RU2781249C1 - Specialized food product for dietary therapeutic and dietic preventive nutrition of children over three years and method of its application - Google Patents

Abstract

FIELD: food industry.

SUBSTANCE: the invention relates to the food industry. A specialized food product for dietary therapeutic and dietary preventive nutrition for children older than 3 years is proposed. The product is a multicomponent dry mixture of essential nutrients and contains phenolic compounds selected from the group consisting of phenolic acids and/or flavonoids and/or polymeric phenolic compounds and/or stilbenes, in an amount of 5 to 200% of their physiological age norm. needs for children over 3 years old; alimentary fiber, selected from the group consisting of cellulose and/or hemicellulose and/or chitin and/or chitosan and/or β-glucans and/or gum and/or inulin and/or oligofructose and/or fructooligosaccharides, and / or lignin, and / or pectins, and / or polydextrose, and / or resistant dextins, and / or resistant starches, in an amount from 5 to 200% of their age norm of physiological requirements for children over 3 years old; L-carnitine, in an amount from 5 to 200% of their age norm of physiological need for children over 3 years old; coenzyme Q10 in an amount from 5 to 200% of their age norm physiological needs for children older than 3 years. Also proposed is a method for preparing dishes for dietary therapeutic and dietary preventive nutrition by introducing the specified specialized food product into dishes during cooking and mixing.

EFFECT: the invention is aimed at restoring the functions of the child's body that were disturbed or lost as a result of the disease, at preventing these disorders, as well as at increasing the adaptive capabilities of the child's body.

13 cl, 9 tbl, 6 ex

Description

Technical field

The present invention relates to the food industry, to products of dietary therapeutic and dietary preventive nutrition for children over 3 years old, in particular, to a specialized food product for dietary therapeutic and dietary preventive nutrition, which is a multicomponent dry mixture of essential nutrients and a method for its use.

The invention can be used for dietary therapeutic and dietary preventive nutrition of children over three years of age in medical organizations, social protection institutions as a component of preparing ready-made meals.

State of the art

It is known that at the modern pace of life, human consumption of the required amount of micronutrients, including biologically active substances, can only be ensured by taking complex preparations that include vitamins, minerals, as well as other micronutrients or essential substances, such as amino acids, unsaturated fatty acids, provitamins, etc., therefore, such drugs are becoming more common.

Physiological norms for the consumption of micronutrients necessary for the human body, including biologically active substances, are established by Rospotrebnadzor on the basis of large-scale epidemiological studies, and are also known from a large array of scientific data.

The composition of medical nutrition in hospitals of medical institutions includes protein mixtures, vitamin-mineral complexes, which have a certain chemical and ingredient composition and a proven therapeutic effect. However, the specialized food products used do not ensure the enrichment of the diet of a sick or convalescent patient with essential biologically active substances with established chemical structure and physiological action, present in food in small quantities (milligrams or micrograms) and playing a proven role in maintaining health, performing the functions of exogenous metabolism regulators.

Known dry mix for a sports drink (see, for example, RU 2428063 C1, published 10.09.2011). The mixture includes 47-55 wt.% maltodextrin, 0.6-0.9 wt.% L-carnitine, 6-8 wt.% fructooligosaccharides and gum arabic, 0.12-0.15 wt.% vitamin complex, 4-7 wt.% natural sea salt, 0.7-0.9 wt.% calcium lactate, 0.5-0.9 wt.% magnesium sulfate, 0.5-0.7 wt.% potassium chloride, 0.3- 6.2 wt.% flavoring additives and fructose - the rest up to 100%. The proposed mixture allows you to increase the nutritional value of the mixture, replenish the supply of salts and vitamins in the cells, lost with sweat during training, the athlete, thereby ensuring the restoration of electrolyte balance, increase endurance and reduce fatigue.

The specified dry mix for a sports drink cannot be used for dietary therapeutic and dietary preventive nutrition of children over 3 years old, since it is not balanced and cannot provide enrichment of the diet of a sick or convalescent patient with an optimal set of both macro- and micronutrients, including essential biologically active substances . In addition, it has not been studied in children over 3 years of age and its therapeutic and / or preventive effect on diseases has not been proven.

A vitamin-mineral complex is known, a method for its manufacture and a method for its administration (see, for example, RU 2250049 C9, published on April 20, 2005), which can be used for the prevention and treatment of vitamin-mineral deficiency in persons predisposed to the appearance of allergic reactions to individual overdose of certain vitamins.

The vitamin-mineral complex is an established set of components - vitamins, macro- and microelements. These components are contained in at least two compositions, which are a mixture of components, the compositions are intended to be taken separately in time. One of the compositions is made as a preparative form, the properties of which, which determine the rate of its decay in the human body, are different from the similar properties of preparative forms representing other compositions of the vitamin-mineral complex. The preparative form of each composition is determined by the place in the human digestive tract of preparation for the assimilation of at least two components included in it. A particular component is assigned to a particular composition based on certain conditions, taking into account the minimization of negative interactions of the composition components in terms of joint storage and assimilation by the human body. The compositions mainly combine components that synergistically affect the assimilation of each other by the human body. The components are also combined taking into account the requirement of the unity of the place in the human digestive tract, preparation for the assimilation of at least two components. The composition components are supplemented with at least one technological material. At the same time, if different compositions of the complex are represented by preparative forms of the same type, then various dyes are included in the mentioned compositions, which makes it possible to identify the compositions.

