PT79890B - Process for preparing tetrahydro-methylimidazolylcarbazolones - Google Patents
Process for preparing tetrahydro-methylimidazolylcarbazolonesInfo
- Publication number
- PT79890B PT79890B PT79890A PT7989085A PT79890B PT 79890 B PT79890 B PT 79890B PT 79890 A PT79890 A PT 79890A PT 7989085 A PT7989085 A PT 7989085A PT 79890 B PT79890 B PT 79890B
- Authority
- PT
- Portugal
- Prior art keywords
- methylimidazolylcarbazolones
- preparing tetrahydro
- tetrahydro
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848401888A GB8401888D0 (en) | 1984-01-25 | 1984-01-25 | Heterocyclic compounds |
GB848425959A GB8425959D0 (en) | 1984-10-15 | 1984-10-15 | Heterocyclic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
PT79890A PT79890A (en) | 1985-02-01 |
PT79890B true PT79890B (en) | 1987-02-03 |
Family
ID=26287221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT79890A PT79890B (en) | 1984-01-25 | 1985-01-25 | Process for preparing tetrahydro-methylimidazolylcarbazolones |
Country Status (29)
Country | Link |
---|---|
KR (1) | KR920003064B1 (en) |
AT (1) | AT392276B (en) |
AU (1) | AU579132B2 (en) |
BE (1) | BE901576A (en) |
CA (1) | CA1252793A (en) |
CH (1) | CH664152A5 (en) |
CY (1) | CY1479A (en) |
CZ (1) | CZ404391A3 (en) |
DE (2) | DE3502508A1 (en) |
DK (1) | DK169521B1 (en) |
ES (3) | ES8609309A1 (en) |
FI (1) | FI84349C (en) |
FR (1) | FR2561244B1 (en) |
GB (1) | GB2153821B (en) |
GR (1) | GR850219B (en) |
HK (1) | HK33189A (en) |
HU (1) | HU193592B (en) |
IE (1) | IE57809B1 (en) |
IL (1) | IL74165A (en) |
IT (1) | IT1182150B (en) |
LU (2) | LU85743A1 (en) |
NL (2) | NL190373C (en) |
NO (2) | NO164025C (en) |
NZ (1) | NZ210940A (en) |
PH (1) | PH22672A (en) |
PT (1) | PT79890B (en) |
SE (1) | SE460359B (en) |
SG (1) | SG7089G (en) |
SK (1) | SK277923B6 (en) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4695578A (en) * | 1984-01-25 | 1987-09-22 | Glaxo Group Limited | 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances |
DE3680123D1 (en) * | 1985-01-23 | 1991-08-14 | Glaxo Group Ltd | Tetrahydrocarbazolonderivate. |
DE201165T1 (en) * | 1985-03-14 | 1989-04-20 | Beecham Group P.L.C., Brentford | MEDICINES FOR TREATING EMESIS, ANXIETAS AND "IRRITABLE BOWEL SYNDROME". |
US5578628A (en) * | 1985-06-25 | 1996-11-26 | Glaxo Group Limited | Medicaments for the treatment of nausea and vomiting |
GB8516083D0 (en) * | 1985-06-25 | 1985-07-31 | Glaxo Group Ltd | Heterocyclic compounds |
GB8518658D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Medicaments |
GB8518743D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
GB8518742D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Process |
GB8518741D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Process |
GB8518745D0 (en) | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
US5204356A (en) * | 1985-07-24 | 1993-04-20 | Glaxo Group Limited | Treatment of anxiety |
GB8617994D0 (en) * | 1986-07-23 | 1986-08-28 | Glaxo Group Ltd | Heterocyclic compounds |
NL8701682A (en) * | 1986-07-30 | 1988-02-16 | Sandoz Ag | METHOD FOR THE THERAPEUTIC USE OF SEROTONIN ANTAGONISTS, ACTIVE COMPOUNDS AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS |
AT396870B (en) * | 1986-08-07 | 1993-12-27 | Sandoz Ag | Process for the production of a pharmaceutical formulation for the nasal administration of serotonin antagonists |
GB8623819D0 (en) * | 1986-10-03 | 1986-11-05 | Glaxo Group Ltd | Heterocyclic compounds |
