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RS20090137A - Sulfonamide derivatives as adrenergic agonists and muscarinic antagonists - Google Patents

Sulfonamide derivatives as adrenergic agonists and muscarinic antagonists

Info

Publication number
RS20090137A
RS20090137A RSP-2009/0137A RSP20090137A RS20090137A RS 20090137 A RS20090137 A RS 20090137A RS P20090137 A RSP20090137 A RS P20090137A RS 20090137 A RS20090137 A RS 20090137A
Authority
RS
Serbia
Prior art keywords
adrenergic agonists
sulfonamide derivatives
muscarinic antagonists
disorders
preparation
Prior art date
Application number
RSP-2009/0137A
Other languages
English (en)
Inventor
David Anthony Price
Lyn Howard Jones
Graham Lunn
Original Assignee
Pfizer Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Limited filed Critical Pfizer Limited
Publication of RS20090137A publication Critical patent/RS20090137A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Ovaj pronalazak se odnosi na jedinjenja formule (1) i postupke za njihovo dobijanje, intermedijere koji se upotrebljavaju za njihovo dobijanje, preparate koji ih sadrže i upotrebu takvih derivata. Jedinjenja prema ovom pronalasku su korisna kod brojnih bolesti, poremećaja i stanja, naročito inflamatornih, alergijskih i respiratornih bolesti, poremećaja i stanja.
RSP-2009/0137A 2006-10-04 2007-09-21 Sulfonamide derivatives as adrenergic agonists and muscarinic antagonists RS20090137A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82809906P 2006-10-04 2006-10-04
PCT/IB2007/002896 WO2008041095A1 (en) 2006-10-04 2007-09-21 Sulfonamide derivatives as adrenergic agonists and muscarinic antagonists

Publications (1)

Publication Number Publication Date
RS20090137A true RS20090137A (en) 2010-06-30

Family

ID=38947725

Family Applications (1)

Application Number Title Priority Date Filing Date
RSP-2009/0137A RS20090137A (en) 2006-10-04 2007-09-21 Sulfonamide derivatives as adrenergic agonists and muscarinic antagonists

Country Status (25)

Country Link
US (1) US20080090873A1 (sr)
EP (1) EP2074094A1 (sr)
JP (1) JP2010505810A (sr)
KR (1) KR20090050104A (sr)
CN (1) CN101522622A (sr)
AP (1) AP2009004791A0 (sr)
AR (1) AR063118A1 (sr)
AU (1) AU2007303909A1 (sr)
BR (1) BRPI0719270A2 (sr)
CA (1) CA2665385A1 (sr)
CL (1) CL2007002791A1 (sr)
CO (1) CO6180437A2 (sr)
CR (1) CR10700A (sr)
EA (1) EA200900337A1 (sr)
IL (1) IL197244A0 (sr)
MA (1) MA30778B1 (sr)
MX (1) MX2009002209A (sr)
NO (1) NO20090910L (sr)
PE (1) PE20080831A1 (sr)
RS (1) RS20090137A (sr)
TN (1) TN2009000112A1 (sr)
TW (1) TW200823185A (sr)
UY (1) UY30617A1 (sr)
WO (1) WO2008041095A1 (sr)
ZA (1) ZA200901320B (sr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
JP5801997B2 (ja) 2009-07-07 2015-10-28 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 薬品の組合せを吸入するための投薬ユニット、投薬ユニットのパック、および吸入器
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
WO2011081937A1 (en) 2009-12-15 2011-07-07 Gilead Sciences, Inc. Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
ITRM20110083U1 (it) 2010-05-13 2011-11-14 De La Cruz Jose Antonio Freire Piastra per la costruzione di carrelli per aeroplani
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
KR20150096732A (ko) 2012-12-18 2015-08-25 알미랄, 에스.에이. 베타2 아드레날린 아고니스트 및 ｍ3 무스카린 안타고니스트 활성을 갖는 새로운 시클로헥실 및 퀴누클리디닐 카르바메이트 유도체
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
CN106336406B (zh) * 2015-07-10 2020-01-03 四川海思科制药有限公司 具有β2受体激动及M受体拮抗活性的八氢并环戊二烯衍生物及其在医药上的用途
CA3047023C (en) 2016-12-14 2022-05-31 Beijing Showby Pharmaceutical Co., Ltd. Class of bifunctional compounds with quaternary ammonium salt structure
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CA3127373A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
JP2021505569A (ja) * 2017-12-04 2021-02-18 フリードリヒ−アレクサンダー−ウニヴェルシテート エアランゲン−ニュルンベルク Ｍ２よりもｍ３に対して選択性を有するフルオロフェニル置換ムスカリン受容体リガンド
EP4171525A1 (en) 2020-06-26 2023-05-03 Mylan Pharma UK Limited Formulations including 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776983A (en) * 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
PE20040950A1 (es) * 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
EP1615881A2 (en) * 2003-04-01 2006-01-18 Theravance, Inc. Diarylmethyl and related compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
ATE435862T1 (de) * 2003-05-28 2009-07-15 Theravance Inc Azabicycloalkanverbindungen als muscarinrezeptor antagonisten
DE602005001929T2 (de) * 2004-01-22 2007-12-06 Pfizer Inc. Sulfonamidderivate zur behandlung von krankheiten
US7320990B2 (en) * 2004-02-13 2008-01-22 Theravance, Inc. Crystalline form of a biphenyl compound
TWI374883B (en) * 2004-08-16 2012-10-21 Theravance Inc Crystalline form of a biphenyl compound

Also Published As

Publication number Publication date
ZA200901320B (en) 2010-04-28
TW200823185A (en) 2008-06-01
UY30617A1 (es) 2008-05-31
WO2008041095A1 (en) 2008-04-10
MX2009002209A (es) 2009-03-16
AU2007303909A1 (en) 2008-04-10
NO20090910L (no) 2009-03-24
CA2665385A1 (en) 2008-04-10
TN2009000112A1 (fr) 2010-08-19
AR063118A1 (es) 2008-12-30
PE20080831A1 (es) 2008-06-20
AP2009004791A0 (en) 2009-04-30
CN101522622A (zh) 2009-09-02
CO6180437A2 (es) 2010-07-19
CL2007002791A1 (es) 2008-04-11
EA200900337A1 (ru) 2009-10-30
KR20090050104A (ko) 2009-05-19
EP2074094A1 (en) 2009-07-01
JP2010505810A (ja) 2010-02-25
MA30778B1 (fr) 2009-10-01
BRPI0719270A2 (pt) 2014-03-11
US20080090873A1 (en) 2008-04-17
CR10700A (es) 2009-04-24
IL197244A0 (en) 2009-12-24

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