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PT2209375E - Compostos inibidores da parp, composições e métodos de uso - Google Patents

Compostos inibidores da parp, composições e métodos de uso Download PDF

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Publication number
PT2209375E
PT2209375E PT88360185T PT08836018T PT2209375E PT 2209375 E PT2209375 E PT 2209375E PT 88360185 T PT88360185 T PT 88360185T PT 08836018 T PT08836018 T PT 08836018T PT 2209375 E PT2209375 E PT 2209375E
Authority
PT
Portugal
Prior art keywords
compositions
methods
inhibitor compounds
parp inhibitor
parp
Prior art date
Application number
PT88360185T
Other languages
English (en)
Inventor
Jie Zhang
Weizheng Xu
Greg Delahanty
Ling Wei
Original Assignee
Eisai Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40526672&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2209375(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai Inc filed Critical Eisai Inc
Publication of PT2209375E publication Critical patent/PT2209375E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT88360185T 2007-10-03 2008-10-02 Compostos inibidores da parp, composições e métodos de uso PT2209375E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97711507P 2007-10-03 2007-10-03

Publications (1)

Publication Number Publication Date
PT2209375E true PT2209375E (pt) 2014-10-08

Family

ID=40526672

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88360185T PT2209375E (pt) 2007-10-03 2008-10-02 Compostos inibidores da parp, composições e métodos de uso

Country Status (28)

Country Link
US (3) US8236802B2 (pt)
EP (2) EP2209375B1 (pt)
JP (1) JP5439380B2 (pt)
KR (1) KR101596526B1 (pt)
CN (1) CN102083314B (pt)
AU (1) AU2008308664B2 (pt)
BR (1) BRPI0820518B1 (pt)
CA (1) CA2700903C (pt)
CL (1) CL2010000320A1 (pt)
CY (1) CY1115747T1 (pt)
DK (1) DK2209375T3 (pt)
ES (1) ES2504690T3 (pt)
HK (1) HK1146792A1 (pt)
HR (1) HRP20140853T1 (pt)
IL (1) IL204776A (pt)
JO (1) JO3170B1 (pt)
MX (1) MX2010003564A (pt)
MY (1) MY155237A (pt)
NZ (1) NZ585012A (pt)
PL (1) PL2209375T3 (pt)
PT (1) PT2209375E (pt)
RU (1) RU2485122C2 (pt)
SG (1) SG185272A1 (pt)
SI (1) SI2209375T1 (pt)
TW (1) TWI426912B (pt)
UA (1) UA99483C2 (pt)
WO (1) WO2009046205A1 (pt)
ZA (1) ZA201002317B (pt)

