RU93004484A - Производные пиразола, способ их получения и содержащие их фармацевтические композиции - Google Patents
Производные пиразола, способ их получения и содержащие их фармацевтические композицииInfo
- Publication number
- RU93004484A RU93004484A RU93004484/04A RU93004484A RU93004484A RU 93004484 A RU93004484 A RU 93004484A RU 93004484/04 A RU93004484/04 A RU 93004484/04A RU 93004484 A RU93004484 A RU 93004484A RU 93004484 A RU93004484 A RU 93004484A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutical compositions
- derivatives
- pyrazoles
- production
- inflammatory
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 150000003217 pyrazoles Chemical class 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 208000008006 Collagen Disease Diseases 0.000 claims 1
- 210000000987 Immune System Anatomy 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000000202 analgesic Effects 0.000 claims 1
- 230000003110 anti-inflammatory Effects 0.000 claims 1
- 230000002785 anti-thrombosis Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 200000000018 inflammatory disease Diseases 0.000 claims 1
- 230000036407 pain Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
- Настоящее изобретение относится к производным пиразола и их фармацевтически приемлемым солям, обладающим противовоспалительной, болеутоляющей и противотромбозной активностью, к способам их получения и к фармацевтическим композициям, содержащим вышеупомянутые соединения в качестве активного ингредиента. Эти соединения могут применяться для профилактики и/или лечения воспалительных заболеваний, различных болей, коллагеноза, различных заболеваний иммунной системы и тромбозов в человеческом организме или у животного.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929202442A GB9202442D0 (en) | 1992-02-05 | 1992-02-05 | Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
GB9202442.1 | 1992-02-05 | ||
GB929220427A GB9220427D0 (en) | 1992-09-28 | 1992-09-28 | Pyrazole derivatives processes for preparation thereof and pharmaceutical composition comprising the same |
GB9220427.0 | 1992-09-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93004484A true RU93004484A (ru) | 1995-05-20 |
RU2128172C1 RU2128172C1 (ru) | 1999-03-27 |
Family
ID=26300272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93004484A RU2128172C1 (ru) | 1992-02-05 | 1993-02-04 | Производные пиразола или их фармацевтически приемлемые соли |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0554829B1 (ru) |
JP (1) | JPH05246997A (ru) |
KR (1) | KR100252151B1 (ru) |
CN (1) | CN1045767C (ru) |
AT (1) | ATE217613T1 (ru) |
AU (1) | AU663149B2 (ru) |
CA (1) | CA2088835A1 (ru) |
DE (1) | DE69331920T2 (ru) |
ES (1) | ES2173875T3 (ru) |
HU (2) | HUT63392A (ru) |
IL (1) | IL104311A (ru) |
MX (1) | MX9300579A (ru) |
PH (1) | PH30916A (ru) |
RU (1) | RU2128172C1 (ru) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2690440B1 (fr) * | 1992-04-27 | 1995-05-19 | Rhone Poulenc Agrochimie | Arylpyrazoles fongicides. |
FR2711140B1 (fr) * | 1993-10-12 | 1996-01-05 | Sanofi Sa | 1-Naphtylpyrazole-3-carboxamides substitués actifs sur la neurotensine, leur préparation, les compositions pharmaceutiques en contenant. |
US6492411B1 (en) | 1993-11-30 | 2002-12-10 | G. D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation |
US6716991B1 (en) | 1993-11-30 | 2004-04-06 | G. D. Searle & Co. | Process for preparing a substituted pyrazolyl benzenesulfonamide for the treatment of inflammation |
US5475018A (en) * | 1993-11-30 | 1995-12-12 | G. D. Searle & Co. | 1,5-diphenyl pyrazole compounds for treatment of inflammation |
