RU2828720C1 - Ointment "voskopant" - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to compositions for external application in poorly granulating wounds, bedsores, frostbites, burns, trophic ulcers. Antiseptic agent is presented in the form of an ointment containing bee wax, refined olive oil, sugar powder and a water extract of antlers at the following ratio of components, wt. %: bee wax – 45; refined olive oil – 35, sugar powder – 10, water extract of antlers – 10.

EFFECT: disclosed ointment reduces the length of wound healing and epithelisation by accelerating the maturation of granulation tissue and epithelial proliferation.

1 cl, 2 ex

Description

The invention relates to medicine, namely to compositions for external use in the treatment of long-term non-healing wounds, purulent wounds, frostbite, burns, bedsores, erythematous-bullous erysipelas, and trophic ulcers.
Purulent-inflammatory diseases and their complications make up, according to various sources, 30-40% in the structure of surgical pathology. The leading place among surgical infections both in frequency of development and in possible complications is occupied by purulent diseases of the skin and soft tissues: abscess, furuncle, carbuncle, erysipelas, etc. In the structure of nosocomial infections, the frequency of surgical infections of soft tissues (postoperative suppuration, post-injection complications, etc.) reaches 36%, in Russia - 24% https://nasci.ru/?id=3392&download=1.

The ointment "Voskopant" contains a composition of pure beeswax, olive vegetable oil, powdered sugar and water extract of antlers in a certain mass proportion. The use of this ointment does not cause an allergic reaction, quickly removes signs of inflammation: hyperemia, tissue edema, promotes rapid maturation of young granulation tissue and complete epithelialization; is plastic; has increased penetrating ability. Maral antlers are characterized by rapid growth, up to 2 mm per day, have a tubular non-keratinized structure with a network of blood vessels. Maral antlers grow, receiving the maximum amount of nutrients and macro-/microelements. Of the 22 amino acids, antlers contain from 20 to 16, depending on the species. In addition, antlers contain phospholipids, esters of unsaturated fatty acids, macro- and microelements (Fe, Mn, Mg, Co, Zn. Cu, Ca, F, I), a balanced set of fat- and water-soluble vitamins, regulators of hormone action and peptides that normalize the reactivity of the immune system.

The antler gel "Neopant" is known, used only for external use in the treatment of arthrosis-arthritis, osteochondrosis; has limited use https://altai-maral.ru/shop/altajskaya-kosmetika/geli-i-mazi-lechebnye/neopant-pantovyj-gel-3-forte-pri-artrite-artroze-osteoxondroze/. It contains such components as formic acid, medicinal leech extract, which can cause an allergic reaction.

A propolis ointment is known, containing propolis soluble in a fat product with the addition of boiled water. However, a fat-based ointment is not acceptable in the early stages of wound healing https://findpatent.ru/patent/215/2155597.html.

There is an ointment with propolis and a base containing polyethylene oxide with a molecular weight of 400 and 1500 and preservatives: nipagin and nipazole. The product is intended for the treatment of wounds. This ointment contains chemicals, and the contact of propolis with the affected area in ointment forms is shorter than in the proposed dosage form. https://www.freepatent.ru/patents/2135159.

As a prototype, we have chosen an antiseptic agent in the form of an ointment containing beeswax, refined olive oil and powdered sugar in the following ratio of components, wt.%: beeswax - 50, refined olive oil - 40 and powdered sugar - 10 https://patents.google.com/patent/RU2803777C1/ru. The proposed wax ointment "Voskosap" promotes the rejection of necrotic tissue, the maturation of granulation tissue, the proliferation of the epithelium and reduces the healing time of wounds. At the same time, it does not contain an aqueous extract of maral antlers, which accelerates the healing process of wounds in weakened patients with chronic iron deficiency anemia, metabolic disorders such as diabetes mellitus, exhaustion, and thyroid disease.

The objective of the present invention is to create a highly effective antiseptic composition with increased bioimmunological activity that accelerates wound healing in weakened patients.

The antiseptic agent in the form of an ointment that we offer, according to the technical solution, contains the following components: beeswax, refined olive oil, powdered sugar and an aqueous extract of maral antlers in the following ratio of components, wt.%: beeswax - 45; refined olive oil - 35, powdered sugar - 10, aqueous extract of antlers - 10. The aqueous extract of maral antlers contains a large number of amino acids, the main share of which falls on oxyproline, aspartic and glutamic acids, proline, glycine, alanine; contains hormones and growth factors that stimulate the development of connective tissue, macronutrients necessary for wound healing and tissue regeneration. The ability of powdered sugar to absorb excess moisture and dry the wound in the composition allows you to quickly stop the signs of inflammation, since microorganisms die from dehydration. Thus, granulation tissue matures faster, the wound defect is tightened, and complete epithelialization of wounds occurs. Refined olive oil contains a significant amount of oleic acid (monounsaturated omega-9 fatty acid) and vitamins that have a powerful antioxidant effect, suppressing the activity of proinflammatory cytokines and the inflammatory focus itself. Wax, of all manufactured products, has the least ability to respond to its use, is a source of obtaining a large number of biologically active compounds necessary for reparative regeneration, for wound healing.

