RU2196594C2 - Agent eliciting recovery, tonic and regenerative effect - Google Patents

Abstract

FIELD: medicine, ophthalmology. SUBSTANCE: invention relates to agents prepared from vegetable raw. The proposed agent comprises bilberry fruits extract and accessory substances that comprise homeopathic supplements additionally taken among of order: eyebright (Euphrasia officinalis), evergreen Carolina jessamine (Gelsemium Juss.) and/or raceme-like bug-bane (Cimicifuga) in the following ratio of components in 100 g of ready product: bilberry fruits, 7.5-10.0 g; homeopathic supplements, 4.0-5.0 g; accessory supplements, the balance. Agent shows wide spectrum of effect: recovery, tonic and regenerative, ecologically pure and without irritating, allergic, inflammatory and other unfavorable effects and excluding mechanical contact with eye surface. EFFECT: valuable medicinal properties of agent. 7 cl, 4 tbl

Description

 The invention relates to medicine, in particular to means from raw materials of plant origin, and can be applied, for example, in ophthalmology.

 The use of funds from raw materials of plant origin is becoming increasingly common in various fields of medicine, in particular in ophthalmology, due to their high environmental friendliness.

 Known drugs aimed at treating certain eye diseases are used, as a rule, in the form of drops or ointments for external use.

 Known ophthalmic drug for the treatment of various eye diseases based on the extract of brown algae (RF patent 2104679, A 61 F 9/00).

 A means of increasing visual acuity based on a water decoction of dried berries of Chinese magnolia vine is introduced either into the conjunctival sac, as an external agent, or into the eye tissue by electrophoresis (ed. St. USSR 171981, A 61 K 35/78).

 These drugs are aimed at improving visual function. However, their use in the form of ointments, films or drops involves mechanical contact with the surface of the eye and its injury. In addition, each of the known means is characterized by a pronounced direction of action.

 At the same time, there are cases when excessive exploitation of the surface of the eye, its irritation and the corresponding psychological trauma to the patient are extremely undesirable, and the impact on visual function is necessary. For this purpose, drugs are administered orally in the form of tablets, capsules, fees, extracts.

 Known use for therapeutic purposes of leaves and fruits of blueberries. A number of preparations containing blueberries in the form of decoctions and infusions have astringent, firming, diuretic, analgesic, anti-inflammatory effect (Mashkovsky M.D. "Medicines". Edition M., - Medicine, 1997, v. 2, p. . 307).

 It has been established that flavonoids contained in blueberries have a strengthening effect on capillaries and reduce the permeability of hematoparenchymal barriers, which underlies the pharmacological, prophylactic and therapeutic effects of drugs using blueberries.

 It has been established that in addition to a wide spectrum of action on the human body, the use of blueberries increases visual acuity, provides an increase in the field of view, reduces eye fatigue without exploiting the surface of the eye and without injuring the human psyche (Gaetan Jail "Blueberry Extract and Vision". TASS, Foreign Bulletin scientific and technical information TASS, 1964, 72 (962), 1964). It has been established that the flavanoids contained in blueberries (rutin, quercetin, vitamin P) strengthen the walls of blood vessels and regulate their permeability.

 It is also known that drugs with vitamin P are used to treat vitamin deficiencies, retinal hemorrhages, capillary toxicosis, and to restore neuro-trophic processes in the cornea.

 The closest solution to the claimed is the preparation of the French ophthalmological laboratory, made in the form of tablets containing blueberry extract and excipients (Gaetan Jail "Blueberry Extract and Vision". TASS, Bulletin of foreign scientific and technical information TASS, 1964, 72 (962), 1964 g.). The drug is used to increase the field of view and regenerate visual purpura, to reduce fatigue during prolonged use in rooms with artificial lighting.

 The specified drug has several advantages compared with the known. Application inside excludes injury to the ocular surface. However, its use is also directed and does not have a prolonging effect.

 The task of the invention is to provide a broad-spectrum agent with a restorative, tonic and regenerative effect, environmentally friendly and devoid of irritating, allergenic, inflammatory and other undesirable effects, as well as excluding mechanical contact with the surface of the eye.

The problem is solved by creating a product containing blueberries and excipients, which additionally contains at least one homeopathic supplement selected from the series: medical eye, evergreen gelsemium (yellow jasmine), black cohosh (Tsimitsifuga) or their mixture with the following content of components of 100 0 g of finished product:
blueberries - 7.5-10.0 g
homeopathic supplements - 4.0-5.0 g
auxiliary additives - the rest
The problem is also solved by the fact that the product contains homeopathic supplements in equal proportions.

 The problem is also solved by the fact that the product contains in its composition an eyeball of the following dilution: D12, D30, D200.

