CN115404219B (en) * 2022-09-09 2023-10-27 中国医学科学院医学生物学研究所 Separation culture method of tree shrew retinal ganglion cells

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010536852A (en) * 2007-08-23 2010-12-02 ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニヴァーシティ Regulation of synapse formation
AU2008331434B2 (en) * 2007-12-04 2013-06-27 Proteobioactives Pty Ltd Protection of progenitor cells and regulation of their differentiation
WO2011028524A1 (en) * 2009-08-24 2011-03-10 Wisconsin Alumni Research Foundation Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same
US9359592B2 (en) * 2009-10-06 2016-06-07 Snu R&Db Foundation Method for differentiation into retinal cells from stem cells
KR102263956B1 (en) * 2013-03-15 2021-06-11 아스텔라스 인스티튜트 포 리제너러티브 메디슨 Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
KR101712556B1 (en) * 2014-08-27 2017-03-08 서울대학교산학협력단 Method for differentiation into retinal ganglion cells from stem cells

Also Published As

Publication number Publication date
IL250924A0 (en) 2017-04-30
EP3189135A4 (en) 2018-04-25
IL277780A (en) 2020-11-30
US20170274019A1 (en) 2017-09-28
WO2016037159A1 (en) 2016-03-10
EP3189135A1 (en) 2017-07-12
ES2883600T3 (en) 2021-12-09
KR20170077117A (en) 2017-07-05
JP2020185004A (en) 2020-11-19
CA2960211A1 (en) 2016-03-10
JP6778181B2 (en) 2020-10-28
PL3189135T3 (en) 2021-12-20
CN107148276A (en) 2017-09-08
SG11201701709YA (en) 2017-04-27
JP2017532954A (en) 2017-11-09
IL277780B (en) 2021-08-31
JP7263293B2 (en) 2023-04-24
AU2021240145A1 (en) 2021-10-28
EP3922717A1 (en) 2021-12-15
IL250924B (en) 2020-10-29
AU2015311702A1 (en) 2017-04-06
IL285258A (en) 2021-09-30
PT3189135T (en) 2021-08-19
EP3189135B1 (en) 2021-06-02
SG10201912296RA (en) 2020-02-27

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