SG10201700889PA - P2x7 modulators - Google Patents
P2x7 modulatorsInfo
- Publication number
- SG10201700889PA SG10201700889PA SG10201700889PA SG10201700889PA SG10201700889PA SG 10201700889P A SG10201700889P A SG 10201700889PA SG 10201700889P A SG10201700889P A SG 10201700889PA SG 10201700889P A SG10201700889P A SG 10201700889PA SG 10201700889P A SG10201700889P A SG 10201700889PA
- Authority
- SG
- Singapore
- Prior art keywords
- modulators
- Prior art date
Links
- 101100135293 Mus musculus P2rx7 gene Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361786260P | 2013-03-14 | 2013-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201700889PA true SG10201700889PA (en) | 2017-03-30 |
Family
ID=50543353
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201507259UA SG11201507259UA (en) | 2013-03-14 | 2014-03-14 | P2x7 modulators |
SG10201700889PA SG10201700889PA (en) | 2013-03-14 | 2014-03-14 | P2x7 modulators |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201507259UA SG11201507259UA (en) | 2013-03-14 | 2014-03-14 | P2x7 modulators |
Country Status (33)
Country | Link |
---|---|
US (8) | US10112937B2 (en) |
EP (3) | EP2970267B3 (en) |
JP (1) | JP6293861B2 (en) |
KR (4) | KR102500076B1 (en) |
CN (2) | CN105209464B (en) |
AR (2) | AR095530A1 (en) |
AU (5) | AU2014239291B2 (en) |
BR (1) | BR112015023142B1 (en) |
CA (1) | CA2906085C (en) |
CL (3) | CL2015002655A1 (en) |
CY (1) | CY1119110T1 (en) |
DK (2) | DK2970267T6 (en) |
EA (1) | EA028816B1 (en) |
ES (2) | ES2635318T7 (en) |
HK (1) | HK1218541A1 (en) |
HR (1) | HRP20171168T4 (en) |
HU (1) | HUE032877T2 (en) |
IL (1) | IL240880B (en) |
JO (1) | JO3773B1 (en) |
LT (1) | LT2970267T (en) |
ME (1) | ME02802B (en) |
MX (2) | MX364796B (en) |
PH (1) | PH12015501930A1 (en) |
PL (1) | PL2970267T6 (en) |
PT (2) | PT3239151T (en) |
RS (1) | RS56315B2 (en) |
SG (2) | SG11201507259UA (en) |
SI (1) | SI2970267T1 (en) |
TW (2) | TWI599567B (en) |
UA (1) | UA116467C2 (en) |
UY (3) | UY39888A (en) |
WO (1) | WO2014152604A1 (en) |
ZA (1) | ZA201507627B (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI599567B (en) | 2013-03-14 | 2017-09-21 | 健生藥品公司 | P2x7 modulators |
MX363936B (en) | 2013-03-14 | 2019-04-09 | Boehringer Ingelheim Int | Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c. |
US9096596B2 (en) | 2013-03-14 | 2015-08-04 | Janssen Pharmaceutica Nv | P2X7 modulators |
JP6467404B2 (en) | 2013-03-14 | 2019-02-13 | ヤンセン ファーマシューティカ エヌ.ベー. | P2X7 modulator |
JO3509B1 (en) | 2013-03-14 | 2020-07-05 | Janssen Pharmaceutica Nv | P2x7 modulators |
GB201321748D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
WO2015172196A1 (en) * | 2014-05-13 | 2015-11-19 | Monash University | Heterocyclic compounds and use of same |
US10150766B2 (en) | 2014-09-12 | 2018-12-11 | Janssen Pharmaceutica Nv | P2X7 modulators |
SI3191487T1 (en) | 2014-09-12 | 2019-12-31 | Boehringer Ingelheim International Gmbh | Spirocyclic inhibitors of cathepsin c |
EP3287443B1 (en) | 2015-04-24 | 2021-10-27 | Shionogi & Co., Ltd | 6-membered heterocyclic derivative and pharmaceutical composition comprising same |
EP3328857B1 (en) * | 2015-07-31 | 2019-08-14 | Merck Patent GmbH | Bicyclic heterocyclic derivatives |
KR102528627B1 (en) | 2016-10-17 | 2023-05-03 | 시오노기 앤드 컴파니, 리미티드 | Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical compositions containing them |
