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RU2224539C2 - Заживление переломов с помощью аналогов пептида, подобного паратироидному гормону (ртнrр) - Google Patents

Заживление переломов с помощью аналогов пептида, подобного паратироидному гормону (ртнrр) Download PDF

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Publication number
RU2224539C2
RU2224539C2 RU2000109305/15A RU2000109305A RU2224539C2 RU 2224539 C2 RU2224539 C2 RU 2224539C2 RU 2000109305/15 A RU2000109305/15 A RU 2000109305/15A RU 2000109305 A RU2000109305 A RU 2000109305A RU 2224539 C2 RU2224539 C2 RU 2224539C2
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Russia
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pthrp
analogous
peptide
parathyroid hormone
analogs
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RU2000109305/15A
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English (en)
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RU2000109305A (ru
Inventor
Брайан Хенри ВИКЕРИ (US)
Брайан Хенри ВИКЕРИ
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Ф.Хоффманн-Ля Рош Аг
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/635Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Изобретение относится к медицине и касается способа заживления кости и репарации перелома, включающего введение пациенту, нуждающемуся в этом, эффективного количества полипептидного аналога пептида, подобного паратиреоидному гормону (РТНrР) и его солей, где остатки аминокислот в положении 22-31 образуют амфипатическую α-спираль, и применение такого полипептида для приготовления лекарственного средства, предназначенного для лечения с целью заживления кости и репарации перелома. Изобретение обеспечивает ускорение заживления кости. 2 с. и 14 з.п. ф-лы, 5 ил., 2 табл.

Description

Текст описания в факсимильном виде (см. графическую часть)

Claims (1)

  1. Текст формулы в факсимильном виде (см. графическую часть).
RU2000109305/15A 1997-09-09 1998-09-02 Заживление переломов с помощью аналогов пептида, подобного паратироидному гормону (ртнrр) RU2224539C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5832497P 1997-09-09 1997-09-09
US60/058,324 1997-09-09

Publications (2)

Publication Number Publication Date
RU2000109305A RU2000109305A (ru) 2002-02-10
RU2224539C2 true RU2224539C2 (ru) 2004-02-27

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ID=22016113

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RU2000109305/15A RU2224539C2 (ru) 1997-09-09 1998-09-02 Заживление переломов с помощью аналогов пептида, подобного паратироидному гормону (ртнrр)

Country Status (32)

Country Link
US (1) US6583114B2 (ru)
EP (1) EP1005359B1 (ru)
JP (1) JP2002509854A (ru)
KR (1) KR100679778B1 (ru)
CN (1) CN1210059C (ru)
AR (1) AR015435A1 (ru)
AT (1) ATE297754T1 (ru)
AU (1) AU752925B2 (ru)
BR (1) BR9812068A (ru)
CA (1) CA2302255C (ru)
CO (1) CO4890856A1 (ru)
CZ (1) CZ298701B6 (ru)
DE (1) DE69830591T2 (ru)
ES (1) ES2244090T3 (ru)
HK (1) HK1030753A1 (ru)
HR (1) HRP20000109A2 (ru)
HU (1) HU226866B1 (ru)
IL (2) IL134719A0 (ru)
MA (1) MA26545A1 (ru)
MY (1) MY121291A (ru)
NO (1) NO323740B1 (ru)
NZ (1) NZ502970A (ru)
PE (1) PE117399A1 (ru)
PL (1) PL195703B1 (ru)
RS (1) RS49707B (ru)
RU (1) RU2224539C2 (ru)
SA (1) SA98190565B1 (ru)
TR (1) TR200000649T2 (ru)
TW (1) TW552139B (ru)
UY (1) UY25172A1 (ru)
WO (1) WO1999012561A2 (ru)
ZA (1) ZA988030B (ru)

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CA2245903A1 (en) * 1998-09-28 2000-03-28 Mcgill University Use of pex in the treatment of metabolic bone diseases
CA2364948C (en) 1999-03-05 2011-04-26 The Procter & Gamble Company C16 unsaturated fp-selective prostaglandins analogs
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US6393328B1 (en) * 2000-05-08 2002-05-21 International Rehabilitative Sciences, Inc. Multi-functional portable electro-medical device
US6560487B1 (en) * 2000-05-08 2003-05-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
US6675048B2 (en) * 2000-05-08 2004-01-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
AU2003207512B2 (en) * 2002-01-10 2008-06-12 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
AU2003272814A1 (en) 2003-10-02 2005-05-19 Ibrahim Al-Habdan Peptide for promoting healing of fractures
EP1804820A4 (en) * 2004-10-08 2009-12-02 Transition Therapeutics Inc PHARMACEUTICAL PRODUCTS BASED ON VASOACTIVE INTESTINAL POLYPEPTIDES
EP1945245A2 (en) * 2005-11-10 2008-07-23 The Board of Control of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US20090022684A1 (en) * 2006-05-09 2009-01-22 Paul Morley Methods for hematopoietic stimulation
SG175580A1 (en) 2006-10-03 2011-11-28 Radius Health Inc Method of drug delivery for bone anabolic protein
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EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
JP5564167B2 (ja) * 2008-05-22 2014-07-30 日本たばこ産業株式会社 苦味マスキング剤及び苦味低減方法
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Also Published As

Publication number Publication date
SA98190565B1 (ar) 2006-07-30
WO1999012561A9 (en) 2000-03-16
HK1030753A1 (en) 2001-05-18
AU752925B2 (en) 2002-10-03
HU226866B1 (en) 2009-12-28
NO20001195L (no) 2000-03-08
HRP20000109A2 (en) 2001-02-28
EP1005359A2 (en) 2000-06-07
TR200000649T2 (tr) 2000-09-21
DE69830591T2 (de) 2006-05-04
CA2302255A1 (en) 1999-03-18
TW552139B (en) 2003-09-11
PL339449A1 (en) 2000-12-18
CZ2000862A3 (cs) 2000-09-13
US20020077281A1 (en) 2002-06-20
US6583114B2 (en) 2003-06-24
RS49707B (sr) 2007-12-31
KR100679778B1 (ko) 2007-02-07
YU12700A (sh) 2004-09-03
AU9740698A (en) 1999-03-29
CA2302255C (en) 2011-11-08
ATE297754T1 (de) 2005-07-15
NZ502970A (en) 2002-03-01
CN1269726A (zh) 2000-10-11
MY121291A (en) 2006-01-28
PL195703B1 (pl) 2007-10-31
DE69830591D1 (de) 2005-07-21
KR20010023795A (ko) 2001-03-26
HUP0004560A2 (hu) 2001-04-28
JP2002509854A (ja) 2002-04-02
WO1999012561A3 (en) 1999-05-14
CO4890856A1 (es) 2000-02-28
UY25172A1 (es) 2001-01-31
PE117399A1 (es) 1999-11-20
AR015435A1 (es) 2001-05-02
IL134719A0 (en) 2001-04-30
BR9812068A (pt) 2000-09-26
ZA988030B (en) 1999-03-09
IL134719A (en) 2010-04-29
NO20001195D0 (no) 2000-03-08
HUP0004560A3 (en) 2005-11-28
CZ298701B6 (cs) 2007-12-27
CN1210059C (zh) 2005-07-13
NO323740B1 (no) 2007-07-02
ES2244090T3 (es) 2005-12-01
WO1999012561A2 (en) 1999-03-18
MA26545A1 (fr) 2004-12-20
EP1005359B1 (en) 2005-06-15

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