PT921125E - Derivados de 1,38-triaza-espiro 4,5 decan-4-ona - Google Patents

Derivados de 1,38-triaza-espiro 4,5 decan-4-ona

Info

Publication number: PT921125E
Authority: PT; Portugal
Prior art keywords: espiro; triaza; decan; ona; derivatives
Prior art date: 1997-12-05

Application number

PT98122511T

Other languages

English (en)

Inventor

Geo Adam

Andrea Cesura

Guido Galley

Francois Jenck

Stephan Roever

Juergen Wichmann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-05

Filing date

1998-11-27

Publication date

2002-06-28

1998-11-27 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2002-06-28 Publication of PT921125E publication Critical patent/PT921125E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Color Printing (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PT98122511T 1997-12-05 1998-11-27 Derivados de 1,38-triaza-espiro 4,5 decan-4-ona PT921125E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97121427		1997-12-05

Publications (1)

Publication Number	Publication Date
PT921125E true PT921125E (pt)	2002-06-28

Family

ID=8227753

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98122511T PT921125E (pt)	1997-12-05	1998-11-27	Derivados de 1,38-triaza-espiro 4,5 decan-4-ona

Country Status (29)

Country	Link
US (1)	US6043366A (pt)
JP (1)	JP3366868B2 (pt)
KR (1)	KR19990062800A (pt)
CN (1)	CN1118467C (pt)
AR (1)	AR016428A1 (pt)
AT (1)	ATE212635T1 (pt)
AU (1)	AU744338B2 (pt)
BR (1)	BR9805297B1 (pt)
CA (1)	CA2255171C (pt)
CO (1)	CO4990965A1 (pt)
CZ (1)	CZ399698A3 (pt)
DE (1)	DE69803653T2 (pt)
DK (1)	DK0921125T3 (pt)
ES (1)	ES2170446T3 (pt)
HR (1)	HRP980613A2 (pt)
HU (1)	HUP9802807A3 (pt)
ID (1)	ID21413A (pt)
IL (1)	IL127399A0 (pt)
MA (1)	MA26573A1 (pt)
NO (1)	NO312161B1 (pt)
NZ (1)	NZ333159A (pt)
PE (1)	PE135299A1 (pt)
PL (1)	PL330062A1 (pt)
PT (1)	PT921125E (pt)
SG (1)	SG71173A1 (pt)
TR (1)	TR199802520A3 (pt)
TW (1)	TW408123B (pt)
YU (1)	YU55198A (pt)
ZA (1)	ZA9811128B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2237047T3 (es) *	1998-10-23	2005-07-16	Pfizer Inc.	Compuestos de 1,3,8-triazaespiro(4,5)decanona como agonistas del receptor orl1.
US6686370B2 (en) *	1999-12-06	2004-02-03	Euro-Celtique S.A.	Triazospiro compounds having nociceptin receptor affinity
US7192964B2 (en) *	2001-07-23	2007-03-20	Banyu Pharmaceutical Co., Ltd.	4-oxoimidazolidine-2-spiropiperidine derivatives
JP4056977B2 (ja)	2002-03-29	2008-03-05	田辺三菱製薬株式会社	睡眠障害治療薬
EA009369B1 (ru) *	2002-09-09	2007-12-28	Янссен Фармацевтика, Н.В.	Производные гидроксизамещенного 1,3,8-триазинспиро[4,5]декан-4-она, полезные для лечения расстройств, опосредованных orl-рецептором
WO2004058727A1 (en) *	2002-12-20	2004-07-15	Bayer Pharmaceuticals Corporation	Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity
ZA200510329B (en) *	2003-05-23	2007-04-25	Zealand Pharma As	Triaza-spiro compounds as nociceptin analogues and uses thereof
US20060178390A1 (en) *	2004-08-02	2006-08-10	Alfonzo Jordan	1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
BRPI0609580A2 (pt) *	2005-03-22	2010-04-20	Hoffmann La Roche	composto, polimorfo cristalino, processo para a sua manufatura, composições farmacêuticas que o contêm, método para o tratamento e/ou profilaxia de enfermidades que estão associadas com dpp-iv e utilização do composto
CA2654262A1 (en) *	2006-06-20	2007-12-27	Wyeth	Kv1.5 potassium channel inhibitors
US8703948B2 (en) *	2006-11-28	2014-04-22	Janssen Pharmaceutica Nv	Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
JP5313865B2 (ja) *	2007-03-01	2013-10-09	田辺三菱製薬株式会社	ベンゾイミダゾール化合物およびその医薬用途
US8741916B2 (en) *	2007-04-09	2014-06-03	Janssen Pharmaceutica Nv	1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the ORL-1 receptor
PA8801401A1 (es) *	2007-10-25	2009-05-15	Janssen Pharmaceutica Nv	Arilindenopirimidinas y su uso como adenosina a2a
TW201016675A (en) *	2008-09-16	2010-05-01	Mitsubishi Tanabe Pharma Corp	Crystalline benzoimidazole compound and salt thereof
US20100076003A1 (en) *	2008-09-19	2010-03-25	Kathleen Battista	5-oxazolidin-2-one substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful as orl-1 receptor modulators
WO2010037081A1 (en) *	2008-09-29	2010-04-01	Palatin Technologies, Inc.	Melanocortin receptor-specific spiro-piperidine compounds
MX2011013691A (es)	2009-06-16	2012-01-20	Merck Sharp & Dohme	1,3,8-triazaespiro[4,5]decano-2,4-dionas sustituidas.
JP7002335B2 (ja) *	2015-07-03	2022-01-20	エフ．ホフマン－ラロシュアーゲー	Ｄｄｒ１阻害剤としてのトリアザ－スピロデカノン