The method of taking the vitamin-mineral complex includes taking the compositions orally separately in time. At the same time, the vitamin-mineral complex is taken depending on the preparative form of the composition, the composition of the components (fat-soluble, water-soluble) and taking into account the nature of the food taken (abundant, non-abundant, fatty, non-greasy). EFFECT: invention allows to reduce the cost of vitamin-mineral complexes and increase their shelf life, provides optimal conditions for the absorption of biologically active substances by the body.

The specified vitamin-mineral complex cannot be used in standard diets for dietary therapeutic and dietary preventive nutrition and in the nutrition of social service recipients in social protection institutions, since it must be prescribed strictly individually, for medical reasons, taking into account possible allergic reactions and idiosyncrasy to certain vitamins and minerals, especially in children.

A known product of dietary and preventive nutrition (see, for example, RU 2403802C1, published on November 20, 2010), which is a mixture filled with liquid, made from a composition containing dried durum wheat grain, heat-treated by the explosion method, oatmeal, flax seeds, milk thistle, grape seeds, as well as crushed particles of clover grass, raspberry leaves, lingonberries and green tea, hawthorn, rose hips, red currant berries or leaves and walnut kernels. The components are in the following ratio, g / 100 g of the finished dry product: durum wheat grain 55.0-57.0, oatmeal 15.0-17.0, flax seeds 4.0-4.2, milk thistle 4.0- 4.2, grape seed 1.1-1.7, clover grass 1.0-1.3, raspberry leaves 1.0-1.3, lingonberry leaves 2.0-2.1, hawthorn fruits 2.0- 2.1, rose hips 4.0-4.2, green tea leaves 2.0-2.1, red currant berries or leaves 2.0-2.1, walnut kernels 2.0-2.1. EFFECT: invention makes it possible to obtain a product that has a prophylactic effect on the human body.

The specified dietary and preventive food product cannot be used as a component in the preparation of ready-made meals in standard therapeutic diets for dietary therapeutic and dietary preventive nutrition of children over 3 years of age and, since it is an independent dish that can only be used individually in personalized diets prescribed in the hospital by the attending physician.

As a well-known technical solution, an instant functional food product for correcting nutritional status disorders is also considered (see, for example, RU 2525338 C1, published on August 10, 2014), which contains protein, carbohydrate and fat components, a vitamin-mineral premix, dietary fiber, flavoring, aromatic and other additives. As a protein component, chicken protein hydrolyzate is used, enriched with skimmed cow's milk protein. As a carbohydrate component - a mixture of mono- or disaccharide with a polysaccharide. The vitamin-mineral premix additionally contains a biologically active substance - a mixture of selenium, molybdenum and chromium. A functional food product allows you to expand the range of instant functional food products, has an increased nutritional and biological value and can be used in the nutrition of people with overweight, for nutritional support for people with a low body mass index, to increase the adaptive capacity of the body.

The specified instant functional food product for the correction of eating disorders cannot be used for dietary therapeutic and dietary preventive nutrition, since, according to the description, it can only be used in the nutrition of overweight adults, for nutritional support for people with a low body mass index and is not a source of biologically active substances.

A specialized food product is known for maintaining the reserve forces of the body (see, for example, RU 2737196) containing fish oil, linseed oil, dihydroquercetin, lipoic acid, eicosapentaenoic acid, docosahexaenoic acid, alpha-linolenic acid, phosphorus, copper, potassium, vitamins A , E and selenium at a given ratio of components. The method for obtaining a specialized food product is characterized by the fact that a semi-finished product of a liposome with dihydroquercetin is prepared by dissolving dihydroquercetin in water when heated to 61 ° C in a homogenizer, then lecithin is added, stirred for an hour, then homogenized for 5 minutes until a homogeneous mass, then dried at a temperature of 72 °C. After that, a mixture for encapsulation is prepared by initially dosing fish oil, linseed oil, lipoic acid, then liposomes with dihydroquercetin are added, then eicosapentaenoic, docosahexaenoic and alpha-linolenic acids, phosphorus, copper, potassium are dosed, then mixed and homogenized for 10 minutes. At the final stage, vitamin A, E, selenium are dosed sequentially into the cooled mixture, then a gelatin solution is prepared by dosing auxiliary components in the following sequence: purified water, glycerin, gelatin. Soft gelatin capsules are obtained from a ready solution of gelatin and a mixture for encapsulation on a capsule machine of the SGM 1010 type, then the capsules are dried in drying tunnels for 53 hours and unloaded.

The specified specialized food product for maintaining the reserve forces of the body cannot be used for dietary therapeutic and dietary preventive nutrition of children over 3 years old, since, according to the description, it can only be used in the nutrition of overweight adults, for nutritional support of adults with a low body mass index and is not a source with an established chemical structure and physiological action, present in food in small quantities (milligrams or micrograms) and playing a proven role in maintaining health, performing the functions of exogenous metabolism regulators.

The essence of the invention

The present invention is directed to the creation of a specialized food product for dietary therapeutic and dietary preventive nutrition of children over 3 years old, which is a multicomponent dry mixture of essential nutrients and a method for its use, ensuring the achievement of a technical result, which consists in restoring impaired or lost functions of the child's body as a result of the disease, prevention of these disorders, as well as to increase the adaptive capabilities of the child's body, which is achieved by introducing essential biologically active substances into the diet in an amount of 5 to 200% of their age norm of physiological need for healthy children over 3 years old.

The specified technical result is achieved by the fact that a specialized food product, which is a multicomponent dry mixture of essential nutrients, is used as a component in the preparation of ready-made meals for dietary therapeutic and dietary preventive nutrition of children over 3 years old.