US5466823A (en) | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
DE69422306T4 (de) * | 1993-11-30 | 2000-09-07 | G.D. Searle & Co., Chicago | Substituierte pyrazolyl-benzolsulfonamide zur behandlung von entzündungen |
US6613789B2 (en) | 1994-07-28 | 2003-09-02 | G. D. Searle & Co. | Heterocyclo-substituted imidazoles for the treatment of inflammation |
US5616601A (en) * | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
AU3815495A (en) * | 1994-11-08 | 1996-05-31 | Eisai Co. Ltd. | Pyrazole derivatives exhibiting anti-inflammatory and analgesic effects |
NZ308875A (en) * | 1995-05-25 | 1999-08-30 | Searle & Co | Method of preparing 3-haloalkyl-1h-pyrazoles |
US5756529A (en) * | 1995-09-29 | 1998-05-26 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies |
GB9520584D0 (en) * | 1995-10-09 | 1995-12-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
ID21775A (id) * | 1996-10-25 | 1999-07-22 | Yoshitomi Pharmaceutical | Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya |
KR20000062284A (ko) * | 1996-12-23 | 2000-10-25 | 블레어 큐. 퍼거슨 | 인자 Xa 억제제로서의 질소 함유 헤테로방향족 화합물 |
ZA985247B (en) * | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
US6339099B1 (en) | 1997-06-20 | 2002-01-15 | Dupont Pharmaceuticals Company | Guanidine mimics as factor Xa inhibitors |
AU750356B2 (en) * | 1997-09-24 | 2002-07-18 | Fujisawa Pharmaceutical Co., Ltd. | 1,5-diphenylpyrazole derivatives |
AUPO941497A0 (en) * | 1997-09-24 | 1997-10-16 | Fujisawa Pharmaceutical Co., Ltd. | Novel compounds |
AU1724499A (en) * | 1997-12-22 | 1999-07-12 | Du Pont Pharmaceuticals Company | Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors |
US6271237B1 (en) | 1997-12-22 | 2001-08-07 | Dupont Pharmaceuticals Company | Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors |
IT1300055B1 (it) * | 1998-04-17 | 2000-04-05 | Boehringer Ingelheim Italia | Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici |
KR19990080440A (ko) * | 1998-04-17 | 1999-11-05 | 성재갑 | 신규한 피라졸 유도체 |
KR19990085450A (ko) * | 1998-05-18 | 1999-12-06 | 성재갑 | 피라졸 구조를 갖는 새로운 mek 단백질 저해제 |
US6294558B1 (en) | 1999-05-31 | 2001-09-25 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
US6727238B2 (en) | 1998-06-11 | 2004-04-27 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
DE19904391A1 (de) * | 1999-02-04 | 2000-08-10 | Bayer Ag | Pyrazol-Alkylamide |
EP1206474B1 (en) * | 1999-08-27 | 2004-05-26 | Abbott Laboratories | Sulfonylphenylpyrazole compounds useful as cox-2 inhibitors |
ATE252576T1 (de) | 1999-12-03 | 2003-11-15 | Pfizer Prod Inc | Heteroarylphenylpyrazolverbindungen zur verwendung als analgetisches/entzündungshemmendes mittel |
PT1104760E (pt) | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
WO2001040216A1 (en) | 1999-12-03 | 2001-06-07 | Pfizer Products Inc. | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents |
CA2326970C (en) | 1999-12-03 | 2004-11-23 | Pfizer Products Inc. | Acetylene derivatives as anti-inflammatory/analgesic agents |
ES2398093T3 (es) | 2000-03-24 | 2013-03-13 | Euro-Celtique S.A. | Pirazoles, triazoles y tetrazoles sustituidos con arilo como bloqueantes de los canales de sodio |
ES2241964T3 (es) | 2001-07-05 | 2005-11-01 | Pfizer Products Inc. | Heterocicloalquilsulfufonilpirazoles como agentes antiinflamatorios/abnalgesicos. |
GT200200183A (es) | 2001-09-28 | 2003-05-23 | Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol | |
WO2003037336A1 (en) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer |
WO2003099794A1 (en) | 2002-05-24 | 2003-12-04 | Pharmacia Corporation | Synthesis of diaryl pyrazoles |
