RU2546290C1 - Method of predicting condition of venous outflow from vessels of brain in flu patients - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, namely to infectology, and can be applied for predicting the condition of the venous outflow from brain vessels in flu patients. The essence of the method: a value of ristomycin-aggregation of platelets in blood serum is determined in the flu patients in seconds. The obtained data are plugged into formula: PI=2.42-A·0.1, where PI is the prediction index of a risk of the emergence of venous waves in the brain vessels; 2.42 is a constant of mathematical calculation for predicting the condition of the emergence of the venous waves in the brain vessels; A is a value of ristomycin-aggregation of platelets in blood serum in seconds. When the PI value is 0, the absence of the venous waves is predicted; if the PI value is from 0 to 1 inclusively, the emergence of slightly expressed venous waves is predicted; if the PI value is higher than 1 - the emergence of expressed venous waves.

EFFECT: PI value can be used to predict the condition of the venous outflow from the brain vessels in the flu patients or patients who have recovered, which makes it possible for the medical specialist to carry out a complex of procedures aimed at the timely detection of disorders of the venous outflow from the brain vessels and perform their correction reasonably.

1 ex

Description

The invention relates to medicine, namely to infectology, and can be used to predict the state of venous outflow from cerebral vessels in patients with influenza.

A known method for determining vascular disorders in patients with influenza by conjunctival biomicroscopy using a capillaroscope [1, 2] with an assessment of the qualitative-quantitative system V.S. Volkova [3].

The disadvantage of this method is the ability to indirectly characterize the venous blood flow in the vessels of the brain, the need to have a capillaroscope and the skill of working with a capillaroscope.

A known method for determining vascular disorders in patients with influenza by determining the propagation velocity of the pulse wave [4, 5].

The disadvantage of this method is the ability to indirectly characterize the venous blood flow in the vessels of the brain, the need to have a sphygmograph, a room for the study.

A known method for determining venous blood flow in the vessels of the brain in patients with influenza by rheoencephalography [6].

The disadvantage of this method is the need to have a rheoencephalograph and the absence of formulas summarizing the parameters of cerebral circulation and hemostasis, allowing to predict the state of venous outflow from the brain vessels in patients with influenza.

This method is taken as a prototype.

Thus, in the available literature, we have not found ways to generalize the parameters of cerebral circulation and hemostasis and on this basis to predict the state of venous outflow from the brain vessels in patients with influenza.

The aim of the invention is to develop a method for predicting the state of venous outflow from blood vessels of the brain in patients with influenza.

This goal is achieved by the fact that in patients with influenza determine the value of ristomycin-platelet aggregation in blood serum in seconds. The obtained data is substituted into the formula:

PP = 2.42-A · 0.1,

where PP is a prognostic indicator of the risk of venous waves in the vessels of the brain;

2.42 - constant mathematical calculations for predicting the appearance of venous waves in the vessels of the brain;

A is the value of ristomycin platelet aggregation in blood serum in seconds.

According to the formula, a prognostic indicator of the risk of venous waves in the vessels of the brain is calculated. When the value of PP 0 predict the absence of venous waves; with a value greater than 0 and up to 1 inclusive, the appearance of weakly expressed venous waves is predicted; with a value of more than 1 - pronounced venous waves.

The proposed method is as follows:

In a patient with influenza, blood is drawn from a vein and the value of ristomycin platelet aggregation in blood serum is determined in seconds. The obtained data is substituted into the formula:

PP = 2.42-A · 0.1,

where PP is a prognostic indicator of the risk of venous waves in the vessels of the brain;

2.42 - constant mathematical calculations for predicting the appearance of venous waves in the vessels of the brain;

A is the value of ristomycin platelet aggregation in blood serum in seconds.

According to the formula, prognostic indicators of the risk of venous waves in the vessels of the brain are calculated. If the PP value is greater than 0 and up to 1 inclusive, the appearance of weakly expressed venous waves is predicted; with a value of more than 1 - pronounced venous waves.

