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PT3986890T - Derivados de benzisoxazol sulfonamida - Google Patents

Derivados de benzisoxazol sulfonamida

Info

Publication number
PT3986890T
PT3986890T PT207437732T PT20743773T PT3986890T PT 3986890 T PT3986890 T PT 3986890T PT 207437732 T PT207437732 T PT 207437732T PT 20743773 T PT20743773 T PT 20743773T PT 3986890 T PT3986890 T PT 3986890T
Authority
PT
Portugal
Prior art keywords
sulfonamide derivatives
benzisoxazole
benzisoxazole sulfonamide
derivatives
sulfonamide
Prior art date
Application number
PT207437732T
Other languages
English (en)
Original Assignee
Ctxt Pty Ltd
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ctxt Pty Ltd, Pfizer filed Critical Ctxt Pty Ltd
Publication of PT3986890T publication Critical patent/PT3986890T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PT207437732T 2019-06-18 2020-06-16 Derivados de benzisoxazol sulfonamida PT3986890T (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962863199P 2019-06-18 2019-06-18
US201962953223P 2019-12-24 2019-12-24
US202063025278P 2020-05-15 2020-05-15

Publications (1)

Publication Number Publication Date
PT3986890T true PT3986890T (pt) 2024-01-17

Family

ID=71738189

Family Applications (1)

Application Number Title Priority Date Filing Date
PT207437732T PT3986890T (pt) 2019-06-18 2020-06-16 Derivados de benzisoxazol sulfonamida

Country Status (30)

Country Link
US (2) US11492346B2 (pt)
EP (2) EP3986890B1 (pt)
JP (2) JP7352662B2 (pt)
KR (1) KR20220024671A (pt)
CN (1) CN114364672B (pt)
AU (2) AU2020296361A1 (pt)
BR (1) BR112021025528A2 (pt)
CA (1) CA3143666C (pt)
CL (1) CL2021003372A1 (pt)
CO (1) CO2021017504A2 (pt)
CR (1) CR20210627A (pt)
DK (1) DK3986890T3 (pt)
EC (1) ECSP21091615A (pt)
ES (1) ES2969616T3 (pt)
FI (1) FI3986890T3 (pt)
HR (1) HRP20231501T1 (pt)
HU (1) HUE064683T2 (pt)
IL (1) IL288802A (pt)
LT (1) LT3986890T (pt)
MD (1) MD3986890T2 (pt)
MX (1) MX2021016085A (pt)
PE (1) PE20220808A1 (pt)
PH (1) PH12021553107A1 (pt)
PL (1) PL3986890T3 (pt)
PT (1) PT3986890T (pt)
RS (1) RS64931B1 (pt)
SI (1) SI3986890T1 (pt)
TW (1) TWI787620B (pt)
UY (1) UY38752A (pt)
WO (1) WO2020254946A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201810092D0 (en) * 2018-06-20 2018-08-08 Ctxt Pty Ltd Compounds
CA3141826A1 (en) 2019-05-31 2020-12-03 Ikena Oncology, Inc. Tead inhibitors and uses thereof
KR20220024671A (ko) * 2019-06-18 2022-03-03 화이자 인코포레이티드 벤즈이속사졸 설폰아마이드 유도체
AU2020295006B2 (en) * 2019-06-19 2023-11-09 Ctxt Pty Ltd Cycloalkyl and heterocycloalkyl benzisoxazole sulfonamide derivatives
US20220024919A1 (en) * 2020-07-15 2022-01-27 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
MX2023000735A (es) * 2020-07-15 2023-02-13 Pfizer Metodos y combinaciones de inhibidor de kat6 para el tratamiento del cancer.
WO2022187693A1 (en) * 2021-03-05 2022-09-09 Umbra Therapeutics Inc. Covalent cdk2-binding compounds for therapeutic purposes
WO2022187688A1 (en) * 2021-03-05 2022-09-09 Umbra Therapeutics Inc. Covalent kras-binding compounds for therapeutic purposes
JP2024521141A (ja) * 2021-05-21 2024-05-28 アウリジーン オンコロジー リミテッド Ｋａｔ６ａ阻害剤としての縮合イソオキサゾリル化合物
CA3225068A1 (en) 2021-07-05 2023-01-12 Hangzhou Innogate Pharma Co., Ltd. Compound serving as kat6 inhibitor
MX2024001777A (es) * 2021-08-10 2024-02-29 Jiangsu Hengrui Pharmaceuticals Co Ltd Derivado de sulfonamida, metodo de preparacion y uso medico del mismo.
CN118556053A (zh) 2021-11-16 2024-08-27 英矽智能科技知识产权有限公司 赖氨酸乙酰基转移酶6a(kat6a)抑制剂及其用途
WO2023114710A1 (en) * 2021-12-13 2023-06-22 Aurigene Oncology Limited Fused benzoisoxazolyl compounds as kat6a inhibitors
US12187732B2 (en) * 2022-03-28 2025-01-07 Isosterix, Inc. Inhibitors of the myst family of lysine acetyl transferases
IL317668A (en) * 2022-06-16 2025-02-01 Prelude Therapeutics Incorporated KAT6-targeted compounds with a ubiquitin ligase-binding residue
AU2023315227A1 (en) 2022-07-29 2025-02-13 Ctxt Pty Ltd Dosing regimens comprising a kat6 inhibitor for the treatment of cancer
WO2024131772A1 (zh) * 2022-12-20 2024-06-27 杭州中美华东制药有限公司 具有sting抑制作用的含肟化合物及其药物组合物和用途
WO2024165035A1 (zh) * 2023-02-10 2024-08-15 江苏恒瑞医药股份有限公司 一种磺酰胺衍生物结晶形式及其制备方法
WO2024199254A1 (zh) * 2023-03-27 2024-10-03 北京康辰药业股份有限公司 磺酰胺化合物、其药物组合物和应用
WO2024201334A1 (en) 2023-03-30 2024-10-03 Pfizer Inc. Kat6a as a predictive biomarker for treatment with a kat6a inhibitor and methods of treatment thereof
WO2024217563A1 (en) * 2023-04-19 2024-10-24 Insilico Medicine Ip Limited Lysine acetyltransferase 6a (kat6a) inhibitor, combinations and uses thereof
WO2024222725A1 (en) * 2023-04-25 2024-10-31 Insilico Medicine Ip Limited Crystalline lysine acetyltransferase 6a (kat6a) inhibitor and uses thereof
WO2025007873A1 (zh) * 2023-07-04 2025-01-09 上海齐鲁制药研究中心有限公司 Kat6抑制剂

