Nothing Special   »   [go: up one dir, main page]

PL381824A1 - The sequence of siRNA, vector, molecular target for siRNA reagents and vectors introduced to cells and tissues, the manner of assessment of specifity of silencing of a mutated transcript, the manner of testing of influences of RNA interference route of enz - Google Patents

The sequence of siRNA, vector, molecular target for siRNA reagents and vectors introduced to cells and tissues, the manner of assessment of specifity of silencing of a mutated transcript, the manner of testing of influences of RNA interference route of enz

Info

Publication number
PL381824A1
PL381824A1 PL381824A PL38182407A PL381824A1 PL 381824 A1 PL381824 A1 PL 381824A1 PL 381824 A PL381824 A PL 381824A PL 38182407 A PL38182407 A PL 38182407A PL 381824 A1 PL381824 A1 PL 381824A1
Authority
PL
Poland
Prior art keywords
manner
sirna
specifity
enz
silencing
Prior art date
Application number
PL381824A
Other languages
Polish (pl)
Inventor
Włodzimierz Krzyżosiak
Jacek Król
Agnieszka Fiszer
Original Assignee
Instytut Chemii Bioorganicznej Pan W Poznaniu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Chemii Bioorganicznej Pan W Poznaniu filed Critical Instytut Chemii Bioorganicznej Pan W Poznaniu
Priority to PL381824A priority Critical patent/PL381824A1/en
Priority to PCT/PL2008/000017 priority patent/WO2008103060A1/en
Publication of PL381824A1 publication Critical patent/PL381824A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL381824A 2007-02-22 2007-02-22 The sequence of siRNA, vector, molecular target for siRNA reagents and vectors introduced to cells and tissues, the manner of assessment of specifity of silencing of a mutated transcript, the manner of testing of influences of RNA interference route of enz PL381824A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL381824A PL381824A1 (en) 2007-02-22 2007-02-22 The sequence of siRNA, vector, molecular target for siRNA reagents and vectors introduced to cells and tissues, the manner of assessment of specifity of silencing of a mutated transcript, the manner of testing of influences of RNA interference route of enz
PCT/PL2008/000017 WO2008103060A1 (en) 2007-02-22 2008-02-15 A sirna sequence, vector, a molecular target for sirna reagents and vectors introduced into cells and tissues, a method of evaluating the specificity of the silencing of the mutated transcript, a method of examining the interactions of enzymes on the rnai pathway with transcripts as well as the application of the sirna sequ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL381824A PL381824A1 (en) 2007-02-22 2007-02-22 The sequence of siRNA, vector, molecular target for siRNA reagents and vectors introduced to cells and tissues, the manner of assessment of specifity of silencing of a mutated transcript, the manner of testing of influences of RNA interference route of enz

Publications (1)

Publication Number Publication Date
PL381824A1 true PL381824A1 (en) 2008-09-01

Family

ID=39472552

Family Applications (1)

Application Number Title Priority Date Filing Date
PL381824A PL381824A1 (en) 2007-02-22 2007-02-22 The sequence of siRNA, vector, molecular target for siRNA reagents and vectors introduced to cells and tissues, the manner of assessment of specifity of silencing of a mutated transcript, the manner of testing of influences of RNA interference route of enz

Country Status (2)

Country Link
PL (1) PL381824A1 (en)
WO (1) WO2008103060A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2914775T3 (en) 2007-10-26 2022-06-16 Academisch Ziekenhuis Leiden Means and methods for counteracting muscle disorders
EP2119783A1 (en) 2008-05-14 2009-11-18 Prosensa Technologies B.V. Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
NZ595955A (en) 2009-04-24 2012-10-26 Prosensa Technologies Bv Oligonucleotide comprising an inosine for treating dmd
CN112251436A (en) 2012-01-27 2021-01-22 比奥马林技术公司 RNA-regulated oligonucleotides with improved properties for the treatment of duchenne muscular dystrophy and becker muscular dystrophy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004239114B2 (en) * 2003-05-14 2008-03-13 Japan Science And Technology Agency Inhibition of the expression of huntingtin gene
US7947658B2 (en) * 2003-09-12 2011-05-24 University Of Massachusetts RNA interference for the treatment of gain-of-function disorders

Also Published As

Publication number Publication date
WO2008103060A1 (en) 2008-08-28

Similar Documents

Publication Publication Date Title
BRPI0906241A2 (en) Isolated nucleic acid molecule, chimeric gene, vector and method of transformation of a bacterial cell.
MX2010008099A (en) Stabilized angiopoietin-2 antibodies and uses thereof.
WO2008061213A3 (en) Genetic variations associated with tumors
WO2011079902A3 (en) Biological inhibitors of ror1 capable of inducing cell death
WO2009100188A3 (en) Methods for detection of corn event das-59132
EA201691664A1 (en) MUTED SYNTHASE ACETOHYDROXYLIC ACID SYNTHESIS IN Brassica
WO2009037438A8 (en) Improved detection of mage-a expression
WO2010062913A3 (en) Methods and systems for analysis of sequencing data
WO2009129505A3 (en) Compositions, methods, and kits using synthetic probes for determining the presence of a target nucleic acid
WO2010117817A3 (en) Methods for generating target specific probes for solution based capture
MX2010002113A (en) Methods for detecting oligonucleotides.
EP1766010A4 (en) ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON JUMPING AND METHODS OF USE
NZ588658A (en) Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
IL210026A (en) Non-small cell lung cancer detection marker, detection method thereof, related reagent kit and biochip
WO2012088348A3 (en) Fetal genetic variation detection
WO2010039852A3 (en) Improved antibody libraries
EA201171131A1 (en) IMPROVED DETERMINATION OF GENE EXPRESSION
WO2008147430A3 (en) Microrna-formatted multitarget interfering rna vector constructs and methods of using the same
EP2473631A4 (en) LINKED INDIA HAIRPIN DETECTION SYSTEM
MX2010001380A (en) In-situ hybridization to detect rna and dna markers.
PL381824A1 (en) The sequence of siRNA, vector, molecular target for siRNA reagents and vectors introduced to cells and tissues, the manner of assessment of specifity of silencing of a mutated transcript, the manner of testing of influences of RNA interference route of enz
PH12012500908A1 (en) Methods of propagating monkey adenoviral vectors
WO2011073675A3 (en) Assay for detecting chlamydia trachomatis
WO2010046493A3 (en) Gene transfer vectors comprising at least one isolated dna molecule having insulator and or boundary properties and methods to identify the same
EP2504348A4 (en) Methods, reagents and kits for detection of nucleic acid molecules

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)