The specified technical result is achieved by the fact that the proposed specialized food product for dietary therapeutic and dietary preventive nutrition, which is a multicomponent dry mixture of essential nutrients, contains:

phenolic compounds selected from the group consisting of phenolic acids and/or flavonoids and/or polymeric phenolic compounds and/or stilbenes in an amount of 5 to 200% of their age norm of physiological requirements for children over 3 years old;

dietary fiber selected from the group consisting of cellulose and/or hemicellulose and/or chitin and/or chitosan and/or β-glucans and/or gum and/or inulin and/or oligofructose and/ or fructooligosaccharides and/or lignin and/or pectins and/or polydextrose and/or resistant dextins and/or oligofructose and/or fructooligosaccharides and/or resistant starches, in an amount of 5 to 200% of their age norm physiological needs for children older than 3 years;

L-carnitine, in an amount from 5 to 200% of their age norm of physiological need for children over 3 years old;

Coenzyme Q10 in an amount from 5 to 200% of their age norm of physiological requirements for children over 3 years old.

At the same time, phenolic compounds selected from the group consisting of phenolic acids and/or flavonoids and/or polymeric phenolic compounds and/or stilbenes are contained in an amount of from 0.02 to 1126 mg.

Dietary fibers selected from the group consisting of cellulose, hemicellulose and/or chitin and/or chitosan and/or β-glucans and/or gum and/or inulin and/or oligofructose and/or fructooligosaccharides, and/or lignin and/or pectins and/or polydextrose and/or resistant dextins and/or resistant starches, be contained in an amount of 0.5 to 44 g.

L-carnitine, contained in an amount of 1.5 to 600 mg;

Coenzyme Q10 is contained in an amount of 0.375 to 60 mg.

It is advisable that hydroxybenzoic acid in an amount of 1.25 to 100 mg and/or hydroxycinnamic acid in an amount of 5 to 400 mg be used as phenolic acids in the specialized food product.

It is advisable that flavonols in an amount of 0.75 to 50 mg and/or flavanones in an amount of 0.75 to 50 mg, and/or flavan-3-ols in an amount of 5 to 200 mg be used as flavonoids in a specialized food product. mg, and/or flavones in an amount of 0.25 to 20 mg, and/or anthocyanins in an amount of 2.5 to 100 mg, and/or isoflavones in an amount of 0.02 to 2 mg.

It is advisable that condensed and hydrolysable tannins in the amount of 5 to 200 mg be used as polymeric phenolic compounds in the specialized food product.

It is advisable that the specialized food product contains stilbenes in an amount of 0.05 to 4 mg.

A specialized food product may additionally contain compounds of a protein and/or carbohydrate and/or fatty nature, and/or vitamins and vitamin-like compounds, and/or minerals, and/or other biologically active substances, and/or nutritional supplements, and/ or flavors and/or processing aids, including those selected from the group of antioxidants and/or defoamers and/or sweeteners and/or fillers and/or carriers and/or stabilizers and/or anti-caking agents, and/ or naturally present in the raw material source of the biologically active substance that is part of the product.

The specialized food product can be used in standard diets for catering for patients older than 3 years in medical institutions and catering in social protection institutions.

This technical result is achieved by the fact that a method for preparing dietary therapeutic and dietary preventive nutrition is proposed, characterized in that a specialized food product according to the invention is introduced during the preparation of dietary therapeutic and dietary preventive nutrition in an amount that ensures the introduction into the daily diet from 5 to 200% the age norm of the physiological need for essential biologically active substances - phenolic compounds, dietary fiber, L-carnitine and coenzyme Q10, then mixed in the mass of the dish.

Detailed description of the preferred embodiments of the invention

The proposed specialized food product for dietary therapeutic and dietary preventive nutrition is a multicomponent dry mixture of essential nutrients used to prepare ready-made meals for dietary therapeutic and dietary preventive nutrition, and contains:

phenolic compounds selected from the group consisting of phenolic acids and/or flavonoids and/or polymeric phenolic compounds and/or stilbenes in an amount of from 0.02 to 1126 mg;

dietary fiber selected from the group consisting of cellulose and/or hemicellulose and/or chitin and/or chitosan and/or β-glucans and/or gum and/or inulin and/or oligofructose and/ or fructooligosaccharides and/or lignin and/or pectins and/or polydextrose and/or resistant dextins and/or resistant starches, in an amount of 0.5 to 44 g;

L-carnitine, in an amount of 1.5 to 600 mg;

Coenzyme Q10 in an amount of 0.375 to 60 mg.

The specialized food product contains, as a source of phenolic acids, a dry extract of at least one component selected from the group consisting of: blueberries, apple leaves and fruits, green coffee beans, green tea, cherry leaves and fruits, rose hips, echinacea purpurea, radiola rosea , pomegranate, eleutherococcus, magnolia vine, wheat, artichoke, lettuce, cocoa beans, onions (husks), black radish, blueberries, plums, cherries, kiwi, cinnamon, coffee, mango, citrus, rice, corn, oats, red wine, potatoes, apricot, barley, malt, rye, eucommia, basket willow, milk thistle, lemon balm, thyme, basil, anise, rosemary, tarragon, marjoram, sage, tomato, peach, cranberry, rapeseed, white cabbage, red cabbage, turnip, radish, broccoli, chicory, dandelion, elecampane, rudbeckia, nettle, common spruce, Canadian goldenrod, carrots, viburnum, bamboo sprouts, asparagus, beets, Chinese cabbage, thyme.

