RU2015118135A - Содержащие заместители бензольные соединения - Google Patents
Содержащие заместители бензольные соединения Download PDFInfo
- Publication number
- RU2015118135A RU2015118135A RU2015118135A RU2015118135A RU2015118135A RU 2015118135 A RU2015118135 A RU 2015118135A RU 2015118135 A RU2015118135 A RU 2015118135A RU 2015118135 A RU2015118135 A RU 2015118135A RU 2015118135 A RU2015118135 A RU 2015118135A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- compound according
- pharmaceutically acceptable
- cancer
- ezh2
- Prior art date
Links
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical class C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 34
- 238000000034 method Methods 0.000 claims abstract 12
- 206010028980 Neoplasm Diseases 0.000 claims abstract 10
- 201000011510 cancer Diseases 0.000 claims abstract 8
- 150000003839 salts Chemical class 0.000 claims abstract 8
- 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 claims abstract 7
- 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 claims abstract 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 7
- 208000035475 disorder Diseases 0.000 claims abstract 7
- 230000001404 mediated effect Effects 0.000 claims abstract 7
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims abstract 4
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims abstract 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims abstract 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims abstract 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims abstract 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims abstract 2
- 206010025323 Lymphomas Diseases 0.000 claims abstract 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims abstract 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims abstract 2
- 208000008938 Rhabdoid tumor Diseases 0.000 claims abstract 2
- 230000007812 deficiency Effects 0.000 claims abstract 2
- 239000003937 drug carrier Substances 0.000 claims abstract 2
- 201000003444 follicular lymphoma Diseases 0.000 claims abstract 2
- 201000003445 large cell neuroendocrine carcinoma Diseases 0.000 claims abstract 2
- 208000032839 leukemia Diseases 0.000 claims abstract 2
- 201000001441 melanoma Diseases 0.000 claims abstract 2
- 101000835860 Homo sapiens SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Proteins 0.000 claims 1
- 102100025746 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Human genes 0.000 claims 1
- 208000036676 acute undifferentiated leukemia Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000002075 main ingredient Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
1. Соединение, выбранное из группы, состоящей изи их фармацевтически приемлемых солей.2. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собойили его фармацевтически приемлемую соль.3. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой.4. Соединение по п. 1, отличающееся тем, что указанноесоединение представляет собойили его фармацевтически приемлемую соль.5. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой.6. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собойили его фармацевтически приемлемую соль.7. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой.8. Фармацевтическая композиция, содержащая соединение по любому из пп. 1-7 и фармацевтически приемлемый носитель.9. Способ лечения EZH2-опосредуемого нарушения, включающий введение нуждающемуся в этом субъекту терапевтически эффективного количества соединения по любому из пп. 1-7.10. Способ по п. 9, отличающийся тем, что EZH2-опосредуемое нарушение представляет собой рак.11. Способ по п. 10, отличающийся тем, что рак представляет собой лимфому, лейкоз или меланому.12. Способ по п. 10, отличающийся тем, что рак представляет собой диффузную крупноклеточную В-клеточную лимфому (ДКВЛ), неходжкинскую лимфому (НХЛ), фолликулярную лимфому, хронический миелогенный лейкоз (ХМЛ), острый миелоидный лейкоз, острый лимфоцитарный лейкоз, недифференцированный лейкоз или миелодиспластические синдромы (МДС).13. Способ по п. 10, отличающийся тем, что рак представляет собой злокачественную рабдоидную опухоль или опухоль с дефицитом INI1.14. Соединение по любому из пп. 1-7 для применения в способе лечения
Claims (16)
1. Соединение, выбранное из группы, состоящей из
и их фармацевтически приемлемых солей.
2. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой 
или его фармацевтически приемлемую соль.
3. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой 
.
4. Соединение по п. 1, отличающееся тем, что указанное
соединение представляет собой 
или его фармацевтически приемлемую соль.
5. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой 
.
6. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой 
или его фармацевтически приемлемую соль.
7. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой 
.
8. Фармацевтическая композиция, содержащая соединение по любому из пп. 1-7 и фармацевтически приемлемый носитель.
9. Способ лечения EZH2-опосредуемого нарушения, включающий введение нуждающемуся в этом субъекту терапевтически эффективного количества соединения по любому из пп. 1-7.