GB8627909D0 (en) * | 1986-11-21 | 1986-12-31 | Glaxo Group Ltd | Medicaments |
DE3777805D1 (en) * | 1986-11-21 | 1992-04-30 | Glaxo Group Ltd | MEDICINES FOR TREATING OR PREVENTING THE WITHDRAWAL SYNDROME. |
GB8812002D0 (en) * | 1988-05-20 | 1988-06-22 | Glaxo Group Ltd | Chemical compounds |
GR871809B (en) * | 1986-11-28 | 1988-03-07 | Glaxo Group Ltd | Process for the preparation of tricyclic ketones |
GB8628475D0 (en) * | 1986-11-28 | 1987-01-07 | Glaxo Group Ltd | Medicaments |
US5202343A (en) * | 1986-11-28 | 1993-04-13 | Glaxo Group Limited | Tricyclic ketones useful as HT3 -receptor antagonists |
US4973594A (en) * | 1986-12-17 | 1990-11-27 | Glaxo Group Limited | Medicaments |
EP0275668B1 (en) * | 1986-12-17 | 1992-09-30 | Glaxo Group Limited | Use of ketone derivatives in the treatment of cognitive disorders |
GB8630071D0 (en) * | 1986-12-17 | 1987-01-28 | Glaxo Group Ltd | Medicaments |
US5190954A (en) * | 1986-12-17 | 1993-03-02 | Glaxo Group Limited | Methods for the treatment of cognitive disorders |
GB8630079D0 (en) * | 1986-12-17 | 1987-01-28 | Glaxo Group Ltd | Medicaments |
US5200414A (en) * | 1986-12-17 | 1993-04-06 | Glaxo Group Limited | Methods for the treatment of cognitive disorders |
EP0291172B1 (en) * | 1987-04-14 | 1992-11-19 | Glaxo Group Limited | Ketone derivatives |
GB2205745B (en) * | 1987-06-16 | 1990-09-19 | Nat Res Dev | Use of dioxopiperidine derivatives as analgesics |
DE3822792C2 (en) * | 1987-07-11 | 1997-11-27 | Sandoz Ag | New use of 5HT¶3¶ antagonists |
GB8723157D0 (en) * | 1987-10-02 | 1987-11-04 | Beecham Group Plc | Compounds |
CA1304082C (en) * | 1987-10-22 | 1992-06-23 | Tetsuya Tahara | Benzoxazine compounds and pharmaceutical use thereof |
US4939144A (en) * | 1987-10-22 | 1990-07-03 | Glaxo Group Limited | Tricyclic ketone derivatives as 5-HT antagonists |
US5225431A (en) * | 1987-10-23 | 1993-07-06 | Burroughs Wellcome Co. | Therapeutic substituted indole compounds and compositions thereof |
GB8805269D0 (en) * | 1988-03-04 | 1988-04-07 | Glaxo Group Ltd | Medicaments |
EP0336759A1 (en) * | 1988-04-07 | 1989-10-11 | Glaxo Group Limited | Imidazole derivatives |
DK185489A (en) * | 1988-04-22 | 1989-10-23 | Duphar Int Res | IMIDAZOLYLMETHYL-CYCLOALKANOEBAA INDOLONES, THEIR PREPARATION AND USE |
US4985422A (en) * | 1988-04-27 | 1991-01-15 | Glaxo Group Limited | Lactam derivatives |
GB8812636D0 (en) * | 1988-05-27 | 1988-06-29 | Glaxo Group Ltd | Chemical compounds |
US5290785A (en) * | 1988-09-27 | 1994-03-01 | Fujisawa Pharmaceutical Co., Ltd. | Therapeutic agent for ischemic diseases |
US5173493A (en) * | 1988-09-27 | 1992-12-22 | Fujisawa Pharmaceutical Company, Ltd. | Pyridoindole derivatives and processes for preparation thereof |
AU627221B2 (en) * | 1988-09-27 | 1992-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Pyridoindole derivatives and processes for preparation thereof |
FR2639944B1 (en) * | 1988-12-06 | 1991-01-18 | Adir | NEW INDOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US5223625A (en) * | 1988-12-22 | 1993-06-29 | Duphar International Research B.V. | Annelated indolo [3,2,-C]lactams |
CA2004911A1 (en) * | 1988-12-22 | 1990-06-22 | Mitsuaki Ohta | 4,5,6,7-tetrahydrobenzimidazole derivatives |
EP0377238A1 (en) * | 1988-12-22 | 1990-07-11 | Duphar International Research B.V | New annelated indolo (3,2-c)-lactams |
