PT1463506E - Derivados de quinazolina substituídos como inibidores de aurora cinases - Google Patents

Derivados de quinazolina substituídos como inibidores de aurora cinases Download PDF

Info

Publication number: PT1463506E
Authority: PT; Portugal
Prior art keywords: inhibitors; quinazoline derivatives; aurora kinases; substituted quinazoline; substituted
Prior art date: 2001-12-24

Application number

PT02788214T

Other languages

English (en)

Inventor

Georges Rene Pasquet

Frederic Henri Jung

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-24

Filing date

2002-12-20

Publication date

2009-12-10

2002-12-20 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2009-12-10 Publication of PT1463506E publication Critical patent/PT1463506E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PT02788214T 2001-12-24 2002-12-20 Derivados de quinazolina substituídos como inibidores de aurora cinases PT1463506E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01403357		2001-12-24

Publications (1)

Publication Number	Publication Date
PT1463506E true PT1463506E (pt)	2009-12-10

Family

ID=8183051

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT02788214T PT1463506E (pt)	2001-12-24	2002-12-20	Derivados de quinazolina substituídos como inibidores de aurora cinases

Country Status (32)

Country	Link
US (2)	US7402585B2 (pt)
EP (1)	EP1463506B1 (pt)
JP (1)	JP4498741B2 (pt)
KR (1)	KR101029281B1 (pt)
CN (1)	CN100491372C (pt)
AR (1)	AR038052A1 (pt)
AT (1)	ATE446093T1 (pt)
AU (1)	AU2002353196B2 (pt)
BR (1)	BRPI0215312B8 (pt)
CA (1)	CA2471577C (pt)
CY (1)	CY1109681T1 (pt)
DE (1)	DE60234125D1 (pt)
DK (1)	DK1463506T3 (pt)
ES (1)	ES2333702T3 (pt)
HK (1)	HK1076598A1 (pt)
HU (1)	HU229477B1 (pt)
IL (1)	IL162541A0 (pt)
IS (1)	IS2758B (pt)
MX (1)	MXPA04006260A (pt)
MY (1)	MY141739A (pt)
NO (1)	NO328159B1 (pt)
NZ (1)	NZ533440A (pt)
PL (1)	PL211694B1 (pt)
PT (1)	PT1463506E (pt)
RU (1)	RU2323215C2 (pt)
SA (1)	SA03230531B1 (pt)
SI (1)	SI1463506T1 (pt)
TW (1)	TWI335818B (pt)
UA (1)	UA82058C2 (pt)
UY (1)	UY27604A1 (pt)
WO (1)	WO2003055491A1 (pt)
ZA (1)	ZA200404923B (pt)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1330444B1 (en)	2000-11-01	2011-03-23	Millennium Pharmaceuticals, Inc.	Nitrogenous heterocyclic compounds and process for making them
AU2002353196B2 (en) *	2001-12-24	2008-01-17	Astrazeneca Ab	Substituted quinazoline derivatives as inhibitors of aurora kinases
JP4703183B2 (ja)	2002-07-15	2011-06-15	シンフォニーエボルーション，インク．	受容体型キナーゼモジュレーターおよびその使用方法
ATE438644T1 (de)	2002-12-24	2009-08-15	Astrazeneca Ab	Chinazolinderivate
EP1613619B1 (en)	2003-04-16	2008-03-26	AstraZeneca AB	Quinazoline derivatives for treatment of cancer
ATE401080T1 (de) *	2003-06-02	2008-08-15	Astrazeneca Ab	(3-((chinazolin-4-yl)amino)-1h-pyrazol-1- yl)acetamid derivate und verwandte verbindungen als aurora kinase inhibitoren zur behandlung von proliferativen erkrankungen wie krebs
TW200505452A (en) *	2003-06-17	2005-02-16	Astrazeneca Ab	Chemical compounds
CA2531142A1 (en) *	2003-07-03	2005-01-13	Cambridge University Technical Services Ltd	Use of aurora kinase inhibitors for reducing the resistance of cancer cells
DK1660090T3 (da) *	2003-08-14	2012-12-17	Array Biopharma Inc	Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer
ATE517091T1 (de)	2003-09-26	2011-08-15	Exelixis Inc	C-met-modulatoren und verwendungsverfahren
