RU2015137610A - Способы лечения и профилактики лекарственной резистентности злокачественных опухолей - Google Patents
Способы лечения и профилактики лекарственной резистентности злокачественных опухолей Download PDFInfo
- Publication number
- RU2015137610A RU2015137610A RU2015137610A RU2015137610A RU2015137610A RU 2015137610 A RU2015137610 A RU 2015137610A RU 2015137610 A RU2015137610 A RU 2015137610A RU 2015137610 A RU2015137610 A RU 2015137610A RU 2015137610 A RU2015137610 A RU 2015137610A
- Authority
- RU
- Russia
- Prior art keywords
- antagonist
- individual
- effective amount
- egfr
- egfr antagonist
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (21)
1. Способ лечения злокачественной опухоли у индивидуума, включающий одновременное введение индивидууму (а) антагониста сигнализации FGFR и (b) антагониста EGFR.
2. Способ по п. 1, в котором соответствующие количества антагониста сигнализации FGFR и антагониста EGFR эффективны для увеличения периода чувствительности злокачественной опухоли и/или задержки развития резистентности злокачественной опухоли к антагонисту EGFR.
3. Способ по п. 1, в котором соответствующие количества антагониста сигнализации FGFR и антагониста EGFR эффективны для повышения чувствительности злокачественной опухоли и/или восстановления чувствительности к антагонисту EGFR.
4. Способ воздействия на злокачественную клетку, в котором злокачественная клетка опухоли устойчива к воздействию антагонистом EGFR у индивидуума, включающий введение индивидууму эффективного количества антагониста сигнализации FGFR и эффективного количества антагониста EGFR.
5. Способ лечения резистентной к антагонисту EGFR злокачественной опухоли у индивидуума, включающий введение индивидууму эффективного количества антагониста сигнализации FGFR и эффективного количества антагониста EGFR.
6. Способ повышения чувствительности и/или восстановления чувствительности к антагонисту EGFR, включающий введение индивидууму эффективного количества антагониста сигнализации FGFR и эффективного количества антагониста EGFR.
7. Способ повышения эффективности лечения злокачественной опухоли, включающий антагонист EGFR у индивидуума, способ включает одновременное введение индивидууму (а) эффективного количества антагониста сигнализации FGFR и (b) эффективного количества антагониста EGFR.
8. Способ задержки и/или профилактики развития резистентной к антагонисту EGFR злокачественной опухоли у индивидуума, включающий одновременное введение индивидууму (а) эффективного количества антагониста сигнализации FGFR и (b) эффективного количества антагониста EGFR.
9. Способ лечения индивидуума со злокачественной опухолью, которая характеризуется повышенной вероятностью развития резистентности к антагонисту EGFR, включающий одновременное введение индивидууму (а) эффективного количества антагониста сигнализации FGFR и (b) эффективного количества антагониста EGFR.
10. Способ повышения чувствительности к антагонисту EGFR у индивидуума со злокачественной опухолью, включающий одновременное введение индивидууму (а) эффективного количества антагониста сигнализации FGFR и (b) эффективного количества антагониста EGFR.
11. Способ продления периода чувствительности к антагонисту EGFR у индивидуума со злокачественной опухолью, включающий одновременное введение индивидууму (а) эффективного количества антагониста сигнализации FGFR и (b) эффективного количества антагониста EGFR.
12. Способ увеличения продолжительности ответа на антагонист EGFR у индивидуума со злокачественной опухолью, включающий одновременное введение индивидууму (а) эффективного количества антагониста сигнализации FGFR и (b) эффективного количества антагониста EGFR.
13. Способ по любому из пп. 1-12, в котором злокачественная опухоль представляет собой рак легких (например, немелкоклеточный рак легких (NSCLC)).
14. Способ по любому из пп. 1-12, в котором злокачественная опухоль претерпела эпителиально-мезенхимальный переход.
15. Способ по любому из пп. 1-12, в котором антагонист сигнализации FGFR представляет собой антитело-ингибитор, низкомолекулярный ингибитор, связующий полипептид-ингибитор и/или полинуклеотид-антагонист.
