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PT3231803T - Derivado de di-hidroindolizinona - Google Patents

Derivado de di-hidroindolizinona

Info

Publication number
PT3231803T
PT3231803T PT158677641T PT15867764T PT3231803T PT 3231803 T PT3231803 T PT 3231803T PT 158677641 T PT158677641 T PT 158677641T PT 15867764 T PT15867764 T PT 15867764T PT 3231803 T PT3231803 T PT 3231803T
Authority
PT
Portugal
Prior art keywords
dihydroindolizinone
derivative
dihydroindolizinone derivative
Prior art date
Application number
PT158677641T
Other languages
English (en)
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of PT3231803T publication Critical patent/PT3231803T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT158677641T 2014-12-10 2015-12-09 Derivado de di-hidroindolizinona PT3231803T (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2014249822 2014-12-10
JP2014263251 2014-12-25
JP2015046150 2015-03-09
JP2015160632 2015-08-17

Publications (1)

Publication Number Publication Date
PT3231803T true PT3231803T (pt) 2020-09-03

Family

ID=56107463

Family Applications (1)

Application Number Title Priority Date Filing Date
PT158677641T PT3231803T (pt) 2014-12-10 2015-12-09 Derivado de di-hidroindolizinona

Country Status (22)

Country Link
US (6) US10065955B2 (pt)
EP (2) EP3702357B1 (pt)
JP (3) JP6610562B2 (pt)
KR (1) KR102525392B1 (pt)
CN (1) CN107001363B (pt)
AU (1) AU2015362422B2 (pt)
BR (1) BR112017012146B1 (pt)
CA (1) CA2970233C (pt)
DK (1) DK3231803T3 (pt)
ES (2) ES2927307T3 (pt)
HU (1) HUE051080T2 (pt)
IL (1) IL252777B (pt)
MX (2) MX2017007551A (pt)
MY (1) MY194106A (pt)
PH (1) PH12017501067A1 (pt)
PL (1) PL3231803T3 (pt)
PT (1) PT3231803T (pt)
RU (1) RU2707887C2 (pt)
SG (1) SG11201704708QA (pt)
TW (1) TWI696620B (pt)
WO (1) WO2016093285A1 (pt)
ZA (1) ZA201704602B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY35971A (es) 2014-01-31 2015-07-31 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Macrociclos con grupos p2? aromáticos como inhibidores del factor xia
NO2760821T3 (pt) 2014-01-31 2018-03-10
JP6526796B2 (ja) 2014-09-04 2019-06-05 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Fxia阻害剤であるジアミドマクロ環
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
JP6992284B2 (ja) * 2016-06-06 2022-01-13 小野薬品工業株式会社 ジヒドロインドリジノン誘導体を含有する医薬組成物
WO2020111268A1 (ja) * 2018-11-30 2020-06-04 小野薬品工業株式会社 (3s)-3-[2-(6-アミノ-2-フルオロピリジン-3-イル)-4-フルオロ-1h-イミダゾール-5-イル]-7-[5-クロロ-2-(1h-テトラゾール-1-イル)フェニル]-2,3-ジヒドロインドリジン-5(1h)-オンの新規結晶
KR102242187B1 (ko) * 2019-06-04 2021-04-20 주식회사 우정바이오 실내 표면 및 공기 살균 정화 장치
US11518766B2 (en) 2019-06-28 2022-12-06 Shanghai Jemincare Pharmaceuticals Co., Ltd. Tricyclic compound, preparation method therefor and use thereof
JP2024125436A (ja) * 2021-07-20 2024-09-19 小野薬品工業株式会社 イミダゾール化合物の製造方法
WO2023179624A1 (zh) * 2022-03-21 2023-09-28 上海济煜医药科技有限公司 三并环类化合物制备方法及其中间体

