PT3540062T - Permuta de cassete de região variável de imunoglobulina - Google Patents
Permuta de cassete de região variável de imunoglobulinaInfo
- Publication number
- PT3540062T PT3540062T PT191691351T PT19169135T PT3540062T PT 3540062 T PT3540062 T PT 3540062T PT 191691351 T PT191691351 T PT 191691351T PT 19169135 T PT19169135 T PT 19169135T PT 3540062 T PT3540062 T PT 3540062T
- Authority
- PT
- Portugal
- Prior art keywords
- variable region
- immunoglobulin variable
- cassette exchange
- region cassette
- exchange
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62858104P | 2004-11-16 | 2004-11-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3540062T true PT3540062T (pt) | 2021-07-06 |
Family
ID=36407771
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT10014128T PT2343380T (pt) | 2004-11-16 | 2005-11-16 | Permuta de cassetes da região variável de imunoglobulina |
PT191691351T PT3540062T (pt) | 2004-11-16 | 2005-11-16 | Permuta de cassete de região variável de imunoglobulina |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT10014128T PT2343380T (pt) | 2004-11-16 | 2005-11-16 | Permuta de cassetes da região variável de imunoglobulina |
Country Status (10)
Country | Link |
---|---|
US (2) | US20060134098A1 (pt) |
EP (3) | EP3540062B1 (pt) |
JP (1) | JP2008520586A (pt) |
AU (1) | AU2005306502B2 (pt) |
CA (1) | CA2587158C (pt) |
DK (2) | DK2343380T3 (pt) |
ES (3) | ES2881353T3 (pt) |
PL (2) | PL3540062T3 (pt) |
PT (2) | PT2343380T (pt) |
WO (1) | WO2006055778A2 (pt) |
Families Citing this family (61)
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US8288322B2 (en) | 2000-04-17 | 2012-10-16 | Dyax Corp. | Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries |
DK1713503T3 (da) * | 2004-02-10 | 2013-11-04 | Univ Colorado Regents | Hæmning af faktor b, den alternative komplemenpathway og dertil relaterede fremgangsmåde |
CA2587158C (en) | 2004-11-16 | 2016-01-12 | Kalobios, Inc. | Immunoglobulin variable region cassette exchange |
US8911733B2 (en) * | 2005-05-26 | 2014-12-16 | Musc Foundation For Research Development | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
JP2009538924A (ja) | 2006-06-01 | 2009-11-12 | エラン ファーマシューティカルズ,インコーポレイテッド | Appの神経活性断片 |
WO2008063898A2 (en) * | 2006-11-08 | 2008-05-29 | Kalobios Pharmaceuticals, Inc. | Methods of treating idiopathic thrombocytopenia purpura using a gm-csf antagonist |
US8398972B2 (en) * | 2006-11-21 | 2013-03-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a GM-CSF antagonist |
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EP2126105A4 (en) | 2007-02-20 | 2010-11-03 | Anaptysbio Inc | SOMATIC HYPERPERMUTATION SYSTEMS |
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WO2009012401A1 (en) * | 2007-07-17 | 2009-01-22 | Irm Llc | Antagonist antibodies of protease activated receptor-1 (par1) |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
WO2009073631A2 (en) | 2007-11-30 | 2009-06-11 | Kalobios Pharmaceuticals, Inc. | Antibodies to the pcrv antigen of pseudomonas aeruginosa |
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US9079942B2 (en) | 2009-02-09 | 2015-07-14 | Epitomics, Inc. | CDR-anchored amplification method |
WO2010093814A1 (en) | 2009-02-11 | 2010-08-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a gm-csf antagonist |
WO2010102244A1 (en) | 2009-03-06 | 2010-09-10 | Kalobios Pharmaceuticals, Inc. | Treatment of leukemias and chronic myeloproliferative diseases with antibodies to epha3 |
WO2010135558A1 (en) * | 2009-05-20 | 2010-11-25 | Novimmune S.A. | Systhetic polypeptide libraries and methods for generating naturally diversified polypeptide variants |
AU2010266127B2 (en) | 2009-07-02 | 2015-11-05 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
WO2011053465A1 (en) | 2009-10-14 | 2011-05-05 | Kalobios Pharmaceuticals, Inc. | Antibodies to epha3 |
AR079336A1 (es) * | 2009-12-11 | 2012-01-18 | Irm Llc | Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) |
JP5686817B2 (ja) | 2009-12-22 | 2015-03-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 配列依存性の凝集 |
BR112012020790B1 (pt) | 2010-02-18 | 2021-09-28 | The Regents Of The University Of California | Anticorpo isolado anti-integrina alfavbeta8 e composição farmacêutica |
US20110245100A1 (en) * | 2010-04-02 | 2011-10-06 | Kalobios Pharmaceuticals, Inc. | Generation of antibodies to an epitope of interest |
CA2827091A1 (en) | 2011-02-11 | 2012-08-16 | Irm Llc | Pcsk9 antagonists |
ES2926988T3 (es) | 2011-03-15 | 2022-10-31 | X Body Inc | Métodos de cribado de anticuerpos |
WO2012170607A2 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Use of pcsk9 antagonists |
WO2012168491A1 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Pharmaceutical formulations of pcsk9 antagonists |
EP2764021A2 (en) * | 2011-10-05 | 2014-08-13 | Kalobios Pharmaceuticals, Inc. | Generation of antibodies to an epitope of interest that contains a phosphomimetic amino acid |
CA2853637C (en) | 2011-10-26 | 2023-04-04 | Novartis Ag | Anti-canine cd20 monoclonal antibodies and methods of use |
