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PL3092003T3 - Nowe przeciwciało przeciw netrynie-1 - Google Patents

Nowe przeciwciało przeciw netrynie-1

Info

Publication number
PL3092003T3
PL3092003T3 PL15700118T PL15700118T PL3092003T3 PL 3092003 T3 PL3092003 T3 PL 3092003T3 PL 15700118 T PL15700118 T PL 15700118T PL 15700118 T PL15700118 T PL 15700118T PL 3092003 T3 PL3092003 T3 PL 3092003T3
Authority
PL
Poland
Prior art keywords
netrin
antibody
novel anti
novel
Prior art date
Application number
PL15700118T
Other languages
English (en)
Inventor
Jean-Guy Delcros
Yann Dean
Original Assignee
Netris Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Netris Pharma filed Critical Netris Pharma
Publication of PL3092003T3 publication Critical patent/PL3092003T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PL15700118T 2014-01-10 2015-01-09 Nowe przeciwciało przeciw netrynie-1 PL3092003T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14305034.2A EP2893939A1 (en) 2014-01-10 2014-01-10 Anti-netrin-1 antibody
PCT/EP2015/050306 WO2015104360A1 (en) 2014-01-10 2015-01-09 Novel anti-netrin-1 antibody
EP15700118.1A EP3092003B1 (en) 2014-01-10 2015-01-09 Novel anti-netrin-1 antibody

Publications (1)

Publication Number Publication Date
PL3092003T3 true PL3092003T3 (pl) 2020-05-18

Family

ID=49958401

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15700118T PL3092003T3 (pl) 2014-01-10 2015-01-09 Nowe przeciwciało przeciw netrynie-1

Country Status (28)

Country Link
US (2) US10494427B2 (pl)
EP (2) EP2893939A1 (pl)
JP (1) JP6586095B2 (pl)
KR (1) KR102360967B1 (pl)
CN (1) CN105979966B (pl)
AR (1) AR099068A1 (pl)
AU (1) AU2015205575B2 (pl)
BR (1) BR112016015811B1 (pl)
CA (1) CA2936308C (pl)
CL (1) CL2016001753A1 (pl)
DK (1) DK3092003T3 (pl)
EA (1) EA034676B1 (pl)
ES (1) ES2770620T3 (pl)
HR (1) HRP20192313T1 (pl)
HU (1) HUE048088T2 (pl)
IL (1) IL246603B (pl)
LT (1) LT3092003T (pl)
MX (1) MX2016009029A (pl)
NZ (1) NZ721975A (pl)
PH (1) PH12016501339A1 (pl)
PL (1) PL3092003T3 (pl)
PT (1) PT3092003T (pl)
RS (1) RS59818B1 (pl)
SG (1) SG11201605562VA (pl)
SI (1) SI3092003T1 (pl)
TW (1) TWI699211B (pl)
WO (1) WO2015104360A1 (pl)
ZA (1) ZA201604640B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2893939A1 (en) * 2014-01-10 2015-07-15 Netris Pharma Anti-netrin-1 antibody
TW201720459A (zh) 2015-11-02 2017-06-16 妮翠斯製藥公司 Ntn1中和劑與抑制後生控制之藥物之組合治療
CN110291105B (zh) * 2017-01-05 2024-03-01 奈特里斯药物公司 导蛋白-1干扰药物和免疫检查点抑制剂药物的组合治疗
EP4037712A4 (en) * 2019-10-04 2023-11-01 Albert Einstein College of Medicine KIR3DL3 AS AN INHIBITOR RECEPTOR OF THE IMMUNE SYSTEM AND ITS USES
EP4377341A1 (en) 2021-07-27 2024-06-05 Netris Pharma Netrin-1 detection, companion test and therapy based on radiations
EP4245772A1 (en) 2022-03-18 2023-09-20 Netris Pharma Anti-netrin-1 antibody to treat liver inflammation
EP4249509A1 (en) 2022-03-22 2023-09-27 Netris Pharma Anti-netrin-1 antibody against arthritis-associated pain
WO2023186968A1 (en) 2022-03-29 2023-10-05 Netris Pharma Novel mcl-1 inhibitor and combination of mcl-1 and a bh3 mimetic, such as a bcl-2 inhibitor
WO2024180085A1 (en) 2023-02-27 2024-09-06 Netris Pharma Anti-netrin-1 monoclonal antibody for treating endometriosis and associated pains

Family Cites Families (35)