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PT2209375E (pt) 2007-10-03 2014-10-08 Eisai Inc Compostos inibidores da parp, composições e métodos de uso
AU2009279944B2 (en) * 2008-08-06 2014-09-11 Medivation Technologies Llc Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP)
EP2322658A1 (en) 2009-11-13 2011-05-18 Centre National de la Recherche Scientifique (CNRS) Signature for the diagnosis of breast cancer aggressiveness and genetic instability
HUE030794T2 (en) * 2010-02-08 2017-06-28 Medivation Technologies Inc Synthesis Processes of Dihydro-Pyrido-Phthalazinone Derivatives
ES2862331T3 (es) 2010-06-18 2021-10-07 Myriad Genetics Inc Métodos para predecir el estado de los genes BRCA1 y BRCA2 en una célula de cáncer
WO2012074840A2 (en) 2010-11-22 2012-06-07 The General Hospital Corporation Compositions and methods for in vivo imaging
US9359605B2 (en) * 2011-03-11 2016-06-07 Sarissa Inc. Method of treating cancer by inhibition of DNA repair proteins
NZ616227A (en) * 2011-04-11 2016-01-29 Abb Vie Inc Parp inhibitors for the treatment of cipn
CA2835339A1 (en) 2011-05-18 2012-11-22 Centre National De La Recherche Scientifique (Cnrs) Signature for the diagnosis of cancer aggressiveness and genetic instability
US9181266B2 (en) * 2011-07-13 2015-11-10 Novartis Ag 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
WO2013028495A1 (en) * 2011-08-19 2013-02-28 Biomarin Pharmaceutical Inc. Dihydropyridophthalazinone inhibitors of poly (adp-ribose) polymerase (parp) for the treatment of multiple myeloma
ES2759533T5 (es) * 2011-12-21 2023-06-22 Myriad Genetics Inc Métodos y materiales para evaluar la pérdida de heterocigosidad
WO2013102680A1 (en) 2012-01-05 2013-07-11 Centre National De La Recherche Scientifique (Cnrs) Signature for the diagnosis of lung cancer aggressiveness and genetic instability
CN105492011A (zh) 2013-04-08 2016-04-13 丹尼斯·M·布朗 不理想给药化学化合物的治疗增效
KR20160099081A (ko) 2013-07-26 2016-08-19 업데이트 파마 인코포레이트 비산트렌의 치료 효과 개선용 조합 방법
JP6783224B2 (ja) 2014-04-04 2020-11-11 デル マー ファーマシューティカルズ 肺の非小細胞癌腫及び卵巣癌を処置するためのジアンヒドロガラクチトール及びその類縁体又は誘導体の使用
JP6648040B2 (ja) * 2014-05-28 2020-02-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 がん治療のための併用療法としてのエリブリン及びポリ（ａｄｐリボース）ポリメラーゼ（ｐａｒｐ）阻害剤の使用
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
US11261466B2 (en) 2015-03-02 2022-03-01 Sinai Health System Homologous recombination factors
CN104945406B (zh) * 2015-05-25 2017-10-10 苏州康润医药有限公司 氮杂非那烯‑3‑酮的衍生物、其制备方法及其作为parp抑制剂的应用
JP6457696B2 (ja) 2015-07-23 2019-01-23 アンスティテュ・キュリＩｎｓｔｉｔｕｔ Ｃｕｒｉｅ 癌を処置するためのＤｂａｉｔ分子とＰＡＲＰインヒビターとの組合せの使用
WO2018162439A1 (en) 2017-03-08 2018-09-13 Onxeo New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
WO2018165615A1 (en) * 2017-03-09 2018-09-13 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Parp-1 and methods of use thereof
US12121518B2 (en) * 2017-03-09 2024-10-22 The Board Of Supervisors Of Louisiana State Universi And Agricultural And Mechanical College PARP-1 and methods of use thereof
MX2019014023A (es) 2017-05-24 2020-02-17 Novartis Ag Proteinas de anticuerpo injertadas con citocina y metodos de uso en el tratamiento del cancer.
WO2019175132A1 (en) 2018-03-13 2019-09-19 Onxeo A dbait molecule against acquired resistance in the treatment of cancer
EP4041391A1 (en) * 2019-10-10 2022-08-17 Esteve Pharmaceuticals, S.A. Homopiperazinyl and homopiperidinyl quinazolin-4(3h)-one derivatives having multimodal activity against pain
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2021249996A1 (en) 2020-06-08 2021-12-16 Oncology Venture ApS Compositions comprising 2x-121 and methods for treating coronavirus infection
CN114053276B (zh) * 2020-07-30 2024-05-07 江苏天士力帝益药业有限公司 一种parp抑制剂tsl-1502中间体tsl-1502m的用途

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PT2209375E (pt) 2007-10-03 2014-10-08 Eisai Inc Compostos inibidores da parp, composições e métodos de uso
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Also Published As

Publication number Publication date
EP2209375A4 (en) 2011-03-09
US20090098084A1 (en) 2009-04-16
TWI426912B (zh) 2014-02-21
BRPI0820518A2 (pt) 2020-01-14
EP2209375A1 (en) 2010-07-28
RU2010117397A (ru) 2011-11-10
HK1146792A1 (en) 2011-07-15
HRP20140853T1 (hr) 2014-10-24
JP2010540655A (ja) 2010-12-24
IL204776A (en) 2015-09-24
KR101596526B1 (ko) 2016-02-22
AU2008308664B2 (en) 2014-07-17
PL2209375T3 (pl) 2014-12-31
US8236802B2 (en) 2012-08-07
SG185272A1 (en) 2012-11-29
EP2842956A1 (en) 2015-03-04
WO2009046205A1 (en) 2009-04-09
US20150141429A1 (en) 2015-05-21
RU2485122C2 (ru) 2013-06-20
CN102083314B (zh) 2014-04-30
CL2010000320A1 (es) 2011-03-11
MY155237A (en) 2015-09-30
CA2700903C (en) 2017-05-30
MX2010003564A (es) 2010-09-10
CN102083314A (zh) 2011-06-01
AU2008308664A1 (en) 2009-04-09
ZA201002317B (en) 2013-09-25
CA2700903A1 (en) 2009-04-09
UA99483C2 (ru) 2012-08-27
DK2209375T3 (da) 2014-10-06
JP5439380B2 (ja) 2014-03-12
BRPI0820518B1 (pt) 2021-09-28
TW200932239A (en) 2009-08-01
CY1115747T1 (el) 2017-01-25
EP2209375B1 (en) 2014-08-27
US20130011365A1 (en) 2013-01-10
IL204776A0 (en) 2010-11-30
JO3170B1 (ar) 2017-09-20
US8894989B2 (en) 2014-11-25
SI2209375T1 (sl) 2014-12-31
KR20100100771A (ko) 2010-09-15
ES2504690T3 (es) 2014-10-08
NZ585012A (en) 2012-06-29

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