16. Способ по любому из пп. 1-12, в котором антагонист сигнализации FGFR представляет собой антагонист сигнализации FGFR1.
17. Способ по любому из пп. 1-12, в котором антагонист сигнализации FGFR1 связывается с одним или несколькими из FGFR1b, FGFR1c, FGF1, FGF2, FGF3, FGF4, FGF5, FGF6 и FGF10.
18. Способ по п. 15, в котором антагонист сигнализации FGFR представляет собой связующий полипептид-ингибитор и связующий полипептид-ингибитор содержит связанную с Fc FGFR область внеклеточного домена.
19. Способ по п. 15, в котором антагонист сигнализации FGFR представляет собой малую молекулу и малая молекула представляет собой N-[2-[[4-(диэтиламино)бутил]амино]-6-(3,5-диметоксифенил)пиридо-[2,3-(3]пиримидин-7-ил]-N'-(1,1-димитилэтил)мочевину или ее фармацевтически приемлемую соль.
20. Способ по любому из пп. 1-12, 18 и 19, в котором антагонист EGFR представляет собой N-(3-этинилфенил)-6,7-бис(2-метоксиэтокси)-4-хиназолинамин и/или его фармацевтически приемлемую соль.
21. Способ по любому из пп. 1-12, 18 и 19, в котором антагонист EGFR представляет собой N-(3-хлор-4-фторфенил)-7-метокси-6-(3-морфолин-4-илпропокси)хиназолин-4-амин или его фармацевтически приемлемую соль.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361773720P | 2013-03-06 | 2013-03-06 | |
| US61/773,720 | 2013-03-06 | ||
| PCT/US2014/021120 WO2014138364A2 (en) | 2013-03-06 | 2014-03-06 | Methods of treating and preventing cancer drug resistance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015137610A true RU2015137610A (ru) | 2017-04-10 |
| RU2015137610A3 RU2015137610A3 (ru) | 2018-03-13 |
Family
ID=50288361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015137610A RU2015137610A (ru) | 2013-03-06 | 2014-03-06 | Способы лечения и профилактики лекарственной резистентности злокачественных опухолей |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9925240B2 (ru) |
| EP (1) | EP2964260A2 (ru) |
| JP (1) | JP2016510751A (ru) |
| KR (1) | KR20150123250A (ru) |
| CN (1) | CN105246511A (ru) |
| BR (1) | BR112015021423A2 (ru) |
| CA (1) | CA2902263A1 (ru) |
| HK (1) | HK1213180A1 (ru) |
| MX (1) | MX2015011428A (ru) |
| RU (1) | RU2015137610A (ru) |
| WO (1) | WO2014138364A2 (ru) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201536293A (zh) | 2013-07-18 | 2015-10-01 | Taiho Pharmaceutical Co Ltd | 對ｆｇｆｒ抑制劑具耐受性之癌的治療藥 |
| KR101974254B1 (ko) | 2013-07-18 | 2019-04-30 | 다이호야쿠힌고교 가부시키가이샤 | Fgfr 저해제의 간헐 투여용 항종양제 |
| WO2016055916A1 (en) * | 2014-10-06 | 2016-04-14 | Novartis Ag | Therapeutic combination for the treatment of cancer |
| WO2016112302A1 (en) * | 2015-01-09 | 2016-07-14 | Metastat, Inc. | Method of predicting sensitivity of tumor cell growth to combination therapy of fgfr inhibitor |
| EP3279202B1 (en) | 2015-03-31 | 2020-06-24 | Taiho Pharmaceutical Co., Ltd. | Crystal of 3,5-disubstituted benzene alkynyl compound |
| FR3039401B1 (fr) * | 2015-07-31 | 2018-07-13 | Les Laboratoires Servier | Nouvelle association entre le 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione et un inhibiteur de la tyr kinase du egfr |
| AU2016366521A1 (en) * | 2015-12-11 | 2018-06-21 | Regeneron Pharmaceuticals, Inc. | Methods for reducing or preventing growth of tumors resistant to EGFR and/or ErbB3 blockade |
| US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
| KR20240014585A (ko) | 2016-03-04 | 2024-02-01 | 다이호야쿠힌고교 가부시키가이샤 | 악성 종양 치료용 제제 및 조성물 |