When developing the method, the multiple regression method was used. To predict the risk of the appearance of venous waves in the vessels of the brain, the method takes into account only significant signs with a reliable probability p> 0.95 or with a significance level p <0.05.

The model and predictor obtained using the multiple regression method (a factor that determines the likelihood of development of signs) included in the model are statistically significant. A model for predicting the risk of venous waves in the vessels of the brain is significant: p <0.002; the predictor included in this model is also significant: for A, the values of ristomycin-platelet aggregation p = 0.002.

The calculation was based on an analysis of the protocols of the study of rheoencephalograms and hemostasis in patients and who have had the flu. The study of cerebral circulation was performed by rheoencephalography. The presence and severity of venous waves characterizing the state of the venous outflow from the brain vessels on the catacrot of the main rheoencephalographic curve and the decrease in the duration of ristomycin platelet aggregation in the blood serum of patients with influenza were determined. A correlation analysis and multiple regression method were performed. An indicator of the presence and severity of venous waves in the vessels of the brain was taken as the determined parameters, and the observation period, age group, and the value of ristomycin platelet aggregation in blood serum were used as predictors. The analysis found that the age and duration of observation are not predictors in predicting the risk of venous waves in the vessels of the brain. As a result, a formula was compiled that made it possible to predict the state of venous outflow from cerebral vessels in patients with influenza, depending on the value of ristomycin-platelet aggregation in blood serum for timely correction.

The proposed method allows to predict the state of venous outflow from the brain vessels in patients and who have had the flu, and enables a specialist doctor to take a set of measures aimed at timely detection of violations of the venous outflow from the brain vessels and reasonably carry out their correction.

CLINICAL EXAMPLE

Patient Z., 58 years old, was admitted for inpatient treatment at the infectious disease clinic of Samara State Medical University on the 1st day of illness. Clinical diagnosis: ″ Influenza, moderate severity ″. Complaints of fever up to 38.8 ° C, headache, weakness, muscle aches, dry cough. Blood was drawn from a vein and the value of ristomycin platelet aggregation in blood serum was determined. At the same time, rheoencephalography (REG) was performed to determine venous waves at the catacrot of the main rheoencephalographic curve. Studies were carried out in dynamics: upon admission to treatment on the 1st day of illness, on the 4th, 7th, 13th day from the onset of the disease, a month after the onset of the disease. The obtained data was substituted into the formula:

PP = PP = 2.42-A · 0.1,

where PP is a prognostic indicator of the risk of venous waves in the vessels of the brain;

2.42 - constant mathematical calculations for predicting the appearance of venous waves in the vessels of the brain;

A is the value of ristomycin platelet aggregation in blood serum in seconds.

1st day of illness. In the patient, the ristomycin-platelet aggregation value was 12 s - for indicator A, the figure 12 was substituted.

For our model:

And - the value of ristomycin-platelet aggregation (s) - 12.

The obtained indicators are inserted into the formula for determining prognostic indicators:

PP = 2.42-12 · 0.1.

We evaluate the results. The value of PP = 1.22 allows us to predict the appearance of venous waves in the vessels of the brain of a pronounced degree.

For comparison, during the study by the REG method, the appearance of pronounced venous waves in the vessels of the brain was determined (the indicator of venous waves was 2).

4th day of illness. The ristomycin platelet aggregation value was 11 s.

For our model:

And - the value of ristomycin-platelet aggregation (s) - 11.

The obtained indicators are inserted into the formula for determining prognostic indicators:

PP = 2.42-11 · 0.1.

We evaluate the results. The value of PP = 1.32 allows you to predict the appearance of venous waves in the vessels of the brain of a pronounced degree.

For comparison, during the study by the REG method, the appearance of pronounced venous waves in the vessels of the brain was determined (the indicator of venous waves was 2).