US20090099165A1 (en)	2003-10-14	2009-04-16	Arizona Board Of Regents On Behalf Of The University Of Arizona	Protein Kinase Inhibitors
PT1678166E (pt)	2003-10-14	2009-10-30	Supergen Inc	Inibidores de proteína-quinase
JP2007514759A (ja) *	2003-12-19	2007-06-07	タケダサンディエゴインコーポレイテッド	キナーゼ阻害剤
WO2005105788A1 (en) *	2004-04-23	2005-11-10	Takeda San Diego, Inc.	Indole derivatives and use thereof as kinase inhibitors
KR20080095915A (ko)	2004-05-06	2008-10-29	워너-램버트 캄파니 엘엘씨	4-페닐아미노-퀴나졸린-6-일-아미드
CA2573999A1 (en) *	2004-07-16	2006-04-06	Sunesis Pharmaceuticals, Inc.	Thienopyrimidines useful as aurora kinase inhibitors
WO2006023931A2 (en) *	2004-08-18	2006-03-02	Takeda San Diego, Inc.	Kinase inhibitors
TW200624431A (en) *	2004-09-24	2006-07-16	Hoffmann La Roche	Phthalazinone derivatives, their manufacture and use as pharmaceutical agents
KR20070084172A (ko)	2004-10-12	2007-08-24	아스트라제네카 아베	퀴나졸린 유도체
EP1812439B2 (en)	2004-10-15	2017-12-06	Takeda Pharmaceutical Company Limited	Kinase inhibitors
JP2008520713A (ja)	2004-11-17	2008-06-19	ミイカナセラピューティクスインコーポレイテッド	キナーゼ阻害剤
GB0427917D0 (en) *	2004-12-21	2005-01-26	Astrazeneca Ab	Chemical compounds
ES2545382T3 (es)	2005-04-28	2015-09-10	Mitsubishi Tanabe Pharma Corporation	Derivado de cianopiridina y su uso como medicamento
GB0510963D0 (en) *	2005-05-28	2005-07-06	Astrazeneca Ab	Chemical compounds
AU2006272876A1 (en) *	2005-07-22	2007-02-01	Sunesis Pharmaceuticals, Inc.	Pyrazolo pyrimidines useful as aurora kinase inhibitors
BRPI0616630B8 (pt) *	2005-09-30	2021-05-25	Miikana Therapeutics Inc	compostos de pirazol substituídos
US8119655B2 (en) *	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
GB0601215D0 (en) *	2006-01-21	2006-03-01	Astrazeneca Ab	Chemical compounds
DK1984353T3 (en)	2006-01-23	2016-03-14	Amgen Inc	Aurorakinasemodulatorer and method of use
US7560551B2 (en)	2006-01-23	2009-07-14	Amgen Inc.	Aurora kinase modulators and method of use
US7868177B2 (en)	2006-02-24	2011-01-11	Amgen Inc.	Multi-cyclic compounds and method of use
UY30183A1 (es)	2006-03-02	2007-10-31	Astrazeneca Ab	Derivados de quinolina
JP2009528336A (ja) *	2006-03-02	2009-08-06	アストラゼネカアクチボラグ	キノリン誘導体
CN101405001A (zh)	2006-03-20	2009-04-08	霍夫曼-拉罗奇有限公司	抑制btk和syk蛋白质激酶的方法
EP1999127A1 (en) *	2006-03-20	2008-12-10	F.Hoffmann-La Roche Ag	Phthalazinone pyrazole derivatives, their manufacture and use as pharmaceutical agents
GB0609617D0 (en)	2006-05-16	2006-06-21	Astrazeneca Ab	Process & intermediate
GB0609621D0 (en) *	2006-05-16	2006-06-21	Astrazeneca Ab	Novel co-crystal
WO2007136592A2 (en) *	2006-05-18	2007-11-29	Amphora Discovery Corporation	2-0x0-l,2-dihydr0quin0line derivatives, compositions, and uses thereof as antiproliferative agents
GB0619342D0 (en) *	2006-09-30	2006-11-08	Vernalis R&D Ltd	New chemical compounds
CA2664356A1 (en)	2006-10-05	2008-04-10	Banyu Pharmaceutical Co., Ltd.	Gene/protein marker for prediction or diagnosis of pharmacological efficacy of aurora a inhibitor
EP2223925A1 (en) *	2006-10-09	2010-09-01	Takeda Pharmaceutical Company Limited	Kinase inhibitors
JP2010505962A (ja)	2006-10-09	2010-02-25	武田薬品工業株式会社	キナーゼ阻害剤
EP2137177B1 (en)	2007-04-05	2014-05-07	Amgen, Inc	Aurora kinase modulators and method of use
WO2008154026A1 (en) *	2007-06-11	2008-12-18	Miikana Therapeutics, Inc.	Substituted pyrazole compounds
