PL2231636T3 - Pochodne pirazolowe i ich zastosowanie jako inhibitorów kinaz zależnych od cyklin - Google Patents
Pochodne pirazolowe i ich zastosowanie jako inhibitorów kinaz zależnych od cyklinInfo
- Publication number
- PL2231636T3 PL2231636T3 PL08857078T PL08857078T PL2231636T3 PL 2231636 T3 PL2231636 T3 PL 2231636T3 PL 08857078 T PL08857078 T PL 08857078T PL 08857078 T PL08857078 T PL 08857078T PL 2231636 T3 PL2231636 T3 PL 2231636T3
- Authority
- PL
- Poland
- Prior art keywords
- inhibitors
- pyrazole derivatives
- cyclin dependent
- dependent kinases
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1227607P | 2007-12-07 | 2007-12-07 | |
| PCT/EP2008/067037 WO2009071701A1 (en) | 2007-12-07 | 2008-12-08 | Pyrazole derivatives and use thereof as inhibitors of cyclin dependent kinases |
| EP08857078A EP2231636B1 (en) | 2007-12-07 | 2008-12-08 | Pyrazole derivatives and use thereof as inhibitors of cyclin dependent kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2231636T3 true PL2231636T3 (pl) | 2012-04-30 |
Family
ID=40343520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08857078T PL2231636T3 (pl) | 2007-12-07 | 2008-12-08 | Pochodne pirazolowe i ich zastosowanie jako inhibitorów kinaz zależnych od cyklin |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8367687B2 (pl) |
| EP (1) | EP2231636B1 (pl) |
| JP (1) | JP2011506303A (pl) |
| KR (1) | KR20100098521A (pl) |
| CN (1) | CN101883764B (pl) |
| AT (1) | ATE524459T1 (pl) |
| AU (1) | AU2008333136B2 (pl) |
| BR (1) | BRPI0821151A2 (pl) |
| CA (1) | CA2707989A1 (pl) |
| EA (1) | EA018459B1 (pl) |
| ES (1) | ES2374480T3 (pl) |
| MX (1) | MX2010006203A (pl) |
| PL (1) | PL2231636T3 (pl) |
| PT (1) | PT2231636E (pl) |
| WO (1) | WO2009071701A1 (pl) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009059943A1 (en) | 2007-11-05 | 2009-05-14 | Novartis Ag | 4-benzylamino-1-carboxyacyl-piperidine derivatives as cetp inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis |
| MX2010006063A (es) | 2007-12-03 | 2010-07-01 | Novartis Ag | Derivados de 4-bencil-amino-pirrolidina 1,2-disustituida como inhibidores de la proteina de transferencia de colesteril-ester (cetp) utiles para el tratamiento de las enfermedades tales como hiperlipidemia o arterioesclerosis. |
| KR20120016247A (ko) * | 2009-05-19 | 2012-02-23 | 다우 아그로사이언시즈 엘엘씨 | 진균 방제를 위한 화합물 및 방법 |
| MX2012011912A (es) * | 2010-04-13 | 2012-11-16 | Novartis Ag | Combinacion que comprende un inhibidor de cinasa 4 dependiente de ciclina o cinasa dependiente de ciclia (cdk4/6) y un inhibidor de mtor para tratar cancer. |
| CA2797947C (en) | 2010-06-04 | 2019-07-09 | Charles Baker-Glenn | Aminopyrimidine derivatives as lrrk2 modulators |
| GB201017345D0 (en) | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
| RS59106B1 (sr) | 2010-11-10 | 2019-09-30 | Genentech Inc | Derivati pirazol aminopirimidina kao lrrk2 modulatori |
| CA2830882C (en) | 2011-03-22 | 2021-03-16 | Dinesh Barawkar | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
| AU2012322660B2 (en) | 2011-10-11 | 2017-07-06 | Dana Farber Cancer Institute, Inc. | Pyrazol-3-ones that activate pro-apoptotic BAX |
| US9593115B2 (en) | 2012-09-21 | 2017-03-14 | Advinus Therapeutics Ltd. | Substituted fused tricyclic compounds, compositions, and medicinal applications thereof |
| UA118094C2 (uk) | 2012-11-21 | 2018-11-26 | Пітісі Терап'Ютикс, Інк. | Заміщені зворотні піримідинові інгібітори bmi-1 |
| AU2013399092A1 (en) * | 2013-08-30 | 2016-03-17 | Ptc Therapeutics, Inc. | Substituted pyrimidine Bmi-1 inhibitors |
| WO2015076800A1 (en) | 2013-11-21 | 2015-05-28 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine bmi-1 inhibitors |
| EA037555B1 (ru) | 2015-04-02 | 2021-04-13 | Проксимэйджен, Элэлси | Применение 6-{4-[1-(пропан-2-ил)пиперидин-4-ил]-1,4-диазепан-1-ил}-n-(пиридин-4-ил)пиридин-2-карбоксамида для лечения раковых заболеваний цнс |
| MX2018001395A (es) * | 2015-08-04 | 2018-04-13 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Derivados de pirazol pirimidina y sus usos. |