 The problem is also solved by the fact that the product contains evergreen gelsemium of the following dilution: D10, D30, D200.

 The problem is also solved by the fact that the product contains a black cohosh racemose following dilution: D10, D30, D200.

 The problem is also solved by the fact that the product contains, as auxiliary additives, sugar syrup or excipients.

 The fruits of blueberries (Fructus myrtilli) contain carbohydrates (glucose, fructose, sucrose, pectin), organic acids (citric, lactic, quinic, oxalic, malic, succinic), vitamins (C, PP, B, carotene), essential oil, triterpenoids (ursalic acid), phenols and their derivatives (hydroquinone, asperuloside, monotropheoside), polyphenols, tannins, catechins (gallocatechin, epicatechin, epigalocatechin, epigalocatechingalate), phenol carboxylic acids and their derivatives (coffee, chlorogenic, astlornogenic) quercetin, isoquercy , Rutin), anthocyanins (delphinidin, malvidin, petunidin, cyanidin, peonidin) leucoanthocyanins. For this reason, blueberries are used to reduce visual acuity and field of view, resulting from general overstrain and overwork, as well as visual disturbances accompanying vertebrobasilar symptoms of the cervical spine: dizziness, fatigue, flashing flies in front of the eyes. Flavonoids and anthocyanins have a capillary-strengthening effect, reduce the permeability of the hematoparenchymal barrier, accelerate the renewal of the light-sensitive retina, and improve the regeneration of visual purpura. The glycokinins that make up blueberries are used for diabetic retinal changes.

 It is known to use the drug eye, evergreen gelsemium and black cohosh racemose in homeopathy.

 Eyebright (Euphrasia officinalis) contains glycosides, essential oils, lipids, bitterness and is used in homeopathy for external eye diseases, eyelid inflammation, lacrimation, conjunctivitis, photophobia.

 Evergreen gelsemium (Gelsemium sempervirens) contains alkaloids, essential oils and is used in homeopathy for heaviness in the head, tiredness, flu, migraine, neuralgia of various origins, myocarditis, dysmenorrhea.

 Black cohosh (Cimicifuga racemosa) contains: alkaloids, actein, cytisine, cimicigenol, saponins, tannins, phenolic acids, essential oils and is used in homeopathy for heart palpitations, cardiological spasms, hormonal dysfunctions.

 The introduction of these substances into the composition of the claimed means of homeopathic supplements allowed us to create a new drug with a wide spectrum of action. It was found that the introduction of at least one of these substances provided the manifestation of a new positive result. Thanks to this, an impact on the human body is ensured, not only visual acuity and field of view are restored, but also working capacity, general physical condition, fatigue is reduced.

 The following describes a method of preparing funds based on the claimed invention.

The preparation of the claimed funds consists of the following steps:
1) preparation of blueberry fruit extract;
2) preparation of the production complex of homeopathic dilutions;
3) mixing the extract of blueberries with the production complex of homeopathic dilutions;
4) the preparation of the finished product in the form of syrup or tablets or capsules.

An example of the preparation of the claimed funds in the form of syrup
First, extract from blueberries. For this, the raw material pre-dried to a certain moisture content (not more than 17%) is crushed to a particle size of not more than 8 mm. Then 25.9 kg of the crushed raw material is loaded into the extractor. The prepared extractant - ethyl alcohol 50% 182.76 kg is pumped there from the extractant container and the raw materials are extracted with periodic stirring at room temperature for 32 hours. After extraction, the resulting water-alcohol extracts are pumped into a collection of water-alcohol extracts, and the meal is squeezed out by centrifuge or press. From the collector, the pump through the cartridge filter water-alcohol extraction is pumped into a tank for sludge.

 Water-alcohol extracts, settled in the tank for sludge, are decanted within 72 hours and fed through another cartridge filter with 5 μm pores to the next collection. The resulting liquid extract is fed into a separation tank and, after separation, is fed through a filter to a vacuum evaporator, where the extract is evaporated to 1/5 of the original volume, followed by feeding the condensed extract into the collector.

 Then determine the compliance of the obtained extract with the established requirements by the following indicators: authenticity, density of the solution, extractive substances, heavy metals, microbiological purity from samples taken from the collection of finished products. Upon receipt of a positive result, the condensed extract is pumped to a storage tank.

 Then, a condensed extract, for example, 9.0 kg, is removed from the storage container and mixed in a separate container with 3.0 kg of the production complex of homeopathic dilutions, which can be prepared from matrix tinctures of euphrasia (medical specimen) or gelzemium (evergreen gelzemium) or tsimitsifugi (black cohosh) or their mixtures in various combinations while maintaining the overall mass index and pre-prepared 48.0 kg of sugar syrup. The result was a finished syrup based on blueberry extract with homeopathic supplements.