EP0392663A1 (en) * | 1989-03-13 | 1990-10-17 | Ono Pharmaceutical Co., Ltd. | Carboline derivative as a 5-HT3 receptor antagonist |
ES2061024T3 (en) * | 1989-04-21 | 1994-12-01 | Sandoz Ag | THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS. |
GB8914804D0 (en) * | 1989-06-28 | 1989-08-16 | Glaxo Group Ltd | Process |
GB8917557D0 (en) * | 1989-08-01 | 1989-09-13 | Glaxo Group Ltd | Medicaments |
US5276050A (en) * | 1989-08-01 | 1994-01-04 | Glaxo Group Limited | Medicaments |
US5126343A (en) * | 1989-09-11 | 1992-06-30 | G. D. Searle & Co. | N-azabicyclo [3.3.0]octane amides of aromatic acids |
GB2236751B (en) | 1989-10-14 | 1993-04-28 | Wyeth John & Brother Ltd | Heterocyclic compounds |
GB8928837D0 (en) * | 1989-12-21 | 1990-02-28 | Beecham Group Plc | Pharmaceuticals |
US5187166A (en) * | 1990-07-31 | 1993-02-16 | Nisshin Flour Milling Co., Ltd. | Azabicyclo derivatives and their use as antiemetics |
CA2112487C (en) | 1991-06-26 | 2003-04-15 | James W. Young | Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron |
JPH05310732A (en) * | 1992-03-12 | 1993-11-22 | Mitsubishi Kasei Corp | Cinnoline-3-carboxylic acid derivative |
ES2043535B1 (en) * | 1992-03-13 | 1994-08-01 | Vita Invest Sa | PROCEDURE FOR OBTAINING 1,2,3,9-TETRAHYDRO-9-METHYL-3- (2-METHYL-1H-IMIDAZOL-1-IL) METHYL * -4H-CARBAZOL-4-ONA. |
HU212934B (en) | 1992-10-14 | 1996-12-30 | Richter Gedeon Vegyeszet | Process for producing novel alkoxalylated carbazolone derivatives |
CA2106642C (en) * | 1992-10-14 | 2005-08-16 | Peter Bod | Carbazolone derivatives and process for preparing the same |
CN1118990A (en) * | 1993-03-08 | 1996-03-20 | 藤泽药品工业株式会社 | Medicament for treating or preventing cerebrovascular diseases |
GB9310756D0 (en) * | 1993-05-25 | 1993-07-14 | Glaxo Lab Sa | Compositions |
GB2290963A (en) * | 1994-06-28 | 1996-01-17 | Kenneth Francis Prendergast | Pharmaceutical uses of ondansetron |
GB9423588D0 (en) * | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
US6365743B1 (en) | 1995-10-13 | 2002-04-02 | Duphar International Research B.V. | Process for the preparation of enantiomerically pure imidazolyl compounds |
AU702594B2 (en) * | 1995-10-13 | 1999-02-25 | Duphar International Research B.V. | Process for the preparation of enantiomerically pure imidazolyl compounds |
US5969137A (en) * | 1996-09-19 | 1999-10-19 | Virginia Commonwealth University | Benzylamidine derivatives with serotonin receptor binding activity |
CA2371822A1 (en) | 1999-03-01 | 2000-09-08 | Sepracor Inc. | Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron |
EP1207160A1 (en) * | 2000-11-20 | 2002-05-22 | Hanmi Pharm. Co., Ltd. | Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one |
PL373191A1 (en) | 2002-04-29 | 2005-08-22 | Teva Gyogyszergyar Reszvenytarsasag | Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-4h-carbazol-4-one |
FI6164U1 (en) * | 2003-01-09 | 2004-03-15 | Synthon Bv | Ondansetronformer |
GB2398071B (en) * | 2003-01-24 | 2006-06-07 | Synthon Bv | Process for making ondansetron and intermediate thereof |
ES2238001B1 (en) * | 2004-01-21 | 2006-11-01 | Vita Cientifica, S.L. | NEW POLYMORPHIC FORMS OF ONDANSETRON, PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANANTIMETICS. |
WO2005108392A2 (en) | 2004-05-07 | 2005-11-17 | Taro Pharmaceutical Industries Ltd. | Process for preparing ondansetron hydrochloride dihydrate having a defined particle size |
US20090170872A1 (en) * | 2005-07-05 | 2009-07-02 | Orchid Research Laboratories Limited | Compounds and Their Pharmaceutical Use |
