RS54860B1 - Spirociklični derivati izoksazolina kao antiparazitska sredstva - Google Patents
Spirociklični derivati izoksazolina kao antiparazitska sredstvaInfo
- Publication number
- RS54860B1 RS54860B1 RS20160432A RSP20160432A RS54860B1 RS 54860 B1 RS54860 B1 RS 54860B1 RS 20160432 A RS20160432 A RS 20160432A RS P20160432 A RSP20160432 A RS P20160432A RS 54860 B1 RS54860 B1 RS 54860B1
- Authority
- RS
- Serbia
- Prior art keywords
- group
- alkyl
- c6alkyl
- halo
- cyano
- Prior art date
Links
- 239000003096 antiparasitic agent Substances 0.000 title 1
- 229940125687 antiparasitic agent Drugs 0.000 title 1
- 150000002547 isoxazolines Chemical class 0.000 title 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 6
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 229910003827 NRaRb Inorganic materials 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004043 oxo group Chemical group O=* 0.000 abstract 3
- -1 C1-C6alkoxy Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Jedinjenje Formule (1)naznačeno time štoX je-O-i W je-CH2- grupa;R1a, R1b i R1c su svaki nezavisno vodonik, halo ili C1-C6haloalkil grupa;R3 je C1-C6haloalkil grupa;R4 je-C(O)R5grupa;R5 je C1-C6alkil, C0-C6alkilC3-C6cikloalkil, C0-C6alkilheteroaril ili C0-C6alkilheterociklil grupa; pri čemu svaki od R5 C1-C6alkil ili C0-C6alkilC3-C6cikloalkil radikala može opciono i nezavisno da bude supstituisan sa najmanje jednim supstituentom izabranim od cijano, halo, hidroksil, okso, C1-C6alkoksi, C1-C6haloalkoksi, C1-C6haloalkil, C1-C6alkil, hidroksilC1-Cealkil-, -S(O)pRc, -SH, -S(O)PNRaRb, -NRaRb, -NRaC(O)Rb, -SC(O)R, -SCN ili -C(O)NRaRb grupe; ipri čemu svaki od R5 C0-C6alkilheteroaril ili C0-C6alkilheterociklil radikala može da bude dalje opciono supstituisan sa najmanje jednim supstituentom izabranim od cijano, halo, okso, =S, =NR7, hidroksi, C1-C6alkoksi, C1-C6alkil, C1-C6haloalkil, hidroksiC1-C6alkil-, -SH, -S(O)pR i C1-C6haloalkoksi grupe;R7 je vodonik, C1-C6alkil, hidroksi, cijano, nitro, -S(O)pRc ili C1-C6alkoksi grupa;R je C1-C6alkil ili C3-C6cikloalkil grupa opciono supstituisana sa najmanje jednim halo supstituentom;Ra je vodonik, C1-C6alkil ili C0-C3alkilC3-C6cikloalkil grupa; pri čemu je alkil i alkilcikloalkil grupa opciono supstituisana sa cijano grupom ili najmanje jednim halo supstituentom;Rb je vodonik, C1-C6alkil, C3-C6cikloalkil, C0-C3alkilfenil, C0-C3alkilheteroaril ili C0-C3alkilheterociklil grupa, svaka opciono supstituisana, gde je to hemijski moguće, sa najmanje jednim supstituentom izabranim od hidroksi, cijano, halo ili -S(O)pR grupe;Rc je C1-Cealkil, C1-C6haloalkil, C1-C6haloalkilC3-C6cikloalkil, C0-C3alkilC3-alkil, C0-C3alkilfenil, C0-C3alkilheteroaril ili C0-C3alkilheterociklil grupa svaka opciono supstituisana sa najmanje jednim supstituentom izabranim od cijano, halo, hidroksi, okso, C1-C6alkoksi, C1-C6haloalkoksi, C1-C6haloalkil, -S(O)pR, -SH, -S(O)pNRaRb, -NRaRb, -NRaC(O)Rb, -SC(O)R, -SCN ili -C(O)NRaRb grupe;p je ceo broj 0, 1 ili 2; i n je ceo broj 0;njegovi stereoizomeri i njegove veterinarski prihvatljive soli.Prijava sadrži još 18 patentnih zahteva.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161451256P | 2011-03-10 | 2011-03-10 | |