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2358031A (en) 1944-09-12 Substituted thiadiazoles
US3064003A (en) 1962-11-13 Carboxylic acid derivatives of sub-
US2525321A (en) 1949-01-07 1950-10-10 American Cyanamid Co Hydroxybenzenesulfonamidoisoxazoles and preparation of same
GB689281A (en) 1950-02-18 1953-03-25 Lunbeck Corp Improvements in or relating to the production of sulphanilamido-thiadiazoles
DE1102745B (de) 1959-06-06 1961-03-23 Boehringer & Soehne Gmbh Verfahren zur Herstellung von 5-Sulfanilamidoisoxazolen
BE617370A (fr) 1961-05-09 1962-11-08 Ciba Geigy Procédé de préparation du 2,5-di-[benzoxazolyl-(2')]-thiofène
US3332942A (en) 1962-11-02 1967-07-25 White Lab Inc Substituted thiadiazoles
JPS498255B1 (pt) 1970-10-08 1974-02-25
US3951967A (en) 1972-03-20 1976-04-20 Merck & Co., Inc. 7-Mercapto(or thio)-benzothiadiazine products
US3960854A (en) 1972-03-20 1976-06-01 Merck & Co., Inc. 7-Mercapto(or thio)-benzothiadiazine products
DE2617809C2 (de) 1976-04-23 1984-09-20 Basf Ag, 6700 Ludwigshafen Verfahren zur Stabilisierung von Chromdioxid-Magnetpigmenten und seine Verwendung
JPS6042794B2 (ja) 1977-09-27 1985-09-25 三共株式会社 イソオキサゾリウム塩，およびその製造方法
US4251664A (en) 1978-05-24 1981-02-17 Henkel Corporation Sulfonamidothiadiazoles, metal complexes thereof, and solutions containing such compounds for use in extraction of metal values
US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
JPS603685B2 (ja) 1980-04-15 1985-01-30 日本コロムビア株式会社 絵入りレコ−ド盤の製造方法
GB8427618D0 (en) 1984-11-01 1984-12-05 Shell Int Research Anticoccidial compositions
GB8607683D0 (en) 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
JPS63238006A (ja) 1987-03-26 1988-10-04 Shionogi & Co Ltd イモチ防除剤
US5962490A (en) 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5591761A (en) 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
NZ231534A (en) 1988-11-29 1992-02-25 Warner Lambert Co 3,5-di-t-butyl-4-hydroxyphenyl-triazoles, oxadiazoles and thiadiazoles; anti-inflammatory compositions
JPH03258771A (ja) 1990-03-09 1991-11-19 Tosoh Corp スルホンアミド誘導体、その製法及びそれを有効成分として含有する除草剤
TW224462B (pt) 1992-02-24 1994-06-01 Squibb & Sons Inc
FR2690160A1 (fr) 1992-04-15 1993-10-22 Rhone Poulenc Rorer Sa Application de dérivés d'acide 2H-1,2,4-benzothiadiazine-1,1-dioxyde-3-carboxylique à la préparation de médicaments, les produits nouveaux, leur préparation et les médicaments les contenant.
NZ247440A (en) 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
EP0626174A3 (en) 1993-04-21 1996-01-03 Takeda Chemical Industries Ltd Method and composition for the prophylaxis and / or treatment of underactive organs.
JP3901229B2 (ja) 1994-05-13 2007-04-04 Ｎｔｎ株式会社 耐熱・潤滑性樹脂組成物
NZ306734A (pt) 1995-04-04 2000-01-28 Texas Biotechnology Corp
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
JP2002514192A (ja) 1996-11-13 2002-05-14 セフアロン・インコーポレーテツド ベンゾチアゾおよび関連の複素環基を含有するシステインおよびセリンプロテアーゼ阻害剤
US5783705A (en) 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
DE69839534D1 (de) 1997-04-28 2008-07-03 Encysive Pharmaceuticals Inc Sulfonamide zur Behandlung von durch Endothelin vermittelten Störungen