CN110139929A (en) * | 2016-12-02 | 2019-08-16 | 德国弗劳恩霍夫应用研究促进协会 | Bacterial glutaminyl cyclase and inhibitors thereof for the treatment of periodontitis |
ES2963044T3 (en) * | 2017-03-13 | 2024-03-25 | Raqualia Pharma Inc | Tetrahydroquinoline derivatives as P2X7 receptor antagonists |
WO2019099509A1 (en) * | 2017-11-14 | 2019-05-23 | Second Genome, Inc. | Use of a p2x7 receptor antagonist to treat an inflammatory disease or disorder |
HRP20220510T1 (en) * | 2018-01-30 | 2022-05-27 | Incyte Corporation | Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one) |
TW202028198A (en) | 2018-09-28 | 2020-08-01 | 比利時商健生藥品公司 | Monoacylglycerol lipase modulators |
KR20210069079A (en) * | 2018-09-28 | 2021-06-10 | 얀센 파마슈티카 엔.브이. | monoacylglycerol lipase modulator |
CN109400605A (en) * | 2018-11-27 | 2019-03-01 | 复旦大学附属中山医院 | A kind of P2X7 receptor developer and preparation method thereof |
EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
CA3156100A1 (en) * | 2019-09-30 | 2021-04-08 | Janssen Pharmaceutica Nv | Radiolabelled mgl pet ligands |
JP7165647B2 (en) | 2019-12-26 | 2022-11-04 | 信越化学工業株式会社 | Thermally conductive silicone resin composition |
MX2022008665A (en) * | 2020-01-13 | 2022-08-10 | Aptabio Therapeutics Inc | Novel pyrazole derivative. |
US11891387B2 (en) | 2020-03-26 | 2024-02-06 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
CN115894452B (en) * | 2021-08-18 | 2024-04-09 | 四川大学 | P2X7 receptor inhibitor |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816463A (en) | 1986-04-01 | 1989-03-28 | Warner-Lambert Company | Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity |
US4812462A (en) | 1986-04-01 | 1989-03-14 | Warner-Lambert Company | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity |
CA2093125C (en) | 1990-10-02 | 2003-12-16 | Warner-Lambert Company | Angiotensin ii antagonists |
WO2004014374A1 (en) | 2002-07-25 | 2004-02-19 | Pharmacia Italia S.P.A. | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
AU2003244649A1 (en) | 2002-07-25 | 2004-02-23 | Pharmacia Italia Spa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
FR2857363B1 (en) | 2003-07-10 | 2007-09-07 | Aventis Pharma Sa | SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO [3,4-C] PYRIDINES COMPOSITIONS CONTAINING SAME AND USE THEREOF |
AR045037A1 (en) * | 2003-07-10 | 2005-10-12 | Aventis Pharma Sa | TETRAHIDRO-1H-PIRAZOLO [3,4-C] SUBSTITUTED PYRIDINS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE. |
US7625888B2 (en) | 2004-08-23 | 2009-12-01 | Merck & Co., Inc. | Fused triazole derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
US20080146612A1 (en) | 2005-01-27 | 2008-06-19 | Astrazeneca Ab | Novel Biaromatic Compounds, Inhibitors of the P2X7-Receptor |
US7297700B2 (en) | 2005-03-24 | 2007-11-20 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
WO2006110516A1 (en) | 2005-04-11 | 2006-10-19 | Abbott Laboratories | Acylhydrazide p2x7 antagonists and uses thereof |
US7943617B2 (en) | 2006-11-27 | 2011-05-17 | Bristol-Myers Squibb Company | Heterobicyclic compounds useful as kinase inhibitors |
KR20100023040A (en) | 2007-06-21 | 2010-03-03 | 쉐링 코포레이션 | Polycyclic guanine derivatives and use thereof |
UA99729C2 (en) * | 2007-08-10 | 2012-09-25 | Х. Луннбек А/С | Heteroaryl amide analogues |
FR2921342B1 (en) | 2007-09-20 | 2010-03-12 | Airbus France | LOWER REAR AERODYNAMIC FAIRING FOR AN AIRCRAFT ENGINE CLAMPING DEVICE |