7th day of illness. The ristomycin platelet aggregation value was 8 s.

For our model:

And - the value of ristomycin-platelet aggregation (s) - 8.

The obtained indicators are inserted into the formula for determining prognostic indicators:

PP = 2.42-8 · 0.1.

We evaluate the results. The value of PP = 1.62 allows you to predict the appearance of venous waves in the vessels of the brain of a pronounced degree.

For comparison, during the study by the REG method, the appearance of pronounced venous waves in the vessels of the brain was determined (the indicator of venous waves was 2).

13th day from the onset of the disease. The ristomycin platelet aggregation value was 10 s.

For our model:

And - the value of ristomycin-platelet aggregation (s) - 10.

The obtained indicators are inserted into the formulas for determining prognostic indicators:

PP = 2.42-10 · 0.1.

We evaluate the results. The value of PP = 1.42 allows you to predict the appearance of venous waves in the vessels of the brain of a pronounced degree.

For comparison, during the study by the REG method, the appearance of pronounced venous waves in the vessels of the brain was determined (the indicator of venous waves was 2).

Clinical examination. Examination a month after the onset of the disease. The value of ristomycin platelet aggregation was 15 s.

For our model:

And - the value of ristomycin-platelet aggregation (s) - 15.

The obtained indicators are inserted into the formulas for determining prognostic indicators:

PP = 2.42-15 · 0.1.

We evaluate the results. The value of PP = 0.92 allows us to predict the appearance of venous waves in the vessels of the brain of a weak degree.

For comparison, during the study by the REG method, the appearance of weakly expressed venous waves in the vessels of the brain was determined (the indicator of venous waves was 1).

Thus, according to the proposed method, it is possible to predict the development of venous waves and the state of venous outflow from the vessels of the brain in patients with influenza.

Literature

1. Bogomolov B.P. Microcirculation and hemostasis in patients with influenza and respiratory infections, aggravated by concomitant diseases / B.P. Bogomolov, A.V. Devyatkin - Clinical Medicine, 2000. - No. 8. - S. 52-56.

2. Mityushina S.A. The state of microcirculation and central hemodynamics in influenza and other acute respiratory infections in patients with hypertension / S.A. Mityushina. Abstract. diss. Ph.D. Moscow. - 2005.

3. Volkov V.S. Assessment of microcirculation by conjunctival biomicroscopy / V.S. Volkov, N.N. Vysotsky, V.V. Trotsyuk, V.I. Mishin - Wedge. the medicine. - 1976. - No. 7. - S.115-119.

4. Bogomolov B.P. The state of the cardiovascular system in influenza in patients with coronary heart disease / B.P. Bogomolov, T.N. Molkova - Ter. Archive, 1980. - No. 1. - S.31-34.

5. Venglovskaya Ya.V. The hemodynamic status in patients with influenza according to a comprehensive study / Ya.V. Venglovskaya, Abstract. diss. Ph.D. Kiev. - 1973.

6. Vashchenko M.A. Clinical and rheoencephalographic parameters in patients with influenza with a predominant lesion of the nervous system / M.A. Vashchenko, L.V. Muravskaya - Doctor. a business. - 1978. - No. 1. - S.146-149.

Claims (1)

A method for predicting the state of venous outflow from blood vessels of the brain, characterized in that in influenza patients determine the value of ristomycin-platelet aggregation in blood serum in seconds; the obtained data is substituted into the formula:
PP = 2.42-A · 0.1,
Where:
PP - a prognostic indicator of the risk of venous waves in the vessels of the brain;
2.42 - constant mathematical calculations for predicting the appearance of venous waves in the vessels of the brain;
A - the value of ristomycin-platelet aggregation in serum in seconds; when the value of PP 0 predict the absence of venous waves; with a value greater than 0 and up to 1 inclusive, the appearance of weakly expressed venous waves is predicted; with a value of more than 1 - pronounced venous waves.