 The obtained blueberry extract with homeopathic supplements is an intermediate product and can be used in the production not only for the preparation of syrups, but also tinctures, tablets, capsules or other dosage forms.

As a result, a syrup was obtained, 100.0 g of which contained:
Eyebright D12, D30, D200 - 1.66 g
Evergreen helsemium D10, D30, D200 - 1.66 g
Black cohosh racemose D10, D30, D200 - 1.66 g
Blueberry Fruit Extract - 10.0 g
Sugar (GOST 22-78) - 58.00 g
Purified water (FS 42-2619-97) - the rest
In the same way, syrups were obtained, in 100.0 g of which the content of homeopathic supplements (dilution) differed in content and quantitative composition (see tables 1 and 2).

Dilution Example
Prepared substances were used as matrix tinctures. The dilutions used to prepare this preparation were obtained according to method 3a (OFS 42-2799-96).

 D1 dilution was obtained by diluting 3.0 g of matrix tincture in 7.0 g of an aqueous-alcoholic solution. D2 dilution was obtained by diluting 1.0 g of D1 in 9.0 g of an aqueous-alcoholic solution. Subsequent decimal dilutions are made from 1.0 g of the previous decimal dilution and 9.0 g of an aqueous-alcoholic solution. So to obtain a dilution of D10, produce 9 serial dilutions of D1, to obtain a dilution of D12, produce 11 serial dilutions of D1, etc. Thus, in the case of the preparation of a syrup with one or two or three homeopathic additives, their total content did not exceed the stated limit (see examples A, B, C, D).

Testing of the claimed funds
The inventive tool in the above formulations has been tested on 30 patients. Evaluation of the effectiveness and safety of the action of the claimed funds was carried out on the basis of dynamic clinical observation, laboratory and functional research methods. The duration of therapy was 8 weeks. The dynamics of subjective sensations was analyzed weekly: visual acuity, sensitivity to bright light, working capacity, fatigue, headaches and a number of other factors.

 In addition to these indicators, a number of objective indicators were recorded, such as visual acuity, clinical and biochemical blood tests, and blood pressure. It was found that these indicators as a result of the application of the claimed funds were restored. The data obtained were recorded in an individual patient observation card.

 As a result, it was found that before the start of treatment, all patients subjectively noted a decrease in visual acuity, and after undergoing treatment, the effect of using the drug was to improve visual acuity. At the same time, the well-being of the patients improved, working capacity was restored, the headache decreased and passed. It was found that the claimed tool is well tolerated by patients. In the course of therapy, no adverse side effects were noted. The results of the dynamics of subjective clinical factors in the studied group of patients are presented in table 3.

The results of clinical trials of the claimed drug made it possible to establish its high efficiency, which was manifested in almost all patients in improving visual functions, as well as in the activation of the whole organism, which consists in increasing recovery and regenerative functions. So in almost all patients after the course, the working capacity increased, the headache passed, the general fatigue of the body decreased. A positive fact is that treating patients with a drug containing at least one homeopathic supplement gives a higher positive result compared to known ones. At the same time, the effectiveness indicator of the claimed drug practically does not change with a change in the dosage form (tinctures, tablets, capsules, etc.)
Thus, this confirms that the claimed tool really has a wide spectrum of action, which is manifested in the improvement of visual functions and a high degree of restorative, tonic and regenerative action. In addition, it is safe and therefore can be widely used for the treatment of patients suffering from a decrease in visual acuity associated with general overstrain caused by a uniform fixed position (working with a computer, driving a car, etc.), as well as with visual disorders, accompanying vertebrobasilar symptoms (osteochondrosis of the cervicothoracic spine) and in other cases.

Claims (6)

1. The tool has a restorative, tonic and regenerative effect, based on blueberries with auxiliary additives, characterized in that it additionally contains at least one homeopathic supplement selected from the series: ocupus officinalis, evergreen gelsemium, black cohosh racemose, or a mixture thereof, with the following content of components in 100.0 g of the finished product, g:
Blueberries - 7.5 - 10.0
Homeopathic Supplements - 4.0 - 5.0
Auxiliary additives - Else
2. The tool according to p. 1, characterized in that it contains a mixture of homeopathic supplements in equal proportions.  3. The tool according to p. 1 or 2, characterized in that it contains a medical specimen of the following dilution: D12, D30, D200.  4. The tool according to p. 1 or 2, characterized in that it contains evergreen gelsemium of the following dilution: D10, D30, D200.  5. The tool according to p. 1 or 2, characterized in that it contains black cohosh of the following dilution: D10, D30, D200.  6. The tool according to p. 1 or 2, characterized in that as auxiliary additives it contains sugar syrup.  7. The tool according to p. 1, characterized in that as auxiliary additives it contains formative fillers.

Images