The specialized food product contains, as a source of flavonoids, a dry extract of at least one component selected from the group consisting of: red grapes, green tea, black tea, citrus, leek, pomegranate, strawberry, blackberry, blackcurrant, blueberry, black elderberry , cranberries, celery, parsley, wheat, millet, tomatoes, cherries, peaches, plums, red onions, red radishes, black beans, eggplant, red cabbage, olives, sweet potatoes (yam), buckwheat, milk thistle, St. John's wort, red wine, apples, spruce bark, cocoa, soybeans, ginkgo biloba, golden mustache, oats, passionflower, Chinese magnolia vine, white tea, clover, quince, turmeric, hawthorn, Japanese Sophora, mint, bergamot, pomegranate, hops, cinquefoil, thyme, oregano, sorghum, dill, beans, alfalfa, red beans, honeysuckle, nectarines, prunes.

The specialized food product contains, as a source of polymeric phenolic compounds, a dry extract of at least one component selected from the group consisting of: grape seeds, red wine, skin, stems and pulp of grapes, black currant, black elderberry, chokeberry (chokeberry) , blueberries, blueberries, cocoa, black tea, green tea, sea pine, apples, plums, pomegranate, cranberries, raspberries, peaches, mangosteens, pears, rose hips, dogwood, honeysuckle, crows, hibiscus, prunes, viburnum, carrots, beans, beans, nectarines, dates, bananas, sorghum, peas, walnuts, cashews, persimmons, acorns, chestnuts, rhubarb, vanilla, tarragon, hazelnuts, pecans, bearberry, thick-leaved bergenia.

The specialized food product contains, as a source of stilbenes, a dry extract of at least one component selected from the group consisting of:

skins, combs and pulp of grapes, mulberries, red wine, peanuts, hops, cocoa, Japanese knotweed, blackberries, peanut butter, pistachios, almonds, blueberries, cranberries, strawberries, carob, blueberries, jackfruit, lingonberries.

The specialty food product contains, as a source of dietary fiber, a dry form of at least one component selected from the group consisting of

- cellulose and hemicellulose, represented by at least one component selected from the group consisting of microcrystalline cotton cellulose, bamboo fiber, psyllium, apple fiber, linen fiber, pumpkin fiber, rye fiber, beet fiber, oat fiber, corn fiber, pea fibers ;

- chitin and chitosan obtained from marine invertebrates;

- β-glucans represented by at least one component selected from the group consisting of oat β-glucan, brewer's yeast β-glucan, shiitake mushrooms, reishi mushrooms (lacquered tinder fungus), oyster mushrooms, algae;

- gums represented by at least one component selected from the group consisting of gellan gum, guar gum, gum arabic, xanthan gum, locust bean gum;

- inulin, oligofructose and fructooligosaccharides represented by at least one component selected from the group consisting of Jerusalem artichoke, chicory, finished forms of fructooligosaccharides;

- lignin represented by at least one component selected from the group consisting of: bamboo fiber, psyllium;

- pectins represented by at least one component selected from the group consisting of apple fiber, citrus pectin, black currant fiber;

- polydextrose;

- resistant dextrins, represented by at least one component selected from the group consisting of water-soluble corn fibers, ready-made substances of resistant dextrins;

- resistant starches represented by at least one component selected from the group consisting of potato starch, tapioca starch, corn starch, oat starch, buckwheat starch, bean flour, unripe banana flour.

The specialty food product contains dry forms of L-carnitine and/or acetyl-L-carnitine as a source of L-carnitine.

The specialty food product contains the dry form of coenzyme Q10 as a source of coenzyme Q10.

These dry extracts are mixed in the required proportions to obtain a finished specialized food product. A specialized food product is used in the preparation of dietary therapeutic and dietary preventive nutrition for children over 3 years of age, for which it is introduced during the preparation of dishes in an amount that ensures the introduction into the daily diet from 5 to 200% of the age norm of the physiological need for essential biologically active substances - phenolic compounds , dietary fiber, L-carnitine and coenzyme Q10. The product is added 2-3 minutes before the readiness of a liquid or viscous dish, for example, in soups, compotes, kissels, cereals, or at the beginning of the cooking process, for example, in stews, casseroles, pastries, etc., then it is thoroughly mixed in weight of the dish.

Distinctive features of a specialized food product, which is a multicomponent dry mixture of essential nutrients, are, on the one hand, ensuring an adequate level of consumption of essential biologically active substances in the standard diets of children over three years of age who are hospitalized in medical organizations and in the diets of people living in institutions of social protection, on the other hand, the presence of biologically active ingredients ensures the correction of a complex of functional and metabolic disorders in diseases and pathological conditions, increases the protective physiological functions of the body, reduces the impact on the body of harmful environmental factors, activates the processes of binding and removing unfavorable metabolic products from the body .

The technical effect is achieved due to the following.

Specialized food product due to the content of phenolic acids represented by hydroxybenzoic and/or hydroxycinnamic acids in its composition reduces the risk of developing neurodegenerative diseases, insulin resistance, type 2 diabetes mellitus, cardiovascular diseases, dyslipidemia, renal dysfunction and obesity due to antioxidant activity, helps to reduce glucose absorption and modulation of hormone secretion in the intestine, has a cytoprotective effect against low-density lipoprotein oxidation.

A specialized food product, due to the content of flavonoids in its composition, represented by flavanones and / or flavan-3-ols, and / or flavones, and / or anthocyanins, and / or isoflavonoids, has a multifaceted effect in maintaining health and performs the functions of exogenous metabolism regulators - have the ability to serve as traps for free radicals, as well as chelate metal ions involved in peroxidation; reduce the synthesis of cytokines in adipose tissue and, thus, prevent the release of free fatty acids into the blood, leading to the development of insulin resistance and type 2 diabetes; interact with various targets in the cell, including the transcription factor NF-kB, which controls the expression of immune response and apoptosis genes. Antioxidant, antiradical, anti-inflammatory, antiallergic, vasodilatory, vaso- and cardioprotective, hypocholesterolemic, antibacterial, antiviral, choleretic, diuretic, cytoprotective properties of various groups of flavonoids contained in the proposed specialized food product are shown.