| CN110536969A (zh) * | 2017-04-24 | 2019-12-03 | 豪夫迈·罗氏有限公司 | 跨膜或近膜域中的erbb2/her2突变 |
| WO2019012174A1 (es) | 2017-07-13 | 2019-01-17 | Fundación De Investigación Hospital 12 De Octubre | pEGFR Y FGFR1 Y/O FGFR4 PARA USO EN LA PREDICCIÓN DE LA RESPUESTA DE LOS PACIENTES A UN TRATAMIENTO DEL CÁNCER DE PULMÓN Y MÉTODO Y KIT BASADOS EN DICHO USO |
| PT3769765T (pt) | 2018-03-19 | 2024-05-13 | Taiho Pharmaceutical Co Ltd | Composição farmacêutica incluindo alquil sulfato de sódio |
| WO2020080656A1 (ko) * | 2018-10-15 | 2020-04-23 | 국립암센터 | Fgf2 또는 api5 유래 펩타이드 및 그의 용도 |
| EP3898615A1 (en) | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer |
| JP2022515198A (ja) | 2018-12-19 | 2022-02-17 | アレイ バイオファーマ インコーポレイテッド | ＦＧＦＲチロシンキナーゼの阻害剤としての置換ピラゾロ［１，５－ａ］ピリジン化合物 |
| KR102210227B1 (ko) * | 2019-08-09 | 2021-01-29 | 국립암센터 | Api5 및 fgf2의 결합 저해 물질 스크리닝 방법 |
Family Cites Families (173)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US555676A (en) | 1896-03-03 | Penholder | ||
| CU22545A1 (es) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| WO1984003506A1 (en) | 1983-03-08 | 1984-09-13 | Commw Serum Lab Commission | Antigenically active amino acid sequences |
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| EP0138854B1 (en) | 1983-03-08 | 1992-11-04 | Chiron Mimotopes Pty. Ltd. | Antigenically active amino acid sequences |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| DE3588239T3 (de) | 1985-03-30 | 2007-03-08 | Kauffman, Stuart A., Santa Fe | Verfahren zum Erhalten von DNS, RNS, Peptiden, Polypeptiden oder Proteinen durch DMS-Rekombinant-Verfahren |
| NZ215865A (en) | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US5763192A (en) | 1986-11-20 | 1998-06-09 | Ixsys, Incorporated | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
| US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
| US5770701A (en) | 1987-10-30 | 1998-06-23 | American Cyanamid Company | Process for preparing targeted forms of methyltrithio antitumor agents |
| US5266684A (en) | 1988-05-02 | 1993-11-30 | The Reagents Of The University Of California | Peptide mixtures |
| US5571689A (en) | 1988-06-16 | 1996-11-05 | Washington University | Method of N-acylating peptide and proteins with diheteroatom substituted analogs of myristic acid |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| KR0184860B1 (ko) | 1988-11-11 | 1999-04-01 | 메디칼 리써어치 카운실 | 단일영역 리간드와 이를 포함하는 수용체 및 이들의 제조방법과 이용(법) |
| US5288855A (en) | 1989-01-23 | 1994-02-22 | Farmitalia Carlo Erba | Extracellular form of the human fibroblast growth factor receptor |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| EP0491007B1 (en) | 1989-09-08 | 1996-03-13 | The Johns Hopkins University | Structural alterations of the egf receptor gene in human gliomas |
| CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| WO1992000999A1 (en) | 1990-07-06 | 1992-01-23 | Rhone-Poulenc Rorer International (Holdings) Inc. | Fibroblast growth factor receptors |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5770434A (en) | 1990-09-28 | 1998-06-23 | Ixsys Incorporated | Soluble peptides having constrained, secondary conformation in solution and method of making same |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| ES2113940T3 (es) | 1990-12-03 | 1998-05-16 | Genentech Inc | Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas. |
