Nothing Special   »   [go: up one dir, main page]

SG10201509145XA - Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers - Google Patents

Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers

Info

Publication number
SG10201509145XA
SG10201509145XA SG10201509145XA SG10201509145XA SG10201509145XA SG 10201509145X A SG10201509145X A SG 10201509145XA SG 10201509145X A SG10201509145X A SG 10201509145XA SG 10201509145X A SG10201509145X A SG 10201509145XA SG 10201509145X A SG10201509145X A SG 10201509145XA
Authority
SG
Singapore
Prior art keywords
receptor alpha
folate receptor
diagnostic
prognostic marker
expressing cancers
Prior art date
Application number
SG10201509145XA
Inventor
Daniel J O'shannessy
Luigi Grasso
Shanhong Wan
Qimin Chao
Elizabeth Brooke Somers
Original Assignee
Morphotek Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphotek Inc filed Critical Morphotek Inc
Publication of SG10201509145XA publication Critical patent/SG10201509145XA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57449—Specifically defined cancers of ovaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG10201509145XA 2010-11-05 2011-11-04 Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers SG10201509145XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41049710P 2010-11-05 2010-11-05
US201161508444P 2011-07-15 2011-07-15

Publications (1)

Publication Number Publication Date
SG10201509145XA true SG10201509145XA (en) 2015-12-30

Family

ID=45003076

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201701933XA SG10201701933XA (en) 2010-11-05 2011-11-04 Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers
SG10201509145XA SG10201509145XA (en) 2010-11-05 2011-11-04 Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers
SG2013030424A SG189957A1 (en) 2010-11-05 2011-11-04 Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201701933XA SG10201701933XA (en) 2010-11-05 2011-11-04 Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2013030424A SG189957A1 (en) 2010-11-05 2011-11-04 Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers

Country Status (14)

Country Link
US (1) US20120207771A1 (en)
EP (2) EP2635304B1 (en)
JP (2) JP6224456B2 (en)
KR (2) KR102057438B1 (en)
CN (2) CN103687618A (en)
AU (3) AU2011323124C1 (en)
BR (1) BR112013011072B1 (en)
CA (1) CA2816991C (en)
ES (2) ES2627061T3 (en)
IL (2) IL225871B (en)
MX (2) MX343607B (en)
RU (2) RU2764592C2 (en)
SG (3) SG10201701933XA (en)
WO (1) WO2012061759A2 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060239910A1 (en) * 2005-04-22 2006-10-26 Morphotek Inc. Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells
EP2538976B8 (en) 2010-02-24 2017-05-24 ImmunoGen, Inc. Immunoconjugates against folate receptor 1 and uses thereof
US20120189620A1 (en) * 2011-01-21 2012-07-26 Emory University Methods for treating non-functioning pituitary adenoma
EP2680839A1 (en) * 2011-03-02 2014-01-08 Morphotek, Inc. Co -administration of eribulin and farletuzumab for the treatment of breast cancer
ES2661466T3 (en) * 2011-04-01 2018-04-02 Immunogen, Inc. Methods to increase the effectiveness of cancer therapy with FOLR1
JP6220333B2 (en) * 2011-07-15 2017-10-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 Antifolate receptor alpha antibodies and uses thereof
MX362497B (en) 2012-05-15 2019-01-21 Eisai Inc Methods for treatment of gastric cancer.
HUE049693T2 (en) 2012-08-31 2020-10-28 Immunogen Inc Diagnostic assays and kits for detection of folate receptor 1
EP3011013A4 (en) * 2013-06-20 2017-03-15 Morphotek, Inc. Methods for treatment of ovarian cancer
JP2016536330A (en) 2013-08-30 2016-11-24 イミュノジェン， インコーポレイテッド Antibodies and assays for detection of folate receptor 1
PT3653228T (en) * 2013-10-08 2024-07-17 Immunogen Inc Anti-folr1 immunoconjugate dosing regimens
EP3747905A1 (en) 2014-11-20 2020-12-09 F. Hoffmann-La Roche AG Common light chains and methods of use
MY192999A (en) 2014-11-20 2022-09-20 Hoffmann La Roche Combination therapy of t cell activating bispecific antigen binding molecules and pd-1 axis binding antagonists
BR112017022320A2 (en) 2015-04-17 2018-07-24 Morphotek Inc Methods for Lung Cancer Treatment
CN116440279A (en) 2015-09-17 2023-07-18 伊缪诺金公司 Therapeutic combinations comprising anti-FOLR 1 immunoconjugates
CA3033077C (en) 2016-08-12 2024-06-18 L.E.A.F. Holdings Group Llc Alpha and gamma-d polyglutamated antifolates and uses thereof
WO2018098277A1 (en) * 2016-11-23 2018-05-31 Eisai R&D Management Co., Ltd Anti-folate receptor alpha antibodies and uses thereof
CN107446021B (en) * 2017-07-26 2020-08-11 中国药科大学 Folate receptor alpha specific binding peptide 5 and application thereof
CN107353325B (en) * 2017-07-26 2020-08-11 中国药科大学 Folate receptor alpha specific binding peptide 1 and application thereof
CN107446020B (en) * 2017-07-28 2019-10-01 中国药科大学 Folacin receptor alpha specific peptide 2 and its application
RU2759410C2 (en) * 2017-09-05 2021-11-12 Иммьюноджен, Инк. Methods for detecting folate receptor 1 in patient sample
EP3749317A4 (en) 2018-02-07 2022-06-22 L.E.A.F Holdings Group LLC Alpha polyglutamated pemetrexed and uses thereof
CA3090509A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated methotrexate and uses thereof
WO2019157129A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated pralatrexate and uses thereof
WO2019157146A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated antifolates and uses thereof
EP3755335A4 (en) 2018-02-14 2022-06-22 L.E.A.F Holdings Group LLC Gamma polyglutamated tetrahydrofolates and uses thereof
CA3090875A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated lometrexol and uses thereof
EP3752156A4 (en) 2018-02-14 2021-10-27 L.E.A.F Holdings Group LLC Gamma polyglutamated pralatrexate and uses thereof
EA202092125A1 (en) * 2018-03-13 2020-12-15 Фейнз Терапьютикс, Инк. ANTIBODIES AGAINST FOLATE 1 RECEPTOR AND THEIR APPLICATION
US11216742B2 (en) 2019-03-04 2022-01-04 Iocurrents, Inc. Data compression and communication using machine learning
SG11202111109UA (en) 2019-04-29 2021-11-29 Immunogen Inc Biparatopic fr-alpha antibodies and immunoconjugates
KR20240017024A (en) * 2021-06-04 2024-02-06 이뮤노젠 아이엔씨 Treatment of cancer in patients with soluble FR-alpha
CN117700557B (en) * 2024-02-05 2024-04-30 卡秋(江苏)生物科技有限公司 Antibody or antigen binding fragment specifically binding to folate receptor alpha