10. Способ по п. 9, отличающийся тем, что EZH2-опосредуемое нарушение представляет собой рак.
11. Способ по п. 10, отличающийся тем, что рак представляет собой лимфому, лейкоз или меланому.
12. Способ по п. 10, отличающийся тем, что рак представляет собой диффузную крупноклеточную В-клеточную лимфому (ДКВЛ), неходжкинскую лимфому (НХЛ), фолликулярную лимфому, хронический миелогенный лейкоз (ХМЛ), острый миелоидный лейкоз, острый лимфоцитарный лейкоз, недифференцированный лейкоз или миелодиспластические синдромы (МДС).
13. Способ по п. 10, отличающийся тем, что рак представляет собой злокачественную рабдоидную опухоль или опухоль с дефицитом INI1.
14. Соединение по любому из пп. 1-7 для применения в способе лечения EZH2-опосредуемого нарушения.
15. Применение соединения по любому из пп. 1-7 для изготовления лекарственного средства для лечения EZH2-опосредуемого нарушения.
16. Фармацевтическая композиция для лечения EZH2-опосредуемого нарушения, содержащая соединение по любому из пп. 1-7 в качестве основного ингредиента.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261714145P | 2012-10-15 | 2012-10-15 | |
| US201261714140P | 2012-10-15 | 2012-10-15 | |
| US61/714,140 | 2012-10-15 | ||
| US61/714,145 | 2012-10-15 | ||
| US201361780703P | 2013-03-13 | 2013-03-13 | |
| US61/780,703 | 2013-03-13 | ||
| US201361786277P | 2013-03-14 | 2013-03-14 | |
| US61/786,277 | 2013-03-14 | ||
| PCT/US2013/065126 WO2014062732A1 (en) | 2012-10-15 | 2013-10-15 | Substituted benzene compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015118135A true RU2015118135A (ru) | 2016-12-10 |
| RU2662436C2 RU2662436C2 (ru) | 2018-07-26 |
Family
ID=50475881
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015118135A RU2662436C2 (ru) | 2012-10-15 | 2013-10-15 | Содержащие заместители бензольные соединения |
| RU2015118145A RU2658919C2 (ru) | 2012-10-15 | 2013-10-15 | Замещенные бензольные соединения |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015118145A RU2658919C2 (ru) | 2012-10-15 | 2013-10-15 | Замещенные бензольные соединения |
Country Status (23)
| Country | Link |
|---|---|
| US (8) | US9006242B2 (ru) |
| EP (4) | EP3725314A1 (ru) |
| JP (4) | JP6461802B2 (ru) |
| KR (2) | KR102057365B1 (ru) |
| CN (3) | CN105102432B (ru) |
| AR (1) | AR093244A1 (ru) |
| AU (2) | AU2013331380B2 (ru) |
| BR (2) | BR112015008480A2 (ru) |
| CA (2) | CA2887562C (ru) |
| CL (2) | CL2015000944A1 (ru) |
| HK (2) | HK1213264A1 (ru) |
| IL (4) | IL238135B (ru) |
| MX (2) | MX353929B (ru) |
| MY (1) | MY180311A (ru) |
| NZ (2) | NZ706738A (ru) |
| PE (2) | PE20150886A1 (ru) |
| PH (2) | PH12015500800B1 (ru) |
| RU (2) | RU2662436C2 (ru) |
| SG (3) | SG11201502820YA (ru) |
| TW (2) | TWI588131B (ru) |
| UA (2) | UA115074C2 (ru) |
| WO (2) | WO2014062733A2 (ru) |
| ZA (2) | ZA201502526B (ru) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011160206A1 (en) | 2010-06-23 | 2011-12-29 | Morin Ryan D | Biomarkers for non-hodgkin lymphomas and uses thereof |
| US9175331B2 (en) * | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
| TWI598336B (zh) | 2011-04-13 | 2017-09-11 | 雅酶股份有限公司 | 經取代之苯化合物 |
| JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| WO2013075084A1 (en) | 2011-11-18 | 2013-05-23 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| JP5989805B2 (ja) | 2012-02-10 | 2016-09-07 | コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | メチル基変更酵素の調節物質、組成物及びその使用 |