| US201161489913P | 2011-05-25 | 2011-05-25 | |
| US201161490804P | 2011-05-27 | 2011-05-27 | |
| PCT/IB2012/050842 WO2012120399A1 (en) | 2011-03-10 | 2012-02-23 | Spirocyclic isoxazoline derivatives as antiparasitic agents |
| EP12709376.3A EP2683723B1 (en) | 2011-03-10 | 2012-02-23 | Spirocyclic isoxazoline derivatives as antiparasitic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS54860B1 true RS54860B1 (sr) | 2016-10-31 |
Family
ID=45852624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20160432A RS54860B1 (sr) | 2011-03-10 | 2012-02-23 | Spirociklični derivati izoksazolina kao antiparazitska sredstva |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8466115B2 (sr) |
| EP (1) | EP2683723B1 (sr) |
| JP (1) | JP5806743B2 (sr) |
| KR (1) | KR101565853B1 (sr) |
| CN (1) | CN103517907B (sr) |
| AR (1) | AR085649A1 (sr) |
| AU (1) | AU2012226475C1 (sr) |
| BR (1) | BR112013023068B8 (sr) |
| CA (1) | CA2828397C (sr) |
| CL (1) | CL2013002516A1 (sr) |
| CO (1) | CO6761337A2 (sr) |
| CY (1) | CY1117987T1 (sr) |
| ES (1) | ES2585555T3 (sr) |
| HK (1) | HK1190393A1 (sr) |
| HR (1) | HRP20160601T1 (sr) |
| HU (1) | HUE029810T2 (sr) |
| ME (1) | ME02412B (sr) |
| MX (1) | MX2013010336A (sr) |
| PL (1) | PL2683723T3 (sr) |
| PT (1) | PT2683723T (sr) |
| RS (1) | RS54860B1 (sr) |
| RU (1) | RU2566083C3 (sr) |
| SI (1) | SI2683723T1 (sr) |
| UY (1) | UY33943A (sr) |
| WO (1) | WO2012120399A1 (sr) |
| ZA (1) | ZA201306817B (sr) |
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| BR112015004135B8 (pt) * | 2012-08-31 | 2022-11-22 | Zoetis Services Llc | Formas cristalinas de 1-(5'-(5-(3,5-dicloro-4-fluorofenil)-5-(trifluorometil)-4,5-di-hidroisoxazol-3-il)-3'h-espiro[azetidina-3,1'-isobenzofuran]-1-il)-2-(metilsulfonil)etanona, sua composição, seu uso e seu processo de preparação |
| CA2882199A1 (en) | 2012-09-04 | 2014-03-13 | Zoetis Llc | Spirocyclic isoxazoline derivatives for treatment of sea lice |
| NZ704627A (en) * | 2012-09-07 | 2016-01-29 | Zoetis Services Llc | Spirocyclic isoxazoline parasiticidal combinations |
| CA2881844A1 (en) | 2012-09-07 | 2014-03-13 | Zoetis Llc | Spirocyclic derivatives as antiparasitic agents |
| EP2892901A1 (en) | 2012-09-07 | 2015-07-15 | Zoetis LLC | Spirocyclic isoxazolines as antiparasitic agents |
| EP2922854B1 (en) * | 2012-11-21 | 2022-05-04 | Zoetis Services LLC | Synthesis of spirocyclic isoxazoline derivatives |
| ES2656012T3 (es) | 2013-02-06 | 2018-02-22 | Bayer Cropscience Aktiengesellschaft | Derivados de pirazol sustituidos con halógeno como pesticidas |