Due to the content of polymeric phenolic compounds represented by condensed and hydrolysable tannins, this specialized food product has an antioxidant, anti-inflammatory, antimicrobial, adaptogenic, memory-improving effect, promotes liver regeneration, inhibits hepatocarciogenesis, stimulates the central nervous system, improves cognitive functions, mental and physical performance in adverse climatic conditions, with high physical exertion and under stress.

The specialized food product, due to the content of stilbenes in its composition, has an antioxidant effect due to the ability to inhibit lipid oxidation, has an antitumor effect that manifests itself in various parts of the cell life cycle (apoptosis and autophagy; the cycle of cell division and their differentiation; cellular redox homeostasis, etc.). ), indirectly affect sirtuin proteins, slowing down the process of cell aging.

Specialized food product due to the content in its composition of dietary fibers represented by cellulose and/or hemicellulose, and/or chitin, and/or chitosan, and/or β-glucan, and/or gums, and/or inulin, and/or oligofructose , and/or fructooligosaccharides, and/or lignin, and/or pectins, and/or polydextrose, and/or resistant dextins, and/or resistant starches, has numerous physiological and metabolic effects, playing a key role in the formation of fecal masses and the regulation of motility intestines; contributing to the accelerated removal of foreign substances, endo- and exotoxins, salts of heavy metals from the body. Dietary fibers have a prebiotic effect, promoting the growth and development of normal human intestinal microflora, including bifidobacteria, which is accompanied by a decrease in chyme pH and suppression of bacterial formation of potential carcinogens, an increase in butyrate formation and protection of intestinal mucosal cells from malignant degeneration, etc. Hypocholesterolemic effect of dietary fibers due to their ability to bind, increase the excretion and accelerate the metabolism of bile acids, slow down the absorption of cholesterol in the small intestine, reduce the absorption of lipids by increasing their excretion, inhibit the synthesis of cholesterol in the liver under the influence of short-chain fatty acids formed during the fermentation of soluble foods in the large intestine fibers. Dietary fiber has a hypoglycemic effect due to a slowdown in gastric emptying, a decrease in the availability of starch for digestive enzymes, and a decrease in glucose absorption in the small intestine.

A specialized food product, due to the content of L-carnitine in its composition, helps to preserve the integrity of membranes, stabilize the immune system, economically use glycogen and glucose reserves during prolonged intense exercise, participates in the metabolism of ketone bodies and cholines, inhibits the formation of lactate, and has immunostimulating properties. The use of L-carnitine helps to reduce the signs of physical and mental overstrain, stimulates performance, has a cardio-, hepato- and neuroprotective effect.

A specialized food product, due to the content of coenzyme Q10 in its composition, takes part in energy metabolism and contractile activity of the heart muscle, in the transfer of electrons in the respiratory chain of mitochondria, oxidative phosphorylation, is necessary for the functioning of the immune system, has antioxidant properties, and the ability to increase cell tolerance to hypoxia.

Below are examples of the use of the proposed specialized food product.

Example 1

A specialized food product, which is a multicomponent dry mixture of essential nutrients, provides 50% of one of the daily age-specific norms of the physiological need for essential nutrients as part of the main version of the standard diet for children undergoing inpatient treatment in medical organizations, and the diet of children over 3 years of age, recipients of social services in in stationary form in social protection institutions (table 1).

Table 1 Ingredient Content phenolic acids,
- hydroxybenzoic acids, mg
- hydroxycinnamic acids, mg 25
100 flavonoids,
- flavonols, mg
- flavanones, mg
- flavan-3-ols, mg
- flavones, mg
- anthocyanins, mg
- isoflavonoids, mg 12.5
12.5
fifty
5
25
0.5 Polymeric phenolic compounds, including condensed and hydrolysable tannins, mg fifty Stilbenes, mg one Dietary fiber, g:
cellulose,
hemicellulose,
chitin eleven L-carnitine, mg 150 Coenzyme Q10, mg fifteen

Example 2

A specialized food product, which is a multi-component dry mixture of essential nutrients, provides 75% of one of the daily age norms of the physiological need for essential nutrients as part of a high-protein version of the standard diet for children undergoing inpatient treatment in medical organizations and the diet of children over 3 years of age receiving social services in a stationary form in social protection institutions (table 2).

table 2 Ingredient Content phenolic acids,
- hydroxybenzoic acids, mg
- hydroxycinnamic acids, mg 37.5
150 flavonoids,
- flavonols, mg
- flavanones, mg
- flavan-3-ols, mg
- flavones, mg
- anthocyanins, mg
- isoflavonoids, mg 18.75
18.75
75
7.5
37.5
0.75 Polymeric phenolic compounds, including condensed and hydrolysable tannins, mg 75 Stilbenes, mg 1.5 Dietary fiber, g:
chitin,
chitosan,
β-glucan 16.5 L-carnitine, mg 225 Coenzyme Q10, mg 22.5

Example 3

A specialized food product, which is a multicomponent dry mixture of essential nutrients, provides 5% of one of the daily age norms of the physiological need for essential nutrients as part of a low-protein version of the standard diet of children undergoing inpatient treatment in medical organizations and the diet of children over 3 years of age receiving social services in a stationary form in social protection institutions (table 3).