EP2432467B1 (en) | 2009-05-20 | 2018-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders |
ES2432618T3 (en) | 2009-05-20 | 2013-12-04 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of a pathology of the inner ear with vestibular deficit |
CN115611864A (en) * | 2022-11-01 | 2023-01-17 | 常州兰陵制药有限公司 | A kind of ondansetron compound and its preparation method and application |
GB202301322D0 (en) | 2023-01-30 | 2023-03-15 | Therakind Ltd | Antiemetic pharmaceutical compositions for nasal delivery |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3634420A (en) * | 1969-05-09 | 1972-01-11 | American Cyanamid Co | 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones |
US3740404A (en) * | 1969-05-09 | 1973-06-19 | American Cyanamid Co | Piperidinomethylenedihydrocarbazolones |
DE3680123D1 (en) * | 1985-01-23 | 1991-08-14 | Glaxo Group Ltd | Tetrahydrocarbazolonderivate. |
-
1985
- 1985-01-25 KR KR1019850000454A patent/KR920003064B1/en not_active IP Right Cessation
- 1985-01-25 IT IT47600/85A patent/IT1182150B/en active Protection Beyond IP Right Term
- 1985-01-25 SE SE8500368A patent/SE460359B/en not_active IP Right Cessation
- 1985-01-25 DE DE19853502508 patent/DE3502508A1/en active Granted
- 1985-01-25 GR GR850219A patent/GR850219B/el active IP Right Revival
- 1985-01-25 HU HU85296A patent/HU193592B/en unknown
- 1985-01-25 CA CA000472888A patent/CA1252793A/en not_active Expired
- 1985-01-25 PH PH31770A patent/PH22672A/en unknown
- 1985-01-25 AT AT204/85A patent/AT392276B/en not_active IP Right Cessation
- 1985-01-25 FI FI850323A patent/FI84349C/en not_active IP Right Cessation
- 1985-01-25 BE BE0/214394A patent/BE901576A/en not_active IP Right Cessation
- 1985-01-25 DE DE1993175046 patent/DE19375046I2/en active Active
- 1985-01-25 NL NLAANVRAGE8500202,A patent/NL190373C/en not_active IP Right Cessation
- 1985-01-25 PT PT79890A patent/PT79890B/en unknown
- 1985-01-25 CH CH346/85A patent/CH664152A5/en not_active IP Right Cessation
- 1985-01-25 IE IE187/85A patent/IE57809B1/en not_active IP Right Cessation
- 1985-01-25 FR FR8501056A patent/FR2561244B1/en not_active Expired
- 1985-01-25 GB GB08501889A patent/GB2153821B/en not_active Expired
- 1985-01-25 ES ES539852A patent/ES8609309A1/en not_active Expired
- 1985-01-25 IL IL74165A patent/IL74165A/en not_active IP Right Cessation
- 1985-01-25 DK DK035785A patent/DK169521B1/en not_active IP Right Cessation
- 1985-01-25 LU LU85743A patent/LU85743A1/en active Protection Beyond IP Right Term
- 1985-01-25 AU AU38097/85A patent/AU579132B2/en not_active Expired
- 1985-01-25 NO NO850300A patent/NO164025C/en not_active IP Right Cessation
- 1985-01-25 NZ NZ210940A patent/NZ210940A/en unknown
- 1985-01-25 LU LU88268C patent/LU88268I2/xx unknown
- 1985-10-31 ES ES548430A patent/ES8708224A1/en not_active Expired
-
1986
- 1986-06-16 ES ES556101A patent/ES8801247A1/en not_active Expired
-
1989
- 1989-02-09 SG SG70/89A patent/SG7089G/en unknown
- 1989-04-20 HK HK331/89A patent/HK33189A/en not_active IP Right Cessation
- 1989-07-21 CY CY1479A patent/CY1479A/en unknown
-
1991
- 1991-12-23 CZ CS914043A patent/CZ404391A3/en unknown
- 1991-12-23 SK SK4043-91A patent/SK277923B6/en unknown
-
1994
- 1994-05-31 NL NL940009C patent/NL940009I2/en unknown
- 1994-11-09 NO NO1994022C patent/NO1994022I1/en unknown
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