| CN105102432B (zh) * | 2012-10-15 | 2019-01-04 | Epizyme股份有限公司 | 经取代的苯化合物 |
| AU2013371541B2 (en) | 2012-12-13 | 2016-10-13 | Glaxosmithkline Llc | Enhancer of Zeste Homolog 2 inhibitors |
| CA2894222A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | 1,4-pyridone bicyclic heteroaryl compounds |
| AU2013361060B2 (en) * | 2012-12-21 | 2018-04-19 | Epizyme, Inc. | 1,4-pyridone compounds |
| PE20151727A1 (es) | 2013-03-14 | 2015-12-17 | Boehringer Ingelheim Int | Acido 2-aza-biciclo[2.2.1]heptano-3-carboxilico (bencil-ciano-metil)-amidas sustituidas inhibidores de catepsina c |
| JO3773B1 (ar) | 2013-03-14 | 2021-01-31 | Janssen Pharmaceutica Nv | معدلات p2x7 |
| TWI627174B (zh) | 2013-03-14 | 2018-06-21 | 比利時商健生藥品公司 | Ｐ２ｘ７調控劑 |
| US9096596B2 (en) | 2013-03-14 | 2015-08-04 | Janssen Pharmaceutica Nv | P2X7 modulators |
| EP2970304B1 (en) | 2013-03-14 | 2018-08-15 | Janssen Pharmaceutica NV | P2x7 modulators |
| EP2970305B1 (en) | 2013-03-15 | 2017-02-22 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| US9556157B2 (en) | 2013-07-10 | 2017-01-31 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of zeste homolog 2 inhibitors |
| EP3022195A2 (en) | 2013-07-19 | 2016-05-25 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| US10150764B2 (en) | 2013-07-19 | 2018-12-11 | Epizyme, Inc. | Substituted benzene compounds |
| US9969716B2 (en) | 2013-08-15 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
| EP3057962B1 (en) | 2013-10-16 | 2023-10-18 | Epizyme, Inc. | Hydrochloride salt form for ezh2 inhibition |
| US20160303135A1 (en) | 2013-12-06 | 2016-10-20 | Epizyme, Inc. | Combination therapy for treating cancer |
| JP6779793B2 (ja) | 2014-06-17 | 2020-11-04 | エピザイム，インコーポレイティド | リンパ腫を治療するためのｅｚｈ２阻害剤 |
| EP3191487B1 (en) | 2014-09-12 | 2019-08-07 | Boehringer Ingelheim International GmbH | Spirocyclic inhibitors of cathepsin c |
| US10150766B2 (en) | 2014-09-12 | 2018-12-11 | Janssen Pharmaceutica Nv | P2X7 modulators |
| WO2016061507A1 (en) * | 2014-10-16 | 2016-04-21 | Epizyme, Inc. | Method for treating cancer |
| CN116650500A (zh) | 2014-11-17 | 2023-08-29 | Epizyme股份有限公司 | 治疗癌症的方法 |
| WO2016101956A2 (en) | 2014-12-23 | 2016-06-30 | University Of Copenhagen | Treatment of cancer by inhibiting ezh2 activity |
| MX2017013142A (es) | 2015-04-20 | 2019-03-28 | Epizyme Inc | Terapia combinada para tratar cáncer. |
| MX2017015938A (es) | 2015-06-10 | 2018-11-09 | Epizyme Inc | Inhibidores de ezh2 para el tratar linfomas. |
| CA2996412A1 (en) | 2015-08-24 | 2017-03-02 | Epizyme, Inc. | Method for treating cancer |
| TW201718598A (zh) | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ｅｚｈ２抑制劑 |
| US10577350B2 (en) | 2015-08-28 | 2020-03-03 | Constellation Pharmaceuticals, Inc. | Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide |
| WO2017132518A1 (en) | 2016-01-29 | 2017-08-03 | Epizyme, Inc. | Combination therapy for treating cancer |
| CA3018270A1 (en) * | 2016-04-22 | 2017-10-26 | Dana-Farber Cancer Institute, Inc. | Ezh2 inhibitors and uses thereof |
| AU2017273726B2 (en) | 2016-06-01 | 2023-10-19 | Epizyme, Inc. | Use of EZH2 inhibitors for treating cancer |
| JP2019521988A (ja) | 2016-06-17 | 2019-08-08 | エピザイム，インコーポレイティド | 癌を処置するためのｅｚｈ２阻害剤 |