EP2090576A1 (en) | 2008-02-01 | 2009-08-19 | Merz Pharma GmbH & Co.KGaA | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators |
KR101598397B1 (en) | 2008-04-22 | 2016-02-29 | 얀센 파마슈티카 엔.브이. | Quinoline or isoquinoline substituted p2x7 antagonists |
WO2010060854A1 (en) | 2008-11-25 | 2010-06-03 | Nerviano Medical Sciences S.R.L. | Bicyclic pyrazole and isoxazole derivatives as antitumor and antineurodegenerative agents |
WO2010066629A2 (en) | 2008-12-09 | 2010-06-17 | F. Hoffmann-La Roche Ag | Novel azaindoles |
US8501946B2 (en) | 2009-04-29 | 2013-08-06 | Glaxo Group Limited | 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine derivatives as P2X7 modulators |
GB0907515D0 (en) | 2009-04-30 | 2009-06-10 | Glaxo Group Ltd | Compounds |
US8871760B2 (en) | 2009-09-21 | 2014-10-28 | Roche Palo Alto Llc | [1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators |
JP5848251B2 (en) | 2009-10-23 | 2016-01-27 | ヤンセン ファーマシューティカ エヌ.ベー. | Fused heterocyclic compounds as orexin receptor modulators |
WO2011103715A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Task channel antagonists |
KR101878888B1 (en) | 2010-04-02 | 2018-08-17 | 오게다 에스.에이. | Novel nk-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in nk-3 receptors mediated disorders |
US20110252717A1 (en) | 2010-04-16 | 2011-10-20 | Graf Fernandez Rodrigo | Foldable structures for a construction |
US20130196986A1 (en) | 2010-09-21 | 2013-08-01 | Marc Labroli | Triazolopyrazinones as p2x7 receptor antagonists |
WO2012145581A1 (en) | 2011-04-20 | 2012-10-26 | Janssen Pharmaceutica Nv | Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators |
US9273947B2 (en) | 2012-02-07 | 2016-03-01 | Lg Innotek Co., Ltd. | Sensing magnet apparatus for motor |
JP5205547B1 (en) | 2012-04-20 | 2013-06-05 | 株式会社ノイズ研究所 | Radiation signal visualization device |
US9056874B2 (en) | 2012-05-04 | 2015-06-16 | Novartis Ag | Complement pathway modulators and uses thereof |
US8952169B2 (en) | 2012-05-22 | 2015-02-10 | Xenon Pharmaceuticals Inc. | N-substituted benzamides and methods of use thereof |
US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
JO3459B1 (en) | 2012-09-09 | 2020-07-05 | H Lundbeck As | Pharmaceutical compositions for treating alzheimer's disease |
CA2888021A1 (en) | 2012-10-15 | 2014-04-24 | Epizyme, Inc. | Substituted n-((2-oxo-1,2-dihydropyridin-3-yl)-methyl)-benzamide compounds and their use in the treatment of ezh2-mediated disorders |
PE20150778A1 (en) | 2012-10-16 | 2015-05-23 | Janssen Pharmaceutica Nv | ROR-GAMMA-T METHYLENE-LINKED QUINOLINYL MODULATORS |
MX2015005428A (en) | 2012-11-01 | 2015-07-21 | Incyte Corp | Tricyclic fused thiophene derivatives as jak inhibitors. |
US9796729B2 (en) | 2012-11-23 | 2017-10-24 | Glaxosmithkline Llc | Compounds as diacylglycerol acyltransferase inhibitors |
SI2935248T1 (en) | 2012-12-21 | 2018-05-31 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
US8952151B2 (en) | 2012-12-21 | 2015-02-10 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
US9233974B2 (en) | 2012-12-21 | 2016-01-12 | Gilead Sciences, Inc. | Antiviral compounds |
WO2014124230A2 (en) | 2013-02-08 | 2014-08-14 | Celgene Avilomics Research, Inc. | Erk inhibitors and uses thereof |
NO335177B1 (en) | 2013-03-06 | 2014-10-13 | Cambi Technology As | Process and apparatus for thermal biodegradation and dewatering of biomass |
US8859575B2 (en) | 2013-03-06 | 2014-10-14 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor |
