Nothing Special   »   [go: up one dir, main page]

SE8703682L - Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner - Google Patents

Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner

Info

Publication number
SE8703682L
SE8703682L SE8703682A SE8703682A SE8703682L SE 8703682 L SE8703682 L SE 8703682L SE 8703682 A SE8703682 A SE 8703682A SE 8703682 A SE8703682 A SE 8703682A SE 8703682 L SE8703682 L SE 8703682L
Authority
SE
Sweden
Prior art keywords
lanthanide
chelate
fluorescence
assay
homogenic
Prior art date
Application number
SE8703682A
Other languages
English (en)
Other versions
SE8703682D0 (sv
Inventor
I Hemmilae
T Loevgren
Original Assignee
Wallac Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallac Oy filed Critical Wallac Oy
Priority to SE8703682A priority Critical patent/SE8703682L/sv
Publication of SE8703682D0 publication Critical patent/SE8703682D0/sv
Priority to DE8888850314T priority patent/DE3877179T2/de
Priority to AT88850314T priority patent/ATE84150T1/de
Priority to EP88850314A priority patent/EP0324323B1/en
Priority to JP63236658A priority patent/JPH01127957A/ja
Publication of SE8703682L publication Critical patent/SE8703682L/sv
Priority to US07/626,528 priority patent/US5637509A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/826—Additives, e.g. buffers, diluents, preservatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SE8703682A 1987-09-24 1987-09-24 Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner SE8703682L (sv)

Priority Applications (6)

Application Number Priority Date Filing Date Title
SE8703682A SE8703682L (sv) 1987-09-24 1987-09-24 Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner
DE8888850314T DE3877179T2 (de) 1987-09-24 1988-09-20 Homogene biospezifische bestimmungsmethode mit lanthanidchelaten-marker.
AT88850314T ATE84150T1 (de) 1987-09-24 1988-09-20 Homogene biospezifische bestimmungsmethode mit lanthanidchelaten-marker.
EP88850314A EP0324323B1 (en) 1987-09-24 1988-09-20 Homogeneous biospecific assay method using lanthanide chelates as labels
JP63236658A JPH01127957A (ja) 1987-09-24 1988-09-22 生物特異的親和反応を利用する均一検定法
US07/626,528 US5637509A (en) 1987-09-24 1990-12-12 Modulated homogeneous fluorescence biospecific affinity assay employing fluorescing lanthanide chelates as covalent labels

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8703682A SE8703682L (sv) 1987-09-24 1987-09-24 Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner

Publications (2)

Publication Number Publication Date
SE8703682D0 SE8703682D0 (sv) 1987-09-24
SE8703682L true SE8703682L (sv) 1989-03-25

Family

ID=20369657

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8703682A SE8703682L (sv) 1987-09-24 1987-09-24 Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner

Country Status (6)