| US5229501A (en) | 1991-01-11 | 1993-07-20 | Chiron Corporation | Expression and use of human fibroblast growth factor receptor |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| EP0940468A1 (en) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| AU675929B2 (en) | 1992-02-06 | 1997-02-27 | Curis, Inc. | Biosynthetic binding protein for cancer marker |
| PT752248E (pt) | 1992-11-13 | 2001-01-31 | Idec Pharma Corp | Aplicacao terapeutica de anticorpos quimericos e marcados radioactivamente contra antigenios de diferenciacao restrita de linfocitos b humanos para o tratamento do linfoma de celulas b |
| US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
| AU6446194A (en) | 1993-03-17 | 1994-10-11 | Whittier Institute For Diabetes And Endocrinology, The | Monoclonal antibodies specific for fibroblast growth factor receptors, immunotoxins, and use thereof |
| AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| DE69428764T2 (de) | 1993-12-24 | 2002-06-20 | Merck Patent Gmbh | Immunokonjugate |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| US5654307A (en) | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| DE69521789T2 (de) | 1994-02-01 | 2002-04-25 | The United States Of Amerika Represented By The Secretary, Department Of Health And Human | Fusionierte proteine die antikörper-teile und nicht-antikörper-teile enthalten |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| EP0831880A4 (en) | 1995-06-07 | 2004-12-01 | Imclone Systems Inc | ANTIBODIES AND FRAGMENTS OF ANTIBODIES INHIBITING TUMOR GROWTH |
| US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| IL122855A (en) | 1995-07-06 | 2004-08-31 | Novartis Ag | History of N-Phenyl (Alkyl) - 7H-Pyrolo [-3,2d] Pyrimidine - 4 Amine, their preparation and pharmaceutical preparations containing them |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| ES2174250T5 (es) | 1996-04-12 | 2010-04-21 | Warner-Lambert Company Llc | Inhibidores irreversibles de tirosina quinasas. |
| EP0912559B1 (en) | 1996-07-13 | 2002-11-06 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
| ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
| US6002008A (en) | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| PT980244E (pt) | 1997-05-06 | 2003-10-31 | Wyeth Corp | Utilizacao de compostos de quinazolina para o tratamento da doenca policistica renal |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| CA2293829C (en) | 1997-06-24 | 2011-06-14 | Genentech, Inc. | Methods and compositions for galactosylated glycoproteins |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| ATE419009T1 (de) | 1997-10-31 | 2009-01-15 | Genentech Inc | Methoden und zusammensetzungen bestehend aus glykoprotein-glykoformen |
| JP2001522802A (ja) | 1997-11-06 | 2001-11-20 | アメリカン・サイアナミド・カンパニー | 大腸ポリープを治療するためのチロシンキナーゼインヒビターとしてのキナゾリン誘導体の使用 |
| US6610833B1 (en) | 1997-11-24 | 2003-08-26 | The Institute For Human Genetics And Biochemistry | Monoclonal human natural antibodies |
| PT1034298E (pt) | 1997-12-05 | 2012-02-03 | Scripps Research Inst | Humanização de anticorpo murino |
| RS49779B (sr) | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| DK1068241T3 (da) | 1998-04-02 | 2008-02-04 | Genentech Inc | Antistofvarianter og fragmenter deraf |
| DK2180007T4 (da) | 1998-04-20 | 2017-11-27 | Roche Glycart Ag | Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet |
| US6335155B1 (en) | 1998-06-26 | 2002-01-01 | Sunesis Pharmaceuticals, Inc. | Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules |
| US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| ES2188254T3 (es) | 1998-11-19 | 2003-06-16 | Warner Lambert Co | N-(4-(3-chloro-4-fluoro-fenilamino)-7-(3-morfolin-4-il-propoxi)-quin azolin-6-il)-acrilamada, un inhibidor irreversible de tirosina quinasas. |
| JP2002533726A (ja) | 1998-12-28 | 2002-10-08 | サネシス ファーマシューティカルス インコーポレイテッド | 結合のための小有機分子リガンドの同定 |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| MX353234B (es) | 1999-01-15 | 2018-01-08 | Genentech Inc | Variantes de polipeptidos con función efectora alterada. |
| AU3224700A (en) | 1999-02-08 | 2000-08-25 | Chiron Corporation | Fibroblast growth factor receptor-immunoglobulin fusion |
| US6297238B1 (en) | 1999-04-06 | 2001-10-02 | Basf Aktiengesellschaft | Therapeutic agents |
| EP2270148A3 (en) | 1999-04-09 | 2011-06-08 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| WO2001029246A1 (fr) | 1999-10-19 | 2001-04-26 | Kyowa Hakko Kogyo Co., Ltd. | Procede de production d'un polypeptide |
| SI1244647T1 (sl) | 1999-11-05 | 2006-10-31 | Astrazeneca Ab | Kinazolinski derivati kot VEGF inhibitorji |
| CA2393869A1 (en) | 1999-12-15 | 2001-06-21 | Genetech,Inc. | Shotgun scanning, a combinatorial method for mapping functional protein epitopes |
| ATE299881T1 (de) | 1999-12-21 | 2005-08-15 | Sugen Inc | 4-substituierte 7-aza-indolin-2-one und ihre anwendung als protein kinase inhibitoren |
| PT1242438E (pt) | 1999-12-29 | 2007-02-28 | Immunogen Inc | Agentes citotóxicos compreendendo dixorrubicinas e daunorrubicinas modificadas e seu uso terapêutico |
| IL151853A0 (en) | 2000-04-11 | 2003-04-10 | Genentech Inc | Multivalent antibodies and uses therefor |
| JP2001302699A (ja) | 2000-04-17 | 2001-10-31 | Nichirei Corp | ヒトｋｇｆｒに対する抗体 |
| FR2812420A1 (fr) | 2000-07-28 | 2002-02-01 | Baptiste Vermes | Procede automatique de mise en forme de pages dynamiques sur un site internet |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| JP4290423B2 (ja) | 2000-10-06 | 2009-07-08 | 協和発酵キリン株式会社 | 抗体組成物を生産する細胞 |
| US7064191B2 (en) | 2000-10-06 | 2006-06-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying antibody |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| CA2430013C (en) | 2000-11-30 | 2011-11-22 | Medarex, Inc. | Transgenic transchromosomal rodents for making human antibodies |
| AU2002329540A1 (en) | 2001-06-20 | 2003-01-02 | Morphosys Ag | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
| NZ581474A (en) | 2001-08-03 | 2011-04-29 | Glycart Biotechnology Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| GB0119249D0 (en) | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
| HUP0600342A3 (en) | 2001-10-25 | 2011-03-28 | Genentech Inc | Glycoprotein compositions |
| US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| US20030199525A1 (en) | 2002-03-21 | 2003-10-23 | Hirst Gavin C. | Kinase inhibitors |
| MXPA04009924A (es) | 2002-04-09 | 2005-07-01 | Kyowa Hakko Kogyo Kk | Celulas de genoma modificado. |
| AU2003236015A1 (en) | 2002-04-09 | 2003-10-20 | Kyowa Hakko Kirin Co., Ltd. | Process for producing antibody composition |
| CA2481658A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Method of enhancing of binding activity of antibody composition to fcy receptor iiia |