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5646253A (en) 1994-03-08 1997-07-08 Memorial Sloan-Kettering Cancer Center Recombinant human anti-LK26 antibodies
ES2338791T3 (en) 1992-08-21 2010-05-12 Vrije Universiteit Brussel IMMUNOGLOBULINS DESPROVISTAS OF LIGHT CHAINS.
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5547835A (en) 1993-01-07 1996-08-20 Sequenom, Inc. DNA sequencing by mass spectrometry
AU687801B2 (en) 1993-03-19 1998-03-05 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
AU738328B2 (en) 1997-01-21 2001-09-13 General Hospital Corporation, The Selection of proteins using RNA-protein fusions
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
US6818418B1 (en) 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
US7115396B2 (en) 1998-12-10 2006-10-03 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
US6933108B2 (en) * 1999-12-09 2005-08-23 The Regents Of The University Of California Methods and compositions for use in the treatment of filovirus mediated disease conditions
JP2004512540A (en) * 2000-11-01 2004-04-22 マウント・サイナイ・ホスピタル Ovarian cancer detection
US20100120078A1 (en) * 2001-08-16 2010-05-13 Tony Baker Urine Stabilization System
AU2002340683C1 (en) * 2001-11-13 2009-11-12 Id Biomedical Corporation Of Quebec Polypeptides of pseudomonas aeruginosa
WO2003091700A2 (en) * 2002-03-26 2003-11-06 Centocor, Inc. Epitope mapping using nuclear magnetic resonance
US20080131366A1 (en) * 2003-03-17 2008-06-05 Manohar Ratnam Folate Receptor Gene Modulation For Cancer Diagnosis And Therapy
US20040235108A1 (en) * 2003-05-23 2004-11-25 Luigi Grasso Monoclonal antibodies that specifically bind a tumor antigen
US20080113344A1 (en) * 2003-10-28 2008-05-15 Ralph Wirtz Methods and Compositions for the Response Prediction of Malignant Neoplasia to Treatment
WO2005080431A2 (en) 2004-02-12 2005-09-01 Morphotek, Inc. Monoclonal antibodies that specifically bind to folate receptor alpha
JP2008537778A (en) * 2005-03-30 2008-09-25 パーデュー・リサーチ・ファウンデーション Cancer prognosis by quantification of cellular folate vitamin receptor
US20060239910A1 (en) * 2005-04-22 2006-10-26 Morphotek Inc. Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells
CN101384903A (en) * 2006-02-09 2009-03-11 南佛罗里达大学 Detection of cancer by elevated levels of bcl-2
CA2685300C (en) * 2006-06-01 2017-01-03 Mayo Foundation For Medical Education And Research Immunity to folate receptors
EP1900752A1 (en) * 2006-09-15 2008-03-19 DOMPE' pha.r.ma s.p.a. Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma
US7754698B2 (en) 2007-01-09 2010-07-13 Isis Pharmaceuticals, Inc. Modulation of FR-alpha expression
US20100216718A1 (en) * 2007-10-19 2010-08-26 Cell Signaling Technology, Inc. Cancer Classification and Methods of Use
WO2009132081A2 (en) 2008-04-24 2009-10-29 The Research Foundation Of State University Of New York Monoclonal antibody-based targeting of folate receptors
US20110177525A1 (en) * 2010-01-19 2011-07-21 Predictive Biosciences, Inc. Antibodies and methods of diagnosing diseases
EP2606353A4 (en) * 2010-08-18 2014-10-15 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease

Also Published As

Publication number Publication date
KR101931936B1 (en) 2018-12-26
ES2627061T3 (en) 2017-07-26
AU2018201760A1 (en) 2018-04-05
CN103687618A (en) 2014-03-26
AU2011323124C1 (en) 2016-09-22
JP6224456B2 (en) 2017-11-01
CN108562744A (en) 2018-09-21
MX2013005067A (en) 2013-07-02
BR112013011072A2 (en) 2017-06-20
RU2017129266A3 (en) 2021-01-25
RU2017129266A (en) 2019-02-04
WO2012061759A3 (en) 2012-07-26
MX343607B (en) 2016-11-11
RU2764592C2 (en) 2022-01-18
SG189957A1 (en) 2013-06-28
WO2012061759A2 (en) 2012-05-10
AU2011323124A1 (en) 2013-05-09
AU2018201760B2 (en) 2019-07-25
US20120207771A1 (en) 2012-08-16
IL260590B (en) 2020-01-30
JP6554152B2 (en) 2019-07-31
KR20180137587A (en) 2018-12-27
EP3130605A1 (en) 2017-02-15
AU2016203408A1 (en) 2016-06-16
RU2013125772A (en) 2014-12-10
JP2018036270A (en) 2018-03-08
SG10201701933XA (en) 2017-05-30
IL225871B (en) 2018-08-30
KR102057438B1 (en) 2019-12-20
BR112013011072B1 (en) 2021-02-02
MX368394B (en) 2019-10-01
AU2011323124B2 (en) 2016-02-25
JP2013544354A (en) 2013-12-12
EP2635304B1 (en) 2017-03-08
KR20140024838A (en) 2014-03-03
CA2816991C (en) 2020-06-09
RU2630608C2 (en) 2017-09-11
EP3130605B1 (en) 2020-01-08
IL225871A0 (en) 2013-06-27
CA2816991A1 (en) 2012-05-10
ES2780192T3 (en) 2020-08-24
EP2635304A2 (en) 2013-09-11

Similar Documents

Publication Publication Date Title
IL260590B (en) Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers
HK1135940A1 (en) Self-powered coordinate probe
EP2585833A4 (en) Methods for detecting cancer
EP2592383A4 (en) Information providing apparatus
EP2630917A4 (en) Breast measurement apparatus
EP2569446A4 (en) Diagnostic markers for neuropsychiatric disease
GB201414085D0 (en) Breast cancer diagnosis and indication marker
EP2636040A4 (en) Copyback operations
EP2748608A4 (en) Lung cancer tests
EP2634544A4 (en) Collective chute for combination scale
GB201012590D0 (en) Methods for diagnosing cancer
EP2524702A4 (en) Diagnostic for cancer
EP2495561A4 (en) Anticancer agent sensitivity-determining marker
EP2686447A4 (en) Prognostic marker sets for prostate cancer
ZA201200888B (en) New tumor marker
HK1176977A1 (en) Marker for gastric cancer and method for detecting gastric cancer
EP2486154A4 (en) Diagnostic and prognostic markers for cancer
EP2531616A4 (en) Diagnostic and prognostic assay for breast cancer
GB2477687B (en) X-ray marker
GB0908071D0 (en) Marker
EP2735571A4 (en) Antibody for colorectal cancer marker
PT2386459E (en) Train location system
GB0905964D0 (en) Marker
GB201017517D0 (en) A tunnelling device
GB201016212D0 (en) Marker device