Country Link
US (1) US5637509A (sv)
EP (1) EP0324323B1 (sv)
JP (1) JPH01127957A (sv)
AT (1) ATE84150T1 (sv)
DE (1) DE3877179T2 (sv)
SE (1) SE8703682L (sv)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801702D0 (sv) * 1988-05-05 1988-05-05 Pharmacia Ab Sett vid bestemning av enzymatisk aktivitet
GB8927503D0 (en) * 1989-12-04 1990-02-07 Kronem Systems Inc Enzyme-amplified lanthanide chelate luminescence
EP0511201A1 (en) * 1990-01-17 1992-11-04 Wallac Oy Oligosaccharide derivates linked to lanthanide chelates and to a reactive group
ATE156522T1 (de) * 1991-02-14 1997-08-15 Dade Microscan Inc Neue oligonukleotide konjugiert zu lanthanide- chelaten
US5578498A (en) * 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
DE4210970C2 (de) * 1992-04-02 1996-10-17 Markus Dipl Chem Sauer Verfahren zur simultanen optischen qualitativen und quantitativen Erfassung von verschiedenen mit Fluorochromen oder Fluorogenen markierten Molekülen eines Gemisches mittels Laserspektroskopie
US6159686A (en) 1992-09-14 2000-12-12 Sri International Up-converting reporters for biological and other assays
US6399397B1 (en) 1992-09-14 2002-06-04 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5736410A (en) 1992-09-14 1998-04-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
DE69434810T2 (de) * 1993-11-16 2007-08-02 Bracco International B.V. Immobilisiertes markierungsverfahren
US5792330A (en) * 1995-05-31 1998-08-11 Board Of Regents, The University Of Texas System Lanthanide metal cations for concurrent detection and separation in capillary electrophoresis
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
AU1517999A (en) 1997-10-15 1999-05-03 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
US6770460B1 (en) * 1998-01-29 2004-08-03 Wallac Oy Fusion protein and its use in an immunoassay for the simultaneous detection of autoantibodies related to insulin-dependent diabetes mellitus
US6030840A (en) * 1998-06-15 2000-02-29 Nen Life Sciences, Inc. Neutral enhancement of lanthanides for time resolved fluorescence
US6103199A (en) * 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
AU768957B2 (en) * 1999-02-18 2004-01-08 Regents Of The University Of California, The Phthalamide-lanthanide complexes for use as luminescent markers
DK1154991T3 (da) * 1999-02-18 2004-11-22 Univ California Salicylamid-lanthanidkomplekser til anvendelse som luminescerende markörer
US6838292B1 (en) 1999-04-19 2005-01-04 Alion Science And Technology Corporation Detection of biological warfare agents
US20020072625A1 (en) * 1999-12-10 2002-06-13 Johnson David Kenneth Materials and methods for measuring chelate: anti-chelate binding by fluorescence polarization immunoassay
AU2002322351A1 (en) * 2001-06-28 2003-03-03 Ia, Inc. Fiber-optic sensor array
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US7211440B2 (en) * 2002-03-08 2007-05-01 Wallac Oy Dissociative fluorescence enhancement assay
US7771922B2 (en) * 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7223368B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7223534B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7214530B2 (en) * 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
GB0210535D0 (en) * 2002-05-08 2002-06-19 Novartis Ag Organic compounds
US7091049B2 (en) * 2002-06-26 2006-08-15 Kimberly-Clark Worldwide, Inc. Enhanced diffraction-based biosensor devices
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7781172B2 (en) 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US7247500B2 (en) * 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US7851209B2 (en) * 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US7815854B2 (en) 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US20060019265A1 (en) * 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US20050244953A1 (en) * 2004-04-30 2005-11-03 Kimberly-Clark Worldwide, Inc. Techniques for controlling the optical properties of assay devices
US7796266B2 (en) * 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US7906276B2 (en) 2004-06-30 2011-03-15 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US7094528B2 (en) * 2004-06-30 2006-08-22 Kimberly-Clark Worldwide, Inc. Magnetic enzyme detection techniques
CA2573869A1 (en) * 2004-07-23 2006-02-09 Amgen Inc. Generic probes for the detection of phosphorylated sequences
US7767834B2 (en) * 2004-08-13 2010-08-03 Elitech Holding B.V. Phosphonylated fluorescent dyes and conjugates
EP1781675B1 (en) * 2004-08-13 2014-03-26 Epoch Biosciences, Inc. Phosphonate fluorescent dyes and conjugates
EP1785724B1 (en) * 2004-08-17 2012-08-08 Japan Science and Technology Agency Method of labeling with use of rare earth fluorescent complex and relevant method of analysis and detection
CA2581639C (en) 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
US20070121113A1 (en) * 2004-12-22 2007-05-31 Cohen David S Transmission-based optical detection systems
US7939342B2 (en) 2005-03-30 2011-05-10 Kimberly-Clark Worldwide, Inc. Diagnostic test kits employing an internal calibration system
US7858384B2 (en) * 2005-04-29 2010-12-28 Kimberly-Clark Worldwide, Inc. Flow control technique for assay devices
US7439079B2 (en) * 2005-04-29 2008-10-21 Kimberly-Clark Worldwide, Inc. Assay devices having detection capabilities within the hook effect region
US7803319B2 (en) * 2005-04-29 2010-09-28 Kimberly-Clark Worldwide, Inc. Metering technique for lateral flow assay devices
DE102005020384A1 (de) * 2005-05-02 2006-11-09 Therainvention Gmbh Spektroskopisches Verfahren zum Nachweis von Analyten
US7504235B2 (en) 2005-08-31 2009-03-17 Kimberly-Clark Worldwide, Inc. Enzyme detection technique
US7829347B2 (en) * 2005-08-31 2010-11-09 Kimberly-Clark Worldwide, Inc. Diagnostic test kits with improved detection accuracy
US7279136B2 (en) * 2005-12-13 2007-10-09 Takeuchi James M Metering technique for lateral flow assay devices
US7645583B2 (en) * 2005-12-14 2010-01-12 Kimberly-Clark Worldwide, Inc. Identification of compounds for inhibiting complexation of C-reactive protein with fibronectin
US7745158B2 (en) * 2005-12-14 2010-06-29 Kimberly-Clark Worldwide, Inc. Detection of secreted aspartyl proteases from Candida species
US7618810B2 (en) * 2005-12-14 2009-11-17 Kimberly-Clark Worldwide, Inc. Metering strip and method for lateral flow assay devices
US8758989B2 (en) * 2006-04-06 2014-06-24 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US7897360B2 (en) 2006-12-15 2011-03-01 Kimberly-Clark Worldwide, Inc. Enzyme detection techniques
US8535617B2 (en) * 2007-11-30 2013-09-17 Kimberly-Clark Worldwide, Inc. Blood cell barrier for a lateral flow device
FI20090306A0 (sv) 2009-08-25 2009-08-25 Qret Technologies Oy Separeringsfritt analysförfarande
US8153442B2 (en) * 2009-10-21 2012-04-10 Siemens Healthcare Diagnostics Inc. Stabilization of signal generation in particles used in assays
RU2767695C2 (ru) 2012-03-16 2022-03-18 Стат-Диагностика Энд Инновэйшн, С.Л. Кассета для тестирования со встроенным передаточным модулем
US20150094234A1 (en) 2012-04-23 2015-04-02 Aqsens Oy Method for characterizing and/or determining samples
WO2015075299A1 (en) 2013-11-19 2015-05-28 Aqsens Oy Method of analysis
WO2015075300A1 (en) 2013-11-19 2015-05-28 Aqsens Oy Method of analysis
EP3559666A1 (en) 2016-12-21 2019-10-30 H. Hoffnabb-La Roche Ag Assay for determining antibody or ligand binding and function
WO2018187385A1 (en) 2017-04-03 2018-10-11 The Regents Of The University Of California Compositions and methods of diagnosing pancreatic cancer