Table 3 Ingredient Content phenolic acids,
- hydroxycinnamic acids, mg 5 flavonoids,
- flavonols, mg
- flavanones, mg
- flavan-3-ols, mg
- flavones, mg
- anthocyanins, mg
- isoflavonoids, mg 0.75
0.75
5
0.25
2.5
0.02 Polymeric phenolic compounds, including condensed and hydrolysable tannins, mg 5 Stilbenes, mg 0.05 Dietary fiber, g:
β-glucan 0.5 L-carnitine, mg 1.5 Coenzyme Q10, mg 0.375

Example 4

A specialized food product, which is a multicomponent dry mixture of essential nutrients, provides 200% of one of the daily age norms of the physiological need for essential nutrients as part of a low-calorie version of the standard diet of children undergoing inpatient treatment in medical organizations and the diet of children over 3 years of age who receive social services. in a stationary form in social protection institutions (table 4).

Table 4 Ingredient Content flavonoids,
- flavonols, mg
- flavanones, mg
- flavan-3-ols, mg
- flavones, mg
- anthocyanins, mg fifty
fifty
200
twenty
100 Polymeric phenolic compounds, including condensed and hydrolysable tannins, mg 200 Stilbenes, mg four Dietary fiber, g:
inulin,
oligofructose,
fructooligosaccharide 44 L-carnitine, mg 600 Coenzyme Q10, mg 60

Example 5

A specialized food product, which is a multicomponent dry mixture of essential nutrients, provides 125% of one of the daily age norms of the physiological need for essential nutrients as part of a high-calorie variant of the standard diet of children undergoing inpatient treatment in medical organizations, and the diet of children over 3 years of age, recipients of social services in in stationary form in social protection institutions (Table 5).

Table 5 Ingredient Content phenolic acids,
- hydroxycinnamic acids, mg 62.5 flavonoids,
- anthocyanins, mg 62.5 Polymeric phenolic compounds, including condensed and hydrolysable tannins, mg 125 Dietary fiber, g:
hemicellulose, g 22.5 L-carnitine, mg 375 Coenzyme Q10, mg 37.5

Example 6. Results of application of a specialized product obtained according to examples 1-5.

Confirmation of the efficacy and safety of the use of a specialized food product in children with hypercholesterolemia was obtained in the course of the study.

The study included 90 patients with hypercholesterolemia, including 22 boys and 68 girls, aged 4 to 17 years (mean age 9.9±0.96 years) in accordance with the inclusion and exclusion criteria. 23 children had a genetically confirmed diagnosis of familial hypercholesterolemia, heterozygous form (FH); 67 had probable FH. At the time of the initial examination, 35.5% of children showed an increase in the level of total cholesterol (CH) more than 1.5N, in 64.5% of the examined patients, the level of total cholesterol was in the range of 1-1.5N; in 14% of patients, an increase in the level of low-density lipoprotein (LDL) was more than 1.5N, in 80 patients (85.8%) the level of LDL was determined in the range of 1-1.5N, in 20% of patients there was a decrease in high-density lipoprotein (HDL) . All patients had aggravated heredity in cases of early development of cardiovascular events (myocardial infarction, stroke, atherosclerotic lesions of large arteries).

To determine the indicators of the physical development of children, certified scales and a stadiometer appropriate for age were used. The physical development of children was assessed using the WHO AnthroPlus 2007 program, followed by the calculation of Z-scores for body mass index (BMI) by age. 57.8% of the examined children had normal body weight, 16.7% were overweight, 3.3% were obese; 22.2% of children were found to be underweight.

The effectiveness of the inclusion of a specialized food product against the background of the use of a normal-calorie diet with restriction of animal fats and cholesterol, as well as taking into account the age of children, was evaluated based on the results reflecting the dynamics of anthropometric indicators with the determination of body weight, BMI, absolute (AMMT) and relative muscle mass (RMB) , absolute (AFBW) and relative body fat mass (BWBM); indicators of lipid metabolism (total cholesterol, LDL cholesterol, HDL cholesterol), the functional state of the liver with an assessment of the activity of cytolysis syndrome markers - alanine and aspartate aminotransferases (ALAT, ASAT); indicators of antioxidant status with the determination of the level of diene conjugates (DC), malondialdehyde (MDA), catalase activity.

Patients with hypercholesterolemia were randomly divided into 2 groups of the same type: the main group (n=45) and the comparison group (n=45) depending on the variant of the normal-calorie diet with restriction of animal fats and cholesterol. In the main group, patients with hypercholesterolemia received a normal-calorie diet with the inclusion of the test product; in the comparison group - a normal-calorie diet that does not contain sources of phenolic compounds, L-carnitine, coenzyme Q10 and dietary fiber. The duration of the diet therapy was 14 days.

The applied dietary rations in terms of nutrient content, energy value and a set of foods included in their composition met the requirements of the methodological recommendations "Recommended norms of therapeutic nutrition (average daily sets of basic foods) for pregnant and lactating women in maternity hospitals (departments) and children of various age groups in children's hospitals (departments) of the Russian Federation (letter of the Ministry of Health of the Russian Federation dated March 24, 2017 N 28-1/10/2-1994).

Informed consent was obtained from the parents of all children participating in the study in accordance with the Declaration of Helsinki of the World Medical Association of 1964.

Research results.

All patients of the main group noted the good tolerance of the normocaloric diet with the inclusion of the test product. For the entire period of clinical observations, not a single case of intolerance, dyspepsia, allergic reactions and other adverse events was noted when using a normal-calorie diet with the inclusion of the test product.

Dynamics of indicators of weight and body composition in patients with hypercholesterolemia who received normocaloric diet with the inclusion of the test product is presented in table.1.