| CN118290402A (zh) | 2018-03-08 | 2024-07-05 | 因赛特公司 | 作为PI3K-γ抑制剂的氨基吡嗪二醇化合物 |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| EP3836932A2 (en) | 2018-08-17 | 2021-06-23 | PTC Therapeutics, Inc. | Method for treating pancreatic cancer |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| WO2020223558A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
| PE20221010A1 (es) | 2019-08-14 | 2022-06-15 | Incyte Corp | Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2 |
| MX2022004390A (es) | 2019-10-11 | 2022-08-08 | Incyte Corp | Aminas biciclicas como inhibidores de la cinasa dependiente de ciclina 2 (cdk2). |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| GB9919778D0 (en) * | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| US20020111353A1 (en) | 2000-12-05 | 2002-08-15 | Mark Ledeboer | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases |
| GB0107901D0 (en) * | 2001-03-29 | 2001-05-23 | Cyclacel Ltd | Anti-cancer compounds |
| WO2002092573A2 (en) | 2001-05-16 | 2002-11-21 | Vertex Pharmaceuticals Incorporated | Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases |
| ES2262899T3 (es) * | 2001-12-17 | 2006-12-01 | Smithkline Beecham Corporation | Derivados de pirazolopiridazina. |
| GB0215844D0 (en) | 2002-07-09 | 2002-08-14 | Novartis Ag | Organic compounds |
| WO2004035588A1 (en) | 2002-10-15 | 2004-04-29 | Smithkline Beecham Corporation | Pyradazine compounds as gsk-3 inhibitors |
| GB0409080D0 (en) * | 2004-04-23 | 2004-05-26 | Biofocus Discovery Ltd | Compounds which interact with protein kinases |
| US20080242667A1 (en) | 2005-08-26 | 2008-10-02 | Smithkline Beecham Corporation | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases |
| AU2007240860A1 (en) * | 2006-04-19 | 2007-11-01 | Merck Serono Sa | Novel heteroaryl-substituted arylaminopyridine derivatives as MEK inhibitors |
| WO2007132220A1 (en) | 2006-05-12 | 2007-11-22 | Cyclacel Limited | Combination of a 2-substituted-4-heter0aryl-pyrimidine amine with a cytotoxic drug and use thereof in the treatment of a proliferative disorder |
| AU2008277730B2 (en) * | 2007-07-13 | 2013-01-31 | Addex Pharma S.A. | Pyrazole derivatives as modulators of metabotropic glutamate receptors |
-
2008
- 2008-12-08 PL PL08857078T patent/PL2231636T3/pl unknown
- 2008-12-08 BR BRPI0821151-5A patent/BRPI0821151A2/pt not_active IP Right Cessation
- 2008-12-08 ES ES08857078T patent/ES2374480T3/es active Active
- 2008-12-08 AT AT08857078T patent/ATE524459T1/de active
- 2008-12-08 US US12/746,265 patent/US8367687B2/en not_active Expired - Fee Related
- 2008-12-08 WO PCT/EP2008/067037 patent/WO2009071701A1/en active Application Filing
- 2008-12-08 PT PT08857078T patent/PT2231636E/pt unknown
- 2008-12-08 EA EA201000879A patent/EA018459B1/ru not_active IP Right Cessation
- 2008-12-08 KR KR1020107012317A patent/KR20100098521A/ko not_active Application Discontinuation
- 2008-12-08 JP JP2010536492A patent/JP2011506303A/ja active Pending
- 2008-12-08 CN CN2008801187516A patent/CN101883764B/zh not_active Expired - Fee Related
- 2008-12-08 AU AU2008333136A patent/AU2008333136B2/en not_active Ceased
- 2008-12-08 EP EP08857078A patent/EP2231636B1/en not_active Not-in-force
- 2008-12-08 MX MX2010006203A patent/MX2010006203A/es active IP Right Grant
- 2008-12-08 CA CA2707989A patent/CA2707989A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0821151A2 (pt) | 2015-06-16 |
| KR20100098521A (ko) | 2010-09-07 |
| AU2008333136B2 (en) | 2012-05-10 |
| ES2374480T3 (es) | 2012-02-17 |
| WO2009071701A1 (en) | 2009-06-11 |
| US20100280033A1 (en) | 2010-11-04 |
| CN101883764B (zh) | 2013-11-13 |
| EP2231636A1 (en) | 2010-09-29 |
| EA018459B1 (ru) | 2013-08-30 |
| EP2231636B1 (en) | 2011-09-14 |
| ATE524459T1 (de) | 2011-09-15 |
| PT2231636E (pt) | 2012-01-02 |
| AU2008333136A1 (en) | 2009-06-11 |
| CN101883764A (zh) | 2010-11-10 |
| MX2010006203A (es) | 2010-06-25 |
| US8367687B2 (en) | 2013-02-05 |
| CA2707989A1 (en) | 2009-06-11 |
| JP2011506303A (ja) | 2011-03-03 |
| EA201000879A1 (ru) | 2010-12-30 |
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