* Cited by examiner, † Cited by third party
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US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
US4716111A (en) 1982-08-11 1987-12-29 Trustees Of Boston University Process for producing human antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
WO1996033735A1 (en) 1995-04-27 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
EP2305027B1 (en) 1996-12-03 2014-07-02 Amgen Fremont Inc. Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
DK0970126T3 (da) 1997-04-14 2001-08-13 Micromet Ag Hidtil ukendt fremgangsmåde til fremstillingen af anti-humant antigen-receptorer og anvendelser deraf
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
AU2001293870A1 (en) 2000-10-16 2002-04-29 Bayer Aktiengesellschaft Regulation of human netrin binding membrane receptor unc5h-1
WO2005074556A2 (en) 2004-01-30 2005-08-18 The General Hospital Corporation Netrin compositions and methods of use thereof
CA2573720A1 (en) 2004-07-14 2006-02-23 University Of Utah Research Foundation Netrin-related compositions and uses
JP5089397B2 (ja) 2004-11-22 2012-12-05 サントル ナシオナル ドゥ ラ ルシェルシェ シアンティフィク 変異ネトリン4、その断片及びこれらの薬剤としての使用
FR2878165A1 (fr) * 2004-11-22 2006-05-26 Centre Nat Rech Scient Nouvelles utilisations des netrines
US20060153840A1 (en) 2005-01-12 2006-07-13 Anne Eichmann Methods for preventing or treating a condition or a disease associated with angiogenesis
SI1989546T1 (sl) * 2006-02-28 2016-12-30 Centre National De La Recherche Scientifique (Cnrs) Presejanje za spojine proti raku z uporabo aktivnosti netrina-1
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
WO2009141440A1 (en) 2008-05-21 2009-11-26 Centre National De La Recherche Scientifique (Cnrs) Netrin-1 overexpression as a biological marker and a survival factor for aggressive neuroblastoma
JP5147062B2 (ja) 2008-07-17 2013-02-20 Necトーキン株式会社 巻線部品
AR074369A1 (es) 2008-11-20 2011-01-12 Genentech Inc Anticuerpos anti-unc 5b (receptor de netrina) y metodos de uso
EP2208738A1 (en) * 2009-01-09 2010-07-21 Centre National pour la Recherche Scientifique (CNRS) Method for the selection of endothelial cells death inducers via netrin-1 and its applications
US8052960B2 (en) * 2009-01-20 2011-11-08 The Penn State Research Foundation Netrin-1 as a biomarker of injury and disease
US20130336972A1 (en) 2010-08-26 2013-12-19 Christian Klein Recombinant fc-fusion protein of the fifth fibronectin type iii domain of dcc
EP2708231A1 (en) * 2012-09-12 2014-03-19 Netris Pharma Combined treatment with netrin-1 interfering drug and chemotherapeutic drug
EP2708241A1 (en) * 2012-09-12 2014-03-19 Netris Pharma Recombinant Fc-fusion protein of the two Immunoglobulin domains of UNC5
AU2014295052B2 (en) * 2013-07-23 2018-08-30 Novaliq Gmbh Stabilized antibody compositions
EP2893939A1 (en) * 2014-01-10 2015-07-15 Netris Pharma Anti-netrin-1 antibody

Also Published As

Publication number Publication date
PT3092003T (pt) 2020-02-03
EP3092003B1 (en) 2019-11-06
IL246603A0 (en) 2016-08-31
US11648309B2 (en) 2023-05-16
DK3092003T3 (da) 2020-01-20
EP3092003A1 (en) 2016-11-16
SI3092003T1 (sl) 2020-03-31
WO2015104360A1 (en) 2015-07-16
HUE048088T2 (hu) 2020-05-28
US20180072800A1 (en) 2018-03-15
CL2016001753A1 (es) 2017-05-19
AU2015205575B2 (en) 2017-09-21
TWI699211B (zh) 2020-07-21
EP2893939A1 (en) 2015-07-15
US20200079842A1 (en) 2020-03-12
JP2017505607A (ja) 2017-02-23
PH12016501339B1 (en) 2016-08-15
US10494427B2 (en) 2019-12-03
KR20160106074A (ko) 2016-09-09
TW201605476A (zh) 2016-02-16
CA2936308A1 (en) 2015-07-16
RS59818B1 (sr) 2020-02-28
JP6586095B2 (ja) 2019-10-02
EA201691212A1 (ru) 2016-12-30
EA034676B1 (ru) 2020-03-05
CN105979966B (zh) 2021-06-08
AR099068A1 (es) 2016-06-29
CA2936308C (en) 2023-02-28
BR112016015811B1 (pt) 2023-09-26
SG11201605562VA (en) 2016-08-30
HRP20192313T1 (hr) 2020-03-20
BR112016015811A2 (pt) 2018-03-27
KR102360967B1 (ko) 2022-02-08
ES2770620T3 (es) 2020-07-02
ZA201604640B (en) 2019-03-27
MX2016009029A (es) 2016-09-09
NZ721975A (en) 2022-07-29
IL246603B (en) 2020-01-30
AU2015205575A1 (en) 2016-07-21
LT3092003T (lt) 2020-01-27
CN105979966A (zh) 2016-09-28
PH12016501339A1 (en) 2016-08-15

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