NZ582349A (en)	2007-06-29	2012-06-29	Sunesis Pharmaceuticals Inc	Heterocyclic compounds useful as raf kinase inhibitors
EP2262796A1 (en)	2008-03-04	2010-12-22	Vitae Pharmaceuticals, Inc.	Aurora kinase inhibitors
ES2413806T3 (es)	2008-03-20	2013-07-17	Amgen Inc.	Moduladores de la aurora cinasa y método de uso
US9126935B2 (en)	2008-08-14	2015-09-08	Amgen Inc.	Aurora kinase modulators and methods of use
EA026425B1 (ru)	2009-01-16	2017-04-28	Экселиксис, Инк.	Малатная соль n-(4-{[6,7-бис(метилокси)хинолин-4-ил]окси}фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида и ее кристаллические формы для лечения рака
CA2751886C (en) *	2009-02-11	2017-08-29	Merck Patent Gmbh	Novel amino azaheterocyclic carboxamides
UA108618C2 (uk)	2009-08-07	2015-05-25		Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
GB201007286D0 (en)	2010-04-30	2010-06-16	Astex Therapeutics Ltd	New compounds
GB201020179D0 (en)	2010-11-29	2011-01-12	Astex Therapeutics Ltd	New compounds
EP2465842A1 (de) *	2010-12-17	2012-06-20	Sika Technology AG	Amine mit sekundären aliphatischen Aminogruppen
EP2680844B1 (en)	2011-03-04	2016-10-19	GlaxoSmithKline Intellectual Property Development Limited	Amino-quinolines as kinase inhibitors
TWI547494B (zh)	2011-08-18	2016-09-01	葛蘭素史克智慧財產發展有限公司	作為激酶抑制劑之胺基喹唑啉類
GB201118656D0 (en)	2011-10-28	2011-12-07	Astex Therapeutics Ltd	New compounds
GB201118652D0 (en)	2011-10-28	2011-12-07	Astex Therapeutics Ltd	New compounds
GB201118654D0 (en)	2011-10-28	2011-12-07	Astex Therapeutics Ltd	New compounds
GB201118675D0 (en)	2011-10-28	2011-12-14	Astex Therapeutics Ltd	New compounds
CA2867467A1 (en)	2012-03-16	2013-09-19	Axikin Pharmaceuticals, Inc.	3,5-diaminopyrazole kinase inhibitors
WO2013143466A1 (zh) *	2012-03-27	2013-10-03	广东东阳光药业有限公司	作为欧若拉激酶抑制剂的取代嘧啶衍生物
GB201209613D0 (en)	2012-05-30	2012-07-11	Astex Therapeutics Ltd	New compounds
GB201209609D0 (en)	2012-05-30	2012-07-11	Astex Therapeutics Ltd	New compounds
TWI592417B (zh)	2012-09-13	2017-07-21	葛蘭素史克智慧財產發展有限公司	胺基喹唑啉激酶抑制劑之前藥
AR092530A1 (es)	2012-09-13	2015-04-22	Glaxosmithkline Llc	Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
CA2902132C (en) *	2013-02-21	2020-09-22	Glaxosmithkline Intellectual Property Development Limited	Quinazolines as kinase inhibitors
CN104098551B (zh) *	2013-04-03	2019-03-22	广东东阳光药业有限公司	作为欧若拉激酶抑制剂的取代喹唑啉类衍生物
GB201307577D0 (en)	2013-04-26	2013-06-12	Astex Therapeutics Ltd	New compounds
CA2922279C (en)	2013-09-16	2022-08-16	Astrazeneca Ab	Therapeutic polymeric nanoparticles and methods of making and using same
NZ631142A (en)	2013-09-18	2016-03-31	Axikin Pharmaceuticals Inc	Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
CA2929188C (en)	2013-11-20	2022-08-09	Signalchem Lifesciences Corp.	Quinazoline derivatives as tam family kinase inhibitors
CA2943682C (en)	2014-03-26	2024-02-13	Astex Therapeutics Ltd	Combinations of fgfr and cmet inhibitors and their use for the treatmentof cancer
JO3512B1 (ar)	2014-03-26	2020-07-05	Astex Therapeutics Ltd	مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
EP3122359B1 (en)	2014-03-26	2020-12-16	Astex Therapeutics Ltd.	Combinations of an fgfr inhibitor and an igf1r inhibitor
US9546163B2 (en)	2014-12-23	2017-01-17	Axikin Pharmaceuticals, Inc.	3,5-diaminopyrazole kinase inhibitors
JOP20200201A1 (ar)	2015-02-10	2017-06-16	Astex Therapeutics Ltd	تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
