PT97944A - Processo para a preparacao de derivados de hexa-hidroazepina - Google Patents

Processo para a preparacao de derivados de hexa-hidroazepina

Info

Publication number: PT97944A
Authority: PT; Portugal
Prior art keywords: derivatives; hydroazepine; hexa; preparation; group
Prior art date: 1990-06-14

Application number

PT97944A

Other languages

English (en)

Other versions

PT97944B (pt

PT97944B1 (pt

Inventor

Serge Lavastre

Jean-Pierre Maignan

Raymond Paul

Martine Poncelet

Vincent Santucci

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-14

Filing date

1991-06-12

Publication date

1992-03-31

1991-06-12 Application filed by Sanofi Sa filed Critical Sanofi Sa

1992-03-31 Publication of PT97944A publication Critical patent/PT97944A/pt

1998-11-30 Publication of PT97944B publication Critical patent/PT97944B/pt

1999-05-31 Publication of PT97944B1 publication Critical patent/PT97944B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Control Of Transmission Device (AREA)
Data Exchanges In Wide-Area Networks (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PT97944A 1990-06-14 1991-06-12 Processo para a preparacao de derivados de hexa-hidroazepina PT97944B1 (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR909007434A FR2663328B1 (fr)	1990-06-14	1990-06-14	Derives d'hexahydroazepines, un procede pour leur preparation et compositions pharmaceutiques les contenant.

Publications (3)

Publication Number	Publication Date
PT97944A true PT97944A (pt)	1992-03-31
PT97944B PT97944B (pt)	1998-11-30
PT97944B1 PT97944B1 (pt)	1999-05-31

Family

ID=9397608

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97944A PT97944B1 (pt)	1990-06-14	1991-06-12	Processo para a preparacao de derivados de hexa-hidroazepina

Country Status (30)

Country	Link
US (2)	US5231092A (pt)
EP (1)	EP0461986B1 (pt)
JP (1)	JP2620422B2 (pt)
KR (1)	KR100213531B1 (pt)
AT (1)	ATE132861T1 (pt)
AU (1)	AU647481B2 (pt)
BR (1)	BR1100207A (pt)
CA (1)	CA2044484C (pt)
CZ (1)	CZ285696B6 (pt)
DE (1)	DE69116237T2 (pt)
DK (1)	DK0461986T3 (pt)
ES (1)	ES2084792T3 (pt)
FI (1)	FI101301B1 (pt)
FR (1)	FR2663328B1 (pt)
GR (1)	GR3019197T3 (pt)
HK (1)	HK1000598A1 (pt)
HU (2)	HU222490B1 (pt)
IE (1)	IE74709B1 (pt)
IL (1)	IL98479A (pt)
LT (1)	LT3550B (pt)
LV (1)	LV10433B (pt)
MX (1)	MX9203360A (pt)
MY (1)	MY135774A (pt)
NO (1)	NO180195C (pt)
NZ (1)	NZ238516A (pt)
PL (1)	PL165842B1 (pt)
PT (1)	PT97944B1 (pt)
RU (2)	RU2070194C1 (pt)
UA (1)	UA27222C2 (pt)
ZA (1)	ZA914572B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2751645B1 (fr) *	1996-07-29	1998-12-24	Sanofi Sa	Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales
US6005102A (en)	1997-10-15	1999-12-21	American Home Products Corporation	Aryloxy-alkyl-dialkylamines
FR2794742B1 (fr) *	1999-06-11	2005-06-03	Sanofi Synthelabo	Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant
FR2795724B1 (fr) *	1999-07-02	2002-12-13	Sanofi Synthelabo	Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant
CA2625153A1 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
AU2006308889A1 (en)	2005-10-31	2007-05-10	Braincells, Inc.	GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
AU2007249435A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 HT receptor mediated neurogenesis
WO2007134136A2 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
EP2471780B1 (en)	2007-05-30	2014-11-26	Ind-Swift Laboratories Limited	Crystalline Ivabradine Oxalate Salts and Polymorphs Thereof
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
EP4213822A1 (en)	2020-09-17	2023-07-26	MELETIOS Therapeutics	Compounds for treating virus infections