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL61385A (en) * 1979-12-06 1984-11-30 Labaz Sanofi Nv 3-(4-(dialkylaminoalkyl)-oxy-benzoyl)-indolizine derivatives,their preparation and pharmaceutical compositions containing them
EP0407342A3 (en) 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
DE4221583A1 (de) 1991-11-12 1993-05-13 Bayer Ag Substituierte biphenylpyridone
DE4407488A1 (de) 1994-03-07 1995-09-14 Bayer Ag Verwendung von Biphenyl- und Pyridylmethylpyridonen
IT1277405B1 (it) * 1995-08-01 1997-11-10 Menarini Farma Ind Derivati di lattami biciclici come inibitori della trombina
GEP20063937B (en) 2002-02-14 2006-10-10 Pharmacia Corp Substituted pyridinones as modulators of p38 map kinase
FR2838123B1 (fr) * 2002-04-04 2005-06-10 Sanofi Synthelabo Nouveaux derives d'indolozine-1,2,3 substituee, inhibiteurs selectifs du b-fgf
WO2005016911A1 (en) 2003-08-13 2005-02-24 Takeda Pharmaceutical Company Limited 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
AU2006325754B2 (en) 2005-12-14 2012-04-12 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIa inhibitors
US7803940B2 (en) 2006-11-24 2010-09-28 Takeda Pharmaceutical Company Limited Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases
WO2008062905A2 (en) 2006-11-24 2008-05-29 Takeda Pharmaceutical Company Limited Heteromonocyclic compound and use thereof
WO2008076805A2 (en) 2006-12-15 2008-06-26 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
CA2708151A1 (en) 2007-12-11 2009-06-18 Schering Corporation Gamma secretase modulators
NZ608499A (en) 2010-10-07 2015-03-27 Takeda Pharmaceutical 1,4-oxazepane derivatives
TW201319068A (zh) * 2011-08-05 2013-05-16 必治妥美雅史谷比公司 作為xia因子抑制劑之環狀p1接合劑
GB2497806A (en) * 2011-12-21 2013-06-26 Ono Pharmaceutical Co Pyridinone and pyrimidinone derivatives as factor XIa inhibitors
AU2012356374B2 (en) * 2011-12-21 2017-06-22 Ono Pharmaceutical Co., Ltd. Pyridinone and pyrimidinone derivatives as factor XIa inhibitors
EP3138839B1 (en) * 2014-02-14 2020-10-28 Sichuan Haisco Pharmaceutical Co., Ltd. Pyridone or pyrimidone derivative, preparation method therefor and application thereof
CN105658641B (zh) * 2014-07-25 2018-04-17 江苏恒瑞医药股份有限公司 氮茚‑酰胺类衍生物、其制备方法及其在医药上的应用

Also Published As

Publication number Publication date
PL3231803T3 (pl) 2020-11-02
EP3231803B1 (en) 2020-07-01
US20200140435A1 (en) 2020-05-07
US11566027B2 (en) 2023-01-31
US10065955B2 (en) 2018-09-04
MX2017007551A (es) 2017-10-31
ES2814098T3 (es) 2021-03-26
BR112017012146A2 (pt) 2018-01-02
ES2927307T3 (es) 2022-11-04
MX2021005869A (es) 2021-07-16
CA2970233A1 (en) 2016-06-16
US10815233B2 (en) 2020-10-27
US20180334458A1 (en) 2018-11-22
DK3231803T3 (da) 2020-08-24
AU2015362422B2 (en) 2019-11-14
BR112017012146B1 (pt) 2023-11-21
US20210009586A1 (en) 2021-01-14
JP6610562B2 (ja) 2019-11-27
TW201629059A (zh) 2016-08-16
RU2707887C2 (ru) 2019-12-02
EP3702357A1 (en) 2020-09-02
CN107001363B (zh) 2019-06-21
TWI696620B (zh) 2020-06-21
WO2016093285A1 (ja) 2016-06-16
KR20170095845A (ko) 2017-08-23
KR102525392B1 (ko) 2023-04-24
US10550119B2 (en) 2020-02-04
EP3231803A1 (en) 2017-10-18
US20190352304A1 (en) 2019-11-21
EP3231803A4 (en) 2018-08-08
JP6791338B2 (ja) 2020-11-25
US20230138003A1 (en) 2023-05-04
SG11201704708QA (en) 2017-07-28
IL252777B (en) 2020-11-30
ZA201704602B (en) 2018-08-29
JPWO2016093285A1 (ja) 2017-09-21
PH12017501067B1 (en) 2017-12-04
PH12017501067A1 (en) 2017-12-04
AU2015362422A1 (en) 2017-07-27
US20170349580A1 (en) 2017-12-07
HUE051080T2 (hu) 2021-03-01
RU2017124150A (ru) 2019-01-09
JP2020012004A (ja) 2020-01-23
RU2017124150A3 (pt) 2019-07-17
US10407426B2 (en) 2019-09-10
IL252777A0 (en) 2017-08-31
EP3702357B1 (en) 2022-08-24
CA2970233C (en) 2023-01-03
CN107001363A (zh) 2017-08-01
JP2021011506A (ja) 2021-02-04
NZ733574A (en) 2024-03-22
MY194106A (en) 2022-11-13

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