| WO2018075598A1 (en) | 2016-10-19 | 2018-04-26 | Constellation Pharmaceuticals, Inc. | Synthesis of inhibitors of ezh2 |
| US20200262813A1 (en) * | 2016-11-11 | 2020-08-20 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 1,5,7-trisubstituted isoquinoline derivatives, preparation thereof, and use thereof in medicines |
| US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
| US11642346B2 (en) | 2017-03-31 | 2023-05-09 | Epizyme, Inc. | Combination therapy for treating cancer |
| CN110944628A (zh) | 2017-06-02 | 2020-03-31 | Epizyme股份有限公司 | 使用ezh2抑制剂治疗癌症 |
| EP3678663A4 (en) | 2017-09-05 | 2021-06-02 | Epizyme, Inc. | POLYTHERAPY FOR CANCER TREATMENT |
| CN112004816B (zh) | 2018-01-31 | 2024-01-05 | 米拉蒂医疗股份有限公司 | Prc2抑制剂 |
| WO2020011607A1 (en) | 2018-07-09 | 2020-01-16 | Fondation Asile Des Aveugles | Inhibition of prc2 subunits to treat eye disorders |
| EP3856178A1 (en) | 2018-09-28 | 2021-08-04 | Janssen Pharmaceutica NV | Monoacylglycerol lipase modulators |
| AU2019349962A1 (en) | 2018-09-28 | 2021-03-18 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
| WO2021035194A1 (en) | 2019-08-22 | 2021-02-25 | Juno Therapeutics, Inc. | Combination therapy of a t cell therapy and an enhancer of zeste homolog 2 (ezh2) inhibitor and related methods |
| US11839663B2 (en) | 2019-09-30 | 2023-12-12 | Janssen Pharmaceutica Nv | Radiolabelled MGL pet ligands |
| CN111303133A (zh) * | 2020-03-25 | 2020-06-19 | 清华大学 | 降解ezh2蛋白的小分子化合物 |
| CA3176946A1 (en) | 2020-03-26 | 2021-09-30 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| JPH0733729A (ja) | 1993-07-26 | 1995-02-03 | Kirin Brewery Co Ltd | Ｎ−シアノ−ｎ′−置換−アリールカルボキシイミダミド化合物の製造法 |
| RU2128644C1 (ru) | 1993-12-27 | 1999-04-10 | Эйсай Ко., Лтд. | Производные антраниловой кислоты или их фармакологически приемлемые соли, промежуточные продукты для их получения и лекарственный препарат на их основе |
| DE19516776A1 (de) | 1995-05-10 | 1996-11-14 | Boehringer Ingelheim Int | Chromatin-Regulatorgene |
| US5741819A (en) | 1995-06-07 | 1998-04-21 | 3-Dimensional Pharmaceuticals, Inc. | Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors |
| US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
| JP3906935B2 (ja) | 1995-12-18 | 2007-04-18 | 杏林製薬株式会社 | Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
| CN1332722A (zh) | 1998-09-30 | 2002-01-23 | 宝洁公司 | 2－取代的酮酰胺 |
| UA71587C2 (ru) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Translated By PlajАМИДЫ АНТРАНИЛОВОЙ КИСЛОТЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕЧЕБНЫХ СРЕДСТВ |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| KR100828982B1 (ko) | 2000-12-28 | 2008-05-14 | 시오노기세이야쿠가부시키가이샤 | 칸나비노이드 2형 수용체 친화 작용을 갖는 피리돈 유도체 |
| US20040102455A1 (en) | 2001-01-30 | 2004-05-27 | Burns Christopher John | Method of inhibiting kinases |
| US7700293B2 (en) | 2001-08-02 | 2010-04-20 | The Regents Of The University Of Michigan | Expression profile of prostate cancer |
| JP5082033B2 (ja) | 2001-12-21 | 2012-11-28 | エグゼリクシス パテント カンパニー エルエルシー | Ｌｘｒのモジュレーター |
| US20050101590A1 (en) | 2002-02-19 | 2005-05-12 | Kiyoshi Yasui | Antipruritics |
| WO2005018578A2 (en) | 2003-08-26 | 2005-03-03 | Aton Pharma, Inc. | Method of treating cancer with hdac inhibitors |