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3161644A (en) *	1962-06-22	1964-12-15	Res Lab Dr C Janssen N V	1-benzyl-4-substituted piperidines
US3155669A (en) *	1962-06-22	1964-11-03	Res Lab Dr C Janssen N V	2, 4, 8-triaza-spiro (4, 5) dec-2-enes
US3155670A (en) *	1962-06-22	1964-11-03	Res Lab Dr C Janssen N V	1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes
US3238216A (en) *	1963-06-20	1966-03-01	Res Lab Dr C Janssen N V	Substituted 1, 3, 8-triaza-spiro (4, 5) decanes
JPS51100084A (pt) *	1975-02-28	1976-09-03	Yoshitomi Pharmaceutical
GB1486546A (en) *	1975-02-28	1977-09-21	Yoshitomo Pharma Ind Ltd	4,4-diphenyl-cyclohexylpiperidine compounds and analogues thereof
JPS5212171A (en) *	1975-07-17	1977-01-29	Yoshitomi Pharmaceut Ind Ltd	Process for preparation of cyclohexane derivatives
JPS5934713B2 (ja) *	1976-01-05	1984-08-24	ウェルファイド株式会社	脂環式誘導体
US4076821A (en) *	1976-02-27	1978-02-28	Yoshitomi Pharmaceutical Industries, Ltd.	4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof
US4329353A (en) *	1980-10-22	1982-05-11	Janssen Pharmaceutica, N.V.	1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
MA19091A1 (fr) *	1980-03-10	1981-10-01	Janssen Pharmaceutica Nv	Nouveaux derives de i-(4-aryl-cyclohexyl)piperidine .
GR73633B (pt) *	1980-03-10	1984-03-26	Janssen Pharmaceutica Nv
ATE67769T1 (de) *	1983-01-25	1991-10-15	Ciba Geigy Ag	Neue peptidderivate.
JPS6012357B2 (ja) *	1984-01-23	1985-04-01	吉富製薬株式会社	脂環式誘導体
CA2226058C (en) *	1997-01-30	2008-01-29	F. Hoffmann-La Roche Ag	8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives

1998
- 1998-11-27 ES ES98122511T patent/ES2170446T3/es not_active Expired - Lifetime
- 1998-11-27 AT AT98122511T patent/ATE212635T1/de active
- 1998-11-27 DK DK98122511T patent/DK0921125T3/da active
- 1998-11-27 PT PT98122511T patent/PT921125E/pt unknown
- 1998-11-27 DE DE69803653T patent/DE69803653T2/de not_active Expired - Lifetime
- 1998-12-03 CA CA002255171A patent/CA2255171C/en not_active Expired - Fee Related
- 1998-12-03 ID IDP981576A patent/ID21413A/id unknown
- 1998-12-03 PE PE1998001176A patent/PE135299A1/es not_active Application Discontinuation
- 1998-12-03 YU YU55198A patent/YU55198A/sh unknown
- 1998-12-03 US US09/204,184 patent/US6043366A/en not_active Expired - Fee Related
- 1998-12-03 NZ NZ333159A patent/NZ333159A/en unknown
- 1998-12-03 SG SG1998005141A patent/SG71173A1/en unknown
- 1998-12-03 PL PL98330062A patent/PL330062A1/xx unknown
- 1998-12-03 AR ARP980106141A patent/AR016428A1/es active IP Right Grant
- 1998-12-04 IL IL12739998A patent/IL127399A0/xx unknown
- 1998-12-04 AU AU96087/98A patent/AU744338B2/en not_active Ceased
- 1998-12-04 CZ CZ983996A patent/CZ399698A3/cs unknown
- 1998-12-04 BR BRPI9805297-7A patent/BR9805297B1/pt not_active IP Right Cessation
- 1998-12-04 JP JP34527898A patent/JP3366868B2/ja not_active Expired - Fee Related
- 1998-12-04 MA MA25369A patent/MA26573A1/fr unknown
- 1998-12-04 CN CN98122759A patent/CN1118467C/zh not_active Expired - Fee Related
- 1998-12-04 HR HR97121427.5A patent/HRP980613A2/hr not_active Application Discontinuation
- 1998-12-04 NO NO19985684A patent/NO312161B1/no not_active IP Right Cessation
- 1998-12-04 CO CO98072457A patent/CO4990965A1/es unknown
- 1998-12-04 ZA ZA9811128A patent/ZA9811128B/xx unknown
- 1998-12-04 TR TR1998/02520A patent/TR199802520A3/tr unknown
- 1998-12-04 TW TW087120132A patent/TW408123B/zh not_active IP Right Cessation
- 1998-12-04 HU HU9802807A patent/HUP9802807A3/hu unknown
- 1998-12-04 KR KR1019980053080A patent/KR19990062800A/ko active Search and Examination