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2881165A (en) *	1956-06-29	1959-04-07	Nl Combinatie Chem Ind	alpha-alpha-diphenyl-gamma-hexamethyleneiminobutyramide
DE1545561A1 (de) *	1965-08-23	1969-12-11	Acraf	Verfahren zur Herstellung von pharmakologisch aktiven N,N-disubstituierten 1-Aryl-3-aminopropinen
GB1475314A (en) *	1973-11-02	1977-06-01	Cm Ind	Phenyl-propylamine derivatives
US4104383A (en) *	1973-11-02	1978-08-01	C M Industries	Derivatives of phenylpropenylamine
DE3019497A1 (de) *	1980-05-22	1981-11-26	Bayer Ag, 5090 Leverkusen	Aminopropiophenon-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
AU4261285A (en) *	1984-06-01	1985-12-05	Tokyo Tanabe Company Limited	1-propanone derivatives
DE3508398A1 (de) *	1985-03-08	1986-11-06	Hoechst Ag, 6230 Frankfurt	Fungizide mittel auf der basis von 3-(hetero)-arylpropylaminen sowie neue (hetero)-aryl-propylamine und verfahren zu ihrer herstellung
US4709094A (en)	1986-07-10	1987-11-24	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon	Sigma brain receptor ligands and their use

1990
- 1990-06-14 FR FR909007434A patent/FR2663328B1/fr not_active Expired - Fee Related
1991
- 1991-06-10 IE IE196391A patent/IE74709B1/en not_active IP Right Cessation
- 1991-06-11 EP EP91401531A patent/EP0461986B1/fr not_active Expired - Lifetime
- 1991-06-11 DE DE69116237T patent/DE69116237T2/de not_active Expired - Fee Related
- 1991-06-11 ES ES91401531T patent/ES2084792T3/es not_active Expired - Lifetime
- 1991-06-11 AT AT91401531T patent/ATE132861T1/de not_active IP Right Cessation
- 1991-06-11 DK DK91401531.8T patent/DK0461986T3/da active
- 1991-06-12 NZ NZ238516A patent/NZ238516A/xx not_active IP Right Cessation
- 1991-06-12 PT PT97944A patent/PT97944B1/pt not_active IP Right Cessation
- 1991-06-13 UA UA4895622A patent/UA27222C2/uk unknown
- 1991-06-13 RU SU4895622/04A patent/RU2070194C1/ru not_active IP Right Cessation
- 1991-06-13 CZ CS911818A patent/CZ285696B6/cs not_active IP Right Cessation
- 1991-06-13 RU RU94038042/04A patent/RU2133741C1/ru not_active IP Right Cessation
- 1991-06-13 US US07/714,832 patent/US5231092A/en not_active Expired - Lifetime
- 1991-06-13 NO NO912283A patent/NO180195C/no unknown
- 1991-06-13 CA CA002044484A patent/CA2044484C/en not_active Expired - Fee Related
- 1991-06-13 IL IL9847991A patent/IL98479A/en not_active IP Right Cessation
- 1991-06-14 PL PL91290675A patent/PL165842B1/pl not_active IP Right Cessation
- 1991-06-14 JP JP3143212A patent/JP2620422B2/ja not_active Expired - Fee Related
- 1991-06-14 HU HU9101983A patent/HU222490B1/hu active IP Right Grant
- 1991-06-14 KR KR1019910009879A patent/KR100213531B1/ko not_active IP Right Cessation
- 1991-06-14 AU AU78434/91A patent/AU647481B2/en not_active Ceased
- 1991-06-14 MY MYPI91001068A patent/MY135774A/en unknown
- 1991-06-14 FI FI912899A patent/FI101301B1/fi active IP Right Grant
- 1991-06-14 ZA ZA914572A patent/ZA914572B/xx unknown
1992
- 1992-06-25 MX MX9203360A patent/MX9203360A/es unknown
1993
- 1993-02-25 LV LVP-93-141A patent/LV10433B/en unknown
- 1993-04-14 US US08/045,722 patent/US5296596A/en not_active Expired - Lifetime
- 1993-06-23 LT LTIP704A patent/LT3550B/lt not_active IP Right Cessation
1995
- 1995-06-30 HU HU95P/P00617P patent/HU211616A9/hu unknown
1996
- 1996-03-05 GR GR960400601T patent/GR3019197T3/el unknown
1997
- 1997-04-02 BR BR1100207-7A patent/BR1100207A/pt active IP Right Grant
- 1997-11-10 HK HK97102148A patent/HK1000598A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
HK1000598A1 (en)	1998-04-09
HU211616A9 (en)	1995-12-28
FR2663328A1 (fr)	1991-12-20
CZ181891A3 (en)	1994-01-19
FI101301B (fi)	1998-05-29
EP0461986A1 (fr)	1991-12-18
JP2620422B2 (ja)	1997-06-11
IL98479A0 (en)	1992-07-15
PL165842B1 (pl)	1995-02-28
NO180195B (no)	1996-11-25
KR100213531B1 (ko)	1999-08-02
HU9101983D0 (en)	1991-12-30
PT97944B (pt)	1998-11-30
HU222490B1 (hu)	2003-07-28
LTIP704A (en)	1995-01-31
NO912283L (no)	1991-12-16
MX9203360A (es)	1992-07-01
US5231092A (en)	1993-07-27
FI101301B1 (fi)	1998-05-29
ES2084792T3 (es)	1996-05-16
IL98479A (en)	1995-11-27
CZ285696B6 (cs)	1999-10-13
RU94038042A (ru)	1996-09-10
KR920000728A (ko)	1992-01-29
ATE132861T1 (de)	1996-01-15
LV10433B (en)	1995-08-20
RU2070194C1 (ru)	1996-12-10
UA27222C2 (uk)	2000-08-15
NZ238516A (en)	1993-09-27
US5296596A (en)	1994-03-22
PL290675A1 (en)	1992-03-23
MY135774A (en)	2008-06-30
DE69116237D1 (de)	1996-02-22
FI912899A0 (fi)	1991-06-14
LT3550B (en)	1995-11-27
CA2044484C (en)	1998-05-26
IE74709B1 (en)	1997-07-30
BR1100207A (pt)	1999-10-05
AU647481B2 (en)	1994-03-24
GR3019197T3 (en)	1996-06-30
NO912283D0 (no)	1991-06-13
DE69116237T2 (de)	1996-07-25
IE911963A1 (en)	1991-12-18
EP0461986B1 (fr)	1996-01-10
AU7843491A (en)	1991-12-19
ZA914572B (en)	1992-03-25
FI912899A (fi)	1991-12-15
PT97944B1 (pt)	1999-05-31
NO180195C (no)	1997-03-05
HUT61736A (en)	1993-03-01
JPH04321676A (ja)	1992-11-11
FR2663328B1 (fr)	1994-08-05
CA2044484A1 (en)	1991-12-15
DK0461986T3 (da)	1996-05-28
RU2133741C1 (ru)	1999-07-27
LV10433A (lv)	1995-02-20