IL148698A0 (en) 1999-09-17 2002-09-12 Cor Therapeutics Inc INHIBITORS OF FACTOR Xa
AU2456701A (en) 1999-12-31 2001-07-16 Texas Biotechnology Corporation Pharmaceutical and veterinary uses of endothelin antagonists
ATE311366T1 (de) 2000-02-29 2005-12-15 Millennium Pharm Inc Benzamide und ähnliche inhibitoren vom faktor xa
GB0127344D0 (en) 2001-11-14 2002-01-02 Cancer Res Ventures Ltd Assay method
CN1649855A (zh) 2001-11-22 2005-08-03 比奥维特罗姆股份公司 11－β－羟基类固醇脱氢酶1型抑制剂
JP2003292485A (ja) 2002-04-01 2003-10-15 Yamanouchi Pharmaceut Co Ltd スルホンアミド誘導体
AR043633A1 (es) 2003-03-20 2005-08-03 Schering Corp Ligandos de receptores de canabinoides
EP1631558A1 (en) 2003-05-21 2006-03-08 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type i
WO2004113310A1 (en) 2003-06-25 2004-12-29 Biovitrum Ab Use of an inhibitor of 11-b-hydroxysteroid dehydrogenase type 1 compounds for promoting wound healing
KR20060097105A (ko) 2003-07-22 2006-09-13 얀센 파마슈티카 엔.브이. Ｃ-ｆｍｓ 키나아제 저해제로서의 퀴놀리논 유도체
KR20060073930A (ko) 2003-08-08 2006-06-29 버텍스 파마슈티칼스 인코포레이티드 통증 치료시 나트륨 또는 칼슘 채널 차단제로서 유용한헤테로아릴아미노설포닐페닐 유도체
US7615563B2 (en) 2003-08-08 2009-11-10 Gonzalez Iii Jesus E Compositions useful as inhibitors of voltage-gated sodium channels
US7973161B2 (en) 2003-11-13 2011-07-05 Abbott Laboratories Apoptosis promoters
US7767684B2 (en) 2003-11-13 2010-08-03 Abbott Laboratories Apoptosis promoters
US7642260B2 (en) 2003-11-13 2010-01-05 Abbott Laboratories, Inc. Apoptosis promoters
US8614318B2 (en) 2003-11-13 2013-12-24 Abbvie Inc. Apoptosis promoters
WO2005049593A2 (en) 2003-11-13 2005-06-02 Abbott Laboratories N-acylsulfonamide apoptosis promoters
MX2007004526A (es) 2004-10-12 2007-09-21 Decode Genetics Inc Arilsulfonamidas biciclicas peri-sustituidas para la enfermedad arterial oclusiva.
AU2006247478A1 (en) 2005-05-16 2006-11-23 Vertex Pharmaceuticals Incorporated Bicyclic derivatives as modulators of ion channels
DE102005038947A1 (de) 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
AU2006299088A1 (en) 2005-10-06 2007-04-12 Sanofi-Aventis Bicyclic aryl-sulfonic acid (1,3,4)-thiadiazol-2-yl-amides, processes for their preparation and their use as pharmaceuticals
WO2007039175A1 (en) 2005-10-06 2007-04-12 Sanofi-Aventis N-[1 ,3,4]-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals
DE102005055355A1 (de) 2005-11-21 2007-10-31 Merck Patent Gmbh 3,6-Dihydro-2-oxo-6H-[1,3,4]thiadiazinderivate
RU2008129821A (ru) 2005-12-21 2010-01-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Гетероциклические производные в качестве модуляторов ионных каналов
WO2008022286A2 (en) 2006-08-16 2008-02-21 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Small molecule inhibitors of kynurenine-3-monooxygenase
US20080182845A1 (en) 2006-11-16 2008-07-31 Abbott Laboratories Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection
US7749996B2 (en) 2006-11-20 2010-07-06 Alantos Pharmaceutical Holdings, Inc. Heterotricyclic metalloprotease inhibitors
US20080194557A1 (en) 2007-01-18 2008-08-14 Joseph Barbosa Methods and compositions for the treatment of pain, inflammation and cancer