Also Published As

Publication number	Publication date
BR9805297B1 (pt)	2010-07-13
HU9802807D0 (en)	1999-02-01
KR19990062800A (ko)	1999-07-26
SG71173A1 (en)	2000-03-21
TW408123B (en)	2000-10-11
MA26573A1 (fr)	2004-12-20
TR199802520A2 (xx)	1999-06-21
HRP980613A2 (en)	1999-08-31
ES2170446T3 (es)	2002-08-01
DE69803653D1 (de)	2002-03-14
NZ333159A (en)	2000-06-23
DK0921125T3 (da)	2002-05-13
AU9608798A (en)	1999-06-24
CO4990965A1 (es)	2000-12-26
JP3366868B2 (ja)	2003-01-14
CZ399698A3 (cs)	1999-06-16
BR9805297A (pt)	2000-02-01
PL330062A1 (en)	1999-06-07
AU744338B2 (en)	2002-02-21
PE135299A1 (es)	2000-01-18
DE69803653T2 (de)	2002-08-29
HUP9802807A3 (en)	2000-01-28
AR016428A1 (es)	2001-07-04
ID21413A (id)	1999-06-10
NO985684D0 (no)	1998-12-04
CA2255171A1 (en)	1999-06-05
ZA9811128B (en)	1999-06-07
NO985684L (no)	1999-06-07
IL127399A0 (en)	1999-10-28
JPH11228575A (ja)	1999-08-24
US6043366A (en)	2000-03-28
HUP9802807A2 (hu)	1999-08-30
CA2255171C (en)	2009-09-29
YU55198A (sh)	2001-12-26
ATE212635T1 (de)	2002-02-15
CN1118467C (zh)	2003-08-20
TR199802520A3 (tr)	1999-06-21
CN1222521A (zh)	1999-07-14
NO312161B1 (no)	2002-04-02

Publication	Publication Date	Title
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PT1005446E (pt)	2004-06-30	Derivados de n-aroilfenilalanina
ATE235220T1 (de)	2003-04-15	Resorcinderivate
ID22781A (id)	1999-12-09	Turunan-turunan nikotinamida
DE69736711D1 (de)	2006-11-02	Substituierte 6,5-heterobicyclische-derivate
DK0925298T3 (da)	2004-08-09	Substituerede 6,6-heterobicykliske derivater
DE69817186D1 (de)	2003-09-18	Diaminorhodamin-derivate
PT915088E (pt)	2003-01-31	Derivados de d-prolina
DE69718771D1 (de)	2003-03-06	Substituierte 1,2,3,4-tetrahydronaphthalinderivate
PT921125E (pt)	2002-06-28	Derivados de 1,38-triaza-espiro 4,5 decan-4-ona
ATE255098T1 (de)	2003-12-15	Substituierte chromanderivate
PT1003719E (pt)	2002-10-31	Derivados microbicidas de n-sulfonil-glicinalquiniloxifenemetilamida
PT1027362E (pt)	2005-08-31	Derivados de cetolidos 2-halogeno-6-o-substituidos
FR2763953B1 (fr)	2005-01-07	Derives de 5'-desoxy-cytidine
ATE255099T1 (de)	2003-12-15	Substituierte chromanderivate
DE69829682D1 (de)	2005-05-12	Cis-disubstituierte aminocycloalkyl-pyrrolidin-derivate
MA26480A1 (fr)	2004-12-20	Derives de phenoxymethylpiperidine
DE69828780D1 (de)	2005-03-03	Amidinocamptpthecin-derivate
PT1060183E (pt)	2003-08-29	Derivados de 5'-desoxicitidina
PT966437E (pt)	2002-11-29	Derivados de 5-aroilnaftaleno
PT796843E (pt)	2003-09-30	Derivados de 1,25-di-hidroxi-16,22,23-trisde-hidro-colecalciferol
DK1015447T3 (da)	2002-06-17	Piperidinylmethyloxazolidinonderivat
ATE243218T1 (de)	2003-07-15	2''-deoxyhygromycinderivate
MA26481A1 (fr)	2004-12-20	Derives d'arylsecocholadiene
ID16434A (id)	1997-09-25	Senyawa-senyawa 1,4-dihidropiridin