RS52492B - Cross-species-specific bispecific binders - Google Patents
Cross-species-specific bispecific bindersInfo
- Publication number
- RS52492B RS52492B RS20120412A RSP20120412A RS52492B RS 52492 B RS52492 B RS 52492B RS 20120412 A RS20120412 A RS 20120412A RS P20120412 A RSP20120412 A RS P20120412A RS 52492 B RS52492 B RS 52492B
- Authority
- RS
- Serbia
- Prior art keywords
- epitope
- species
- cross
- binding
- specific bispecific
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Polipeptid koji sadrži prvi vezivni domen, koji je antitelo sposobno da se veže za epitop CD3ε lanca čoveka i Callithrix jacchusa, Saguinus oedipusa ili Saimiri sciureusa, naznačen time, stoje taj epitop deo aminokiselinske sekvence sadržane u grupi koju čine SEQ ID br:2, 4, 6, ili 8 i sadrži najmanje aminokiselinsku sekvencu Gln-Asp-Gly-Asn-Glu, i drugi vezivni domen koji je u stanju da se veže za EGFR, Her2/neu ili IgE čoveka i/ili primata koji nisu šimpanze.Prijava sadrži još 17 patentnih zahteva.A polypeptide comprising a first binding domain, which is an antibody capable of binding to the epitope of the human CD3ε epitope and Callithrix jacchus, Saguinus oedipus or Saimiri sciureus, comprising that epitope part of the amino acid sequence contained in the group consisting of SEQ ID no: 2, 4 , 6, or 8 and containing at least the amino acid sequence Gln-Asp-Gly-Asn-Glu, and another binding domain capable of binding to human and / or non-chimpanzee EGFR, Her2 / neu or IgE primates. another 17 patent claims.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07006988 | 2007-04-03 | ||
| EP07006990 | 2007-04-03 | ||
| US91366807P | 2007-04-24 | 2007-04-24 | |
| EP07020646 | 2007-10-22 | ||
| EP07020640 | 2007-10-22 | ||
| EP07020641 | 2007-10-22 | ||
| EP08004741 | 2008-03-13 | ||
| PCT/EP2008/002663 WO2008119566A2 (en) | 2007-04-03 | 2008-04-03 | Cross-species-specific bispecific binders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS52492B true RS52492B (en) | 2013-02-28 |
Family
ID=42582614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20120412A RS52492B (en) | 2007-04-03 | 2008-04-03 | Cross-species-specific bispecific binders |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JP2010524435A (en) |
| DK (1) | DK2155788T3 (en) |
| ES (1) | ES2390243T3 (en) |
| NZ (1) | NZ580746A (en) |
| PT (1) | PT2155788E (en) |
| RS (1) | RS52492B (en) |
| RU (1) | RU2535992C2 (en) |
| SI (1) | SI2155788T1 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0809594A2 (en) * | 2007-04-03 | 2019-08-27 | Micromet Ag | polypeptide, nucleic acid sequence, vector, host, process for producing a polypeptide, pharmaceutical composition, use of a polypeptide, method for preventing, treating or ameliorating a disease in an individual in need thereof, kit, method for the identification of a polypeptide (s) |
| AU2008234019B2 (en) * | 2007-04-03 | 2014-05-29 | Amgen Research (Munich) Gmbh | Cross-species-specific bispecific binders |
| WO2012066058A1 (en) * | 2010-11-16 | 2012-05-24 | Boehringer Ingelheim International Gmbh | Agents and methods for treating diseases that correlate with bcma expression |
| JP6400470B2 (en) * | 2011-05-16 | 2018-10-03 | ジェネロン（シャンハイ）コーポレイション リミテッド | Multispecific Fab fusion proteins and methods of use |
| SG10201703425RA (en) * | 2011-05-21 | 2017-05-30 | Macrogenics Inc | Cd3-binding molecules capable of binding to human and non-human cd3 |
| CA3131724A1 (en) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Anti-cd3 antibodies and methods of use |
| RU2016151235A (en) * | 2014-05-28 | 2018-06-28 | Ф. Хоффманн-Ля Рош Аг | ANTIBODIES CONTACTING CD3 HUMAN EPSILON AND MONKEY ZINOMOLGUS |
| BR112017001579A2 (en) * | 2014-07-25 | 2017-11-21 | Cytomx Therapeutics Inc | anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable cd3 antibodies and methods of use |
| WO2016016415A1 (en) * | 2014-07-31 | 2016-02-04 | Amgen Research (Munich) Gmbh | Bispecific single chain antibody construct with enhanced tissue distribution |
| JP2018520642A (en) * | 2015-05-01 | 2018-08-02 | ジェネンテック， インコーポレイテッド | Mask anti-CD3 antibody and method of use thereof |
| US10870701B2 (en) | 2016-03-15 | 2020-12-22 | Generon (Shanghai) Corporation Ltd. | Multispecific fab fusion proteins and use thereof |
| CN109923128A (en) | 2016-11-15 | 2019-06-21 | 基因泰克公司 | Administration for being treated with anti-CD20/ AntiCD3 McAb bispecific antibody |
| US10426424B2 (en) | 2017-11-21 | 2019-10-01 | General Electric Company | System and method for generating and performing imaging protocol simulations |
| AR115360A1 (en) | 2018-02-08 | 2021-01-13 | Genentech Inc | ANTIGEN BINDING MOLECULES AND METHODS OF USE |
| US20230067182A1 (en) * | 2019-11-29 | 2023-03-02 | Boe Technology Group Co., Ltd. | Data Processing Device and Method, and Computer Readable Storage Medium |
| US11845799B2 (en) | 2019-12-13 | 2023-12-19 | Genentech, Inc. | Anti-Ly6G6D antibodies and methods of use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD272473B3 (en) * | 1988-06-13 | 1993-01-21 | Univ Leipzig | PROCESS FOR THE PREPARATION OF MONOCLONAL ANTIBODY AGAINST THE EPSILON CHAIN OF CD 3 ANTIGEN HUMAN T-LYMPHOCYTES |
| US7235641B2 (en) * | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
-
2008
- 2008-04-03 RU RU2009136913/10A patent/RU2535992C2/en active
- 2008-04-03 RS RS20120412A patent/RS52492B/en unknown
- 2008-04-03 PT PT08735000T patent/PT2155788E/en unknown
- 2008-04-03 JP JP2010501433A patent/JP2010524435A/en not_active Revoked
- 2008-04-03 ES ES08735000T patent/ES2390243T3/en active Active
- 2008-04-03 NZ NZ580746A patent/NZ580746A/en unknown
- 2008-04-03 SI SI200830762T patent/SI2155788T1/en unknown
- 2008-04-03 DK DK08735000.5T patent/DK2155788T3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2009136913A (en) | 2011-06-20 |
| SI2155788T1 (en) | 2012-11-30 |
| DK2155788T3 (en) | 2012-10-08 |
| PT2155788E (en) | 2012-09-25 |
| NZ580746A (en) | 2012-05-25 |
| ES2390243T3 (en) | 2012-11-07 |
| JP2010524435A (en) | 2010-07-22 |
| RU2535992C2 (en) | 2014-12-20 |
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