The proposed antiseptic is prepared as follows. In a water bath, beeswax is melted until completely dissolved, refined olive oil, powdered sugar, and water extract of maral antlers are added. Mix until a homogeneous mass is obtained and boil for 2 minutes. There is no need to filter the hot mixture. Pour it hot into forms of the required configuration and volume (jars, tubes, etc.) for subsequent natural cooling. The result is a packaged ointment.

The ointment is stored in a cool dark place for up to 5 years without losing its original activity. At room temperature, the ointment is a homogeneous composition of a semi-solid consistency of gray-yellow color. When in contact with the body or heated above 25 ° C, the ointment softens and becomes plastic. It does not dissolve in water and alcohol. It is not toxic. Contraindication to use is individual intolerance to the components of the ointment (allergy).

The cooled ointment is applied to the wound surface in a thin layer using a medical spatula. This wound treatment product has a pronounced regenerative effect, accelerating wound healing in weakened patients; it has an anti-inflammatory, anti-edematous, antioxidant, trophic effect and stimulates the regeneration processes of integumentary tissues. Examples of practical use of the proposed wax ointment "Voscopant":

Example 1

Patient A., 63 years old. Admitted on a planned basis on 23.07.23 to the surgical department with the diagnosis: Sluggish granulating wound of the left shin. Chronic iron deficiency anemia of moderate severity.

Locally on admission: on the anterior surface of the left shin there was a round wound up to 10 cm in diameter, slight swelling, oozing, flaccid granulation in the center of the wound. In the surgical department, dressings with this ointment "Voscopant" were applied daily 2 times a day. The ointment was applied to the wound surface in a thin layer using a medical spatula. After 4 days, the swelling completely disappeared, pronounced granulation appeared, the wound decreased in diameter to 4 cm. On 31.07.23, the patient was discharged in satisfactory condition, the wound defect was completely closed.

Example 2

Patient S., 72 years old, was admitted on an emergency basis on 10/12/2023 with a trophic ulcer in the lower third of the right leg, pain, tissue edema. Diagnosis: Obliterating atherosclerosis of the arteries of the lower extremities, stage II B. Chronic arterial insufficiency, stage I. Diabetes mellitus type 2, subcompensation.

Locally upon admission: on the anterior surface in the lower third of the right leg there was a trophic ulcer 4 cm in diameter, with undermined edges, with a fibrin coating. Around the ulcer - hyperemia, tissue edema, pain on palpation. In the surgical department, dressings with this ointment "Voscopant" were performed daily 2 times a day. The ointment was applied to the wound surface in a thin layer using a medical spatula. After 6 days, swelling, hyperemia, tissue pain passed, the trophic ulcer decreased in diameter to 1 cm. On October 21, 2023, the trophic ulcer completely closed, epithelialized; the patient was discharged in a satisfactory condition,

The proposed ointment "Voscopant" for local treatment of wounds was introduced at the base of: "Private Healthcare Institution "Clinical Hospital" RZhD-Medicine", Tyumen". This product was used in 5 patients with trophic ulcers, in 2 patients with a mixed form of erysipelas (erythematous-bullous), in 3 patients with bedsores, in 5 patients with burns of I-III A degree. It should be noted that tissue regeneration in weakened patients against the background of chronic iron deficiency anemia, metabolic disorders such as diabetes mellitus, body weight deficiency, thyroid disease, who used the new product, was more pronounced, complete wound healing was noted on average 5-7 days faster than in patients who did not use the proposed product for local treatment of wounds.

Thus, the proposed ointment "Voscopant" accelerates the development of young granulation tissue, proliferation of the epithelium, promotes rapid growth of connective tissue, which plays a major role in wound healing.

From the patent and scientific literature we are not aware of any medicinal ointments containing the combination of the above ingredients in the proposed quantitative ratio, which allows us to conclude that the claimed technical solution is novel.

Claims (1)

An antiseptic agent in the form of an ointment containing beeswax, refined olive oil, powdered sugar and an aqueous extract of antlers in the following ratio of components, wt.%: beeswax - 45; refined olive oil - 35, powdered sugar - 10, aqueous extract of antlers - 10.