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PL2508523T5 - Odmiany polimorficzne dasatynibu i sposób ich wytwarzania - Google Patents

Odmiany polimorficzne dasatynibu i sposób ich wytwarzania

Info

Publication number
PL2508523T5
PL2508523T5 PL11194987T PL11194987T PL2508523T5 PL 2508523 T5 PL2508523 T5 PL 2508523T5 PL 11194987 T PL11194987 T PL 11194987T PL 11194987 T PL11194987 T PL 11194987T PL 2508523 T5 PL2508523 T5 PL 2508523T5
Authority
PL
Poland
Prior art keywords
dasatinib
polymorphs
preparation
Prior art date
Application number
PL11194987T
Other languages
English (en)
Other versions
PL2508523T3 (pl
Inventor
Ondrej Simo
Roman Gabriel
Jiri Filipcik
Alexandr Martaus
Alexandr Jegorov
Ales Gavenda
Judith Aronhime
Pavel Vraspir
Tamas Koltai
Jiri Faustmann
Original Assignee
Teva Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40580164&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2508523(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of PL2508523T3 publication Critical patent/PL2508523T3/pl
Publication of PL2508523T5 publication Critical patent/PL2508523T5/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL11194987T 2007-10-23 2008-10-23 Odmiany polimorficzne dasatynibu i sposób ich wytwarzania PL2508523T5 (pl)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US99999807P 2007-10-23 2007-10-23
US869907P 2007-12-20 2007-12-20
US1910608P 2008-01-04 2008-01-04
US3901108P 2008-03-24 2008-03-24
US4138408P 2008-04-01 2008-04-01
US5251308P 2008-05-12 2008-05-12
US5530908P 2008-05-22 2008-05-22
US5687608P 2008-05-29 2008-05-29
US6105408P 2008-06-12 2008-06-12
US7362808P 2008-06-18 2008-06-18
US7954808P 2008-07-10 2008-07-10
US8038208P 2008-07-14 2008-07-14
US9160708P 2008-08-25 2008-08-25
EP11194987.1A EP2508523B2 (en) 2007-10-23 2008-10-23 Polymorphs of dasatinib and process for preparation thereof
PCT/IB2008/003862 WO2009053854A2 (en) 2007-10-23 2008-10-23 Polymorphs of dasatinib and process for preparation thereof
EP08843260A EP2207777A2 (en) 2007-10-23 2008-10-23 Polymorphs of dasatinib and process for preparation thereof

Publications (2)

Publication Number Publication Date
PL2508523T3 PL2508523T3 (pl) 2016-06-30
PL2508523T5 true PL2508523T5 (pl) 2020-08-10

Family

ID=40580164

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11194987T PL2508523T5 (pl) 2007-10-23 2008-10-23 Odmiany polimorficzne dasatynibu i sposób ich wytwarzania

Country Status (8)