| WO2003084569A1 (fr) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Medicament contenant une composition anticorps |
| EP1502603A4 (en) | 2002-04-09 | 2006-12-13 | Kyowa Hakko Kogyo Kk | AN ANTIBODY COMPOSITION CONTAINING MEDICAMENT FOR PATIENTS WITH Fc gamma RIIIa POLYMORPHISM |
| DE60336548D1 (de) | 2002-04-09 | 2011-05-12 | Kyowa Hakko Kirin Co Ltd | Zelle mit erniedrigter oder deletierter aktivität eines am gdp-fucosetransport beteiligten proteins |
| NZ556507A (en) | 2002-06-03 | 2010-03-26 | Genentech Inc | Synthetic antibody phage libraries |
| US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| PL212899B1 (pl) | 2002-12-16 | 2012-12-31 | Genentech Inc | Humanizowane przeciwcialo, kompozycja zawierajaca to przeciwcialo, wyrób fabryczny, przeciwcialo lub jego fragment do zastosowania w sposobie indukowania apoptozy, izolowany kwas nukleinowy, wektor ekspresji, komórka gospodarza, sposób wytwarzania przeciwciala lub jego fragmentu, plynny preparat i zastosowanie przeciwciala do wytwarzania leku |
| AU2004205631A1 (en) | 2003-01-16 | 2004-08-05 | Genentech, Inc. | Synthetic antibody phage libraries |
| US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| US20050106667A1 (en) | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
| EP1688439A4 (en) | 2003-10-08 | 2007-12-19 | Kyowa Hakko Kogyo Kk | HYBRID PROTEIN COMPOSITION |
| AU2004280065A1 (en) | 2003-10-09 | 2005-04-21 | Kyowa Hakko Kirin Co., Ltd. | Process for producing antibody composition by using RNA inhibiting the function of alpha1,6-fucosyltransferase |
| JP4686465B2 (ja) | 2003-10-16 | 2011-05-25 | イムクローン・リミテッド・ライアビリティ・カンパニー | 繊維芽細胞増殖因子レセプター−１阻害物質及びその治療方法 |
| PT2380910E (pt) | 2003-11-05 | 2015-11-26 | Roche Glycart Ag | Moléculas de ligação ao antigénio com uma maior afinidade de ligação ao recetor de fc e uma melhor função efetora |
| EP2478912B1 (en) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy |
| WO2005053742A1 (ja) | 2003-12-04 | 2005-06-16 | Kyowa Hakko Kogyo Co., Ltd. | 抗体組成物を含有する医薬 |
| CA2550245A1 (en) | 2003-12-19 | 2005-07-21 | Five Prime Therapeutics, Inc. | Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention |
| JP2007522243A (ja) | 2004-02-13 | 2007-08-09 | ボストン・バイオメデイカル・リサーチ・インステイテユート | Ｆｇｆシグナリングの阻害 |
| TW200530236A (en) | 2004-02-23 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Heteroaryl phenylurea |
| EP1740615B1 (en) | 2004-03-31 | 2014-11-05 | Genentech, Inc. | Humanized anti-tgf-beta antibodies |
| US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
| ES2403055T3 (es) | 2004-04-13 | 2013-05-13 | F. Hoffmann-La Roche Ag | Anticuerpos anti-P-selectina |
| GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| US7521541B2 (en) | 2004-09-23 | 2009-04-21 | Genetech Inc. | Cysteine engineered antibodies and conjugates |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| AU2006272759B2 (en) | 2005-07-22 | 2012-01-12 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with FGFR fusion proteins |
| ES2577292T3 (es) | 2005-11-07 | 2016-07-14 | Genentech, Inc. | Polipéptidos de unión con secuencias hipervariables de VH/VL diversificadas y consenso |
| WO2007064919A2 (en) | 2005-12-02 | 2007-06-07 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| JP2009536527A (ja) | 2006-05-09 | 2009-10-15 | ジェネンテック・インコーポレーテッド | 最適化されたスキャフォールドを備えた結合ポリペプチド |