AU2014230815B2 (en) | 2013-03-14 | 2016-12-08 | Glaxosmithkline Intellectual Property (No.2) Limited | 2,3-disubstituted 1 -acyl-4-amino-1,2,3,4-tetrahydroquinoline derivatives and their use as bromodomain inhibitors |
JP6467404B2 (en) | 2013-03-14 | 2019-02-13 | ヤンセン ファーマシューティカ エヌ.ベー. | P2X7 modulator |
JO3383B1 (en) | 2013-03-14 | 2019-03-13 | Lilly Co Eli | CDC7 Inhibitors |
TWI599567B (en) | 2013-03-14 | 2017-09-21 | 健生藥品公司 | P2x7 modulators |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
US9096596B2 (en) | 2013-03-14 | 2015-08-04 | Janssen Pharmaceutica Nv | P2X7 modulators |
MX363936B (en) | 2013-03-14 | 2019-04-09 | Boehringer Ingelheim Int | Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c. |
JO3509B1 (en) | 2013-03-14 | 2020-07-05 | Janssen Pharmaceutica Nv | P2x7 modulators |
JP6093903B2 (en) | 2013-03-14 | 2017-03-08 | ニューリンク ジェネティクス コーポレイション | Inhibitors of immunosuppression mediated by tryptophan metabolism |
PE20151719A1 (en) | 2013-03-14 | 2015-11-19 | Curadev Pharma Private Ltd | INHIBITORS OF THE QUINURENINE ROUTE |
CA2907814C (en) | 2013-03-29 | 2021-07-13 | Euroscreen Sa | Novel n-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders |
US10150766B2 (en) | 2014-09-12 | 2018-12-11 | Janssen Pharmaceutica Nv | P2X7 modulators |
EA201790600A1 (en) | 2014-09-12 | 2017-07-31 | Янссен Фармацевтика Нв | MODULATING P2X7 N-ACYL TRIAZOLOPIRASINS |
TW202028198A (en) | 2018-09-28 | 2020-08-01 | 比利時商健生藥品公司 | Monoacylglycerol lipase modulators |
CA3156100A1 (en) | 2019-09-30 | 2021-04-08 | Janssen Pharmaceutica Nv | Radiolabelled mgl pet ligands |
-
2014
- 2014-03-12 TW TW103108579A patent/TWI599567B/en active
- 2014-03-12 TW TW106128537A patent/TWI644671B/en active
- 2014-03-12 JO JOP/2014/0094A patent/JO3773B1/en active
- 2014-03-14 US US14/775,432 patent/US10112937B2/en active Active
- 2014-03-14 DK DK14718857.7T patent/DK2970267T6/en active
- 2014-03-14 HU HUE14718857A patent/HUE032877T2/en unknown
- 2014-03-14 MX MX2015012095A patent/MX364796B/en active IP Right Grant
- 2014-03-14 EP EP14718857.7A patent/EP2970267B3/en active Active
- 2014-03-14 ME MEP-2017-160A patent/ME02802B/en unknown
- 2014-03-14 SI SI201430279T patent/SI2970267T1/en unknown
- 2014-03-14 US US14/212,669 patent/US9066946B2/en active Active
- 2014-03-14 KR KR1020217034732A patent/KR102500076B1/en active IP Right Grant
- 2014-03-14 KR KR1020237010674A patent/KR20230049754A/en not_active IP Right Cessation
- 2014-03-14 CN CN201480027363.2A patent/CN105209464B/en active Active
- 2014-03-14 AU AU2014239291A patent/AU2014239291B2/en active Active
- 2014-03-14 EP EP17172541.9A patent/EP3239151B1/en active Active
- 2014-03-14 PL PL14718857T patent/PL2970267T6/en unknown
- 2014-03-14 LT LTEP14718857.7T patent/LT2970267T/en unknown
- 2014-03-14 KR KR1020227010005A patent/KR102516711B1/en active IP Right Grant
- 2014-03-14 PT PT17172541T patent/PT3239151T/en unknown
- 2014-03-14 ES ES14718857T patent/ES2635318T7/en active Active
- 2014-03-14 UY UY0001039888A patent/UY39888A/en active IP Right Grant
- 2014-03-14 EA EA201591748A patent/EA028816B1/en unknown
- 2014-03-14 UA UAA201510002A patent/UA116467C2/en unknown
- 2014-03-14 SG SG11201507259UA patent/SG11201507259UA/en unknown
- 2014-03-14 CN CN201811523767.7A patent/CN110003200B/en active Active
- 2014-03-14 PT PT147188577T patent/PT2970267T/en unknown