Country Link
US (2) US8067423B2 (pl)
EP (3) EP2537847A1 (pl)
JP (2) JP2010539156A (pl)
KR (2) KR20100058660A (pl)
ES (1) ES2565521T5 (pl)
HR (1) HRP20160208T4 (pl)
PL (1) PL2508523T5 (pl)
WO (1) WO2009053854A2 (pl)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
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WO2010067374A2 (en) * 2008-12-08 2010-06-17 Hetero Research Foundation Polymorphs of dasatinib
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WO2010139979A2 (en) * 2009-06-03 2010-12-09 Generics [Uk] Limited Processes for preparing crystalline forms
WO2010139981A2 (en) * 2009-06-03 2010-12-09 Generics [Uk] Limited Processes for preparing crystalline forms
KR101456347B1 (ko) * 2010-02-02 2014-11-03 난징 카벤디쉬 바이오-엔지니어링 테크놀러지 컴퍼니 리미티드 다사티닙의 합성방법 및 중간체
CN101812060B (zh) * 2010-02-02 2011-08-17 南京卡文迪许生物工程技术有限公司 一种简捷制备高纯度达沙替尼的新方法以及中间体化合物
EP2359813A1 (en) * 2010-02-04 2011-08-24 Ratiopharm GmbH Pharmaceutical composition comprising N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamid
CN102250084A (zh) * 2010-02-08 2011-11-23 南京卡文迪许生物工程技术有限公司 达沙替尼多晶型物及其制备方法和药用组合物
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CN104788446A (zh) * 2011-06-24 2015-07-22 南京圣和药业股份有限公司 无水达沙替尼的制备及精制方法
CN102898424A (zh) * 2011-07-29 2013-01-30 江苏奥赛康药业股份有限公司 达沙替尼新的多晶型物及其制备方法
CN104130251A (zh) * 2011-07-29 2014-11-05 江苏奥赛康药业股份有限公司 达沙替尼化合物及其制备方法
CN103059013B (zh) * 2011-10-18 2016-11-23 北京本草天源药物研究院 达沙替尼一水合物的晶型及其制备方法
WO2013065063A1 (en) 2011-11-03 2013-05-10 Cadila Healthcare Limited Anhydrous form of dasatinib, process for its preparation and its use
WO2013078973A1 (zh) * 2011-11-29 2013-06-06 上海创诺制药有限公司 一种大粒径达沙替尼及其制备和应用
CN102408423B (zh) * 2011-11-29 2013-12-25 上海希迪制药有限公司 一种制备大粒径达沙替尼的方法
CN104379582A (zh) * 2012-06-15 2015-02-25 巴斯夫欧洲公司 包含达沙替尼和所选择的共晶体形成剂的多组分晶体
CN103664929B (zh) * 2012-08-30 2016-08-03 石药集团中奇制药技术（石家庄）有限公司 达沙替尼多晶型药物及制备方法
CN103819469A (zh) * 2012-11-16 2014-05-28 重庆医药工业研究院有限责任公司 一种达沙替尼的晶型及其制备方法
CZ306598B6 (cs) * 2012-12-06 2017-03-22 Zentiva, K.S. Způsob přípravy a čištění nových i známých polymorfů a solvátů dasatinibu
US9249134B2 (en) * 2013-03-26 2016-02-02 Cadila Healthcare Limited Process for preparation of amorphous form of dasatinib
CN105377842A (zh) 2013-07-25 2016-03-02 巴斯夫欧洲公司 呈无定形形式的达沙替尼的盐
EP3024830A2 (en) 2013-07-25 2016-06-01 Basf Se Salts of dasatinib in crystalline form
CN104341410A (zh) * 2013-08-09 2015-02-11 上海科胜药物研发有限公司 一种达沙替尼新晶型及其制备方法
WO2015049645A2 (en) * 2013-10-04 2015-04-09 Alembic Pharmaceuticals Limited An improved process for the preparation of dasatinib
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CA2932353A1 (en) 2013-12-13 2015-06-18 Steven P. Treon Methods to treat lymphoplasmacytic lymphoma
CZ306732B6 (cs) * 2013-12-19 2017-05-31 Zentiva, K.S. Způsob přípravy bezvodé polymorfní formy N-6 Dasatinibu
WO2016001025A1 (en) 2014-06-30 2016-01-07 Basf Se Multicomponent crystals of dasatinib with menthol or vanillin