US10478494B2 (en)	2015-04-03	2019-11-19	Astex Therapeutics Ltd	FGFR/PD-1 combination therapy for the treatment of cancer
MX2018003563A (es)	2015-09-23	2018-06-18	Janssen Pharmaceutica Nv	Nuevos compuestos.
EP3353164B1 (en)	2015-09-23	2021-11-03	Janssen Pharmaceutica, N.V.	Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
CN112939948B (zh) *	2019-12-11	2022-05-17	苏州美诺医药科技有限公司	新型含喹唑啉类化合物及其中间体与应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL89029A (en)	1988-01-29	1993-01-31	Lilly Co Eli	Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them
WO1992020642A1 (en)	1991-05-10	1992-11-26	Rhone-Poulenc Rorer International (Holdings) Inc.	Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
US5721237A (en) *	1991-05-10	1998-02-24	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties
US5710158A (en) *	1991-05-10	1998-01-20	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5480883A (en) *	1991-05-10	1996-01-02	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
GB9510757D0 (en)	1994-09-19	1995-07-19	Wellcome Found	Therapeuticaly active compounds
TW321649B (pt)	1994-11-12	1997-12-01	Zeneca Ltd
GB9514265D0 (en)	1995-07-13	1995-09-13	Wellcome Found	Hetrocyclic compounds
ZA986732B (en)	1997-07-29	1999-02-02	Warner Lambert Co	Irreversible inhibitiors of tyrosine kinases
ATE294796T1 (de) *	1998-10-08	2005-05-15	Astrazeneca Ab	Chinazolin derivate
WO2001021596A1 (en) *	1999-09-21	2001-03-29	Astrazeneca Ab	Quinazoline derivatives and their use as pharmaceuticals
GB9922171D0 (en)	1999-09-21	1999-11-17	Zeneca Ltd	Chemical compounds
GB0006864D0 (en) *	2000-03-21	2000-05-10	Smithkline Beecham Plc	New use
HUP0301236A2 (hu) *	2000-06-28	2003-10-28	Astrazeneca Ab,	Szubsztituált kinazolinszármazékok és felhasználásuk inhibitorokként
US6610677B2 (en) *	2000-09-15	2003-08-26	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
GB0124299D0 (en) *	2001-10-10	2001-11-28	Astrazeneca Ab	Crystal structure of enzyme and uses thereof
AU2002353196B2 (en) *	2001-12-24	2008-01-17	Astrazeneca Ab	Substituted quinazoline derivatives as inhibitors of aurora kinases
US7105425B1 (en) *	2002-05-16	2006-09-12	Advanced Micro Devices, Inc.	Single electron devices formed by laser thermal annealing
ATE438644T1 (de) *	2002-12-24	2009-08-15	Astrazeneca Ab	Chinazolinderivate
EP1613619B1 (en) *	2003-04-16	2008-03-26	AstraZeneca AB	Quinazoline derivatives for treatment of cancer
ATE401080T1 (de) *	2003-06-02	2008-08-15	Astrazeneca Ab	(3-((chinazolin-4-yl)amino)-1h-pyrazol-1- yl)acetamid derivate und verwandte verbindungen als aurora kinase inhibitoren zur behandlung von proliferativen erkrankungen wie krebs
EP1802608A1 (en) *	2004-10-12	2007-07-04	AstraZeneca AB	Quinazoline derivatives for use against cancer
GB0427917D0 (en) *	2004-12-21	2005-01-26	Astrazeneca Ab	Chemical compounds
EP1888572A1 (en) *	2005-05-28	2008-02-20	AstraZeneca AB	Quinazolines and their use as aurora kinase inhibitors
GB0601215D0 (en) *	2006-01-21	2006-03-01	Astrazeneca Ab	Chemical compounds
GB0609617D0 (en) *	2006-05-16	2006-06-21	Astrazeneca Ab	Process & intermediate
GB0609619D0 (en) *	2006-05-16	2006-06-21	Astrazeneca Ab	Combination
GB0609621D0 (en) *	2006-05-16	2006-06-21	Astrazeneca Ab	Novel co-crystal
US20100004247A1 (en) *	2007-12-12	2010-01-07	Astrazeneca Ab	Combination comprising a mek inhibitor and an aurora kinase inhibitor 188

