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SE9901901D0 - Compounds - Google Patents

Compounds

Info

Publication number
SE9901901D0
SE9901901D0 SE9901901A SE9901901A SE9901901D0 SE 9901901 D0 SE9901901 D0 SE 9901901D0 SE 9901901 A SE9901901 A SE 9901901A SE 9901901 A SE9901901 A SE 9901901A SE 9901901 D0 SE9901901 D0 SE 9901901D0
Authority
SE
Sweden
Prior art keywords
compounds
racemates
tautomers
inhibitors
therapy
Prior art date
Application number
SE9901901A
Other languages
Swedish (sv)
Inventor
James E Macdonald
James R Matz
Edwin Wu
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9901901A priority Critical patent/SE9901901D0/en
Publication of SE9901901D0 publication Critical patent/SE9901901D0/en
Priority to AU51195/00A priority patent/AU5119500A/en
Priority to PCT/SE2000/001034 priority patent/WO2000073313A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

There are provided novel compounds of formula (I), wherein R<1>, R<2>, A and X are as defined in the specification, and optical isomers, racemates and tautomers thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase.
SE9901901A 1999-05-26 1999-05-26 Compounds SE9901901D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE9901901A SE9901901D0 (en) 1999-05-26 1999-05-26 Compounds
AU51195/00A AU5119500A (en) 1999-05-26 2000-05-23 New tricyclic amidine derivatives as inhibitors of nitric oxide synthase
PCT/SE2000/001034 WO2000073313A1 (en) 1999-05-26 2000-05-23 New tricyclic amidine derivatives as inhibitors of nitric oxide synthase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9901901A SE9901901D0 (en) 1999-05-26 1999-05-26 Compounds

Publications (1)

Publication Number Publication Date
SE9901901D0 true SE9901901D0 (en) 1999-05-26

Family

ID=20415733

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9901901A SE9901901D0 (en) 1999-05-26 1999-05-26 Compounds

Country Status (3)

Country Link
AU (1) AU5119500A (en)
SE (1) SE9901901D0 (en)
WO (1) WO2000073313A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2002002647A0 (en) * 2000-04-10 2002-12-31 Pfizer Prod Inc Benzoamide piperidine compounds as substance p antagonists
US7119207B2 (en) 2000-04-10 2006-10-10 Pfizer Inc Benzoamide piperidine containing compounds and related compounds
GB0108592D0 (en) * 2001-04-05 2001-05-23 Merck Sharp & Dohme Therapeutic agents
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
TW200808810A (en) 2006-02-23 2008-02-16 Novartis Ag Organic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH476743A (en) * 1962-06-08 1969-08-15 Wander Ag Dr A Process for the preparation of amidines of the dibenzo (b, e) (1,4) -diazepine series
US5605897A (en) * 1991-04-23 1997-02-25 Eli Lilly And Company 2-methyl-thieno-benzodiazepine
TW458978B (en) * 1995-11-07 2001-10-11 Astra Ab Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Also Published As

Publication number Publication date
AU5119500A (en) 2000-12-18
WO2000073313A1 (en) 2000-12-07

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