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| PT3063144T (pt) | 2013-11-01 | 2021-10-28 | Boehringer Ingelheim Animal Health Usa Inc | Compostos de isoxazolina antiparasitários e pesticidas |
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| WO2023046853A1 (en) | 2021-09-23 | 2023-03-30 | Syngenta Crop Protection Ag | Insect, acarina and nematode pest control |
| US20230312207A1 (en) | 2022-02-17 | 2023-10-05 | Boehringer Ingelheim Vetmedica Gmbh | Method and system for providing a fluid product mailer |
| WO2023203038A1 (en) | 2022-04-19 | 2023-10-26 | Syngenta Crop Protection Ag | Insect, acarina and nematode pest control |
| FI20225388A1 (en) | 2022-05-05 | 2023-11-06 | Equinorm Ltd | New heterocyclic compounds, preparation methods and their uses |
| DK202470076A1 (en) | 2023-03-13 | 2024-10-10 | Zoetis Services Llc | Degradation of isoxazolines in ozonated sea water |
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| US5554753A (en) | 1993-08-25 | 1996-09-10 | Indiana University Foundation | Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis |
| TW524667B (en) | 1996-12-05 | 2003-03-21 | Pfizer | Parasiticidal pyrazoles |
| GB0329314D0 (en) | 2003-12-18 | 2004-01-21 | Pfizer Ltd | Substituted arylpyrazoles |
| RS53639B1 (sr) * | 2004-03-05 | 2015-04-30 | Nissan Chemical Industries Ltd. | Izoksazolinom supstituisano benzamidno jedinjenje i sredstvo za kontrolu štetnih organizama |
| KR100974967B1 (ko) | 2005-07-14 | 2010-08-09 | 에프. 호프만-라 로슈 아게 | Ｖ1ａ 수용체 길항물질로서의인돌-3-카본일-스피로-피페리딘 유도체 |
| TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| DE602007006288D1 (de) | 2006-03-10 | 2010-06-17 | Nissan Chemical Ind Ltd | Substituierte isoxazolin-verbindung und schädlingsbekämpfungsmittel |
| US8575167B2 (en) | 2007-02-06 | 2013-11-05 | Takeda Pharmaceutical Company Limited | Spiro compounds having stearoyl-CoA desaturase action |
| EP2181100A2 (en) | 2007-04-10 | 2010-05-05 | Bayer CropScience AG | Insecticidal aryl isoxazoline derivatives |
| JP5184057B2 (ja) * | 2007-08-10 | 2013-04-17 | 日本曹達株式会社 | 含窒素複素環化合物および有害生物防除剤 |
| JP5365806B2 (ja) | 2007-09-10 | 2013-12-11 | 日産化学工業株式会社 | 置換イソキサゾリン化合物及び有害生物防除剤 |
| JP5365807B2 (ja) * | 2007-11-12 | 2013-12-11 | 日産化学工業株式会社 | 光学活性イソキサゾリン化合物の触媒的不斉合成方法 |
| JP2009286773A (ja) * | 2008-03-14 | 2009-12-10 | Bayer Cropscience Ag | 殺虫性縮環式アリール類 |
| JP2012501989A (ja) | 2008-09-04 | 2012-01-26 | シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト | 殺虫化合物 |
| JP5488835B2 (ja) * | 2008-09-04 | 2014-05-14 | 日産化学工業株式会社 | 置換アセトフェノン化合物、その製造方法及び用途 |
| WO2010032437A1 (ja) * | 2008-09-18 | 2010-03-25 | 日本曹達株式会社 | 含窒素複素環化合物および有害生物防除剤 |
| US20110288089A1 (en) * | 2009-01-22 | 2011-11-24 | Syngenta Crop Protection Llc | Insecticidal compounds |
| US20140206633A1 (en) | 2010-02-25 | 2014-07-24 | Syngenta Crop Protection Llc | Process for the preparation of isoxazoline derivatives |
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