2002
- 2002-12-20 AU AU2002353196A patent/AU2002353196B2/en not_active Expired
- 2002-12-20 KR KR1020047010003A patent/KR101029281B1/ko active IP Right Grant
- 2002-12-20 US US10/499,684 patent/US7402585B2/en not_active Expired - Lifetime
- 2002-12-20 HU HU0402454A patent/HU229477B1/hu unknown
- 2002-12-20 UA UA20040706026A patent/UA82058C2/uk unknown
- 2002-12-20 PT PT02788214T patent/PT1463506E/pt unknown
- 2002-12-20 WO PCT/GB2002/005845 patent/WO2003055491A1/en active Application Filing
- 2002-12-20 NZ NZ533440A patent/NZ533440A/en not_active IP Right Cessation
- 2002-12-20 PL PL371253A patent/PL211694B1/pl unknown
- 2002-12-20 RU RU2004122926/04A patent/RU2323215C2/ru active
- 2002-12-20 DK DK02788214T patent/DK1463506T3/da active
- 2002-12-20 CA CA2471577A patent/CA2471577C/en not_active Expired - Lifetime
- 2002-12-20 JP JP2003556068A patent/JP4498741B2/ja not_active Expired - Lifetime
- 2002-12-20 ES ES02788214T patent/ES2333702T3/es not_active Expired - Lifetime
- 2002-12-20 IL IL16254102A patent/IL162541A0/xx unknown
- 2002-12-20 SI SI200230864T patent/SI1463506T1/sl unknown
- 2002-12-20 MX MXPA04006260A patent/MXPA04006260A/es active IP Right Grant
- 2002-12-20 BR BRPI0215312A patent/BRPI0215312B8/pt not_active IP Right Cessation
- 2002-12-20 EP EP02788214A patent/EP1463506B1/en not_active Expired - Lifetime
- 2002-12-20 DE DE60234125T patent/DE60234125D1/de not_active Expired - Lifetime
- 2002-12-20 CN CNB028283058A patent/CN100491372C/zh not_active Expired - Lifetime
- 2002-12-20 AT AT02788214T patent/ATE446093T1/de active
- 2002-12-23 AR ARP020105081A patent/AR038052A1/es active IP Right Grant
- 2002-12-23 MY MYPI20024859A patent/MY141739A/en unknown
- 2002-12-24 TW TW091137139A patent/TWI335818B/zh not_active IP Right Cessation
- 2002-12-24 UY UY27604A patent/UY27604A1/es not_active Application Discontinuation
2003
- 2003-01-28 SA SA03230531A patent/SA03230531B1/ar unknown
2004
- 2004-06-21 IS IS7328A patent/IS2758B/is unknown
- 2004-06-22 ZA ZA2004/04923A patent/ZA200404923B/en unknown
- 2004-07-23 NO NO20043158A patent/NO328159B1/no not_active IP Right Cessation
2005
- 2005-09-28 HK HK05108559.1A patent/HK1076598A1/xx not_active IP Right Cessation
2008
- 2008-05-28 US US12/128,479 patent/US20090215770A1/en not_active Abandoned
2009
- 2009-12-17 CY CY20091101316T patent/CY1109681T1/el unknown