WO2004002420A2 (en) | 2002-06-28 | 2004-01-08 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use |
US20060079566A1 (en) | 2003-10-03 | 2006-04-13 | Ching-Shih Chen | PDK-1/Akt signaling inhibitors |
WO2005044130A1 (en) | 2003-10-03 | 2005-05-19 | The Ohio State University Research Foundation | Pdk-1/akt signaling inhibitors |
EP1675585A2 (en) * | 2003-10-17 | 2006-07-05 | Tanabe Seiyaku Co., Ltd. | Large conductance calcium-activated k channel opener |
US8039502B2 (en) | 2007-07-24 | 2011-10-18 | The Ohio State University Research Foundation | Anti-infective agents against intracellular pathogens |
US7888354B2 (en) * | 2007-11-13 | 2011-02-15 | Taisho Pharmaceutical Co., Ltd | Phenylpyrazole derivatives |
DE102008015032A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
DE102008015033A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
DE102008062863A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung |
DE102008062878A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte Furancarboxamide und ihre Verwendung |
US20120108823A1 (en) | 2009-04-22 | 2012-05-03 | The Ohio State University Research Foundation | Anti-francisella agents |
DE102009036604A1 (de) | 2009-07-30 | 2011-02-03 | Aicuris Gmbh & Co. Kg | Substituierte Bis-Arylpyrazolamide mit terminaler primärer Amidfunktionalisierung und ihre Verwendung |
HUE031408T2 (en) * | 2010-09-21 | 2017-07-28 | Eisai R&D Man Co Ltd | Pharmaceutical preparation |
DE102011055815A1 (de) | 2011-11-29 | 2013-05-29 | Aicuris Gmbh & Co. Kg | Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung |
DE102012016908A1 (de) | 2012-08-17 | 2014-02-20 | Aicuris Gmbh & Co. Kg | Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1130808A (en) * | 1979-10-05 | 1982-08-31 | Ronald G. Micetich | 3-(or 5-) trifluoromethyl-1-aryl pyrazoles |
US4826868A (en) * | 1986-05-29 | 1989-05-02 | Ortho Pharmaceutical Corporation | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use |
AU611437B2 (en) * | 1987-05-29 | 1991-06-13 | Ortho Pharmaceutical Corporation | Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-n-hydroxypropanamides and method for synthesizing the same |
PH27357A (en) * | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
FR2665898B1 (fr) * | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
JPH08181316A (ja) * | 1994-12-22 | 1996-07-12 | Mitsubishi Electric Corp | 半導体装置及びその製造方法 |
-
1993
- 1993-01-05 IL IL104311A patent/IL104311A/xx not_active IP Right Cessation
- 1993-01-26 JP JP5010379A patent/JPH05246997A/ja active Pending
- 1993-02-02 AT AT93101569T patent/ATE217613T1/de not_active IP Right Cessation
- 1993-02-02 AU AU32174/93A patent/AU663149B2/en not_active Ceased
- 1993-02-02 EP EP93101569A patent/EP0554829B1/en not_active Expired - Lifetime
- 1993-02-02 ES ES93101569T patent/ES2173875T3/es not_active Expired - Lifetime
- 1993-02-02 DE DE69331920T patent/DE69331920T2/de not_active Expired - Fee Related
- 1993-02-03 MX MX9300579A patent/MX9300579A/es not_active IP Right Cessation
- 1993-02-04 RU RU93004484A patent/RU2128172C1/ru active
- 1993-02-04 KR KR1019930001455A patent/KR100252151B1/ko not_active IP Right Cessation
- 1993-02-04 CA CA002088835A patent/CA2088835A1/en not_active Abandoned
- 1993-02-04 CN CN93101069A patent/CN1045767C/zh not_active Expired - Fee Related
- 1993-02-05 HU HU9300309A patent/HUT63392A/hu unknown
- 1993-06-06 PH PH45530A patent/PH30916A/en unknown
-
1995
- 1995-06-22 HU HU95P/P00347P patent/HU211509A9/hu unknown
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