- 2014-03-14 CA CA2906085A patent/CA2906085C/en active Active
- 2014-03-14 KR KR1020157029102A patent/KR102319857B1/en active IP Right Grant
- 2014-03-14 UY UY0001039887A patent/UY39887A/en not_active Application Discontinuation
- 2014-03-14 UY UY0001035469A patent/UY35469A/en active IP Right Grant
- 2014-03-14 WO PCT/US2014/027522 patent/WO2014152604A1/en active Application Filing
- 2014-03-14 ES ES17172541T patent/ES2704024T3/en active Active
- 2014-03-14 EP EP18204727.4A patent/EP3495365A1/en not_active Withdrawn
- 2014-03-14 AR ARP140101138A patent/AR095530A1/en active IP Right Grant
- 2014-03-14 JP JP2016502469A patent/JP6293861B2/en active Active
- 2014-03-14 DK DK17172541.9T patent/DK3239151T3/en active
- 2014-03-14 SG SG10201700889PA patent/SG10201700889PA/en unknown
- 2014-03-14 RS RS20170758A patent/RS56315B2/en unknown
- 2014-03-14 BR BR112015023142-0A patent/BR112015023142B1/en active IP Right Grant
-
2015
- 2015-05-18 US US14/714,714 patent/US9464084B2/en active Active
- 2015-08-27 IL IL240880A patent/IL240880B/en active IP Right Grant
- 2015-09-02 PH PH12015501930A patent/PH12015501930A1/en unknown
- 2015-09-09 MX MX2022011795A patent/MX2022011795A/en unknown
- 2015-09-14 CL CL2015002655A patent/CL2015002655A1/en unknown
- 2015-10-13 ZA ZA2015/07627A patent/ZA201507627B/en unknown
-
2016
- 2016-06-07 HK HK16106529.9A patent/HK1218541A1/en unknown
- 2016-09-07 US US15/258,320 patent/US10150765B2/en active Active
-
2017
- 2017-07-17 AU AU2017206153A patent/AU2017206153B2/en active Active
- 2017-07-25 CY CY20171100794T patent/CY1119110T1/en unknown
- 2017-07-31 HR HRP20171168TT patent/HRP20171168T4/en unknown
- 2017-10-16 CL CL2017002610A patent/CL2017002610A1/en unknown
- 2017-10-16 CL CL2017002609A patent/CL2017002609A1/en unknown
-
2018
- 2018-11-20 US US16/196,140 patent/US10703749B2/en active Active
-
2019
- 2019-05-07 AU AU2019203186A patent/AU2019203186B2/en active Active
-
2020
- 2020-06-25 US US16/911,428 patent/US11225478B2/en active Active
-
2021
- 2021-07-23 AR ARP210102071A patent/AR123048A2/en unknown
- 2021-09-21 AU AU2021236451A patent/AU2021236451B2/en active Active
-
2022
- 2022-01-14 US US17/576,644 patent/US11820770B2/en active Active
-
2023
- 2023-10-18 US US18/381,554 patent/US20240116930A1/en active Pending
-
2024
- 2024-03-15 AU AU2024201709A patent/AU2024201709A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20171168T1 (en) | P2x7 modulators | |
HK1254111A1 (en) | P2x7 modulators | |
HK1218652A1 (en) | P2x7 modulators p2x7 | |
HK1218651A1 (en) | P2x7 modulators p2x7 | |
HK1217489A1 (en) | Flap modulators flap | |
GB201317802D0 (en) | SmartHaler patent application | |
HK1218542A1 (en) | Flap modulators flap | |
IL242777A (en) | Construction-set elements | |
EP2975313A4 (en) | Fluid-throttling member | |
GB201315731D0 (en) | Sealing member | |
PL2803518T3 (en) | Sealing member | |
GB201321601D0 (en) | Modulator | |
GB2518649B (en) | Sealing member | |
GB201312727D0 (en) | Modulators | |
GB201316031D0 (en) | Alignment member | |
GB201318298D0 (en) | Modulators | |
GB2517462B (en) | Sealing member | |
GB201317988D0 (en) | Modulators | |
GB201304473D0 (en) | Modulators | |
GB201310637D0 (en) | Sealing member | |
GB201317911D0 (en) | E e e | |
AP00812S1 (en) | Stumbelbloc | |
AU2013231V (en) | Bonsca7200 Scaevola aemula | |
AP2013000703S (en) | Adwura wura | |
AP2013000704S (en) | Gramoquat |