EP2173743A2 (en) 2007-07-13 2010-04-14 Icagen, Inc. Sodium channel inhibitors
CN101918371A (zh) 2007-11-01 2010-12-15 西特里斯药业公司 作为瑟土因调节剂的酰胺衍生物
AU2008345225A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
EP2240474B1 (en) 2007-12-26 2012-03-14 Sanofi Cyclic pyridyl-n-(1,3,4)-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals
US8475505B2 (en) 2008-08-13 2013-07-02 Smed-Ta/Td, Llc Orthopaedic screws
WO2010046780A2 (en) 2008-10-22 2010-04-29 Institut Pasteur Korea Anti viral compounds
WO2010121963A1 (en) 2009-04-21 2010-10-28 Nerviano Medical Sciences S.R.L. Resorcinol derivatives as hsp90 inhibitors
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
WO2011082400A2 (en) 2010-01-04 2011-07-07 President And Fellows Of Harvard College Modulators of immunoinhibitory receptor pd-1, and methods of use thereof
CN101845043A (zh) 2010-01-15 2010-09-29 江苏省农药研究所股份有限公司 邻杂环甲酰苯胺类化合物及其合成方法和应用
WO2011085575A1 (zh) 2010-01-15 2011-07-21 江苏省农药研究所股份有限公司 邻杂环甲酰苯胺类化合物及其合成方法和应用
CN101747325A (zh) 2010-01-15 2010-06-23 江苏省农药研究所股份有限公司 邻杂环甲酰苯胺类化合物及其合成方法和应用
WO2011137089A1 (en) 2010-04-29 2011-11-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Activators of human pyruvate kinase
TW201210597A (en) 2010-06-09 2012-03-16 Gilead Sciences Inc Inhibitors of hepatitis C virus
CA2804716A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds
ES2553610T3 (es) 2010-12-14 2015-12-10 Electrophoretics Limited Inhibidores de la caseína cinasa 1 delta (CK1delta)
EP2655334B1 (en) 2010-12-22 2018-10-03 Eutropics Pharmaceuticals, Inc. Compositions and methods useful for treating diseases
US9464065B2 (en) 2011-03-24 2016-10-11 The Scripps Research Institute Compounds and methods for inducing chondrogenesis
PL220630B1 (pl) 2012-12-28 2015-11-30 Inst Immunologii I Terapii Doświadczalnej Pan Nowe sulfonamidowe pochodne izoksazolo[5,4-b]pirydyny o aktywności przeciwbakteryjnej, sposób ich wytwarzania oraz nowe zastosowanie 3-aminoizoksazolo[5,4-b]pirydyny
RU2015143834A (ru) 2013-03-15 2017-04-24 Дженентек, Инк. Замещенные бензоксазолы и способы их применения
WO2015102929A1 (en) 2013-12-30 2015-07-09 Novartis Ag Tricyclic sulfonamide derivatives
EP3097101B1 (en) 2014-01-24 2020-12-23 Merck Sharp & Dohme Corp. Isoquinoline derivatives as mgat2 inhibitors
GB201510019D0 (en) 2015-06-09 2015-07-22 Cancer Therapeutics Crc Pty Ltd Compounds
WO2017002120A1 (en) 2015-07-02 2017-01-05 Yeda Research And Development Co. Ltd. Selective inhibitors of senescent cells and uses thereof
WO2017098421A1 (en) 2015-12-08 2017-06-15 Glaxosmithkline Intellectual Property Development Limited Benzothiadiazine compounds
CN107098846B (zh) * 2016-02-26 2020-10-09 中国医学科学院药物研究所 N-酰基磺酰胺类FBPase抑制剂、其制备方法、药物组合物及用途
US11970486B2 (en) 2016-10-24 2024-04-30 Janssen Pharmaceutica Nv Compounds and uses thereof
US20220267260A1 (en) * 2016-11-29 2022-08-25 Epizyme, Inc. Compounds containing a sulfonic group as kat inhibitors
US11542248B2 (en) 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
GB201810092D0 (en) * 2018-06-20 2018-08-08 Ctxt Pty Ltd Compounds
KR20220024671A (ko) 2019-06-18 2022-03-03 화이자 인코포레이티드 벤즈이속사졸 설폰아마이드 유도체

