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PT991640E - SYNTHESIS OF UTERIC INTERMEDIARIES IN THE PREPARATION OF TRICYLIC COMPOUNDS REPLACED BY BROMO - Google Patents

SYNTHESIS OF UTERIC INTERMEDIARIES IN THE PREPARATION OF TRICYLIC COMPOUNDS REPLACED BY BROMO

Info

Publication number
PT991640E
PT991640E PT98928873T PT98928873T PT991640E PT 991640 E PT991640 E PT 991640E PT 98928873 T PT98928873 T PT 98928873T PT 98928873 T PT98928873 T PT 98928873T PT 991640 E PT991640 E PT 991640E
Authority
PT
Portugal
Prior art keywords
uteric
intermediaries
bromo
synthesis
preparation
Prior art date
Application number
PT98928873T
Other languages
Portuguese (pt)
Inventor
Xing Chen
Marc Poirier
Yee-Shing Wong
Guang-Zhong Wu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PT991640E publication Critical patent/PT991640E/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
PT98928873T 1997-06-16 1998-06-15 SYNTHESIS OF UTERIC INTERMEDIARIES IN THE PREPARATION OF TRICYLIC COMPOUNDS REPLACED BY BROMO PT991640E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/882,753 US5760232A (en) 1997-06-16 1997-06-16 Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds

Publications (1)

Publication Number Publication Date
PT991640E true PT991640E (en) 2002-07-31

Family

ID=25381267

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98928873T PT991640E (en) 1997-06-16 1998-06-15 SYNTHESIS OF UTERIC INTERMEDIARIES IN THE PREPARATION OF TRICYLIC COMPOUNDS REPLACED BY BROMO

Country Status (15)

Country Link
US (1) US5760232A (en)
EP (1) EP0991640B1 (en)
JP (1) JP3210023B2 (en)
AR (1) AR015886A1 (en)
AT (1) ATE214062T1 (en)
AU (1) AU8056898A (en)
CA (1) CA2293709C (en)
DE (1) DE69804100T2 (en)
DK (1) DK0991640T3 (en)
ES (1) ES2169917T3 (en)
IN (1) IN187755B (en)
MY (1) MY133531A (en)
PT (1) PT991640E (en)
WO (1) WO1998057958A1 (en)
ZA (1) ZA985207B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998620A (en) * 1997-03-25 1999-12-07 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
EP2189447B1 (en) 2002-10-03 2011-11-16 Schering Corporation Enantioselective alkylation of tricyclic compounds
PT3738434T (en) 2011-12-28 2023-11-13 Global Blood Therapeutics Inc Intermediates to obtain substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
EP2797597B1 (en) 2011-12-28 2020-02-26 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN112500338A (en) 2013-03-15 2021-03-16 全球血液疗法股份有限公司 Compounds and their use for modulating hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2014145040A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
KR20190041548A (en) 2013-03-15 2019-04-22 글로벌 블러드 테라퓨틱스, 인크. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
AU2014237330A1 (en) 2013-03-15 2015-09-17 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA202092627A1 (en) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. COMPOUNDS AND THEIR APPLICATIONS FOR HEMOGLOBIN MODULATION
EP3102208B2 (en) 2014-02-07 2024-07-17 Global Blood Therapeutics, Inc. Crystalline polymorph of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
MA41841A (en) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc ALDEHYDE COMPOUNDS FOR THE TREATMENT OF PULMONARY FIBROSIS, HYPOXIA, AND AUTOIMMUNE AND CONNECTIVE TISSUE DISEASES
WO2017096230A1 (en) 2015-12-04 2017-06-08 Global Blood Therapeutics, Inc. Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
TWI752307B (en) 2016-05-12 2022-01-11 美商全球血液治療公司 Novel compound and method of preparing compound
TWI778983B (en) 2016-10-12 2022-10-01 美商全球血液治療公司 Tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
WO2020072377A1 (en) 2018-10-01 2020-04-09 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease
CN112341433A (en) * 2020-11-16 2021-02-09 成都大学 Preparation method of loratadine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Pharmaceutical compositions for inhibition of g-protein function and for treatment of proliferative diseases containing tricyclic compounds some such compounds and process for preparing part of them
ATE210652T1 (en) * 1993-10-15 2001-12-15 Schering Corp TRICYCLIC CARBAMAT DERIVATIVES FOR INHIBITING G-PROTEIN FUNCTION AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES
CA2358394C (en) * 1995-12-22 2006-05-02 Schering Corporation Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
CA2293709A1 (en) 1998-12-23
WO1998057958A1 (en) 1998-12-23
US5760232A (en) 1998-06-02
DK0991640T3 (en) 2002-05-27
JP2000513032A (en) 2000-10-03
DE69804100T2 (en) 2002-10-31
EP0991640A1 (en) 2000-04-12
CA2293709C (en) 2004-02-10
EP0991640B1 (en) 2002-03-06
JP3210023B2 (en) 2001-09-17
MY133531A (en) 2007-11-30
ZA985207B (en) 1999-04-07
AR015886A1 (en) 2001-05-30
DE69804100D1 (en) 2002-04-11
AU8056898A (en) 1999-01-04
ES2169917T3 (en) 2002-07-16
IN187755B (en) 2002-06-15
ATE214062T1 (en) 2002-03-15

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