CN104327067B (zh) * 2014-10-11 2017-03-22 深圳市浩瑞实业发展有限公司 无定形达沙替尼的制备方法
JP6788583B2 (ja) 2014-10-22 2020-11-25 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド 増殖性疾患を処置するためのチアゾリル含有化合物
CN105130977B (zh) * 2015-07-22 2018-04-20 山东罗欣药业集团股份有限公司 一种达沙替尼化合物、及其组合物
CN105055327A (zh) * 2015-07-30 2015-11-18 青岛蓝盛洋医药生物科技有限责任公司 一种治疗血癌的药物达沙替尼组合物颗粒剂
CN104997737A (zh) * 2015-08-05 2015-10-28 青岛蓝盛洋医药生物科技有限责任公司 一种治疗白血病的药物达沙替尼组合物干混悬剂
CN105055367A (zh) * 2015-08-18 2015-11-18 青岛蓝盛洋医药生物科技有限责任公司 一种治疗白血病的药物达沙替尼组合物胶囊
CN105237529A (zh) * 2015-10-29 2016-01-13 四川协力制药有限公司 高纯度无水达沙替尼的精制方法
WO2017098391A1 (en) * 2015-12-11 2017-06-15 Shilpa Medicare Limited Process for the preparation of dasatinib
ES2794804T3 (es) * 2015-12-16 2020-11-19 Synthon Bv Composición farmacéutica que comprende dasatinib anhidro
WO2017108605A1 (en) 2015-12-22 2017-06-29 Synthon B.V. Pharmaceutical composition comprising amorphous dasatinib
CN105503854A (zh) * 2015-12-31 2016-04-20 哈药集团技术中心 一种达沙替尼无水合物的新晶型物及其制备方法
WO2017134617A1 (en) * 2016-02-03 2017-08-10 Dr. Reddy's Laboratories Limited Process for the preparation of amorphous dasatinib
US10464933B2 (en) * 2016-02-03 2019-11-05 Dr. Reddy's Laboratories Limited Solid state forms of dasatinib and processes for their preparation
WO2018078392A1 (en) * 2016-10-29 2018-05-03 Cipla Limited Polymorphs of dasatinib
US10800771B2 (en) 2016-12-01 2020-10-13 Natco Pharma Limited Process for the preparation of dasatinib polymorph
US11059813B2 (en) 2017-07-07 2021-07-13 Biocon Limited Polymorphic forms of Dasatinib
JP7166754B2 (ja) 2017-11-22 2022-11-08 沢井製薬株式会社 ダサチニブ無水物含有製剤
JP7249397B2 (ja) * 2017-12-27 2023-03-30 日本化薬株式会社 ダサチニブを有効成分とする医薬組成物
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WO2020217235A1 (en) * 2019-04-24 2020-10-29 Aizant Drug Research Solutions Private Limited Solid dosage form of dasatinib
US10799459B1 (en) 2019-05-17 2020-10-13 Xspray Microparticles Ab Rapidly disintegrating solid oral dosage forms containing dasatinib
KR20220032578A (ko) 2019-07-09 2022-03-15 엔테그리스, 아이엔씨. 옥시할라이드 전구체
CN112569236A (zh) * 2019-09-28 2021-03-30 鲁南制药集团股份有限公司 一种达沙替尼甲醇溶剂合物及其制备方法
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Also Published As

Publication number Publication date
EP2508523B2 (en) 2019-04-17
EP2508523B1 (en) 2016-02-17
JP2010539156A (ja) 2010-12-16
US20090118297A1 (en) 2009-05-07
JP6081763B2 (ja) 2017-02-15
US8067423B2 (en) 2011-11-29
ES2565521T5 (es) 2019-12-10
EP2207777A2 (en) 2010-07-21
PL2508523T3 (pl) 2016-06-30
JP2013047238A (ja) 2013-03-07
EP2508523A3 (en) 2013-02-27
WO2009053854A3 (en) 2009-12-03
EP2537847A1 (en) 2012-12-26
WO2009053854A2 (en) 2009-04-30
KR20100058660A (ko) 2010-06-03
EP2508523A2 (en) 2012-10-10
KR20120033357A (ko) 2012-04-06
US20100256158A1 (en) 2010-10-07
HRP20160208T4 (hr) 2019-08-09
HRP20160208T1 (hr) 2016-03-25
US7973045B2 (en) 2011-07-05
ES2565521T3 (es) 2016-04-05

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