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1111762A (en) * 1977-12-28 1981-11-03 David S. Frank Fluorescent rare earth chelate in polymeric latex particles
SE428332B (sv) * 1979-03-08 1983-06-20 Wallac Oy Forfarande for fluorescensspektroskopisk bestemning av biologiskt aktivt emne, sasom hapten, antikropp eller antigen
SE425439B (sv) * 1981-04-30 1982-09-27 Wallac Oy Immunologisk analys med lantanidkelatkomplex som markor
US4837169A (en) * 1981-07-01 1989-06-06 Eastman Kodak Company Polypyridine Fluorescent labels for immunoassay
US4637988A (en) * 1981-07-01 1987-01-20 Eastman Kodak Company Fluorescent labels for immunoassay
US4468469A (en) * 1981-11-04 1984-08-28 Miles Laboratories, Inc. Substituted phenylacetic acids and salts as TBP blocking agents in iodothyronine immunoassays
US4454232A (en) * 1982-06-07 1984-06-12 Bio-Rad Laboratories, Inc. Estriol assay
SE454115B (sv) * 1982-09-13 1988-03-28 Wallac Oy Homogenfasanalys med lantanidkelat som merksubstans
SE8301395L (sv) * 1983-03-15 1984-09-16 Wallac Oy Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler
US4640898A (en) * 1983-08-01 1987-02-03 University Of Health Sciences/The Chicago Medical School Homogeneous fluorescence ligang binding assay based upon preferential alteration of the respective intensities of bound and free label by solvent components
US4816419A (en) * 1983-08-01 1989-03-28 University Of Health Sciences/The Chicago Medical School Fluorescence ligand binding assay using charge-matched dye and solvent components
GB8420521D0 (en) * 1984-08-13 1984-09-19 Hsc Res Dev Corp Fluorescent label
GB8421318D0 (en) * 1984-08-22 1984-09-26 Ekins R P Potentiating antibodies/other macro-molecules
US4680275A (en) * 1985-02-11 1987-07-14 Becton, Dickinson And Company Homogeneous fluorescence immunoassay using a light absorbing material
US4761481A (en) * 1985-03-18 1988-08-02 Baxter Travenol Laboratories, Inc. Substituted pyridine derivatives
SE8502573D0 (sv) * 1985-05-23 1985-05-23 Jouko Kanakre Fluorescent lanthanide chelates useful as labels of physiologically active materials
US4734378A (en) * 1985-06-26 1988-03-29 Abbott Laboratories Precipitation of interfering proteins in fluorescence polarization immunoassay for digoxin
US4751190A (en) * 1985-07-22 1988-06-14 Abbott Laboratories Fluorescence polarization immunoassay and reagents for use therein
US4925804A (en) * 1986-06-17 1990-05-15 Baxter International Inc. Interligand metal transfer assay
JP2802921B2 (ja) * 1986-06-17 1998-09-24 マイクロスキャン、インコーポレイテッド 蛍光バックグラウンド消去および水溶性希土類金属キレートフルオロフォルを使用する均質蛍光アッセイ