| TW200306155A (en) | 2002-03-19 | 2003-11-16 | Du Pont | Benzamides and advantageous compositions thereof for use as fungicides |
| BRPI0317740B8 (pt) | 2002-12-27 | 2021-05-25 | Sucampo Ag | uso do composto 13,14-diidro-15-ceto-16,16-diflúorprostaglandina e1 |
| WO2005014599A1 (en) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
| US7442685B2 (en) | 2003-06-13 | 2008-10-28 | The University Of North Carolina At Chapel Hill | DOT1 histone methyltransferases as a target for identifying therapeutic agents for leukemia |
| WO2004112719A2 (en) | 2003-06-19 | 2004-12-29 | Smithkline Beecham Corporation | Chemical compounds |
| EP1663978B1 (en) | 2003-07-23 | 2007-11-28 | Bayer Pharmaceuticals Corporation | Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
| US20050059682A1 (en) | 2003-09-12 | 2005-03-17 | Supergen, Inc., A Delaware Corporation | Compositions and methods for treatment of cancer |
| ATE470443T1 (de) * | 2004-03-11 | 2010-06-15 | Actelion Pharmaceuticals Ltd | Indol-1-yl-essigsäurederivate |
| CN1286973C (zh) | 2004-04-12 | 2006-11-29 | 上海第二医科大学附属瑞金医院 | 一种组蛋白甲基转移酶及其制备方法 |
| DE602005017781D1 (de) | 2004-06-01 | 2009-12-31 | Univ North Carolina | Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafür |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| WO2006130720A2 (en) | 2005-06-02 | 2006-12-07 | University Of North Carolina At Chapel Hill | Purification, characterization and reconstitution of a ubiquitin e3 ligase |
| FR2889526B1 (fr) | 2005-08-04 | 2012-02-17 | Aventis Pharma Sa | 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
| US8710233B2 (en) | 2005-10-19 | 2014-04-29 | Gruenenthal Gmbh | Vanilloid receptor ligands and use thereof for the production of pharmaceutical preparations |
| CN101291910A (zh) | 2005-10-21 | 2008-10-22 | 默克公司 | 钾通道抑制剂 |
| WO2007053480A2 (en) | 2005-10-28 | 2007-05-10 | The University Of North Carolina At Chapel Hill | Protein demethylases comprising a jmjc domain |
| JP5984324B2 (ja) | 2005-12-01 | 2016-09-06 | メディカル プログノシス インスティテュート エー／エス | 治療反応のバイオマーカーを同定するための方法および装置、ならびに治療効果を推定するためのその使用 |
| CN101341124A (zh) | 2005-12-14 | 2009-01-07 | 布里斯托尔-迈尔斯斯奎布公司 | 可用作丝氨酸蛋白酶抑制剂的6元杂环 |
| US8524467B2 (en) | 2006-01-20 | 2013-09-03 | The University Of North Carolina At Chapel Hill | Diagnostic and therapeutic targets for leukemia |
| UA93548C2 (ru) * | 2006-05-05 | 2011-02-25 | Айерем Елелсі | Соединения и композиции kak модуляторы хеджхоговского сигнального пути |
| CN101443007A (zh) | 2006-05-15 | 2009-05-27 | Irm责任有限公司 | Terephthalamate化合物和组合物及其作为hiv整合酶抑制剂的用途 |
| WO2007136592A2 (en) | 2006-05-18 | 2007-11-29 | Amphora Discovery Corporation | 2-0x0-l,2-dihydr0quin0line derivatives, compositions, and uses thereof as antiproliferative agents |
| JP2010505958A (ja) | 2006-10-10 | 2010-02-25 | バーンハム インスティトゥート フォー メディカル リサーチ | 神経防護作用組成物および方法 |
| WO2008103277A2 (en) | 2007-02-16 | 2008-08-28 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors |
| US8338437B2 (en) | 2007-02-28 | 2012-12-25 | Methylgene Inc. | Amines as small molecule inhibitors |
| WO2008109534A1 (en) | 2007-03-02 | 2008-09-12 | Mdrna, Inc. | Nucleic acid compounds for inhibiting ezh2 gene expression and uses thereof |
| WO2008113006A1 (en) | 2007-03-14 | 2008-09-18 | Xenon Pharmaceuticals Inc. | Methods of using quinolinone compounds in treating sodium channel-mediated diseases or conditions |