Table 1 - Dynamics of indicators of weight and body composition in patients with hypercholesterolemia who received a normocaloric diet with the inclusion of the test product (M±m) Indicators Main group Comparison group Body weight, kg
before taking the product
after taking the product 28.1±2.67
29.1±2.51 27.9±2.57
28.2±2.78 BMI, kg/m2
before taking the product
after taking the product 15.5±1.44
16.0±1.51 15.3±1.41
15.5±1.62 AMMT, kg
before taking the product
after taking the product 14.1±1.53
14.8±1.42* 14.0±1.31
14.3±1.56 OMMT, %
before taking the product
after taking the product 35.6±2.15
37.5±2.91* 35.5±3.25
36.1±3.63 AZHMT, kg
before taking the product
after taking the product 4.13±0.43
4.55±0.46 4.11±0.41
4.21±0.42 WBC, %
before taking the product
after taking the product 10.4±1.15
10.9±1.11 10.3±1.24
10.5±1.32

Here and below: 1 - before treatment; 2 - after the course of treatment; * - p<0.05 - compared with baseline

The results of the study showed that in patients of the main group who received a normal-calorie diet with the inclusion of the product under study, there was a more pronounced tendency to improve indicators of weight and body composition compared to those in patients of the comparison group.

From the presented table.1 it follows that in patients of the main group there was an increase in body weight and BMI by an average of 3.6% and 3.2% of the initial level, respectively, in patients of the comparison group - by 1.1% and 1.3 % of baseline resp. When assessing body composition parameters in children included in the study, an improvement in lean body mass was noted under the influence of a normocaloric diet with the inclusion of the product under study, which manifested itself in a statistically significant increase in the content of AMMT and OMMT by an average of 5.0% and 5.3% of the initial level. (p<0.05). In patients of the comparison group, the dynamics of the content of AMMT and OMMT was less pronounced and not statistically significant.

In table. Figure 2 shows the dynamics of blood lipid parameters in patients with hypercholesterolemia who received a normocaloric diet with the inclusion of the test product.

Table 2 - Blood lipid parameters in patients with hypercholesterolemia who received a normal-calorie diet with the inclusion of the test product (M±m) Indicators Main group Comparison group Total cholesterol, mmol/l
before taking the product
after taking the product 6.88±0.55
5.11±0.43* 6.79±0.67
6.35±0.61 LDL cholesterol, mmol/l
before taking the product
after taking the product 4.94±0.43
3.47±0.34* 4.71±0.41
4.31±0.45 HDL cholesterol, mmol/l
before taking the product
after taking the product 1.11±0.11
1.42±0.12* 1.15±0.11
1.17±0.16

From the data presented in table. 2, it follows that in the course of treatment in patients with hypercholesterolemia who received a normal-calorie diet with the inclusion of the test product, there was a statistically significant decrease in the content of total cholesterol in the blood serum (by an average of 25.7% of the initial level, p<0.05) and LDL cholesterol (by an average of 29.8%, p<0.05), as well as an increase in HDL cholesterol (by an average of 27.9%, p<0.05). In patients of the comparison group, the decrease in the content of total cholesterol and LDL cholesterol was less pronounced and unreliable. The content of HDL-C in the blood serum of patients of the comparison group practically did not change.

In table. 3 shows the dynamics of indicators of the functional state of the liver in patients with hypercholesterolemia, who received a normocaloric diet with the inclusion of the test product.

Table 3 - Indicators of the functional state of the liver in patients with hypercholesterolemia who received a normocaloric diet with the inclusion of the test product (M ± m) Indicators Main group Comparison group ALAT, IU/l
before taking the product
after taking the product 31.5±3.12
24.6±2.56* 32.0±3.17
29.7±2.57 ASAT, IU/l
before taking the product
after taking the product 30.1±2.78
21.8±2.01* 31.3±2.45
28.7±2.14

From the data presented in Table 3, it follows that in the main group there was a statistically significant decrease in the activity of ALAT and ASAT in patients with hypercholesterolemia who received a normocaloric diet with the inclusion of the test product, on average by 21.9% and 27.6% of the original level resp. (p<0.05). In patients of the comparison group, the dynamics of ALAT and ASAT activity was less pronounced and not statistically significant.

The dynamics of antioxidant status in patients with hypercholesterolemia who received a normocaloric diet with the inclusion of the test product is presented in Table 3.

Table 4 - Dynamics of antioxidant status indicators in patients with hypercholesterolemia who received a normocaloric diet with the inclusion of the test product (M±m) Indicators Main group Comparison group DC, µnmol/ml
before taking the product
after taking the product 1.87±0.17
1.56±0.14* 1.95±0.15
1.80±0.18 MDA, nmol/ml
before taking the product
after taking the product 5.31±0.31
3.62±0.32* 5.25±0.35
4.79±0.34 Catalase, mkatal/l
before taking the product
after taking the product 0.71±0.09
1.13±0.11* 0.75±0.08
0.96±0.09

From Table. 4 it follows that the inclusion of the test product in the normal-calorie diet of the test product was accompanied by a statistically significant decrease in the content of DC and MDA in the blood serum by an average of 16.6% and 31.8% of the initial level, respectively. (p<0.05). The dynamics of the level of DC and MDA in blood serum in patients of the comparison group was less pronounced and not statistically significant.

The inclusion of the studied product in the normocaloric diet was also accompanied by a statistically significant increase in catalase activity in the blood serum by an average of 59.2% of the initial level, respectively. in the absence of significant differences in the dynamics of catalase activity in patients of the comparison group (Table 4).