WO2013177035A2 (en) | 2012-05-24 | 2013-11-28 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor b antibody |
WO2014084859A1 (en) | 2012-11-30 | 2014-06-05 | Novartis Ag | Molecules and methods for modulating tmem16a activities |
AR096601A1 (es) | 2013-06-21 | 2016-01-20 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
WO2015089117A1 (en) | 2013-12-09 | 2015-06-18 | Allakos Inc. | Anti-siglec-8 antibodies and methods of use thereof |
EP4014995A1 (en) | 2014-02-28 | 2022-06-22 | Allakos Inc. | Methods and compositions for treating siglec-8 associated diseases |
DK3157951T3 (da) * | 2014-06-17 | 2020-08-17 | Academia Sinica | Humaniserede anti-ige-antistoffer, der tværbinder cd23 på b-lymfocytter, men ikke sensibiliserer mastceller |
MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
CA2987797A1 (en) | 2015-06-17 | 2016-12-22 | Christopher Robert Bebbington | Methods and compositions for treating fibrotic diseases |
US10604577B2 (en) | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
PE20181358A1 (es) | 2015-12-04 | 2018-08-22 | Novartis Ag | Composiciones de anticuerpo injertado con citoquina y metodos para su uso en inmunorregulacion |
US11052111B2 (en) | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
WO2018053032A1 (en) | 2016-09-13 | 2018-03-22 | Humanigen, Inc. | Epha3 antibodies for the treatment of pulmonary fibrosis |
US11078298B2 (en) | 2016-10-28 | 2021-08-03 | Banyan Biomarkers, Inc. | Antibodies to ubiquitin C-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) and related methods |
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US11203638B2 (en) | 2017-05-05 | 2021-12-21 | Allakos Inc. | Methods and compositions for treating perennial allergic conjunctivitis and keratoconjunctivitis |
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MX2019014023A (es) | 2017-05-24 | 2020-02-17 | Novartis Ag | Proteinas de anticuerpo injertadas con citocina y metodos de uso en el tratamiento del cancer. |
WO2018215937A1 (en) | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
JOP20190271A1 (ar) | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
US11130805B2 (en) | 2017-10-02 | 2021-09-28 | Humanigen, Inc. | Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist |
US10927168B2 (en) | 2017-10-02 | 2021-02-23 | Humanicen, Inc. | Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab |
US10899831B2 (en) | 2017-10-02 | 2021-01-26 | Humanigen, Inc. | Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity |
US10870703B2 (en) | 2017-10-02 | 2020-12-22 | Humanigen, Inc. | Methods of treating immunotherapy-related toxicity using a GM-CSF antagonist |
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WO2022187270A1 (en) | 2021-03-01 | 2022-09-09 | Xilio Development, Inc. | Combination of ctla4 and pd1/pdl1 antibodies for treating cancer |
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-
2005
- 2005-11-16 CA CA2587158A patent/CA2587158C/en active Active
- 2005-11-16 DK DK10014128.2T patent/DK2343380T3/da active
- 2005-11-16 PL PL19169135T patent/PL3540062T3/pl unknown
- 2005-11-16 ES ES19169135T patent/ES2881353T3/es active Active
- 2005-11-16 ES ES05851809T patent/ES2429541T3/es active Active
- 2005-11-16 PL PL10014128T patent/PL2343380T3/pl unknown
- 2005-11-16 DK DK19169135.1T patent/DK3540062T3/da active
- 2005-11-16 WO PCT/US2005/041825 patent/WO2006055778A2/en active Application Filing
- 2005-11-16 AU AU2005306502A patent/AU2005306502B2/en not_active Ceased
- 2005-11-16 ES ES10014128T patent/ES2744149T3/es active Active
- 2005-11-16 US US11/282,107 patent/US20060134098A1/en not_active Abandoned
- 2005-11-16 PT PT10014128T patent/PT2343380T/pt unknown
- 2005-11-16 EP EP19169135.1A patent/EP3540062B1/en active Active
- 2005-11-16 PT PT191691351T patent/PT3540062T/pt unknown
- 2005-11-16 EP EP10014128.2A patent/EP2343380B1/en active Active
- 2005-11-16 JP JP2007541495A patent/JP2008520586A/ja active Pending
- 2005-11-16 EP EP05851809.3A patent/EP1824987B1/en not_active Revoked
-
2015
- 2015-12-14 US US14/968,709 patent/US10919983B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP1824987B1 (en) | 2013-08-21 |
EP1824987A4 (en) | 2008-03-19 |
PT2343380T (pt) | 2019-09-18 |
CA2587158C (en) | 2016-01-12 |
US20060134098A1 (en) | 2006-06-22 |
ES2881353T3 (es) | 2021-11-29 |
DK3540062T3 (da) | 2021-06-28 |
PL3540062T3 (pl) | 2021-12-27 |
US20160102152A1 (en) | 2016-04-14 |
EP2343380B1 (en) | 2019-06-12 |
AU2005306502A1 (en) | 2006-05-26 |
AU2005306502B2 (en) | 2012-11-15 |
WO2006055778A3 (en) | 2006-11-23 |
CA2587158A1 (en) | 2006-05-26 |
US10919983B2 (en) | 2021-02-16 |
JP2008520586A (ja) | 2008-06-19 |
EP1824987A2 (en) | 2007-08-29 |
ES2744149T3 (es) | 2020-02-21 |
PL2343380T3 (pl) | 2020-03-31 |
DK2343380T3 (da) | 2019-09-09 |
ES2429541T3 (es) | 2013-11-15 |
EP3540062B1 (en) | 2021-05-12 |
EP2343380A1 (en) | 2011-07-13 |
EP3540062A1 (en) | 2019-09-18 |
WO2006055778A2 (en) | 2006-05-26 |
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