| DE102007017884A1 (de) | 2007-04-13 | 2008-10-16 | Grünethal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
| US20090012031A1 (en) | 2007-07-03 | 2009-01-08 | The Regents Of The University Of Michigan | EZH2 Cancer Markers |
| US8110572B2 (en) | 2007-07-16 | 2012-02-07 | Abbott Laboratories | Inhibitors of protein kinases |
| WO2009058298A1 (en) | 2007-10-31 | 2009-05-07 | Merck & Co., Inc. | P2x3, receptor antagonists for treatment of pain |
| NZ586418A (en) | 2007-12-19 | 2012-09-28 | Cancer Rec Tech Ltd | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
| ES2531396T3 (es) | 2008-01-23 | 2015-03-13 | Bristol Myers Squibb Co | Proceso para preparar compuestos de piridinona |
| WO2009124137A2 (en) | 2008-04-01 | 2009-10-08 | Mount Sinai School Of Medicine Of New York University | Method of suppressing gene transcription through histone lysine methylation |
| US20100113415A1 (en) | 2008-05-29 | 2010-05-06 | Rajapakse Hemaka A | Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer |
| UY31982A (es) | 2008-07-16 | 2010-02-26 | Boehringer Ingelheim Int | Derivados de 1,2-dihidropiridin-3-carboxamidas n-sustituidas |
| WO2010017355A2 (en) | 2008-08-08 | 2010-02-11 | New York Blood Center | Small molecule inhibitors of retroviral assembly and maturation |
| FR2934995B1 (fr) | 2008-08-14 | 2010-08-27 | Sanofi Aventis | Composes d'azetidines polysubstitues, leur preparation et leur application en therapeutique |
| CA2756152A1 (fr) | 2009-03-24 | 2010-09-30 | Sanofi | Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique |
| EP2411007A4 (en) | 2009-03-27 | 2012-12-05 | Uab Research Foundation | MODULATION OF IRES-MEDIATED TRANSLATION |
| US20110021362A1 (en) | 2009-07-20 | 2011-01-27 | Constellation Pharmaceuticals | Agents for stimulating activity of methyl modifying enzymes and methods of use thereof |
| EP2521558A4 (en) | 2009-12-30 | 2013-07-03 | Avon Prod Inc | TOPICAL LIGHTING COMPOSITION AND USES THEREOF |
| US8846935B2 (en) | 2010-05-07 | 2014-09-30 | Glaxosmithkline Llc | Indazoles |
| US8637509B2 (en) | 2010-05-07 | 2014-01-28 | Glaxosmithkline Llc | Azaindazoles |
| ES2627085T3 (es) | 2010-05-07 | 2017-07-26 | Glaxosmithkline Llc | Indoles |
| WO2011160206A1 (en) | 2010-06-23 | 2011-12-29 | Morin Ryan D | Biomarkers for non-hodgkin lymphomas and uses thereof |
| US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
| CN105797158B (zh) * | 2010-09-10 | 2019-11-08 | Epizyme股份有限公司 | 人ezh2抑制剂及其应用方法 |
| WO2012068589A2 (en) | 2010-11-19 | 2012-05-24 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| JP5908493B2 (ja) | 2010-12-01 | 2016-04-26 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | インドール |
| CA2819625A1 (en) | 2010-12-03 | 2012-06-07 | Epizyme, Inc. | 7-deazapurine modulators of histone methyltransferase, and methods of use thereof |
| US8791782B2 (en) * | 2011-01-28 | 2014-07-29 | Uses, Inc. | AC power conditioning circuit |
| JP2014511389A (ja) | 2011-02-28 | 2014-05-15 | エピザイム インコーポレイテッド | 置換６，５−縮合二環式ヘテロアリール化合物 |
| JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| TWI598336B (zh) * | 2011-04-13 | 2017-09-11 | 雅酶股份有限公司 | 經取代之苯化合物 |
| WO2013049770A2 (en) | 2011-09-30 | 2013-04-04 | Glaxosmithkline Llc | Methods of treating cancer |