Also Published As

Publication number	Publication date
CN100491372C (zh)	2009-05-27
CY1109681T1 (el)	2014-08-13
SA03230531A (ar)	2005-12-03
UA82058C2 (uk)	2008-03-11
NZ533440A (en)	2006-08-31
MXPA04006260A (es)	2005-03-31
MY141739A (en)	2010-06-15
BRPI0215312B8 (pt)	2021-05-25
CA2471577A1 (en)	2003-07-10
SI1463506T1 (sl)	2010-01-29
JP2005525307A (ja)	2005-08-25
ES2333702T3 (es)	2010-02-26
HUP0402454A3 (en)	2009-08-28
UY27604A1 (es)	2003-07-31
IL162541A0 (en)	2005-11-20
PL211694B1 (pl)	2012-06-29
AU2002353196A1 (en)	2003-07-15
EP1463506B1 (en)	2009-10-21
PL371253A1 (en)	2005-06-13
RU2004122926A (ru)	2005-07-10
KR20040066929A (ko)	2004-07-27
NO328159B1 (no)	2009-12-21
BR0215312A (pt)	2004-12-07
JP4498741B2 (ja)	2010-07-07
US7402585B2 (en)	2008-07-22
CN1620296A (zh)	2005-05-25
DE60234125D1 (de)	2009-12-03
DK1463506T3 (da)	2010-01-11
HK1076598A1 (en)	2006-01-20
TWI335818B (en)	2011-01-11
KR101029281B1 (ko)	2011-04-18
HU229477B1 (en)	2014-01-28
WO2003055491A1 (en)	2003-07-10
BRPI0215312B1 (pt)	2018-03-27
IS2758B (is)	2011-10-15
CA2471577C (en)	2011-08-02
TW200410697A (en)	2004-07-01
ZA200404923B (en)	2005-11-30
RU2323215C2 (ru)	2008-04-27
AU2002353196B2 (en)	2008-01-17
HUP0402454A2 (hu)	2005-03-29
US20090215770A1 (en)	2009-08-27
NO20043158L (no)	2004-09-16
SA03230531B1 (ar)	2008-09-08
EP1463506A1 (en)	2004-10-06
ATE446093T1 (de)	2009-11-15
IS7328A (is)	2004-06-21
AR038052A1 (es)	2004-12-22
US20050070561A1 (en)	2005-03-31

Publication	Publication Date	Title
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HK1079195A1 (en)	2006-03-31	Quinazoline derivatives as src tyrosine kinase inhibitors
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ZA200500492B (en)	2006-08-30	Novel inhibitors of kinases
AU2002255130A1 (en)	2002-11-18	Isoquinolinone derivatives as parp inhibitors
AU2002307475A1 (en)	2002-11-05	Inhibition of jun kinase