| US8101721B2 (en) | 2006-06-15 | 2012-01-24 | Fibron Ltd. | Antibodies blocking fibroblast growth factor receptor activation and methods of use thereof |
| EP2059533B1 (en) | 2006-08-30 | 2012-11-14 | Genentech, Inc. | Multispecific antibodies |
| EP2433966A1 (en) | 2006-11-03 | 2012-03-28 | U3 Pharma GmbH | FGFR4 antibodies |
| AR063975A1 (es) | 2006-11-28 | 2009-03-04 | Centelion | Fusiones fc con receptor para fgf soluble modificadas con actividad biologica mejorada |
| US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
| US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
| US8377636B2 (en) * | 2007-04-13 | 2013-02-19 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to kinase inhibitors |
| CN100592373C (zh) | 2007-05-25 | 2010-02-24 | 群康科技(深圳)有限公司 | 液晶显示面板驱动装置及其驱动方法 |
| US8481497B2 (en) | 2007-05-29 | 2013-07-09 | Sapporo Medical University | Therapeutic agent for cancer, and method for treatment of cancer |
| US20110053932A1 (en) | 2007-06-21 | 2011-03-03 | Irm Llc | Protein Kinase Inhibitors and Methods for Using Thereof |
| SI2235064T1 (sl) | 2008-01-07 | 2016-04-29 | Amgen Inc. | Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov |
| EP2966076A1 (en) | 2008-03-19 | 2016-01-13 | ChemBridge Corporation | Novel tyrosine kinase inhibitors |
| EP2288717B1 (en) | 2008-05-29 | 2017-07-05 | Galaxy Biotech, LLC | Monoclonal antibodies to basic fibroblast growth factor |
| EP2313435A4 (en) | 2008-07-01 | 2012-08-08 | Aveo Pharmaceuticals Inc | FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) BINDING PROTEINS |
| JP5787757B2 (ja) | 2008-08-04 | 2015-09-30 | ファイブ プライム セラピューティックス インコーポレイテッド | Ｆｇｆｒ細胞外ドメイン酸性領域突然変異タンパク質 |
| AR073770A1 (es) | 2008-10-20 | 2010-12-01 | Imclone Llc | Anticuerpo aislado que se enlaza especificamente con, e induce la degradacion del receptor-3 del factor de crecimiento del fibroblasto humano (fgfr-3), fragmento de enlace fgfr-3 humano del mismo, composicion farmaceutica y producto que lo comprenden |
| JP5627591B2 (ja) | 2008-11-07 | 2014-11-19 | ギャラクシー バイオテック， エルエルシー | 線維芽増殖因子受容体２に対するモノクローナル抗体 |
| HRP20221471T1 (hr) | 2009-03-25 | 2023-02-03 | Genentech, Inc. | Protutijela anti-fgfr3 i postupci za njihovu uporabu |
| WO2011035922A2 (en) | 2009-09-25 | 2011-03-31 | European Molecular Biology Laboratory (Embl) | Inhibitors of fgf2 phosphorylation and their use for treating angiogenesis-related diseases |
| JP2013509444A (ja) | 2009-10-30 | 2013-03-14 | アリアド・ファーマシューティカルズ・インコーポレイテッド | がんの治療方法及び治療用組成物 |
| LT2498799T (lt) | 2009-11-13 | 2016-11-10 | Five Prime Therapeutics, Inc. | Fgfr1 ekstraląstelinio domeno baltymų panaudojimas gydymui vėžio su nuo ligando priklausančiomis, aktyvuojančiomis fgfr2 mutacijomis |
| AU2010326024A1 (en) | 2009-12-02 | 2012-07-05 | Amgen Inc. | Binding proteins that bind to human FGFR1c, human beta-Klotho and both human FGFR1c and human beta-Klotho |
| EP2535410A4 (en) | 2010-02-12 | 2014-08-13 | Ribomic Inc | APTAMER FOR FGF2 AND USE THEREOF |
| SG185832A1 (en) | 2011-05-10 | 2012-12-28 | Agency Science Tech & Res | Fgfr1 antibodies and treatment of cancer |
| EP2686344A1 (en) | 2011-03-16 | 2014-01-22 | Protaffin Biotechnologie AG | Fgfr1-based antagonists with improved glycosaminoglycan affinity and methods of using same |
-
2014
