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SE8003874L - PROCEDURE FOR PREPARING BROMHEXINE AND AGENTS FOR USING THE PROCEDURE - Google Patents

PROCEDURE FOR PREPARING BROMHEXINE AND AGENTS FOR USING THE PROCEDURE

Info

Publication number
SE8003874L
SE8003874L SE8003874A SE8003874A SE8003874L SE 8003874 L SE8003874 L SE 8003874L SE 8003874 A SE8003874 A SE 8003874A SE 8003874 A SE8003874 A SE 8003874A SE 8003874 L SE8003874 L SE 8003874L
Authority
SE
Sweden
Prior art keywords
procedure
agents
benzoxazin
cyclohexylamine
dihydro
Prior art date
Application number
SE8003874A
Other languages
Swedish (sv)
Other versions
SE433847B (en
Inventor
B Alhede
N Gelting
H Preikschat
Original Assignee
Gea As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK230179A external-priority patent/DK145718C/en
Priority claimed from DK230079A external-priority patent/DK145714C/en
Application filed by Gea As filed Critical Gea As
Publication of SE8003874L publication Critical patent/SE8003874L/en
Publication of SE433847B publication Critical patent/SE433847B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

N-(2-amino-3,5-dibromobenzyl)- N-methyl-cyclohexylamine, the hydrochloride of which has the formula <IMAGE> is prepared by brominating 1,4- dihydro-2H-3,1-benzoxazin-2-one with free bromine to form the hitherto unknown intermediate 6,8-dibromo- 1,4-dihydro-2H-3,1-benzoxazin-2- one, and reacting this with N-methyl- cyclohexylamine to bromhexin. Preferably, the reaction takes place by heating in N-monomethylformamide to the boiling point of the latter.
SE8003874A 1979-06-01 1980-05-23 PROCEDURE FOR PREPARING BROMHEXIN SE433847B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK230179A DK145718C (en) 1979-06-01 1979-06-01 DIBROME COMPOUND USE AS INTERMEDIATE IN THE PREPARATION OF N- (2-AMINO-3,5-DIBROMBENZYL) -N-METYLCYCLOHEXYLAMINE
DK230079A DK145714C (en) 1979-06-01 1979-06-01 METHOD FOR PREPARING N- (2-AMINO-3,5-DIBROMBENZYL) -N-METYLYCYLOHEXYLAMINE

Publications (2)

Publication Number Publication Date
SE8003874L true SE8003874L (en) 1980-12-02
SE433847B SE433847B (en) 1984-06-18

Family

ID=26066477

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8003874A SE433847B (en) 1979-06-01 1980-05-23 PROCEDURE FOR PREPARING BROMHEXIN

Country Status (11)

Country Link
AT (1) AT371800B (en)
CH (1) CH642617A5 (en)
DE (1) DE3020604A1 (en)
ES (1) ES492005A0 (en)
FI (1) FI68808C (en)
GB (1) GB2053900B (en)
IE (1) IE49820B1 (en)
KE (1) KE3302A (en)
NL (1) NL8003153A (en)
NO (2) NO148372C (en)
SE (1) SE433847B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2881955B1 (en) 2005-02-11 2007-05-11 Oreal COSMETIC NANOEMULSION CONTAINING HYDROXYL UREA COMPOUND
CN102775316B (en) * 2012-08-17 2013-06-12 夏智红 Bromhexine hydrochloride compound and medicine composition thereof
CN102924295B (en) * 2012-10-09 2014-10-29 石家庄东方药业有限公司 Bromhexine hydrochloride crystal as well as preparation method and application of crystal
CN103145564B (en) * 2013-03-15 2014-06-18 湖北美林药业有限公司 Bromhexine hydrochloride compound and pharmaceutical composition thereof

Also Published As

Publication number Publication date
NO148372C (en) 1983-09-28
IE801081L (en) 1980-12-01
NO148415C (en) 1983-10-12
ATA288580A (en) 1982-12-15
NO823977L (en) 1980-12-02
AT371800B (en) 1983-07-25
FI801705A (en) 1980-12-02
NO148372B (en) 1983-06-20
GB2053900B (en) 1983-04-20
IE49820B1 (en) 1985-12-25
KE3302A (en) 1983-08-19
SE433847B (en) 1984-06-18
DE3020604A1 (en) 1980-12-11
CH642617A5 (en) 1984-04-30
FI68808C (en) 1985-11-11
NO148415B (en) 1983-06-27
GB2053900A (en) 1981-02-11
NO801617L (en) 1980-12-02
NL8003153A (en) 1980-12-03
ES8104185A1 (en) 1981-04-01
FI68808B (en) 1985-07-31
ES492005A0 (en) 1981-04-01

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