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NO307379B1 (no)	2000-03-27	3-merkapto-1-(1,3-tiazolin-2-yl)azetidin-derivater
ES533916A0 (es)	1985-12-01	Un metodo para producir acidos 1,4-dihidro-4-oxo-quinolin-3-carboxilico
PT97944A (pt)	1992-03-31	Processo para a preparacao de derivados de hexa-hidroazepina
NZ220546A (en)	1989-02-24	Benzothiophene- and benzofuran- amides and compositions
BR9201854A (pt)	1993-01-05	Composto derivado de pridazinas,processo para sua preparacao,e,composicao farmaceutica
PT97796A (pt)	1992-02-28	Processo para a preparacao de piperidinas substituidas
PT99970A (pt)	1993-02-26	Processo e intermediarios para a preparacao de azabiciclo {2.2.2.} octan-3-iminas
ITMI931012A1 (it)	1994-11-18	Composti spiro-piranici dotati di caratteristiche fotocromatiche
BR9400016A (pt)	1995-05-02	Processo para preparação de compostos, e compostos
PT83334B (pt)	1989-05-12	Processo para a preparacao de compostos beta-lactamicos
ES2112867T3 (es)	1998-04-16	Sales de acidos acil-(2'-hidroxibifenil-2-il)-fosfinicos, su produccion y su utilizacion.
DK0623620T3 (da)	1999-06-07	5-HT3-pyrrolopyrazinderivater
BR0210512A (pt)	2004-06-22	Processo de decomposição papa o ácido (r)-(-)-2-hidroxi-2-(2-clorofenil) acético
DE69928610D1 (de)	2006-01-05	Verfahren zur Herstellung von 2-Carbamoyl-Pyridinen
PT96178A (pt)	1991-09-30	Metodo para a utilizacao de naftoxazinas no tratamento de condicoes associadas com a esquemia cerebral
HUT50833A (en)	1990-03-28	Process for producing indolo/3,2-1-de/ /1,4/-oxazino/2,3,4-ij/ /1,5/-naphthyridine derivatives
ATE67194T1 (de)	1991-09-15	Thiadiazolylacetamid-derivate, verfahren zu ihrer herstellung und ihre verwendung.
TW217985B (en)	1993-12-21	Polythiophenecarboxylic acid derivatives used for increasing immunity
AR247567A1 (es)	1995-01-31	Procedimiento para preparar carbonitrilos azatetraciclicos

Legal Events

Date	Code	Title	Description
1992-03-31	BB1A	Laying open of patent application	Effective date: 19911115
1998-11-30	FG3A	Patent granted, date of granting	Effective date: 19980804
1999-05-31	FG3A	Patent granted, date of granting	Effective date: 19990212
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