Thus, the results of the study showed that the inclusion of the study product in the normocaloric diet is accompanied by a positive effect on body weight and composition, blood lipids, cytolysis syndrome markers and antioxidant status in patients with hypercholesterolemia, which manifests itself in a statistically significant increase in absolute and relative muscle mass of the body, a decrease in the content of total cholesterol and LDL cholesterol, an increase in the level of HDL cholesterol, a decrease in the content of DC and MDA with an increase in catalase activity in blood serum in the blood serum of this group of patients.

Thus, a technical result is achieved, which consists in restoring disturbed or lost body functions as a result of the disease, preventing these disorders, as well as increasing the adaptive capabilities of the body in children older than 3 years.

The specialized food product has a powder form, the advantages of which are due to the convenience of its introduction into the dishes of dietary therapeutic and dietary preventive nutrition 2-3 minutes before they are ready. The dry form of the product has a number of additional advantages related to transportation and storage, microbiological stability, which ensures long shelf life.

The content of essential biologically active substances in one daily portion of the product complies with the methodological recommendations and scientific data for children over three years of age who are hospitalized in medical organizations, and children over 3 years of age who receive social services in a stationary form in social protection institutions.

The introduction of a specialized food product of a mixture of essential nutrients in a multicomponent dry diet in the dietary therapeutic and dietary preventive nutrition of children over three years of age who are inpatient treatment in medical organizations, and children over 3 years of age, recipients of social services in a stationary form in social protection institutions, as a component of preparation ready-made meals allows you to have a positive impact on the functions of the body that have been disturbed or lost as a result of diseases and pathological conditions, to ensure the prevention of these disorders, and to increase the adaptive capabilities of the body.

Claims (17)

1. A specialized food product for dietary therapeutic and dietary preventive nutrition for children over 3 years old, which is a multicomponent dry mixture of essential nutrients, characterized in that it contains: phenolic compounds selected from the group consisting of phenolic acids and/or flavonoids and/or polymeric phenolic compounds and/or stilbenes, in an amount of 5 to 200% of their age norm of physiological requirements for children over 3 years old; dietary fiber selected from the group consisting of cellulose and/or hemicellulose and/or chitin and/or chitosan and/or β-glucans and/or gum and/or inulin and/or oligofructose and/ or fructooligosaccharides, and/or lignin, and/or pectins, and/or polydextrose, and/or resistant dextins, and/or resistant starches, in an amount of 5 to 200% of their age norm of physiological requirements for children over 3 years old; L-carnitine in an amount from 5 to 200% of their age norm of physiological need for children over 3 years old; coenzyme Q10 in an amount from 5 to 200% of their age norm of physiological requirements for children over 3 years old. 2. A specialized food product according to claim 1, characterized in that phenolic compounds selected from the group consisting of phenolic acids and/or flavonoids and/or polymeric phenolic compounds and/or stilbenes are contained in an amount of 0.02 up to 1126 mg. 3. Specialized food product according to claim 1, characterized in that dietary fibers selected from the group consisting of cellulose and/or hemicellulose and/or chitin and/or chitosan and/or β-glucans and/or gums, inulin, and/or oligofructose, and/or fructooligosaccharides, and/or lignin, and/or pectins, and/or polydextrose, and/or resistant dextins, and/or resistant starches, are contained in an amount of 0.5 to 44 G. 4. Specialized food product according to claim 1, characterized in that L-carnitine is contained in an amount of from 1.5 to 600 mg. 5. Specialized food product according to claim 1, characterized in that coenzyme Q10 is contained in an amount of from 0.375 to 60 mg. 6. A specialized food product according to claim 1, characterized in that the proposed product contains hydroxybenzoic acid in an amount of 1.25 to 100 mg and/or hydroxycinnamic acid in an amount of 5 to 400 mg as phenolic acids. 7. Specialized food product according to claim 1, characterized in that as flavonoids, the proposed product contains flavonols in an amount of 0.75 to 50 mg and/or flavanones in an amount of 0.75 to 50 mg, and/or flavan-3 -ols in an amount of 5 to 200 mg, and/or flavones in an amount of 0.25 to 20 mg, and/or anthocyanins in an amount of 2.5 to 100 mg, and/or isoflavonoids in an amount of 0.02 to 2 mg. 8 . Specialized food product according to claim 1, characterized in that the proposed product contains condensed and hydrolysable tannins in the amount of 5 to 200 mg as polymeric phenolic compounds. 9. Specialized food product according to claim 1, characterized in that the proposed product contains stilbenes in an amount of 0.05 to 4 mg. 10. Specialized food product according to claims 1-9, characterized in that it can be used for dietary therapeutic and dietary preventive nutrition of children over 3 years old. 11. A specialized food product according to claims 1 to 9, characterized in that it additionally contains compounds of a protein and/or carbohydrate and/or fatty nature, and/or vitamins and vitamin-like compounds, and/or minerals, and/or other biologically active substances and/or food additives and/or flavors and/or processing aids, including those selected from the group of antioxidants and/or defoamers and/or sweeteners and/or fillers and/or carriers, and / or stabilizers and / or anti-caking agents, and / or naturally present in the raw material source of the biologically active substance that is part of the product. 12. Specialized food product according to claims 1-9, characterized in that it can be used in standard diets for catering for children over 3 years old in medical organizations and social protection institutions. 13. A method for preparing dietary therapeutic and dietary preventive nutrition, characterized in that the specialized food product according to claims 1-11 is introduced during the preparation of dietary therapeutic and dietary preventive nutrition in an amount that ensures the introduction into the daily diet from 5 to 200% of the age the norms of the physiological need for essential biologically active substances - phenolic compounds, dietary fiber, L-carnitine and coenzyme Q10, then mixed in the mass of the dish.