| EP2825161B1 (en) * | 2012-03-12 | 2019-01-02 | Epizyme, Inc. | Inhibitors of human ezh2, and methods of use thereof |
| SI2836491T1 (sl) * | 2012-04-13 | 2017-06-30 | Epizyme, Inc. | Oblike soli inhibitorja humane histon metiltransferaze EZH2 |
| US10301290B2 (en) | 2012-04-13 | 2019-05-28 | Epizyme, Inc. | Combination therapy for treating cancer |
| US9562041B2 (en) | 2012-05-16 | 2017-02-07 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
| NZ746054A (en) * | 2012-10-15 | 2020-07-31 | Epizyme Inc | Methods of treating cancer |
| CN105102432B (zh) | 2012-10-15 | 2019-01-04 | Epizyme股份有限公司 | 经取代的苯化合物 |
-
2013
- 2013-10-15 CN CN201380065683.2A patent/CN105102432B/zh active Active
- 2013-10-15 MX MX2015004722A patent/MX353929B/es active IP Right Grant
- 2013-10-15 CA CA2887562A patent/CA2887562C/en active Active
- 2013-10-15 SG SG11201502820YA patent/SG11201502820YA/en unknown
- 2013-10-15 CN CN201380065677.7A patent/CN105102431B/zh active Active
- 2013-10-15 EP EP20161557.2A patent/EP3725314A1/en not_active Withdrawn
- 2013-10-15 AU AU2013331380A patent/AU2013331380B2/en active Active
- 2013-10-15 CA CA2888021A patent/CA2888021A1/en not_active Abandoned
- 2013-10-15 JP JP2015537018A patent/JP6461802B2/ja active Active
- 2013-10-15 UA UAA201504700A patent/UA115074C2/uk unknown
- 2013-10-15 PE PE2015000488A patent/PE20150886A1/es active IP Right Grant
- 2013-10-15 WO PCT/US2013/065127 patent/WO2014062733A2/en active Application Filing
- 2013-10-15 WO PCT/US2013/065126 patent/WO2014062732A1/en active Application Filing
- 2013-10-15 CN CN201811510752.7A patent/CN110041250A/zh active Pending
- 2013-10-15 AU AU2013331381A patent/AU2013331381B2/en active Active
- 2013-10-15 KR KR1020157012670A patent/KR102057365B1/ko active IP Right Grant
- 2013-10-15 JP JP2015537019A patent/JP6461803B2/ja active Active
- 2013-10-15 RU RU2015118135A patent/RU2662436C2/ru active
- 2013-10-15 NZ NZ706738A patent/NZ706738A/en unknown
- 2013-10-15 AR ARP130103745A patent/AR093244A1/es active IP Right Grant
- 2013-10-15 SG SG11201502803VA patent/SG11201502803VA/en unknown
- 2013-10-15 TW TW102137117A patent/TWI588131B/zh active
- 2013-10-15 MX MX2015004721A patent/MX2015004721A/es active IP Right Grant
- 2013-10-15 NZ NZ706739A patent/NZ706739A/en unknown
- 2013-10-15 EP EP19188699.3A patent/EP3628662A1/en active Pending
- 2013-10-15 EP EP13847763.3A patent/EP2906538A4/en not_active Withdrawn
- 2013-10-15 TW TW106111749A patent/TWI651303B/zh active
- 2013-10-15 KR KR1020157012673A patent/KR102057366B1/ko active IP Right Grant
- 2013-10-15 BR BR112015008480A patent/BR112015008480A2/pt not_active Application Discontinuation
- 2013-10-15 UA UAA201504699A patent/UA119136C2/uk unknown
- 2013-10-15 RU RU2015118145A patent/RU2658919C2/ru active
- 2013-10-15 US US14/054,695 patent/US9006242B2/en active Active
- 2013-10-15 SG SG10201705989YA patent/SG10201705989YA/en unknown
- 2013-10-15 PE PE2015000489A patent/PE20150887A1/es active IP Right Grant
- 2013-10-15 BR BR112015008487-7A patent/BR112015008487B1/pt active IP Right Grant
- 2013-10-15 MY MYPI2015000966A patent/MY180311A/en unknown
- 2013-10-15 EP EP13846696.6A patent/EP2906537B1/en active Active
- 2013-10-15 US US14/435,704 patent/US10092572B2/en active Active
-
2015
- 2015-03-05 US US14/639,878 patent/US9089575B2/en active Active