Also Published As

Publication number Publication date
HUE064683T2 (hu) 2024-04-28
TWI787620B (zh) 2022-12-21
PE20220808A1 (es) 2022-05-20
PL3986890T3 (pl) 2024-03-11
ES2969616T3 (es) 2024-05-21
KR20220024671A (ko) 2022-03-03
EP3986890B1 (en) 2023-11-15
LT3986890T (lt) 2023-12-11
AU2020296361A1 (en) 2022-01-06
EP4299135A2 (en) 2024-01-03
EP3986890A1 (en) 2022-04-27
CR20210627A (es) 2022-02-08
DK3986890T3 (da) 2023-12-18
TW202115048A (zh) 2021-04-16
US20230174522A1 (en) 2023-06-08
CN114364672B (zh) 2024-09-06
JP2022537285A (ja) 2022-08-25
CN114364672A (zh) 2022-04-15
CO2021017504A2 (es) 2022-01-17
US20200399258A1 (en) 2020-12-24
MX2021016085A (es) 2022-04-20
SI3986890T1 (sl) 2024-03-29
FI3986890T3 (fi) 2024-01-15
US11492346B2 (en) 2022-11-08
CL2021003372A1 (es) 2022-10-07
ECSP21091615A (es) 2022-01-31
HRP20231501T1 (hr) 2024-03-01
EP4299135A3 (en) 2024-02-28
CA3143666C (en) 2024-06-11
CA3143666A1 (en) 2020-12-24
JP2023175821A (ja) 2023-12-12
UY38752A (es) 2021-01-29
JP7352662B2 (ja) 2023-09-28
AU2023274178A1 (en) 2024-02-15
PH12021553107A1 (en) 2022-08-01
RS64931B1 (sr) 2023-12-29
MD3986890T2 (ro) 2024-04-30
BR112021025528A2 (pt) 2022-04-19
IL288802A (en) 2022-02-01
WO2020254946A1 (en) 2020-12-24

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