- 2014-03-06 RU RU2015137610A patent/RU2015137610A/ru not_active Application Discontinuation
- 2014-03-06 MX MX2015011428A patent/MX2015011428A/es unknown
- 2014-03-06 WO PCT/US2014/021120 patent/WO2014138364A2/en active Application Filing
- 2014-03-06 JP JP2015561643A patent/JP2016510751A/ja active Pending
- 2014-03-06 KR KR1020157024167A patent/KR20150123250A/ko not_active Application Discontinuation
- 2014-03-06 BR BR112015021423A patent/BR112015021423A2/pt not_active IP Right Cessation
- 2014-03-06 US US15/029,960 patent/US9925240B2/en not_active Expired - Fee Related
- 2014-03-06 CN CN201480012066.0A patent/CN105246511A/zh active Pending
- 2014-03-06 EP EP14710782.5A patent/EP2964260A2/en not_active Withdrawn
- 2014-03-06 CA CA2902263A patent/CA2902263A1/en not_active Abandoned
-
2016
- 2016-02-01 HK HK16101114.1A patent/HK1213180A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2015137610A3 (ru) | 2018-03-13 |
| WO2014138364A3 (en) | 2014-10-30 |
| WO2014138364A2 (en) | 2014-09-12 |
| US9925240B2 (en) | 2018-03-27 |
| JP2016510751A (ja) | 2016-04-11 |
| HK1213180A1 (zh) | 2016-06-30 |
| MX2015011428A (es) | 2016-02-03 |
| CN105246511A (zh) | 2016-01-13 |
| KR20150123250A (ko) | 2015-11-03 |
| US20160250287A1 (en) | 2016-09-01 |
| EP2964260A2 (en) | 2016-01-13 |
| BR112015021423A2 (pt) | 2017-07-18 |
| CA2902263A1 (en) | 2014-09-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015137610A (ru) | Способы лечения и профилактики лекарственной резистентности злокачественных опухолей | |
| RU2015143437A (ru) | Способы лечения рака и предотвращения устойчивости к лекарственным препаратам для лечения рака | |
| HRP20210977T1 (hr) | Ciljano inhibiranje tgf beta | |
| ATE504299T1 (de) | Verfahren zur behandlung von gefitinib- resistentem krebs | |
| EA202091514A1 (ru) | СПОСОБЫ ЛЕЧЕНИЯ РАКА ТОЛСТОЙ КИШКИ С ИСПОЛЬЗОВАНИЕМ КОМБИНИРОВАННОЙ ТЕРАПИИ НАНОЧАСТИЦАМИ С ИНГИБИТОРОМ mTOR | |
| RU2019106663A (ru) | Комбинированная терапия рака | |
| EA201691487A1 (ru) | Антитела человека к pd-l1 | |
| RU2019102009A (ru) | Специфические антитела к pd-l1 и способы их применения | |
| HRP20191145T1 (hr) | Postupak predviđanja ishoda liječenja s afliberceptom kod pacijenta za kojeg se sumnja da ima rak | |
| RU2014138474A (ru) | Новые модуляторы и способы применения | |
| EA201691482A1 (ru) | Человеческие антитела к pd-1 | |
| RU2017136709A (ru) | Комбинированное лечение немелкоклеточного рака легкого с выявленной мутацией в egfr | |
| WO2015200806A3 (en) | Humanized anti-tau antibodies | |
| JP2014530226A5 (ru) | ||
| EA200970953A1 (ru) | СПЕЦИФИЧНЫЕ ИНГИБИТОРЫ PDGFRβ | |
| RU2012149227A (ru) | Биологические материалы, относящиеся к her3 | |
| RU2019143403A (ru) | Комбинированные терапии для лечения онкологических заболеваний | |
| RU2014110228A (ru) | Диагностические маркеры | |
| JP2018536682A5 (ru) | ||
| EA200800014A1 (ru) | Аминохинолиновые и аминохиназолиновые модуляторы киназы | |
| JP2014534237A5 (ru) | ||
| RU2013104301A (ru) | Способ идентификации пациента с повышенной вероятностью ответа на противораковую терапию | |
| SI2838998T1 (en) | EGFR AND ROS1 PRI CRAK | |
| EA201500373A1 (ru) | Маситиниб или его соль для лечения рака, фармацевтическая композиция, лекарственное средство и набор | |
| NZ626742A (en) | Co-use of a clusterin inhibitor with an egfr inhibitor to treat cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20180730 |