- 2015-04-02 IL IL238135A patent/IL238135B/en active IP Right Grant
- 2015-04-10 PH PH12015500800A patent/PH12015500800B1/en unknown
- 2015-04-12 IL IL238197A patent/IL238197A0/en active IP Right Grant
- 2015-04-15 CL CL2015000944A patent/CL2015000944A1/es unknown
- 2015-04-15 ZA ZA2015/02526A patent/ZA201502526B/en unknown
- 2015-04-15 PH PH12015500825A patent/PH12015500825B1/en unknown
- 2015-04-15 CL CL2015000942A patent/CL2015000942A1/es unknown
- 2015-04-16 ZA ZA2015/02560A patent/ZA201502560B/en unknown
- 2015-06-17 US US14/742,466 patent/US9532992B2/en active Active
-
2016
- 2016-02-04 HK HK16101355.9A patent/HK1213264A1/zh unknown
- 2016-02-05 HK HK16101447.9A patent/HK1213552A1/zh unknown
- 2016-11-22 US US15/359,538 patent/US10098888B2/en active Active
-
2018
- 2018-02-21 JP JP2018028891A patent/JP2018087238A/ja not_active Withdrawn
- 2018-02-21 JP JP2018028907A patent/JP6559275B2/ja active Active
- 2018-09-04 US US16/120,702 patent/US20190060322A1/en not_active Abandoned
- 2018-09-26 IL IL261964A patent/IL261964B/en active IP Right Grant
-
2019
- 2019-03-18 IL IL265437A patent/IL265437A/en unknown
-
2020
- 2020-07-09 US US16/924,962 patent/US11642348B2/en active Active
-
2023
- 2023-03-23 US US18/188,700 patent/US20240165121A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015118135A (ru) | Содержащие заместители бензольные соединения | |
| JP2015533176A5 (ru) | ||
| RU2475484C2 (ru) | Полициклические производные индазола и их применение в качестве ингибиторов erk для лечения рака | |
| CY1125292T1 (el) | Παραγωγα 6,7,8,9-tetpaϋδpo-3h-πypazoλo[4,3-f iσοκινολινης χρησιμα στη θεραπευτικη αντιμετωπιση του καρκινου | |
| NZ718826A (en) | Pyrrolobenzodiazepines and conjugates thereof | |
| RU2016122232A (ru) | Комбинированная терапия на основе антитела к cd20 и ингибитора втк | |
| HRP20171727T1 (hr) | Novi terapeutici | |
| NZ706999A (en) | Inhibitors of mutant isocitrate dehydrogenase and therapeutical uses thereof | |
| GEP20217286B (en) | Pyridone amides as modulators of sodium channels | |
| EP4219563A3 (en) | Methods of treating cancer with anti-pd-1 antibodies | |
| JP2017008088A5 (ru) | ||
| EA201690608A1 (ru) | Способы лечения раковых заболеваний | |
| MX2021015234A (es) | Composiciones y metodos que comprenden bupropion o compuestos relacionados y dextrometorfano. | |
| GEP20237479B (en) | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer | |
| RU2018107668A (ru) | Пиразолпиримидиновое производное и его применение | |
| EA201600204A1 (ru) | Производные хиназолина, фармацевтическая композиция на их основе и их применение для профилактики или лечения опухоли | |
| EA201691747A1 (ru) | Варианты комбинированной терапии с антителами анти-cd38 | |
| MX2016016744A (es) | Inhibidores de ezh2 para tratar linfomas. | |
| EP3466423A3 (en) | Treatment of cancer with tor kinase inhibitors | |
| RU2014123781A (ru) | Комбинированная терапия с применением антитела к cd20 и человеческого il-15 | |
| EA201690785A1 (ru) | Новая комбинированная терапия острого миелоидного лейкоза (омл) | |
| RU2012147340A (ru) | КОМБИНИРОВАННАЯ ТЕРАПИЯ АФУКОЗИЛИРОВАННЫМ АНТИТЕЛОМ CD20 И ИНГИБИТОРОМ mTOR | |
| UA114944C2 (uk) | Піридинільні і конденсовані піридинільні похідні триазолону | |
| EA201691342A1 (ru) | Пиразолоновые соединения и их применение | |
| JP2017524013A5 (ru) |