Also Published As

Publication number Publication date
JPH01127957A (ja) 1989-05-19
SE8703682D0 (sv) 1987-09-24
EP0324323B1 (en) 1992-12-30
EP0324323A1 (en) 1989-07-19
US5637509A (en) 1997-06-10
DE3877179D1 (de) 1993-02-11
ATE84150T1 (de) 1993-01-15
DE3877179T2 (de) 1993-04-29

Similar Documents

Publication Publication Date Title
SE8703682D0 (sv) Homogen bestemningsmetod som utnyttjar affinitetsreaktioner
EP0190111B1 (en) Method for non-segmented continuous flow analysis based on the interaction of radiation with a solid material situated in a flow-through cell
US4859583A (en) Chemiluminescent immunochemical technique for low molecular weight antigens
CA2322858A1 (en) Detection of analytes by fluorescent lanthanide chelates
DE69535522D1 (de) Kupplungsfarbstoff zur spektrophotometrischen Bestimmung von Analyten
DE69616243D1 (de) Testvorrichtung mit einem stabilen Kopplungsfarbstoff zur Bestimmung von Analyten
Yeung Chemical analysis of single human erythrocytes
ES481519A1 (es) Un aparato para la determinacion luminiscente de la canti- dad o concentracion de un analito en una muestra.
SG54160A1 (en) Electrochemiluminescent rhenium moeities and methods
JPS62110155A (ja) 免疫分析用試薬および免疫分析方法
CN108623522A (zh) 一种快速高选择性检测次氯酸的方法
NO903748L (no) Fremgangsmaate ved enzymatisk bestemmelse av analyttkonsentrasjoner.
Seiter et al. Automated fluorometric micromethod for blood glucose
KR960018583A (ko) 면역 분석법
CN108587606A (zh) 一种快速高选择性分析次氯酸的荧光探针的用途
JP3881415B2 (ja) 免疫分析装置
SU1755137A1 (ru) Способ определени пирокатехина
FI96365C (sv) Förfarande och givare för analysering av ett ämne fotometriskt
SU1605195A1 (ru) Способ определени свинца
RU2141108C1 (ru) Способ определения люизита в водно-спиртовых экстрактах
DE3618100A1 (de) Immunoassayverfahren und reagens zu seiner durchfuehrung
SU1262372A1 (ru) Способ определени меди /п/
RU2017137C1 (ru) Способ фотометрического определения кобальта в окислительных ваннах производства уксусного ангидрида и уксусной кислоты
SU455274A1 (ru) Способ количественного определени металлов подгруппы меди
Su et al. A new system for the determination of trace copper (II) by fluorometry

Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 8703682-8

Effective date: 19920401